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ARIC Publications

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Graff M, Justice AE, Young KL, et al. "Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry." Am J Hum Genet. 2021;108(4):564-582.
Raffield LM, Iyengar AK, Wang B, et al. "Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts." Am J Hum Genet. 2020;106(1):112-120.
Bick AG, Weinstock JS, Nandakumar SK, et al. "Inherited causes of clonal haematopoiesis in 97,691 whole genomes." Nature. 2020;586(7831):763-768.
Love S-AM, North KE, Zeng D, et al. "Nine-Year Ethanol Intake Trajectories and Their Association With 15-Year Cognitive Decline Among Black and White Adults." Am J Epidemiol. 2020;189(8):788-800.
Wojcik GL, Graff M, Nishimura KK, et al. "Genetic analyses of diverse populations improves discovery for complex traits." Nature. 2019;570(7762):514-518.
Kilpeläinen TO, Bentley AR, Noordam R, et al. "Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity." Nat Commun. 2019;10(1):376.
Folsom AR, Basu S, Hong C-P, Heckbert SR, Lutsey PL, Rosamond WD. "Reasons for Differences in the Incidence of Venous Thromboembolism in Black Versus White Americans." Am J Med. 2019;132(8):970-976.
Wang S, Fashanu OE, Zhao D, et al. "Relation of Elevated Resting Heart Rate in Mid-Life to Cognitive Decline Over 20 Years (from the Atherosclerosis Risk in Communities [ARIC] Study)." Am J Cardiol. 2019;123(2):334-340.
Nandakumar P, Morrison AC, Grove ML, Boerwinkle E. "Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation." Medicine (Baltimore). 2018;97(33):e11865.
Liu C, Marioni RE, Hedman ÅK, et al. "A DNA methylation biomarker of alcohol consumption." Mol Psychiatry. 2018;23(2):422-433.
Prins BP, Mead TJ, Brody JA, et al. "Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6." Genome Biol. 2018;19(1):87.
Robinson-Cohen C, Bartz TM, Lai D, et al. "Genetic Variants Associated with Circulating Fibroblast Growth Factor 23." J Am Soc Nephrol. 2018;29(10):2583-2592.
Xu J, Bartz TM, Chittoor G, et al. "Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function." Br J Nutr. 2018;120(10):1159-1170.
González HM, Tarraf W, Harrison K, et al. "Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results." Alzheimers Dement. 2018;14(5):579-589.
Wyss AB, Sofer T, Lee MKyeong, et al. "Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function." Nat Commun. 2018;9(1):2976.
Michaud DS, Lu J, Peacock-Villada AY, et al. "Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study." J Natl Cancer Inst. 2018;110(8):843-854.
Gottesman RF, Schneider ALC, Zhou Y, et al. "Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition." JAMA. 2017;317(14):1443-1450.
Gottesman RF, Albert MS, Alonso A, et al. "Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort." JAMA Neurol. 2017;74(10):1246-1254.
C Y Ng M, Graff M, Lu Y, et al. "Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium." PLoS Genet. 2017;13(4):e1006719.
Savoca MR, Steffen LM, Bertoni AG. "From Neighborhood to Genome: Three Decades of Nutrition-Related Research from the Atherosclerosis Risk in Communities Study." J Acad Nutr Diet. 2017;117(12):1881-1886.e10.
Yoneyama S, Yao J, Guo X, et al. "Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations." Int J Obes (Lond). 2017;41(2):324-331.
Bressler J, Mosley TH, Penman A, et al. "Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study." Am J Med Genet B Neuropsychiatr Genet. 2017;174(3):269-282.
Li M, Carey J, Cristiano S, et al. "Genome-Wide Association of Copy Number Polymorphisms and Kidney Function." PLoS One. 2017;12(1):e0170815.
B Windham G, Griswold ME, Wang W, et al. "The Importance of Mid-to-Late-Life Body Mass Index Trajectories on Late-Life Gait Speed." J Gerontol A Biol Sci Med Sci. 2017;72(8):1130-1136.
Bressler J, Yu B, Mosley TH, et al. "Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study." Transl Psychiatry. 2017;7(7):e1173.
Walker KA, Power MC, Hoogeveen RC, et al. "Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study." Stroke. 2017;48(12):3196-3202.
Chin K, Zhao D, Tibuakuu M, et al. "Physical Activity, Vitamin D, and Incident Atherosclerotic Cardiovascular Disease in Whites and Blacks: The ARIC Study." J Clin Endocrinol Metab. 2017;102(4):1227-1236.
Dong J, Pinto JM, Guo X, et al. "The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults." J Gerontol A Biol Sci Med Sci. 2017;72(8):1080-1086.
Nandakumar P, Lee D, Richard MA, et al. "Rare coding variants associated with blood pressure variation in 15 914 individuals of African ancestry." J Hypertens. 2017;35(7):1381-1389.
B Windham G, Harrison KL, Lirette ST, et al. "Relationship Between Midlife Cardiovascular Health and Late-Life Physical Performance: The ARIC Study." J Am Geriatr Soc. 2017;65(5):1012-1018.
Stevens J, Erber-Oakkar E, Cui Z, Cai J, Virani SS, Di Angelantonio E. "Cardiovascular disease risk by assigned treatment using the 2013 and 1998 obesity guidelines." Obesity (Silver Spring). 2016;24(7):1554-60.
Fox ER, Samdarshi TE, Musani SK, et al. "Development and Validation of Risk Prediction Models for Cardiovascular Events in Black Adults: The Jackson Heart Study Cohort." JAMA Cardiol. 2016;1(1):15-25.
McKibben RA, Zhao D, Lutsey PL, Schneider ALC, Guallar E, Mosley TH. "Factors Associated With Change in 25-Hydroxyvitamin D Levels Over Longitudinal Follow-Up in the ARIC Study." J Clin Endocrinol Metab. 2016;101(1):33-43.
Roberts JD, Hu D, Heckbert SR, et al. "Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals." JAMA Cardiol. 2016;1(4):442-50.
Ehret GB, Ferreira T, Chasman DI, et al. "The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals." Nat Genet. 2016;48(10):1171-1184.
Cheng Y-C, Stanne TM, Giese A-K, et al. "Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2." Stroke. 2016;47(2):307-16.
Bell EJ, Lutsey PL, Basu S, Cushman M, Heckbert SR, Lloyd-Jones DM. "Lifetime Risk of Venous Thromboembolism in Two Cohort Studies." Am J Med. 2016;129(3):339.e19-26.
Henderson CM, Lutsey PL, Misialek JR, Laha TJ, Selvin E, Eckfeldt JH. "Measurement by a Novel LC-MS/MS Methodology Reveals Similar Serum Concentrations of Vitamin D-Binding Protein in Blacks and Whites." Clin Chem. 2016;62(1):179-87.
Natarajan P, Bis JC, Bielak LF, et al. "Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis." Circ Cardiovasc Genet. 2016;9(6):511-520.
Zhang Z-M, Rautaharju PM, Prineas RJ, et al. "Race and Sex Differences in the Incidence and Prognostic Significance of Silent Myocardial Infarction in the Atherosclerosis Risk in Communities (ARIC) Study." Circulation. 2016;133(22):2141-8.
Magnani JW, Norby FL, Agarwal SK, Soliman EZ, Chen LYee, Loehr LR. "Racial Differences in Atrial Fibrillation-Related Cardiovascular Disease and Mortality: The Atherosclerosis Risk in Communities (ARIC) Study." JAMA Cardiol. 2016;1(4):433-41.
Kapoor A, Bakshy K, Xu L, et al. "Rare coding TTN variants are associated with electrocardiographic QT interval in the general population." Sci Rep. 2016;6:28356.
Yu B, Pulit SL, Hwang S-J, et al. "Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk." Circ Cardiovasc Genet. 2016;9(1):64-70.
Rooney MR, Pankow JS, Sibley SD, Selvin E, Reis JP, Michos ED. "Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study." Am J Clin Nutr. 2016;104(4):1023-1029.
Liu C-T, Raghavan S, Maruthur N, et al. "Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin." Am J Hum Genet. 2016;99(1):56-75.
Amendola LM, Dorschner MO, Robertson PD, et al. "Actionable exomic incidental findings in 6503 participants: challenges of variant classification." Genome Res. 2015;25(3):305-15.
Kim Y, Matsushita K, Sang Y, et al. "Association of high-sensitivity cardiac troponin T and natriuretic peptide with incident ESRD: the Atherosclerosis Risk in Communities (ARIC) study." Am J Kidney Dis. 2015;65(4):550-8.
Takiar R, Lutsey PL, Zhao D, et al. "The associations of 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms, and race with risk of incident fracture-related hospitalization: Twenty-year follow-up in a bi-ethnic cohort (the ARIC Study)." Bone. 2015;78:94-101.
Salfati E, Morrison AC, Boerwinkle E. "Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC)." PLoS One. 2015;10(7):e0133031.
Wei GS, Coady SA, Reis JP, et al. "Duration and Degree of Weight Gain and Incident Diabetes in Younger Versus Middle-Aged Black and White Adults: ARIC, CARDIA, and the Framingham Heart Study." Diabetes Care. 2015;38(11):2042-9.
Wessel J, Chu AY, Willems SM, et al. "Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility." Nat Commun. 2015;6:5897.
Song J, Chen F, Campos M, et al. "Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects." PLoS One. 2015;10(8):e0132626.
Reis JP, Michos ED, Selvin E, Pankow JS. "Race, vitamin D-binding protein gene polymorphisms, 25-hydroxyvitamin D, and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Clin Nutr. 2015;101(6):1232-40.
Power MC, Deal JA, Sharrett ARichey, Jack CR, Knopman D, Mosley TH. "Smoking and white matter hyperintensity progression: the ARIC-MRI Study." Neurology. 2015;84(8):841-8.
Schneider ALC, Lutsey PL, Selvin E, et al. "Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study." Eur J Neurol. 2015;22(8):1220-7.
Li J, Agarwal SK, Alonso A, et al. "Airflow obstruction, lung function, and incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study." Circulation. 2014;129(9):971-80.
Peloso GM, Auer PL, Bis JC, et al. "Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks." Am J Hum Genet. 2014;94(2):223-32.
Huxley RR, Bell EJ, Lutsey PL, et al. "A comparative analysis of risk factors for stroke in blacks and whites: the Atherosclerosis Risk in Communities study." Ethn Health. 2014;19(6):601-16.
Bekwelem W, Misialek JR, Konety S, et al. "Echocardiographic measures of cardiac structure and function are associated with risk of atrial fibrillation in blacks: the Atherosclerosis Risk in Communities (ARIC) study." PLoS One. 2014;9(10):e110111.
Jensen PN, Gronroos NN, Chen LYee, Folsom AR, deFilippi C, Heckbert SR. "Incidence of and risk factors for sick sinus syndrome in the general population." J Am Coll Cardiol. 2014;64(6):531-8.
Simino J, Kume R, Kraja AT, et al. "Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program." Atherosclerosis. 2014;235(1):84-93.
Crosby J, Peloso GM, Auer PL, et al. "Loss-of-function mutations in APOC3, triglycerides, and coronary disease." N Engl J Med. 2014;371(1):22-31.
Kocarnik JM, Pendergrass SA, Carty CL, et al. "Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study." Circ Cardiovasc Genet. 2014;7(2):178-88.
Zhou Z, Yu F, Buchanan A, et al. "Possible race and gender divergence in association of genetic variations with plasma von Willebrand factor: a study of ARIC and 1000 genome cohorts." PLoS One. 2014;9(1):e84810.
Zakai NA, McClure LA, Judd SE, Safford MM, Folsom AR, Lutsey PL. "Racial and regional differences in venous thromboembolism in the United States in 3 cohorts." Circulation. 2014;129(14):1502-9.
Maynard JW, McAdams-Demarco MA, Law A, Kao L, Gelber AC, Coresh JJ. "Racial differences in gout incidence in a population-based cohort: Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2014;179(5):576-83.
Wen CPang, Matsushita K, Coresh JJ, et al. "Relative risks of chronic kidney disease for mortality and end-stage renal disease across races are similar." Kidney Int. 2014;86(4):819-27.
Koton S, Schneider ALC, Rosamond WD, Shahar E, Sang Y, Gottesman RF. "Stroke incidence and mortality trends in US communities, 1987 to 2011." JAMA. 2014;312(3):259-68.
Cheng S, Claggett B, Correia AW, et al. "Temporal trends in the population attributable risk for cardiovascular disease: the Atherosclerosis Risk in Communities Study." Circulation. 2014;130(10):820-8.
Schneider ALC, Lutsey PL, Alonso A, et al. "Vitamin D and cognitive function and dementia risk in a biracial cohort: the ARIC Brain MRI Study." Eur J Neurol. 2014;21(9):1211-8, e69-70.
Michos ED, Carson KA, Schneider ALC, et al. "Vitamin D and subclinical cerebrovascular disease: the Atherosclerosis Risk in Communities brain magnetic resonance imaging study." JAMA Neurol. 2014;71(7):863-71.