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ARIC Publications

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2019
Tang W, Yao L, Hoogeveen RC, et al. "The Association of Biomarkers of Inflammation and Extracellular Matrix Degradation With the Risk of Abdominal Aortic Aneurysm: The ARIC Study." Angiology. 2019;70(2):130-140.
Wu A, Sharrett ARichey, Gottesman RF, et al. "Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment." JAMA Netw Open. 2019;2(5):e193359.
Patel RS, Schmidt AF, Tragante V, et al. "Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events." Circ Genom Precis Med. 2019;12(4):e002471.
Travis RC, Perez-Cornago A, Appleby PN, et al. "A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk." Cancer Res. 2019;79(1):274-285.
Flannick J, Mercader JM, Fuchsberger C, et al. "Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls." Nature. 2019;570(7759):71-76.
Sakornsakolpat P, Prokopenko D, Lamontagne M, et al. "Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations." Nat Genet. 2019;51(3):494-505.
Kunkle BW, Grenier-Boley B, Sims R, et al. "Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing." Nat Genet. 2019;51(3):414-430.
Irvin MR, Sitlani CM, Floyd JS, et al. "Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group." Am J Hypertens. 2019;32(12):1146-1153.
Marrone MT, Selvin E, Barber JR, Platz EA. "Hyperglycemia, Classified with Multiple Biomarkers Simultaneously in Men without Diabetes, and Risk of Fatal Prostate Cancer." Cancer Prev Res (Phila). 2019;12(2):103-112.
Lindström S, Brody JA, Turman C, et al. "A large-scale exome array analysis of venous thromboembolism." Genet Epidemiol. 2019;43(4):449-457.
Folsom AR, Tang W, Basu S, Misialek JR, Couper DJ, Heckbert SR. "Plasma Concentrations of High Molecular Weight Kininogen and Prekallikrein and Venous Thromboembolism Incidence in the General Population." Thromb Haemost. 2019;119(5):834-843.
Justice AE, Karaderi T, Highland HM, et al. "Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution." Nat Genet. 2019;51(3):452-469.
2018
Choi SHoan, Weng L-C, Roselli C, et al. "Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation." JAMA. 2018;320(22):2354-2364.
Blue EE, Bis JC, Dorschner MO, et al. "Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project." Dement Geriatr Cogn Disord. 2018;45(1-2):1-17.
Keaton JM, Gao C, Guan M, et al. "Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
Cowan LT, Lutsey PL, Pankow JS, Matsushita K, Ishigami J. "Inpatient and Outpatient Infection as a Trigger of Cardiovascular Disease: The ARIC Study." J Am Heart Assoc. 2018;7(22):e009683.
Roselli C, Chaffin MD, Weng L-C, et al. "Multi-ethnic genome-wide association study for atrial fibrillation." Nat Genet. 2018;50(9):1225-1233.
Keogh RH, Seaman SR, Bartlett JW. "Multiple imputation of missing data in nested case-control and case-cohort studies." Biometrics. 2018;74(4):1438-1449.
Rawlings AM, Sharrett ARichey, Golden SH, Windham BG. "Prevalence and correlates of depressive symptoms in older adults across the glycaemic spectrum: the Atherosclerosis Risk in Communities (ARIC) study." Diabet Med. 2018;35(5):583-587.
de Haan HG, A Vlieg vanHylckama, Lotta LA, et al. "Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes." J Thromb Haemost. 2018;16(12):2432-2441.
2017
Stitziel NO, Khera AV, Wang X, et al. "ANGPTL3 Deficiency and Protection Against Coronary Artery Disease." J Am Coll Cardiol. 2017;69(16):2054-2063.
Lindström S, Germain M, Crous-Bou M, et al. "Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study." Hum Genet. 2017;136(7):897-902.
Aro AL, Reinier K, Rusinaru C, et al. "Electrical risk score beyond the left ventricular ejection fraction: prediction of sudden cardiac death in the Oregon Sudden Unexpected Death Study and the Atherosclerosis Risk in Communities Study." Eur Heart J. 2017;38(40):3017-3025.
Gregson JM, Freitag DF, Surendran P, et al. "Genetic invalidation of Lp-PLA as a therapeutic target: Large-scale study of five functional Lp-PLA-lowering alleles." Eur J Prev Cardiol. 2017;24(5):492-504.
Keaton JM, Hellwege JN, C Y Ng M, et al. "GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS." Pac Symp Biocomput. 2017;22:242-253.
Sims R, van der Lee SJ, Naj AC, et al. "Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease." Nat Genet. 2017;49(9):1373-1384.
Liang J, Le TH, Edwards DRVelez, et al. "Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations." PLoS Genet. 2017;13(5):e1006728.
McMahon GM, Hwang S-J, Clish CB, et al. "Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease." Kidney Int. 2017;91(6):1426-1435.
2016
Rebholz CM, Grams ME, Lutsey PL, et al. "Biomarkers of Vitamin D Status and Risk of ESRD." Am J Kidney Dis. 2016;67(2):235-42.
Luft VC, Duncan BB, Schmidt MI, et al. "Carboxymethyl lysine, an advanced glycation end product, and incident diabetes: a case-cohort analysis of the ARIC Study." Diabet Med. 2016;33(10):1392-8.
Khera AV, Won H-H, Peloso GM, et al. "Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia." J Am Coll Cardiol. 2016;67(22):2578-89.
Joehanes R, Just AC, Marioni RE, et al. "Epigenetic Signatures of Cigarette Smoking." Circ Cardiovasc Genet. 2016;9(5):436-447.
Joshi AD, Andersson C, Buch S, et al. "Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies." Gastroenterology. 2016;151(2):351-363.e28.
Guo D-C, Grove ML, Prakash SK, et al. "Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections." Am J Hum Genet. 2016;99(3):762-769.
Cowan LT, Alonso A, Pankow JS, Folsom AR, Rosamond WD, Gottesman RF. "Hospitalized Infection as a Trigger for Acute Ischemic Stroke: The Atherosclerosis Risk in Communities Study." Stroke. 2016;47(6):1612-7.
"Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study." Lancet Neurol. 2016;15(2):174-184.
2015
Tandon A, Chen CJ, Penman A, et al. "African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans." Invest Ophthalmol Vis Sci. 2015;56(6):3999-4005.
Rebholz CM, Astor BC, Grams ME, et al. "Association of plasma levels of soluble receptor for advanced glycation end products and risk of kidney disease: the Atherosclerosis Risk in Communities study." Nephrol Dial Transplant. 2015;30(1):77-83.
Ray D, Li X, Pan W, Pankow JS. "A Bayesian Partitioning Model for the Detection of Multilocus Effects in Case-Control Studies." Hum Hered. 2015;79(2):69-79.
Do R, Stitziel NO, Won H-H, et al. "Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature. 2015;518(7537):102-6.
Nettleton JA, Follis JL, Ngwa JS, et al. "Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry." Hum Mol Genet. 2015;24(16):4728-38.
Gaulton KJ, Ferreira T, Lee Y, et al. "Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci." Nat Genet. 2015;47(12):1415-25.
Jansen H, Loley C, Lieb W, et al. "Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk." Atherosclerosis. 2015;241(2):419-26.
Xu H, Zhang H, Yang W, et al. "Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children." Nat Commun. 2015;6:7553.
Rebholz CM, Coresh JJ, Ballew SH, McMahon B, Whelton SP, Selvin E. "Kidney Failure and ESRD in the Atherosclerosis Risk in Communities (ARIC) Study: Comparing Ascertainment of Treated and Untreated Kidney Failure in a Cohort Study." Am J Kidney Dis. 2015;66(2):231-9.
Holmes MV, Asselbergs FW, Palmer TM, et al. "Mendelian randomization of blood lipids for coronary heart disease." Eur Heart J. 2015;36(9):539-50.
Carty CL, Keene KL, Cheng Y-C, et al. "Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans." Stroke. 2015;46(8):2063-8.
Zhao J, Zhu Y, Boerwinkle E. "Pathway analysis with next-generation sequencing data." Eur J Hum Genet. 2015;23(4):507-15.
Sanders AE, Divaris K, Naorungroj S, Heiss G. "Telomere length attrition and chronic periodontitis: an ARIC Study nested case-control study." J Clin Periodontol. 2015;42(1):12-20.
Foster MC, Coresh JJ, Bonventre JV, et al. "Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study." Clin J Am Soc Nephrol. 2015;10(11):1956-63.
2014
Dearborn JL, Schneider ALC, Gottesman RF, et al. "Adiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study." Neurology. 2014;83(24):2211-8.
Ageno W, Di Minno MND, Ay C, et al. "Association between the metabolic syndrome, its individual components, and unprovoked venous thromboembolism: results of a patient-level meta-analysis." Arterioscler Thromb Vasc Biol. 2014;34(11):2478-85.
Ilkhanoff L, Arking DE, Lemaitre RN, et al. "A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans." J Cardiovasc Electrophysiol. 2014;25(11):1150-7.
Lemaitre RN, Johnson CO, Hesselson S, et al. "Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest." Heart Rhythm. 2014;11(3):471-7.
Escott-Price V, Bellenguez C, San Wang L-, et al. "Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease." PLoS One. 2014;9(6):e94661.
Mahajan A, Go MJin, Zhang W, et al. "Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility." Nat Genet. 2014;46(3):234-44.
Holmes MV, Exeter HJ, Folkersen L, et al. "Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels." Circ Cardiovasc Genet. 2014;7(2):144-50.
Xing C, Dupuis J. "Performance of statistical methods on CHARGE targeted sequencing data." BMC Genet. 2014;15:104.
Ibrahim-Verbaas CA, Fornage M, Bis JC, et al. "Predicting stroke through genetic risk functions: the CHARGE Risk Score Project." Stroke. 2014;45(2):403-12.
2013
Adib-Samii P, Rost N, Traylor M, et al. "17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status." Stroke. 2013;44(6):1609-15.
Foster MC, Coresh JJ, Fornage M, et al. "APOL1 variants associate with increased risk of CKD among African Americans." J Am Soc Nephrol. 2013;24(9):1484-91.
Hamidovic A, Goodloe RJ, Young TR, et al. "Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites." J Clin Psychopharmacol. 2013;33(2):206-10.
Lieb W, Jansen H, Loley C, et al. "Genetic predisposition to higher blood pressure increases coronary artery disease risk." Hypertension. 2013;61(5):995-1001.
Tang W, Teichert M, Chasman DI, et al. "A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium." Genet Epidemiol. 2013;37(5):512-521.
Demerath EW, Liu C-T, Franceschini N, et al. "Genome-wide association study of age at menarche in African-American women." Hum Mol Genet. 2013;22(16):3329-46.
Berndt SI, Gustafsson S, Mägi R, et al. "Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture." Nat Genet. 2013;45(5):501-12.
Juraschek SP, Shantha GPalamaner, Chu AY, et al. "Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study." PLoS One. 2013;8(1):e55113.
Kang S, Cai J. "Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study." Biostatistics. 2013;14(1):28-41.
Monda KL, Chen GK, Taylor KC, et al. "A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry." Nat Genet. 2013;45(6):690-6.
Huxley RR, Norby FL, Maclehose RF, et al. "Novel association between plasma matrix metalloproteinase-9 and risk of incident atrial fibrillation in a case-cohort study: the Atherosclerosis Risk in Communities study." PLoS One. 2013;8(3):e59052.
Raynor LA, Pankow JS, Duncan BB, et al. "Novel risk factors and the prediction of type 2 diabetes in the Atherosclerosis Risk in Communities (ARIC) study." Diabetes Care. 2013;36(1):70-6.
Simone B, De Stefano V, Leoncini E, et al. "Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls." Eur J Epidemiol. 2013;28(8):621-47.
C Y Ng M, Saxena R, Li J, et al. "Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study." Diabetes. 2013;62(3):965-76.

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