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ARIC Publications

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Adib-Samii P, Rost N, Traylor M, et al. "17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status." Stroke. 2013;44(6):1609-15.
Ageno W, Di Minno MND, Ay C, et al. "Association between the metabolic syndrome, its individual components, and unprovoked venous thromboembolism: results of a patient-level meta-analysis." Arterioscler Thromb Vasc Biol. 2014;34(11):2478-85.
Aleksic N, Ahn C, Wang Y-W, et al. "Factor XIIIA Val34Leu polymorphism does not predict risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study." Arterioscler Thromb Vasc Biol. 2002;22(2):348-52.
Aleksic N, Folsom AR, Cushman M, Heckbert SR, Tsai MY, Wu KK. "Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE Study." J Thromb Haemost. 2003;1(1):88-94.
Aleksic N, Juneja H, Folsom AR, et al. "Platelet Pl(A2) allele and incidence of coronary heart disease: results from the Atherosclerosis Risk In Communities (ARIC) Study." Circulation. 2000;102(16):1901-5.
de Andrade M, Thandi I, Brown S, Gotto A, Patsch W, Boerwinkle E. "Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis." Am J Hum Genet. 1995;56(6):1379-90.
Arking DE, Reinier K, Post W, et al. "Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest." PLoS One. 2010;5(3):e9879.
Aro AL, Reinier K, Rusinaru C, et al. "Electrical risk score beyond the left ventricular ejection fraction: prediction of sudden cardiac death in the Oregon Sudden Unexpected Death Study and the Atherosclerosis Risk in Communities Study." Eur Heart J. 2017;38(40):3017-3025.
Assimes TL, Knowles JW, Priest JR, et al. "Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease." Hum Genet. 2008;123(4):399-408.
Astor BC, Köttgen A, Hwang S-J, Bhavsar N, Fox CS, Coresh J. "Trefoil factor 3 predicts incident chronic kidney disease: a case-control study nested within the Atherosclerosis Risk in Communities (ARIC) study." Am J Nephrol. 2011;34(4):291-7.
Bare LA, Morrison AC, Rowland CM, et al. "Five common gene variants identify elevated genetic risk for coronary heart disease." Genet Med. 2007;9(10):682-9.
Berndt SI, Gustafsson S, Mägi R, et al. "Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture." Nat Genet. 2013;45(5):501-12.
Bhavsar NA, Köttgen A, Coresh J, Astor BC. "Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Kidney Dis. 2012;60(2):233-40.
Blue EE, Bis JC, Dorschner MO, et al. "Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project." Dement Geriatr Cogn Disord. 2018;45(1-2):1-17.
Bressler J, Fornage M, Hanis CL, et al. "The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts." BMC Med Genet. 2009;10:56.
Bressler J, Folsom AR, Couper DJ, Volcik KA, Boerwinkle E. "Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study." Am J Epidemiol. 2010;171(1):14-23.
Brown SA, Morrisett JD, Boerwinkle E, Hutchinson R, Patsch W. "The relation of lipoprotein[a] concentrations and apolipoprotein[a] phenotypes with asymptomatic atherosclerosis in subjects of the Atherosclerosis Risk in Communities (ARIC) Study." Arterioscler Thromb. 1993;13(11):1558-66.
de Haan HG, A Vlieg vanHylckama, Lotta LA, et al. "Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes." J Thromb Haemost. 2018;16(12):2432-2441.
Deal JA, Power MC, Palta P, et al. "Relationship of Cigarette Smoking and Time of Quitting with Incident Dementia and Cognitive Decline." J Am Geriatr Soc. 2020;68(2):337-345.
Dearborn JL, Schneider ALC, Gottesman RF, et al. "Adiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study." Neurology. 2014;83(24):2211-8.
Dekker JM, Crow RS, Folsom AR, et al. "Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: the ARIC Study. Atherosclerosis Risk In Communities." Circulation. 2000;102(11):1239-44.
Demerath EW, Liu C-T, Franceschini N, et al. "Genome-wide association study of age at menarche in African-American women." Hum Mol Genet. 2013;22(16):3329-46.
Mahajan A, Go MJin, Zhang W, et al. "Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility." Nat Genet. 2014;46(3):234-44.
Do R, Stitziel NO, Won H-H, et al. "Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature. 2015;518(7537):102-6.
Duncan BB, Schmidt M I, Pankow JS, et al. "Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study." Diabetes. 2003;52(7):1799-805.
Elbein SC, Wang X, Karim MA, et al. "Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes." Diabetes. 2006;55(10):2909-14.
Ellinor PT, Lunetta KL, Glazer NL, et al. "Common variants in KCNN3 are associated with lone atrial fibrillation." Nat Genet. 2010;42(3):240-4.
Escott-Price V, Bellenguez C, San Wang L-, et al. "Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease." PLoS One. 2014;9(6):e94661.
Flannick J, Mercader JM, Fuchsberger C, et al. "Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls." Nature. 2019;570(7759):71-76.
Folsom AR, Cushman M, Heckbert SR, Rosamond WD, Aleksic N. "Prospective study of fibrinolytic markers and venous thromboembolism." J Clin Epidemiol. 2003;56(6):598-603.
Folsom AR, Tang W, Basu S, Misialek JR, Couper DJ, Heckbert SR. "Plasma Concentrations of High Molecular Weight Kininogen and Prekallikrein and Venous Thromboembolism Incidence in the General Population." Thromb Haemost. 2019;119(5):834-843.
Folsom AR, Cushman M, Tsai MY, Heckbert SR, Aleksic N. "Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism." Am J Hematol. 2002;71(4):285-90.
Folsom AR, Aleksic N, Catellier D, Juneja HS, Wu KK. "C-reactive protein and incident coronary heart disease in the Atherosclerosis Risk In Communities (ARIC) study." Am Heart J. 2002;144(2):233-8.
Folsom AR, Cushman M, Rasmussen-Torvik LJ, Heckbert SR, Tsai MY. "Prospective study of polymorphisms of the protein Z-dependent protease inhibitor and risk of venous thromboembolism." Thromb Haemost. 2007;97(3):493-4.
Foster MC, Coresh JJ, Fornage M, et al. "APOL1 variants associate with increased risk of CKD among African Americans." J Am Soc Nephrol. 2013;24(9):1484-91.
Foster MC, Coresh JJ, Bonventre JV, et al. "Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study." Clin J Am Soc Nephrol. 2015;10(11):1956-63.
Gaulton KJ, Ferreira T, Lee Y, et al. "Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci." Nat Genet. 2015;47(12):1415-25.
Ghaddar HB, Cortes J, Salomaa V, et al. "Correlation of specific platelet activation markers with carotid arterial wall thickness." Thromb Haemost. 1995;74(3):943-8.
Golden S H, Maguire A, Ding J, et al. "Endogenous postmenopausal hormones and carotid atherosclerosis: a case-control study of the atherosclerosis risk in communities cohort." Am J Epidemiol. 2002;155(5):437-45.
Golden S H, Ding J, Szklo M, Schmidt M I, Duncan BB, Dobs A. "Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study." Am J Epidemiol. 2004;160(6):540-8.
Gottesman RF, Cummiskey C, Chambless L, et al. "Hemostatic factors and subclinical brain infarction in a community-based sample: the ARIC study." Cerebrovasc Dis. 2009;28(6):589-94.
Gregson JM, Freitag DF, Surendran P, et al. "Genetic invalidation of Lp-PLA as a therapeutic target: Large-scale study of five functional Lp-PLA-lowering alleles." Eur J Prev Cardiol. 2017;24(5):492-504.
Guo D-C, Grove ML, Prakash SK, et al. "Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections." Am J Hum Genet. 2016;99(3):762-769.
Hallman MD, Brown SA, Ballantyne CM, A Sharrett R, Boerwinkle E. "Relationship between low-density lipoprotein subclasses and asymptomatic atherosclerosis in subjects from the Atherosclerosis Risk in Communities (ARIC) Study." Biomarkers. 2004;9(2):190-202.
Hamidovic A, Goodloe RJ, Young TR, et al. "Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites." J Clin Psychopharmacol. 2013;33(2):206-10.
He C, Chasman DI, Dreyfus J, et al. "Reproductive aging-associated common genetic variants and the risk of breast cancer." Breast Cancer Res. 2012;14(2):R54.
Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C. "Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study." Am J Epidemiol. 1991;134(3):250-6.
Holliday EG, Maguire JM, Evans T-J, et al. "Common variants at 6p21.1 are associated with large artery atherosclerotic stroke." Nat Genet. 2012;44(10):1147-51.
Holmes MV, Exeter HJ, Folkersen L, et al. "Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels." Circ Cardiovasc Genet. 2014;7(2):144-50.
Holmes MV, Asselbergs FW, Palmer TM, et al. "Mendelian randomization of blood lipids for coronary heart disease." Eur Heart J. 2015;36(9):539-50.
Hoogeveen RC, Ballantyne CM, Bang H, et al. "Circulating oxidised low-density lipoprotein and intercellular adhesion molecule-1 and risk of type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study." Diabetologia. 2007;50(1):36-42.
Hsu CC, Kao WL, Steffes MW, et al. "Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) study." BMC Med Genet. 2011;12:16.
Hunsberger S, Sorlie P, Geller NL. "Stochastic curtailing and conditional power in matched case-control studies." Stat Med. 1994;13(5-7):663-70.
Huxley RR, Lopez FL, Maclehose RF, et al. "Novel association between plasma matrix metalloproteinase-9 and risk of incident atrial fibrillation in a case-cohort study: the Atherosclerosis Risk in Communities study." PLoS One. 2013;8(3):e59052.
Jansen H, Loley C, Lieb W, et al. "Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk." Atherosclerosis. 2015;241(2):419-26.
Jehn ML, Guallar E, Clark JM, et al. "A prospective study of plasma ferritin level and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Epidemiol. 2007;165(9):1047-54.
Joehanes R, Just AC, Marioni RE, et al. "Epigenetic Signatures of Cigarette Smoking." Circ Cardiovasc Genet. 2016;9(5):436-447.
Joshi AD, Andersson C, Buch S, et al. "Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies." Gastroenterology. 2016;151(2):351-363.e28.
Juraschek SP, Shantha GPalamaner, Chu AY, et al. "Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study." PLoS One. 2013;8(1):e55113.
Justice AE, Karaderi T, Highland HM, et al. "Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution." Nat Genet. 2019;51(3):452-469.
Kang S, Cai J, Chambless L. "Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study." Biostatistics. 2013;14(1):28-41.
Keaton JM, Gao C, Guan M, et al. "Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
Keogh RH, Seaman SR, Bartlett JW. "Multiple imputation of missing data in nested case-control and case-cohort studies." Biometrics. 2018;74(4):1438-1449.
Khera AV, Won H-H, Peloso GM, et al. "Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia." J Am Coll Cardiol. 2016;67(22):2578-89.
Knol MJ, Lu D, Traylor M, et al. "Association of common genetic variants with brain microbleeds: A genome-wide association study." Neurology. 2020;95(24):e3331-e3343.
Knowles JW, Assimes TL, Boerwinkle E, et al. "Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD." BMC Med Genet. 2008;9:23.
Köttgen A, Hwang S-J, Larson MG, et al. "Uromodulin levels associate with a common UMOD variant and risk for incident CKD." J Am Soc Nephrol. 2010;21(2):337-44.
Kunkle BW, Grenier-Boley B, Sims R, et al. "Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing." Nat Genet. 2019;51(3):414-430.