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ARIC Publications

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1996
Surguchov AP, Page GP, Smith L, Patsch W, Boerwinkle E. "Polymorphic markers in apolipoprotein C-III gene flanking regions and hypertriglyceridemia." Arterioscler Thromb Vasc Biol. 1996;16(8):941-7.
Iso H, Harada S, Shimamoto T, et al. "Polymorphism of the apolipoprotein B gene and blood lipid concentrations in Japanese and Caucasian population samples." Atherosclerosis. 1996;126(2):233-41.
2000
Larson N, Hutchinson R, Boerwinkle E. "Lack of association of 3 functional gene variants with hypertension in African Americans." Hypertension. 2000;35(6):1297-300.
Aleksic N, Juneja H, Folsom AR, et al. "Platelet Pl(A2) allele and incidence of coronary heart disease: results from the Atherosclerosis Risk In Communities (ARIC) Study." Circulation. 2000;102(16):1901-5.
2001
Shachter NS. "Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism." Curr Opin Lipidol. 2001;12(3):297-304.
Folsom AR, Aleksic N, Ahn C, Boerwinkle E, Wu KK. "Beta-fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: the Atherosclerosis Risk in Communities (ARIC) Study." Ann Epidemiol. 2001;11(3):166-70.
Morrison AC, Doris PA, Folsom AR, Nieto FJ, Boerwinkle E. "G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical stroke." Stroke. 2001;32(4):822-9.
2002
Morrison AC, Bray MS, Folsom AR, Boerwinkle E. "ADD1 460W allele associated with cardiovascular disease in hypertensive individuals." Hypertension. 2002;39(6):1053-7.
Cakir B, Pankow JS, Salomaa V, et al. "Distribution of Lewis (FUT3)genotype and allele: frequencies in a biethnic United States population." Ann Hematol. 2002;81(10):558-65.
2004
Afshar-Kharghan V, Matijevic-Aleksic N, Ahn C, Boerwinkle E, Wu KK, López JA. "The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease." Blood. 2004;103(3):963-5.
2005
Blair CK, Folsom AR, Knopman DS, Bray MS, Mosley TH, Boerwinkle E. "APOE genotype and cognitive decline in a middle-aged cohort." Neurology. 2005;64(2):268-76.
2007
Liew G, Shankar A, Wang J J, et al. "Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study." Arch Ophthalmol. 2007;125(6):813-8.
Cushman M, Cornell A, Folsom AR, et al. "Associations of the beta-fibrinogen Hae III and factor XIII Val34Leu gene variants with venous thrombosis." Thromb Res. 2007;121(3):339-45.
McPherson R, Pertsemlidis A, Kavaslar N, et al. "A common allele on chromosome 9 associated with coronary heart disease." Science. 2007;316(5830):1488-91.
Folsom AR, Cushman M, Heckbert SR, Ohira T, Rasmussen-Torvik L, Tsai MY. "Factor VII coagulant activity, factor VII -670A/C and -402G/A polymorphisms, and risk of venous thromboembolism." J Thromb Haemost. 2007;5(8):1674-8.
2013
Fu W, O'Connor TD, Jun G, et al. "Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants." Nature. 2013;493(7431):216-20.
Maxwell TJ, Ballantyne CM, Cheverud JM, Guild CS, Ndumele CE. "APOE modulates the correlation between triglycerides, cholesterol, and CHD through pleiotropy, and gene-by-gene interactions." Genetics. 2013;195(4):1397-405.
Foster MC, Coresh JJ, Fornage M, et al. "APOL1 variants associate with increased risk of CKD among African Americans." J Am Soc Nephrol. 2013;24(9):1484-91.
Grove ML, Yu B, Cochran BJ, et al. "Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium." PLoS One. 2013;8(7):e68095.
Divaris K, Monda KL, North KE, et al. "Exploring the genetic basis of chronic periodontitis: a genome-wide association study." Hum Mol Genet. 2013;22(11):2312-24.
Lieb W, Jansen H, Loley C, et al. "Genetic predisposition to higher blood pressure increases coronary artery disease risk." Hypertension. 2013;61(5):995-1001.
Fesinmeyer MD, North KE, Ritchie MD, et al. "Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study." Obesity (Silver Spring). 2013;21(4):835-46.
Fesinmeyer MD, Meigs JB, North KE, et al. "Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study." BMC Med Genet. 2013;14:98.
Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA. "Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study." Genet Epidemiol. 2013;37(8):840-5.
Evans DM, Brion MJo A, Paternoster L, et al. "Mining the human phenome using allelic scores that index biological intermediates." PLoS Genet. 2013;9(10):e1003919.
Dastani Z, Johnson T, Kronenberg F, Nelson CP, Assimes TL, März W. "The shared allelic architecture of adiponectin levels and coronary artery disease." Atherosclerosis. 2013;229(1):145-8.
Peters U, North KE, Sethupathy P, et al. "A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study." PLoS Genet. 2013;9(1):e1003171.
2014
Carty CL, Bhattacharjee S, Haessler J, et al. "Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study." Circ Cardiovasc Genet. 2014;7(4):505-13.
Peloso GM, Auer PL, Bis JC, et al. "Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks." Am J Hum Genet. 2014;94(2):223-32.
Lemaitre RN, Johnson CO, Hesselson S, et al. "Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest." Heart Rhythm. 2014;11(3):471-7.
Qi Q, Kilpeläinen TO, Downer MK, et al. "FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals." Hum Mol Genet. 2014;23(25):6961-72.
Yu B, Zheng Y, Alexander D, Morrison AC, Coresh JJ. "Genetic determinants influencing human serum metabolome among African Americans." PLoS Genet. 2014;10(3):e1004212.
Mahajan A, Go MJin, Zhang W, et al. "Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility." Nat Genet. 2014;46(3):234-44.
Hardy DS, Racette SB. "Macronutrient intake as a mediator with FTO to increase body mass index." J Am Coll Nutr. 2014;33(4):256-66.
Holmes MV, Exeter HJ, Folkersen L, et al. "Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels." Circ Cardiovasc Genet. 2014;7(2):144-50.
Perry JRb, Day F, Elks CE, et al. "Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche." Nature. 2014;514(7520):92-97.
Tabor HK, Auer PL, Jamal SM, et al. "Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results." Am J Hum Genet. 2014;95(2):183-93.
2015
Chauhan G, Adams HHH, Bis JC, et al. "Association of Alzheimer's disease GWAS loci with MRI markers of brain aging." Neurobiol Aging. 2015;36(4):1765.e7-1765.e16.
Yu B, Li AH, Muzny D, et al. "Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine: Levels and Incident Coronary Heart Disease." Circ Cardiovasc Genet. 2015;8(2):351-5.
Takiar R, Lutsey PL, Zhao D, et al. "The associations of 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms, and race with risk of incident fracture-related hospitalization: Twenty-year follow-up in a bi-ethnic cohort (the ARIC Study)." Bone. 2015;78:94-101.
"Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis." Lancet Diabetes Endocrinol. 2015;3(4):243-53.
Do R, Stitziel NO, Won H-H, et al. "Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature. 2015;518(7537):102-6.
Holliday EG, Traylor M, Malik R, et al. "Genetic overlap between diagnostic subtypes of ischemic stroke." Stroke. 2015;46(3):615-9.
Maruthur NM, Li M, Halushka MK, et al. "Genetics of Plasma Soluble Receptor for Advanced Glycation End-Products and Cardiovascular Outcomes in a Community-based Population: Results from the Atherosclerosis Risk in Communities Study." PLoS One. 2015;10(6):e0128452.
Tin A, Grams ME, Maruthur NM, et al. "Hemostatic Factors, APOL1 Risk Variants, and the Risk of ESRD in the Atherosclerosis Risk in Communities Study." Clin J Am Soc Nephrol. 2015;10(5):784-90.
Pokharel Y, Sun W, Polfus LM, et al. "Lipoprotein associated phospholipase A2 activity, apolipoprotein C3 loss-of-function variants and cardiovascular disease: The Atherosclerosis Risk In Communities Study." Atherosclerosis. 2015;241(2):641-8.
Folsom AR, Tang W, Roetker NS, Heckbert SR, Cushman M. "Prospective study of circulating factor XI and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE)." Am J Hematol. 2015;90(11):1047-51.
2016
Gottesman RF, Schneider ALC, Zhou Y, et al. "The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE." Neurology. 2016;87(5):473-80.
Rosenthal EA, Makaryan V, Burt AA, et al. "Association Between Absolute Neutrophil Count and Variation at TCIRG1: The NHLBI Exome Sequencing Project." Genet Epidemiol. 2016;40(6):470-4.
van der Laan SW, Fall T, Soumaré A, et al. "Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study." J Am Coll Cardiol. 2016;68(9):934-45.
J Smith G, Felix JF, Morrison AC, et al. "Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure." PLoS Genet. 2016;12(5):e1006034.
Evans DS, Avery CL, Nalls MA, et al. "Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans." Hum Mol Genet. 2016;25(19):4350-4368.
Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen RC, Young JH. "GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study." Diabet Med. 2016;33(7):968-75.
Scott RA, Freitag DF, Li L, et al. "A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease." Sci Transl Med. 2016;8(341):341ra76.
Harel T, Yesil G, Bayram Y, et al. "Monoallelic and Biallelic Variants in EMC1 Identified in Individuals with Global Developmental Delay, Hypotonia, Scoliosis, and Cerebellar Atrophy." Am J Hum Genet. 2016;98(3):562-570.
Jensen RA, Sim X, Smith A V, et al. "Novel Genetic Loci Associated With Retinal Microvascular Diameter." Circ Cardiovasc Genet. 2016;9(1):45-54.
White J, Beck CR, Harel T, et al. "POGZ truncating alleles cause syndromic intellectual disability." Genome Med. 2016;8(1):3.

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