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ARIC Publications

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A
London SJ, Gao W, Gharib SA, et al. "ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):350-8.
Matsushita K, Ballew SH, Sang Y, et al. "Ankle-brachial index and physical function in older individuals: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2017;257:208-215.
Klein R, Sharrett AR, Klein BE, et al. "Are retinal arteriolar abnormalities related to atherosclerosis?: The Atherosclerosis Risk in Communities Study." Arterioscler Thromb Vasc Biol. 2000;20(6):1644-50.
Gottesman RF, Schneider ALC, Zhou Y, et al. "The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE." Neurology. 2016;87(5):473-80.
Chauhan G, Adams HHH, Bis JC, et al. "Association of Alzheimer's disease GWAS loci with MRI markers of brain aging." Neurobiol Aging. 2015;36(4):1765.e7-1765.e16.
Poon AK, Meyer ML, Tanaka H, et al. "Association of insulin resistance, from mid-life to late-life, with aortic stiffness in late-life: the Atherosclerosis Risk in Communities Study." Cardiovasc Diabetol. 2020;19(1):11.
Cornes BK, Brody JA, Nikpoor N, et al. "Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):374-382.
Ashar FN, Moes A, Moore AZ, et al. "Association of mitochondrial DNA levels with frailty and all-cause mortality." J Mol Med (Berl). 2015;93(2):177-186.
Conlan MG, Folsom AR, Finch A, et al. "Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study." Thromb Haemost. 1993;70(3):380-5.
B
Grove ML, Yu B, Cochran BJ, et al. "Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium." PLoS One. 2013;8(7):e68095.
Gottesman RF, Fornage M, Knopman DS. "Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience." Curr Alzheimer Res. 2015;12(7):607-13.
C
Knopman DS, Mosley TH, Catellier DJ, A Sharrett R. "Cardiovascular risk factors and cerebral atrophy in a middle-aged cohort." Neurology. 2005;65(6):876-81.
Knopman D, Boland LL, Mosley T, et al. "Cardiovascular risk factors and cognitive decline in middle-aged adults." Neurology. 2001;56(1):42-8.
Raina A, Zhao X, Grove ML, et al. "Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study." Clin Epigenetics. 2017;9:21.
Ben-Avraham D, Karasik D, Verghese J, et al. "The complex genetics of gait speed: genome-wide meta-analysis approach." Aging (Albany NY). 2017;9(1):209-246.
Cerhan JR, Folsom AR, Mortimer JA, et al. "Correlates of cognitive function in middle-aged adults. Atherosclerosis Risk in Communities (ARIC) Study Investigators." Gerontology. 1998;44(2):95-105.
D
Houston DK, Stevens J, Cai J, Haines PS. "Dairy, fruit, and vegetable intakes and functional limitations and disability in a biracial cohort: the Atherosclerosis Risk in Communities Study." Am J Clin Nutr. 2005;81(2):515-22.
Folsom AR, Wu KK, Rasmussen M, Chambless LE, Aleksic N, Nieto FJ. "Determinants of population changes in fibrinogen and factor VII over 6 years: the Atherosclerosis Risk in Communities (ARIC) Study." Arterioscler Thromb Vasc Biol. 2000;20(2):601-6.
Butler KR, Penman AD, Minor DS. "Determinants of pulse pressure and annual rates of change in the Atherosclerosis Risk in Communities study." J Hypertens. 2015;33(12):2463-70.
Ward-Caviness CK, Huffman JE, Everett K, et al. "DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis." Blood. 2018;132(17):1842-1850.
Chen BH, Marioni RE, Colicino E, et al. "DNA methylation-based measures of biological age: meta-analysis predicting time to death." Aging (Albany NY). 2016;8(9):1844-1865.
Howard G, Manolio TA, Burke GL, Wolfson SK, O'Leary DH. "Does the association of risk factors and atherosclerosis change with age? An analysis of the combined ARIC and CHS cohorts. The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS) investigators." Stroke. 1997;28(9):1693-701.
E
Bressler J, Marioni RE, Walker RM, et al. "Epigenetic Age Acceleration and Cognitive Function in African American Adults in Midlife: The Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2020;75(3):473-480.
Roberts JD, Vittinghoff E, Lu AT, et al. "Epigenetic Age and the Risk of Incident Atrial Fibrillation." Circulation. 2021;144(24):1899-1911.
F
Boerwinkle E. "Following-up genome-wide association study signals: lessons learned from Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):332-4.
G
Sitlani CM, Rice KM, Lumley T, et al. "Generalized estimating equations for genome-wide association studies using longitudinal phenotype data." Stat Med. 2015;34(1):118-30.
Hofer E, Roshchupkin GV, Adams HHH, et al. "Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults." Nat Commun. 2020;11(1):4796.
Hahn J, Fu Y-P, Brown MR, et al. "Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium." PLoS One. 2020;15(11):e0230035.
Dong J, Wyss A, Yang J, et al. "Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans." Mol Neurobiol. 2017;54(10):8021-8032.
Tang W, Teichert M, Chasman DI, et al. "A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium." Genet Epidemiol. 2013;37(5):512-521.
Walter S, Atzmon G, Demerath EW, et al. "A genome-wide association study of aging." Neurobiol Aging. 2011;32(11):2109.e15-28.
Guan W, Steffen BT, Lemaitre RN, et al. "Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2014;7(3):321-331.
Merino J, Dashti HS, Li SX, et al. "Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium." Mol Psychiatry. 2019;24(12):1920-1932.
Jones G, Trajanoska K, Santanasto AJ, et al. "Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women." Nat Commun. 2021;12(1):654.
Debette S, Verbaas CAIbrahim, Bressler J, et al. "Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium." Biol Psychiatry. 2015;77(8):749-63.
H
Tanaka H, Palta P, Folsom AR, et al. "Habitual physical activity and central artery stiffening in older adults: the Atherosclerosis Risk in Communities study." J Hypertens. 2018;36(9):1889-1894.
Wong E, Ballew SH, Daya N, et al. "Hospitalization Risk among Older Adults with Chronic Kidney Disease." Am J Nephrol. 2019;50(3):212-220.
I
Shah AM, Claggett B, Folsom AR, Lutsey PL, Ballantyne CM, Heiss G. "Ideal Cardiovascular Health During Adult Life and Cardiovascular Structure and Function Among the Elderly." Circulation. 2015;132(21):1979-89.
Miedema MD, Norby FL, Blaha MJ, Virani SS, Coresh JJ, Ballantyne CM. "Implications of the Eighth Joint National Committee Guidelines for the Management of High Blood Pressure for Aging Adults: Atherosclerosis Risk in Communities Study." Hypertension. 2015;66(3):474-80.
B Windham G, Griswold ME, Wang W, et al. "The Importance of Mid-to-Late-Life Body Mass Index Trajectories on Late-Life Gait Speed." J Gerontol A Biol Sci Med Sci. 2017;72(8):1130-1136.
Rywik SL, Williams OD, Pajak A, et al. "Incidence and correlates of hypertension in the Atherosclerosis Risk in Communities (ARIC) study and the Monitoring Trends and Determinants of Cardiovascular Disease (POL-MONICA) project." J Hypertens. 2000;18(8):999-1006.
Warren B, Rawlings AM, Lee AK, Grams M, Coresh JJ. "Increases in Biomarkers of Hyperglycemia With Age in the Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2017;40(8):e96-e97.
Graff M, Gordon-Larsen P, Lim U, et al. "The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study." Diabetes. 2013;62(5):1763-7.
K
Wattanakit K, Folsom AR, Selvin E, Coresh J, Hirsch AT, Weatherley BD. "Kidney function and risk of peripheral arterial disease: results from the Atherosclerosis Risk in Communities (ARIC) Study." J Am Soc Nephrol. 2007;18(2):629-36.
L
Day FR, Ruth KS, Thompson DJ, et al. "Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair." Nat Genet. 2015;47(11):1294-1303.
Power MC, Schneider ALC, Wruck L, et al. "Life-course blood pressure in relation to brain volumes." Alzheimers Dement. 2016;12(8):890-9.
M
Xu J, Bartz TM, Chittoor G, et al. "Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function." Br J Nutr. 2018;120(10):1159-1170.
Bis JC, Kavousi M, Franceschini N, et al. "Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque." Nat Genet. 2011;43(10):940-7.
González HM, Tarraf W, Harrison K, et al. "Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results." Alzheimers Dement. 2018;14(5):579-589.
Jia X, Sun C, Nambi V, et al. "Midlife determinants of healthy cardiovascular aging: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2022;350:82-89.
P
Seyerle AA, Sitlani CM, Noordam R, et al. "Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology." Pharmacogenomics J. 2018;18(2):215-226.
Beydoun MA, Kaufman JS, Satia JA, Rosamond W, Folsom AR. "Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study." Am J Clin Nutr. 2007;85(4):1103-11.
Dong J, Pinto JM, Guo X, et al. "The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults." J Gerontol A Biol Sci Med Sci. 2017;72(8):1080-1086.
de Moraes SA, Szklo M, Knopman D, Park E. "Prospective assessment of estrogen replacement therapy and cognitive functioning: atherosclerosis risk in communities study." Am J Epidemiol. 2001;154(8):733-9.
R
Pavlik VN, de Moraes S A, Szklo M, Knopman DS, Mosley TH, Hyman DJ. "Relation between cognitive function and mortality in middle-aged adults: the atherosclerosis risk in communities study." Am J Epidemiol. 2003;157(4):327-34.
Folsom AR, Eckfeldt JH, Weitzman S, et al. "Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators." Stroke. 1994;25(1):66-73.
Wong T Y, Klein R, A Sharrett R, et al. "Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons." JAMA. 2002;287(19):2528-33.
Wong TY, Mosley TH, Klein R, et al. "Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people." Neurology. 2003;61(6):806-11.
S
Morrison AC, Bis JC, Hwang S-J, et al. "Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study." PLoS One. 2014;9(10):e109155.
Liu C-T, Young KL, Brody JA, et al. "Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):344-9.
Bis JC, White CC, Franceschini N, et al. "Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):359-64.
Magnani JW, Brody JA, Prins BP, et al. "Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium." Circ Cardiovasc Genet. 2014;7(3):365-73.
Tsai AW, Cushman M, Tsai MY, et al. "Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE)." Am J Hematol. 2003;72(3):192-200.
Nadruz W, Claggett B, Gonçalves A, et al. "Smoking and Cardiac Structure and Function in the Elderly: The ARIC Study (Atherosclerosis Risk in Communities)." Circ Cardiovasc Imaging. 2016;9(9):e004950.
Diez Roux AV, Chambless L, Merkin S S, et al. "Socioeconomic disadvantage and change in blood pressure associated with aging." Circulation. 2002;106(6):703-10.
Lin H, Wang M, Brody JA, et al. "Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):335-43.
U
Riley WA, Barnes RW, Evans GW, Burke GL. "Ultrasonic measurement of the elastic modulus of the common carotid artery. The Atherosclerosis Risk in Communities (ARIC) Study." Stroke. 1992;23(7):952-6.
V
Guo X, Arsiwala LT, Dong Y, et al. "Visual Function, Physical Function, and Activities of Daily Living in Two Aging Communities." Transl Vis Sci Technol. 2021;10(14):15.