ARIC Publications
Filters: Keyword is Genetic Predisposition to Disease [Clear All Filters]
Kidney Risk Variants and Proteomics." Clin J Am Soc Nephrol. 2022;17(5):684-692.
"Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices." Nat Commun. 2021;12(1):2182.
"Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes." Nat Commun. 2021;12(1):3505.
"Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women." Nat Commun. 2021;12(1):654.
"Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts." Am J Hum Genet. 2020;106(1):112-120.
"Association of common genetic variants with brain microbleeds: A genome-wide association study." Neurology. 2020;95(24):e3331-e3343.
"Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities." Stroke. 2020;51(7):2111-2121.
"Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale." Nat Genet. 2020;52(9):969-983.
"Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke." Stroke. 2020;51(8):2454-2463.
"Inherited causes of clonal haematopoiesis in 97,691 whole genomes." Nature. 2020;586(7831):763-768.
"Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction." Nat Commun. 2020;11(1):2542.
"Rare and duplications containing in clubfoot." J Med Genet. 2020;57(12):851-857.
"Replication of Newly Identified Genetic Associations Between Abdominal Aortic Aneurysm and SMYD2, LINC00540, PCIF1/MMP9/ZNF335, and ERG." Eur J Vasc Endovasc Surg. 2020;59(1):92-97.
"Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events." Circ Genom Precis Med. 2019;12(4):e002471.
"A catalog of genetic loci associated with kidney function from analyses of a million individuals." Nat Genet. 2019;51(6):957-972.
"Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology." Am J Hum Genet. 2019;105(1):15-28.
"Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations." Nat Genet. 2019;51(3):494-505.
"Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing." Nat Genet. 2019;51(3):414-430.
"Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data." Nat Commun. 2019;10(1):2773.
"Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria." Nat Commun. 2019;10(1):4130.
"A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology." Blood. 2019;133(9):967-977.
"Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels." Circulation. 2019;139(5):620-635.
"Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease." Nat Commun. 2019;10(1):4267.
"Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium." Mol Psychiatry. 2019;24(12):1920-1932.
"Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism." Blood. 2019;134(19):1645-1657.
"HFE H63D Polymorphism and the Risk for Systemic Hypertension, Myocardial Remodeling, and Adverse Cardiovascular Events in the ARIC Study." Hypertension. 2019;73(1):68-74.
"A large-scale exome array analysis of venous thromboembolism." Genet Epidemiol. 2019;43(4):449-457.
"New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders." Nat Hum Behav. 2019;3(9):950-961.
"Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution." Nat Genet. 2019;51(3):452-469.
"Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels." Nat Genet. 2019;51(10):1459-1474.
" " "Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation." JAMA. 2018;320(22):2354-2364.
"Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation." Medicine (Baltimore). 2018;97(33):e11865.
"Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study." PLoS One. 2018;13(4):e0195719.
"Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits." Nat Genet. 2018;50(10):1412-1425.
"Genetic variants in microRNA genes and targets associated with cardiovascular disease risk factors in the African-American population." Hum Genet. 2018;137(1):85-94.
"Genetics of Obesity in Diverse Populations." Curr Diab Rep. 2018;18(12):145.
"Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE." Int J Obes (Lond). 2018;42(6):1161-1176.
"Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study." Diabetes. 2018;67(8):1684-1696.
"Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
"GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes." Nat Commun. 2018;9(1):5141.
"Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels." Nat Commun. 2018;9(1):4228.
"Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes." Nat Genet. 2018;50(4):524-537.
"Multi-ethnic genome-wide association study for atrial fibrillation." Nat Genet. 2018;50(9):1225-1233.
"Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function." Nat Commun. 2018;9(1):2976.
"Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries." PLoS One. 2018;13(6):e0198166.
"The PPARG Pro12Ala Polymorphism and 20-year Cognitive Decline: Race and Sex Heterogeneity." Alzheimer Dis Assoc Disord. 2018;32(2):131-136.
"Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes." Nat Genet. 2018;50(4):559-571.
"Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function." Nat Commun. 2018;9(1):2098.
"Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes." J Thromb Haemost. 2018;16(12):2432-2441.
"An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype." Biol Psychiatry. 2017;82(5):322-329.
"Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study." JAMA Oncol. 2017;3(5):636-651.
"Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos." J Dent Res. 2017;96(1):64-72.
"Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium." PLoS Genet. 2017;13(4):e1006719.
"Discovery of novel heart rate-associated loci using the Exome Chip." Hum Mol Genet. 2017;26(12):2346-2363.
"Epigenome-wide association studies identify DNA methylation associated with kidney function." Nat Commun. 2017;8(1):1286.
"Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index." Mol Psychiatry. 2017;22(2):192-201.
"Exome-wide association study of plasma lipids in >300,000 individuals." Nat Genet. 2017;49(12):1758-1766.
"Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms." Nat Genet. 2017;49(7):1113-1119.
"From Neighborhood to Genome: Three Decades of Nutrition-Related Research from the Atherosclerosis Risk in Communities Study." J Acad Nutr Diet. 2017;117(12):1881-1886.e10.
"Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations." Int J Obes (Lond). 2017;41(2):324-331.
"Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis." Nat Genet. 2017;49(3):426-432.
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