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ARIC Publications

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Chang AR, Grams ME, Ballew SH, et al. "Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium." BMJ. 2019;364:k5301.
Huang T, Wang T, Zheng Y, et al. "Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study." JAMA Netw Open. 2019;2(9):e1910915.
Mandaviya PR, Joehanes R, Brody J, et al. "Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals." Am J Clin Nutr. 2019;110(2):437-450.
Kytömaa S, Hegde S, Claggett B, et al. "Association of Influenza-like Illness Activity With Hospitalizations for Heart Failure: The Atherosclerosis Risk in Communities Study." JAMA Cardiol. 2019;4(4):363-369.
Walker KA, Sharrett ARichey, Wu A, et al. "Association of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia." JAMA. 2019;322(6):535-545.
Zhang Y, Vittinghoff E, Pletcher MJ, et al. "Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events." J Am Coll Cardiol. 2019;74(3):330-341.
Agha G, Mendelson MM, Ward-Caviness CK, et al. "Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease." Circulation. 2019;140(8):645-657.
Gregson J, Kaptoge S, Bolton T, et al. "Cardiovascular Risk Factors Associated With Venous Thromboembolism." JAMA Cardiol. 2019;4(2):163-173.
Georgakis MK, Malik R, Björkbacka H, et al. "Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals." Circ Res. 2019;125(8):773-782.
Sikdar S, Joehanes R, Joubert BR, et al. "Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking." Epigenomics. 2019;11(13):1487-1500.
Yu B, Zanetti KA, Temprosa M, et al. "The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies." Am J Epidemiol. 2019;188(6):991-1012.
George KM, Folsom AR, Steffen LM, Wagenknecht LE. "Differences in Cardiovascular Mortality Risk among African Americans in the Minnesota Heart Survey: 1985-2015 vs The Atherosclerosis Risk in Communities Study Cohort: 1987-2015." Ethn Dis. 2019;29(1):47-52.
Syme C, Shin J, Richer L, Gaudet D, Fornage M, Paus T. "Epigenetic Loci of Blood Pressure." Circ Genom Precis Med. 2019;12(1):e002341.
Spracklen CN, Karaderi T, Yaghootkar H, et al. "Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology." Am J Hum Genet. 2019;105(1):15-28.
Petty LE, Highland HM, Gamazon ER, et al. "Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample." Hum Mol Genet. 2019;28(7):1212-1224.
Sakornsakolpat P, Prokopenko D, Lamontagne M, et al. "Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations." Nat Genet. 2019;51(3):494-505.
Lutsey PL, Chen N, Mirabelli MC, et al. "Impaired Lung Function, Lung Disease, and Risk of Incident Dementia." Am J Respir Crit Care Med. 2019;199(11):1385-1396.
Pandey A, Patel KV, Vongpatanasin W, et al. "Incorporation of Biomarkers Into Risk Assessment for Allocation of Antihypertensive Medication According to the 2017 ACC/AHA High Blood Pressure Guideline: A Pooled Cohort Analysis." Circulation. 2019;140(25):2076-2088.
Liu J, Carnero-Montoro E, van Dongen J, et al. "An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis." Nat Commun. 2019;10(1):2581.
Matsushita K, Sang Y, Ning H, et al. "Lifetime Risk of Lower-Extremity Peripheral Artery Disease Defined by Ankle-Brachial Index in the United States." J Am Heart Assoc. 2019;8(18):e012177.
Gondalia R, Baldassari A, Holliday KM, et al. "Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation." Environ Int. 2019;132:104723.
de Vries PS, Brown MR, Bentley AR, et al. "Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions." Am J Epidemiol. 2019;188(6):1033-1054.
Bentley AR, Sung YJ, Brown MR, et al. "Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids." Nat Genet. 2019;51(4):636-648.
Noordam R, Bos MM, Wang H, et al. "Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration." Nat Commun. 2019;10(1):5121.
Kilpeläinen TO, Bentley AR, Noordam R, et al. "Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity." Nat Commun. 2019;10(1):376.
Evangelou E, Gao H, Chu C, et al. "New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders." Nat Hum Behav. 2019;3(9):950-961.
Matsushita K, Sang Y, Chen J, et al. "Novel "Predictor Patch" Method for Adding Predictors Using Estimates From Outside Datasets - A Proof-of-Concept Study Adding Kidney Measures to Cardiovascular Mortality Prediction." Circ J. 2019;83(9):1876-1882.
Merino J, Guasch-Ferré M, Ellervik C, et al. "Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis." BMJ. 2019;366:l4292.
Wang S, Fashanu OE, Zhao D, et al. "Relation of Elevated Resting Heart Rate in Mid-Life to Cognitive Decline Over 20 Years (from the Atherosclerosis Risk in Communities [ARIC] Study)." Am J Cardiol. 2019;123(2):334-340.
Alonso A, Yu B, Sun YV, et al. "Serum Metabolomics and Incidence of Atrial Fibrillation (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2019;123(12):1955-1961.
Lu J, Zaimi I, Barber JR, et al. "SES and correlated factors do not explain the association between periodontal disease, edentulism, and cancer risk." Ann Epidemiol. 2019;38:35-41.
Caughey MC, Derebail VK, Key NS, Reiner AP, Gottesman RF, Kshirsagar AV. "Thirty-year risk of ischemic stroke in individuals with sickle cell trait and modification by chronic kidney disease: The atherosclerosis risk in communities (ARIC) study." Am J Hematol. 2019;94(12):1306-1313.
Morris AP, Le TH, Wu H, et al. "Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies." Nat Commun. 2019;10(1):29.
Arora S, Stouffer GA, Kucharska-Newton AMaria, et al. "Twenty Year Trends and Sex Differences in Young Adults Hospitalized With Acute Myocardial Infarction." Circulation. 2019;139(8):1047-1056.
Kowalski MH, Qian H, Hou Z, et al. "Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations." PLoS Genet. 2019;15(12):e1008500.
Choi SHoan, Weng L-C, Roselli C, et al. "Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation." JAMA. 2018;320(22):2354-2364.
Walker KA, Gottesman RF, Wu A, et al. "Association of Hospitalization, Critical Illness, and Infection with Brain Structure in Older Adults." J Am Geriatr Soc. 2018;66(10):1919-1926.
Guo L, Akahori H, Harari E, et al. "CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis." J Clin Invest. 2018;128(3):1106-1124.
Lin H, van Setten J, Smith AV, et al. "Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval." Circ Genom Precis Med. 2018;11(5):e002037.
"Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies." Clin Chem. 2018;64(1):183-191.
Liu C, Marioni RE, Hedman ÅK, et al. "A DNA methylation biomarker of alcohol consumption." Mol Psychiatry. 2018;23(2):422-433.
Arora S, Matsushita K, Qamar A, R Stacey B. "Early versus late percutaneous revascularization in patients hospitalized with non ST-segment elevation myocardial infarction: The atherosclerosis risk in communities surveillance study." Catheter Cardiovasc Interv. 2018;91(2):253-259.
Wang X, Pan Y, Zhu H, et al. "An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression." Clin Epigenetics. 2018;10:3.
Arora S, Stouffer GA, Kucharska-Newton AMaria, et al. "Fifteen-Year Trends in Management and Outcomes of Non-ST-Segment-Elevation Myocardial Infarction Among Black and White Patients: The ARIC Community Surveillance Study, 2000-2014." J Am Heart Assoc. 2018;7(19):e010203.
Evangelou E, Warren HR, Mosen-Ansorena D, et al. "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits." Nat Genet. 2018;50(10):1412-1425.
Li C, Grove ML, Yu B, Jones BC, Morrison A, Boerwinkle E. "Genetic variants in microRNA genes and targets associated with cardiovascular disease risk factors in the African-American population." Hum Genet. 2018;137(1):85-94.
Ligthart S, Vaez A, Võsa U, et al. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders." Am J Hum Genet. 2018;103(5):691-706.
Klimentidis YC, Raichlen DA, Bea J, et al. "Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE." Int J Obes (Lond). 2018;42(6):1161-1176.
Loomis SJ, Li M, Maruthur NM, et al. "Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study." Diabetes. 2018;67(8):1684-1696.
Keaton JM, Gao C, Guan M, et al. "Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
Smith CE, Follis JL, Dashti HS, et al. "Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent." Mol Nutr Food Res. 2018;62(3).
"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017." Lancet. 2018;392(10159):1789-1858.
Oelsner EC, Balte PP, Cassano PA, et al. "Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study." Am J Epidemiol. 2018;187(11):2265-2278.
Lin J, Sun J, Wang S, et al. "In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study." Psychoneuroendocrinology. 2018;96:179-187.
Xu J, Bartz TM, Chittoor G, et al. "Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function." Br J Nutr. 2018;120(10):1159-1170.
Marioni RE, McRae AF, Bressler J, et al. "Meta-analysis of epigenome-wide association studies of cognitive abilities." Mol Psychiatry. 2018;23(11):2133-2144.
Geurts YM, Dugué P-A, Joo JE, et al. "Novel associations between blood DNA methylation and body mass index in middle-aged and older adults." Int J Obes (Lond). 2018;42(4):887-896.
Feitosa MF, Kraja AT, Chasman DI, et al. "Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries." PLoS One. 2018;13(6):e0198166.
Morelli T, Moss KL, Preisser JS, Beck JD, Divaris K, Wu D. "Periodontal profile classes predict periodontal disease progression and tooth loss." J Periodontol. 2018;89(2):148-156.
Seyerle AA, Sitlani CM, Noordam R, et al. "Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology." Pharmacogenomics J. 2018;18(2):215-226.
Turcot V, Lu Y, Highland HM, et al. "Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity." Nat Genet. 2018;50(1):26-41.
Rosenthal EA, Shirts BH, Amendola LM, et al. "Rare loss of function variants in candidate genes and risk of colorectal cancer." Hum Genet. 2018;137(10):795-806.
Davies G, Lam M, Harris SE, et al. "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function." Nat Commun. 2018;9(1):2098.
de Haan HG, A Vlieg vanHylckama, Lotta LA, et al. "Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes." J Thromb Haemost. 2018;16(12):2432-2441.
Hong J, Hatchell KE, Bradfield JP, et al. "Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations." J Clin Endocrinol Metab. 2018;103(4):1380-1392.
Ndumele CE, Cobb L, Lazo M, et al. "Weight History and Subclinical Myocardial Damage." Clin Chem. 2018;64(1):201-209.
Stitziel NO, Khera AV, Wang X, et al. "ANGPTL3 Deficiency and Protection Against Coronary Artery Disease." J Am Coll Cardiol. 2017;69(16):2054-2063.
Lindström S, Germain M, Crous-Bou M, et al. "Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study." Hum Genet. 2017;136(7):897-902.
Haycock PC, Burgess S, Nounu A, et al. "Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study." JAMA Oncol. 2017;3(5):636-651.
Gottesman RF, Albert MS, Alonso A, et al. "Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort." JAMA Neurol. 2017;74(10):1246-1254.
Agarwal SK, Norby FL, Whitsel EA, et al. "Cardiac Autonomic Dysfunction and Incidence of Atrial Fibrillation: Results From 20 Years Follow-Up." J Am Coll Cardiol. 2017;69(3):291-299.
Sanders AE, Sofer T, Wong Q, et al. "Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos." J Dent Res. 2017;96(1):64-72.
Jensen MK, Jensen RA, Mukamal KJ, et al. "Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium." Hum Mol Genet. 2017;26(11):2156-2163.
Haring B, Selvin E, Liang M, et al. "Dietary Protein Sources and Risk for Incident Chronic Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study." J Ren Nutr. 2017;27(4):233-242.
van den Berg ME, Warren HR, Cabrera CP, et al. "Discovery of novel heart rate-associated loci using the Exome Chip." Hum Mol Genet. 2017;26(12):2346-2363.