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ARIC Publications

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Rattani A, Claxton J'NS, Ali MK, Chen LYee, Soliman EZ. "Association and impact of hypertension defined using the 2017 AHA/ACC guidelines on the risk of atrial fibrillation in The Atherosclerosis Risk in Communities study." BMC Cardiovasc Disord. 2019;19(1):262.
Reed NS, Huddle MG, Betz J, et al. "Association of Midlife Hypertension with Late-Life Hearing Loss." Otolaryngol Head Neck Surg. 2019;161(6):996-1003.
Walker KA, Sharrett ARichey, Wu A, et al. "Association of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia." JAMA. 2019;322(6):535-545.
Zhang Y, Vittinghoff E, Pletcher MJ, et al. "Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events." J Am Coll Cardiol. 2019;74(3):330-341.
Palta P, Sharrett ARichey, Wei J, et al. "Central Arterial Stiffness Is Associated With Structural Brain Damage and Poorer Cognitive Performance: The ARIC Study." J Am Heart Assoc. 2019;8(2):e011045.
Syme C, Shin J, Richer L, Gaudet D, Fornage M, Paus T. "Epigenetic Loci of Blood Pressure." Circ Genom Precis Med. 2019;12(1):e002341.
Barrett JK, Huille R, Parker R, Yano Y. "Estimating the association between blood pressure variability and cardiovascular disease: An application using the ARIC Study." Stat Med. 2019;38(10):1855-1868.
Petty LE, Highland HM, Gamazon ER, et al. "Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample." Hum Mol Genet. 2019;28(7):1212-1224.
Irvin MR, Sitlani CM, Floyd JS, et al. "Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group." Am J Hypertens. 2019;32(12):1146-1153.
He KY, Li X, Kelly TN, et al. "Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data." Hum Genet. 2019;138(2):199-210.
Wang SY, Tan ASL, Claggett B, et al. "Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities Study." JAMA Cardiol. 2019;4(12):1203-1212.
Madan N, Lee AK, Matsushita K, Hoogeveen RC, Ballantyne CM, Selvin E. "Relation of Isolated Systolic Hypertension and Pulse Pressure to High-Sensitivity Cardiac Troponin-T and N-Terminal pro-B-Type Natriuretic Peptide in Older Adults (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2019;124(2):245-252.
Morris AP, Le TH, Wu H, et al. "Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies." Nat Commun. 2019;10(1):29.
Mok Y, Sang Y, Ballew SH, et al. "American Heart Association's Life's Simple 7 at Middle Age and Prognosis After Myocardial Infarction in Later Life." J Am Heart Assoc. 2018;7(4).
Rawlings AM, Juraschek SP, Heiss G, et al. "Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline." Neurology. 2018;91(8):e759-e768.
Nandakumar P, Morrison AC, Grove ML, Boerwinkle E. "Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation." Medicine (Baltimore). 2018;97(33):e11865.
Silvestre OM, Nadruz W, Roca GQuerejeta, et al. "Declining Lung Function and Cardiovascular Risk: The ARIC Study." J Am Coll Cardiol. 2018;72(10):1109-1122.
Warren B, Rebholz CM, Sang Y, Lee AK, Coresh JJ, Selvin E. "Diabetes and Trajectories of Estimated Glomerular Filtration Rate: A Prospective Cohort Analysis of the Atherosclerosis Risk in Communities Study." Diabetes Care. 2018;41(8):1646-1653.
Evangelou E, Warren HR, Mosen-Ansorena D, et al. "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits." Nat Genet. 2018;50(10):1412-1425.
Tanaka H, Palta P, Folsom AR, et al. "Habitual physical activity and central artery stiffening in older adults: the Atherosclerosis Risk in Communities study." J Hypertens. 2018;36(9):1889-1894.
Sengeløv M, Cheng S, Biering-Sørensen T, et al. "Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients." J Am Heart Assoc. 2018;7(3).
Sung YJ, Winkler TW, Fuentes Lde Las, et al. "A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure." Am J Hum Genet. 2018;102(3):375-400.
Yano Y, Griswold M, Wang W, et al. "Long-Term Blood Pressure Level and Variability From Midlife to Later Life and Subsequent Cognitive Change: The ARIC Neurocognitive Study." J Am Heart Assoc. 2018;7(15):e009578.
Gurka MJ, Guo Y, Filipp SL. "Metabolic syndrome severity is significantly associated with future coronary heart disease in Type 2 diabetes." Cardiovasc Diabetol. 2018;17(1):17.
Feitosa MF, Kraja AT, Chasman DI, et al. "Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries." PLoS One. 2018;13(6):e0198166.
Juraschek SP, Daya N, Appel LJ, et al. "Orthostatic Hypotension and Risk of Clinical and Subclinical Cardiovascular Disease in Middle-Aged Adults." J Am Heart Assoc. 2018;7(10).
Rebholz CM, Selvin E, Liang M, et al. "Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease." Kidney Int. 2018;93(1):252-259.
Kubota Y, Alonso A, Shah AM, Chen LYee. "Television Watching as Sedentary Behavior and Atrial Fibrillation: The Atherosclerosis Risk in Communities Study." J Phys Act Health. 2018;15(12):895-899.
Meyer ML, Palta P, Tanaka H, et al. "Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia: The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS)." J Alzheimers Dis. 2017;57(1):195-204.
Juraschek SP, Daya N, Rawlings AM, et al. "Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults." JAMA Intern Med. 2017;177(9):1316-1323.
Mahmoodi BK, Cushman M, Næss IAnne, et al. "Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies." Circulation. 2017;135(1):7-16.
Nadruz W, Kitzman D, Windham BGwen, et al. "Cardiovascular Dysfunction and Frailty Among Older Adults in the Community: The ARIC Study." J Gerontol A Biol Sci Med Sci. 2017;72(7):958-964.
Alburikan KA, Aldemerdash A, Savitz ST, et al. "Contribution of medications and risk factors to QTc interval lengthening in the atherosclerosis risk in communities (ARIC) study." J Eval Clin Pract. 2017;23(6):1274-1280.
Haring B, Selvin E, Liang M, et al. "Dietary Protein Sources and Risk for Incident Chronic Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study." J Ren Nutr. 2017;27(4):233-242.
Richard MA, Huan T, Ligthart S, et al. "DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation." Am J Hum Genet. 2017;101(6):888-902.
Smith JA, Zhao W, Yasutake K, et al. "Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies." Int J Environ Res Public Health. 2017;14(12).
Yong F, Heiss G, Couper DJ, Meyer ML, Cheng S. "Measurement Repeatability of Central and Peripheral Blood Pressures: The ARIC Study." Am J Hypertens. 2017;30(10):978-984.
Hess PL, Al-Khalidi HR, Friedman DJ, et al. "The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2017;6(8).
Balakrishnan P, Beaty T, Young HJ, Colantuoni E. "Methods to estimate underlying blood pressure: The Atherosclerosis Risk in Communities (ARIC) Study." PLoS One. 2017;12(7):e0179234.
Power MC, Tingle JV, Reid RI, et al. "Midlife and Late-Life Vascular Risk Factors and White Matter Microstructural Integrity: The Atherosclerosis Risk in Communities Neurocognitive Study." J Am Heart Assoc. 2017;6(5).
Kraja AT, Cook JP, Warren HR, et al. "New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals." Circ Cardiovasc Genet. 2017;10(5).
Juraschek SP, Daya N, Appel LJ, et al. "Orthostatic Hypotension in Middle-Age and Risk of Falls." Am J Hypertens. 2017;30(2):188-195.
Seidelmann SB, Vardeny O, Claggett B, et al. "An Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality." J Am Heart Assoc. 2017;6(4).
Nandakumar P, Lee D, Richard MA, et al. "Rare coding variants associated with blood pressure variation in 15 914 individuals of African ancestry." J Hypertens. 2017;35(7):1381-1389.
Liang J, Le TH, Edwards DRVelez, et al. "Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations." PLoS Genet. 2017;13(5):e1006728.
Wong ND, Zhao Y, Patel R, et al. "Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes: A Pooling Project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study." Diabetes Care. 2016;39(5):668-76.
Meyer ML, Tanaka H, Palta P, Cheng S, Gouskova N, Aguilar D. "Correlates of Segmental Pulse Wave Velocity in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study." Am J Hypertens. 2016;29(1):114-22.
McEvoy JW, Chen Y, Rawlings A, et al. "Diastolic Blood Pressure, Subclinical Myocardial Damage, and Cardiac Events: Implications for Blood Pressure Control." J Am Coll Cardiol. 2016;68(16):1713-1722.
Sung YJu, Winkler TW, Manning AK, et al. "An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group." Genet Epidemiol. 2016;40(5):404-15.
Ehret GB, Ferreira T, Chasman DI, et al. "The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals." Nat Genet. 2016;48(10):1171-1184.
Tanaka H, Heiss G, McCabe EL, et al. "Hemodynamic Correlates of Blood Pressure in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study." J Clin Hypertens (Greenwich). 2016;18(12):1222-1227.
Ogunwale AN, Morrison AC, Sun W, et al. "The impact of multiple single day blood pressure readings on cardiovascular risk estimation: The Atherosclerosis Risk in Communities study." Eur J Prev Cardiol. 2016;23(14):1529-36.
Power MC, Schneider ALC, Wruck L, et al. "Life-course blood pressure in relation to brain volumes." Alzheimers Dement. 2016;12(8):890-9.
Liu C, Kraja AT, Smith JA, et al. "Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci." Nat Genet. 2016;48(10):1162-70.
Bell EJ, Agarwal SK, Cushman M, Heckbert SR, Lutsey PL. "Orthostatic Hypotension and Risk of Venous Thromboembolism in 2 Cohort Studies." Am J Hypertens. 2016;29(5):634-40.
Santos ABS, Gupta DK, Bello NA, et al. "Prehypertension is Associated With Abnormalities of Cardiac Structure and Function in the Atherosclerosis Risk in Communities Study." Am J Hypertens. 2016;29(5):568-74.
Yu B, Pulit SL, Hwang S-J, et al. "Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk." Circ Cardiovasc Genet. 2016;9(1):64-70.
Tandon A, Chen CJ, Penman A, et al. "African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans." Invest Ophthalmol Vis Sci. 2015;56(6):3999-4005.
Folsom AR, Olson NC, Lutsey PL, Roetker NS. "American Heart Association's Life's Simple 7 and incidence of venous thromboembolism." Am J Hematol. 2015;90(5):E92.
Folsom AR, Shah AM, Lutsey PL, et al. "American Heart Association's Life's Simple 7: Avoiding Heart Failure and Preserving Cardiac Structure and Function." Am J Med. 2015;128(9):970-6.e2.
Butler KR, Penman AD, Minor DS. "Determinants of pulse pressure and annual rates of change in the Atherosclerosis Risk in Communities study." J Hypertens. 2015;33(12):2463-70.
Salfati E, Morrison AC, Boerwinkle E. "Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC)." PLoS One. 2015;10(7):e0133031.
Joshi PK, Esko T, Mattsson H, et al. "Directional dominance on stature and cognition in diverse human populations." Nature. 2015;523(7561):459-462.
Pokharel Y, Sun W, de Lemos JA, et al. "High-sensitivity troponin T and cardiovascular events in systolic blood pressure categories: atherosclerosis risk in communities study." Hypertension. 2015;65(1):78-84.
Miedema MD, Norby FL, Blaha MJ, Virani SS, Coresh JJ, Ballantyne CM. "Implications of the Eighth Joint National Committee Guidelines for the Management of High Blood Pressure for Aging Adults: Atherosclerosis Risk in Communities Study." Hypertension. 2015;66(3):474-80.
Parrinello CM, Rastegar I, Godino JG, Miedema MD, Matsushita K. "Prevalence of and Racial Disparities in Risk Factor Control in Older Adults With Diabetes: The Atherosclerosis Risk in Communities Study." Diabetes Care. 2015;38(7):1290-8.
Hardy ST, Loehr LR, Butler KR, et al. "Reducing the Blood Pressure-Related Burden of Cardiovascular Disease: Impact of Achievable Improvements in Blood Pressure Prevention and Control." J Am Heart Assoc. 2015;4(10):e002276.
Holmes MV, Lange LA, Palmer T, et al. "Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis." Am J Hum Genet. 2014;94(2):198-208.
Huxley RR, Bell EJ, Lutsey PL, et al. "A comparative analysis of risk factors for stroke in blacks and whites: the Atherosclerosis Risk in Communities study." Ethn Health. 2014;19(6):601-16.
Ganesh SK, Chasman DI, Larson MG, et al. "Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations." Am J Hum Genet. 2014;95(1):49-65.
Simino J, Shi G, Bis JC, et al. "Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia." Am J Hum Genet. 2014;95(1):24-38.
Tragante V, Barnes MR, Ganesh SK, et al. "Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci." Am J Hum Genet. 2014;94(3):349-60.
Simino J, Kume R, Kraja AT, et al. "Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program." Atherosclerosis. 2014;235(1):84-93.
Morrison AC, Bis JC, Hwang S-J, et al. "Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study." PLoS One. 2014;9(10):e109155.
Rodriguez CJ, Swett K, Agarwal SK, et al. "Systolic blood pressure levels among adults with hypertension and incident cardiovascular events: the atherosclerosis risk in communities study." JAMA Intern Med. 2014;174(8):1252-61.