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ARIC Publications

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2022
Jia X, Sun C, Nambi V, et al. "Midlife determinants of healthy cardiovascular aging: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2022;350:82-89.
2021
Zhang Y, Pletcher MJ, Vittinghoff E, et al. "Association Between Cumulative Low-Density Lipoprotein Cholesterol Exposure During Young Adulthood and Middle Age and Risk of Cardiovascular Events." JAMA Cardiol. 2021;6(12):1406-1413.
Kou M, Ding N, Ballew SH, et al. "Conventional and Novel Lipid Measures and Risk of Peripheral Artery Disease." Arterioscler Thromb Vasc Biol. 2021;41(3):1229-1238.
2020
Bennett EE, Gianattasio KZ, Hughes TM, Mosley TH, Wong DF, Gottesman RF. "The association between midlife lipid levels and late-life brain amyloid deposition." Neurobiol Aging. 2020;92:73-74.
Li X, Li Z, Zhou H, et al. "Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale." Nat Genet. 2020;52(9):969-983.
2019
Pokharel Y, Mouhanna F, Nambi V, et al. "ApoB, small-dense LDL-C, Lp(a), LpPLA activity, and cognitive change." Neurology. 2019;92(22):e2580-e2593.
Zhang Y, Vittinghoff E, Pletcher MJ, et al. "Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events." J Am Coll Cardiol. 2019;74(3):330-341.
de Vries PS, Brown MR, Bentley AR, et al. "Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions." Am J Epidemiol. 2019;188(6):1033-1054.
Kilpeläinen TO, Bentley AR, Noordam R, et al. "Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity." Nat Commun. 2019;10(1):376.
2018
Natarajan P, Peloso GM, Zekavat SMaryam, et al. "Deep-coverage whole genome sequences and blood lipids among 16,324 individuals." Nat Commun. 2018;9(1):3391.
Weng L-C, Roetker NS, Lutsey PL, et al. "Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study." PLoS One. 2018;13(4):e0195719.
Saeed A, Feofanova EV, Yu B, et al. "Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease." J Am Coll Cardiol. 2018;72(2):156-169.
2017
Pankow JS, Tang W, Pankratz N, et al. "Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities)." Arterioscler Thromb Vasc Biol. 2017;37(3):589-597.
Morrison AC, Huang Z, Yu B, et al. "Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood-Related Traits." Am J Hum Genet. 2017;100(2):205-215.
Jansen H, Willenborg C, Lieb W, et al. "Rheumatoid Arthritis and Coronary Artery Disease: Genetic Analyses Do Not Support a Causal Relation." J Rheumatol. 2017;44(1):4-10.
2016
"Are There Clinical Implications of Racial Differences in HbA1c? A Difference, to Be a Difference, Must Make a Difference." Diabetes Care. 2016;39(8):1462-7.
Norby FL, Eryd SAdamsson, Niemeijer MN, et al. "Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium." PLoS One. 2016;11(3):e0151932.
Colantonio LD, Bittner V, Reynolds K, et al. "Association of Serum Lipids and Coronary Heart Disease in Contemporary Observational Studies." Circulation. 2016;133(3):256-64.
Wong ND, Zhao Y, Patel R, et al. "Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes: A Pooling Project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study." Diabetes Care. 2016;39(5):668-76.
Khera AV, Won H-H, Peloso GM, et al. "Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia." J Am Coll Cardiol. 2016;67(22):2578-89.
Zubair N, Graff M, Ambite JLuis, et al. "Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci." Hum Mol Genet. 2016;25(24):5500-5512.
Natarajan P, Bis JC, Bielak LF, et al. "Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis." Circ Cardiovasc Genet. 2016;9(6):511-520.
2015
"Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis." Lancet Diabetes Endocrinol. 2015;3(4):243-53.
Joshi PK, Esko T, Mattsson H, et al. "Directional dominance on stature and cognition in diverse human populations." Nature. 2015;523(7561):459-462.
Do R, Stitziel NO, Won H-H, et al. "Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature. 2015;518(7537):102-6.
Swerdlow DI, Preiss D, Kuchenbaecker KB, et al. "HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials." Lancet. 2015;385(9965):351-61.
Parrinello CM, Rastegar I, Godino JG, Miedema MD, Matsushita K. "Prevalence of and Racial Disparities in Risk Factor Control in Older Adults With Diabetes: The Atherosclerosis Risk in Communities Study." Diabetes Care. 2015;38(7):1290-8.
Shetty PB, Tang H, Feng T, et al. "Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families." Circ Cardiovasc Genet. 2015;8(1):106-13.
2014
Peloso GM, Auer PL, Bis JC, et al. "Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks." Am J Hum Genet. 2014;94(2):223-32.
Holmes MV, Lange LA, Palmer T, et al. "Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis." Am J Hum Genet. 2014;94(2):198-208.
Simino J, Kume R, Kraja AT, et al. "Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program." Atherosclerosis. 2014;235(1):84-93.
Ndumele CE, Coresh JJ, Lazo M, et al. "Obesity, subclinical myocardial injury, and incident heart failure." JACC Heart Fail. 2014;2(6):600-7.
Postmus I, Trompet S, Deshmukh HA, et al. "Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins." Nat Commun. 2014;5:5068.
Hoogeveen RC, Gaubatz JW, Sun W, et al. "Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study." Arterioscler Thromb Vasc Biol. 2014;34(5):1069-77.
Lange LA, Hu Y, Zhang H, et al. "Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol." Am J Hum Genet. 2014;94(2):233-45.
2013
Do R, Willer CJ, Schmidt EM, et al. "Common variants associated with plasma triglycerides and risk for coronary artery disease." Nat Genet. 2013;45(11):1345-52.
Whelton SP, Roy P, Astor BC, Zhang L, Hoogeveen RC, Ballantyne CM. "Elevated high-sensitivity C-reactive protein as a risk marker of the attenuated relationship between serum cholesterol and cardiovascular events at older age. The ARIC Study." Am J Epidemiol. 2013;178(7):1076-84.
Folsom AR, Lutsey PL, Roetker NS, Ballantyne CM, Hoogeveen RC, Rosamond WD. "Lipoprotein-associated phospholipase A2 and venous thromboembolism: a prospective study." Thromb Res. 2013;132(1):44-6.
Dumitrescu L, Carty CL, Franceschini N, et al. "No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population." Hum Genet. 2013;132(12):1427-31.
Wu Y, Waite LL, Jackson AU, et al. "Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained." PLoS Genet. 2013;9(3):e1003379.
2012
Carty CL, Bůžková P, Fornage M, et al. "Associations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study." Circ Cardiovasc Genet. 2012;5(2):210-6.
Buyske S, Wu Y, Carty CL, et al. "Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study." PLoS One. 2012;7(4):e35651.
Ma L, Brautbar A, Boerwinkle E, Sing CF, Clark AG, Keinan A. "Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations." PLoS Genet. 2012;8(5):e1002714.
Asselbergs FW, Guo Y, van Iperen EPA, et al. "Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci." Am J Hum Genet. 2012;91(5):823-38.
Musunuru K, Romaine SPR, Lettre G, et al. "Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project." PLoS One. 2012;7(5):e36473.
Voight BF, Peloso GM, Orho-Melander M, et al. "Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study." Lancet. 2012;380(9841):572-80.
Lutsey PL, Rasmussen-Torvik LJ, Pankow JS, et al. "Relation of lipid gene scores to longitudinal trends in lipid levels and incidence of abnormal lipid levels among individuals of European ancestry: the Atherosclerosis Risk in Communities (ARIC) study." Circ Cardiovasc Genet. 2012;5(1):73-80.
2011
Muntner P, Lee F, Astor BC. "Association of high-density lipoprotein cholesterol with coronary heart disease risk across categories of low-density lipoprotein cholesterol: the atherosclerosis risk in communities study." Am J Med Sci. 2011;341(3):173-80.
Selvin E, Ning Y, Steffes MW, et al. "Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes." Diabetes. 2011;60(1):298-305.
Virani SS, Catellier DJ, Pompeii LA, et al. "Relation of cholesterol and lipoprotein parameters with carotid artery plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) carotid MRI study." Atherosclerosis. 2011;219(2):596-602.
2010
Teslovich TM, Musunuru K, Smith AV, et al. "Biological, clinical and population relevance of 95 loci for blood lipids." Nature. 2010;466(7307):707-13.
2009
Yang EY, Nambi V, Tang Z, et al. "Clinical implications of JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) in a U.S. population insights from the ARIC (Atherosclerosis Risk in Communities) study." J Am Coll Cardiol. 2009;54(25):2388-95.
Wagenknecht L, Wasserman B, Chambless L, et al. "Correlates of carotid plaque presence and composition as measured by MRI: the Atherosclerosis Risk in Communities Study." Circ Cardiovasc Imaging. 2009;2(4):314-22.
Monda KL, Ballantyne CM, North KE. "Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study." J Lipid Res. 2009;50(8):1685-91.
Folsom AR, Aleksic N, Sanhueza A, Boerwinkle E. "Risk factor correlates of platelet and leukocyte markers assessed by flow cytometry in a population-based sample." Atherosclerosis. 2009;205(1):272-8.
Folsom AR, Peacock JM, Boerwinkle E. "Variation in PCSK9, low LDL cholesterol, and risk of peripheral arterial disease." Atherosclerosis. 2009;202(1):211-5.
2008
Klos K, Shimmin L, Ballantyne C, et al. "APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels." Hum Mol Genet. 2008;17(13):2039-46.
Pankow JS, Boerwinkle E, Adams PC, et al. "HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study." Transl Res. 2008;152(1):3-10.
Chamberlain AM, Folsom AR, Schreiner PJ, Boerwinkle E, Ballantyne CM. "Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2008;200(2):322-8.
Volcik KA, Nettleton JA, Ballantyne CM, Boerwinkle E. "Peroxisome proliferator-activated receptor [alpha] genetic variation interacts with n-6 and long-chain n-3 fatty acid intake to affect total cholesterol and LDL-cholesterol concentrations in the Atherosclerosis Risk in Communities Study." Am J Clin Nutr. 2008;87(6):1926-31.
2007
Sturgeon JD, Folsom AR, Longstreth WT, Shahar E, Rosamond WD, Cushman M. "Risk factors for intracerebral hemorrhage in a pooled prospective study." Stroke. 2007;38(10):2718-25.
Folsom AR, Peacock JM, Boerwinkle E. "Sequence variation in proprotein convertase subtilisin/kexin type 9 serine protease gene, low LDL cholesterol, and cancer incidence." Cancer Epidemiol Biomarkers Prev. 2007;16(11):2455-8.
2006
Volcik KA, Barkley R A, Hutchinson RG, et al. "Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants." Am J Epidemiol. 2006;164(4):342-8.
Hozawa A, Folsom AR, A Sharrett R, Payne TJ, Chambless LE. "Does the impact of smoking on coronary heart disease differ by low-density lipoprotein cholesterol level?: the Atherosclerosis Risk in Communities (ARIC) Study." Circ J. 2006;70(9):1105-10.
Everett CJ, Mainous AG, Koopman RJ, Diaz VA. "Multiple lipid scoring system for prediction of coronary heart disease risk: application to African Americans." J Natl Med Assoc. 2006;98(11):1740-5.
Cohen JC, Boerwinkle E, Mosley TH, Hobbs HH. "Sequence variations in PCSK9, low LDL, and protection against coronary heart disease." N Engl J Med. 2006;354(12):1264-72.
2005
Selvin E, Coresh J, Golden SH, Boland LL, Brancati FL, Steffes MW. "Glycemic control, atherosclerosis, and risk factors for cardiovascular disease in individuals with diabetes: the atherosclerosis risk in communities study." Diabetes Care. 2005;28(8):1965-73.
Ballantyne CM, Hoogeveen RC, Bang H, et al. "Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study." Arch Intern Med. 2005;165(21):2479-84.
2004
A Sharrett R, Coady SA, Folsom AR, Couper DJ, Heiss G. "Smoking and diabetes differ in their associations with subclinical atherosclerosis and coronary heart disease-the ARIC Study." Atherosclerosis. 2004;172(1):143-9.
2003
Shahar E, Chambless LE, Rosamond WD, et al. "Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2003;34(3):623-31.
2002
Klein R, A Sharrett R, Klein BEK, et al. "The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes : the atherosclerosis risk in communities study." Ophthalmology. 2002;109(7):1225-34.
Boland LL, Folsom AR, Sorlie PD, et al. "Occurrence of unrecognized myocardial infarction in subjects aged 45 to 65 years (the ARIC study)." Am J Cardiol. 2002;90(9):927-31.
Garant MJ, Kao LWH, Brancati F, et al. "SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study." Diabetes. 2002;51(1):231-7.
2001
Perova NV, Davis CE, Tao S, et al. "Multi-country comparison of plasma lipid relationship to years of schooling in men and women." Int J Epidemiol. 2001;30(2):371-9.
1999
Sharrett AR, Sorlie PD, Chambless LE, et al. "Relative importance of various risk factors for asymptomatic carotid atherosclerosis versus coronary heart disease incidence: the Atherosclerosis Risk in Communities Study." Am J Epidemiol. 1999;149(9):843-52.
1997
Howard G, Manolio TA, Burke GL, Wolfson SK, O'Leary DH. "Does the association of risk factors and atherosclerosis change with age? An analysis of the combined ARIC and CHS cohorts. The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS) investigators." Stroke. 1997;28(9):1693-701.
1996
Råstam L, Lindberg G, Folsom AR, Burke GL, Nilsson-Ehle P, Lundblad A. "Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study." Int J Epidemiol. 1996;25(5):953-8.
Robinson JC, Folsom AR, Nabulsi AA, Watson R, Brancati FL, Cai J. "Can postmenopausal hormone replacement improve plasma lipids in women with diabetes? The Atherosclerosis Risk in Communities Study Investigators." Diabetes Care. 1996;19(5):480-5.
Folsom AR, McGovern PG, Nabulsi AA, et al. "Changes in plasma lipids and lipoproteins associated with starting or stopping postmenopausal hormone replacement therapy. Atherosclerosis Risk in Communities Study." Am Heart J. 1996;132(5):952-8.
Schreiner PJ, Heiss G, Tyroler HA, Morrisett JD, Davis CE, Smith R. "Race and gender differences in the association of Lp(a) with carotid artery wall thickness. The Atherosclerosis Risk in Communities (ARIC) Study." Arterioscler Thromb Vasc Biol. 1996;16(3):471-8.

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