ARIC Publications
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Midlife determinants of healthy cardiovascular aging: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2022;350:82-89.
"Association Between Cumulative Low-Density Lipoprotein Cholesterol Exposure During Young Adulthood and Middle Age and Risk of Cardiovascular Events." JAMA Cardiol. 2021;6(12):1406-1413.
"Conventional and Novel Lipid Measures and Risk of Peripheral Artery Disease." Arterioscler Thromb Vasc Biol. 2021;41(3):1229-1238.
"The association between midlife lipid levels and late-life brain amyloid deposition." Neurobiol Aging. 2020;92:73-74.
" "ApoB, small-dense LDL-C, Lp(a), LpPLA activity, and cognitive change." Neurology. 2019;92(22):e2580-e2593.
"Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events." J Am Coll Cardiol. 2019;74(3):330-341.
"Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions." Am J Epidemiol. 2019;188(6):1033-1054.
"Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity." Nat Commun. 2019;10(1):376.
"Deep-coverage whole genome sequences and blood lipids among 16,324 individuals." Nat Commun. 2018;9(1):3391.
"Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study." PLoS One. 2018;13(4):e0195719.
"Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease." J Am Coll Cardiol. 2018;72(2):156-169.
"Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities)." Arterioscler Thromb Vasc Biol. 2017;37(3):589-597.
"Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood-Related Traits." Am J Hum Genet. 2017;100(2):205-215.
"Rheumatoid Arthritis and Coronary Artery Disease: Genetic Analyses Do Not Support a Causal Relation." J Rheumatol. 2017;44(1):4-10.
""Are There Clinical Implications of Racial Differences in HbA1c? A Difference, to Be a Difference, Must Make a Difference." Diabetes Care. 2016;39(8):1462-7.
Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium." PLoS One. 2016;11(3):e0151932.
"Association of Serum Lipids and Coronary Heart Disease in Contemporary Observational Studies." Circulation. 2016;133(3):256-64.
"Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes: A Pooling Project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study." Diabetes Care. 2016;39(5):668-76.
"Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia." J Am Coll Cardiol. 2016;67(22):2578-89.
"Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci." Hum Mol Genet. 2016;25(24):5500-5512.
"Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis." Circ Cardiovasc Genet. 2016;9(6):511-520.
""Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis." Lancet Diabetes Endocrinol. 2015;3(4):243-53.
Directional dominance on stature and cognition in diverse human populations." Nature. 2015;523(7561):459-462.
"Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature. 2015;518(7537):102-6.
"HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials." Lancet. 2015;385(9965):351-61.
"Prevalence of and Racial Disparities in Risk Factor Control in Older Adults With Diabetes: The Atherosclerosis Risk in Communities Study." Diabetes Care. 2015;38(7):1290-8.
"Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families." Circ Cardiovasc Genet. 2015;8(1):106-13.
"Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks." Am J Hum Genet. 2014;94(2):223-32.
"Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis." Am J Hum Genet. 2014;94(2):198-208.
"Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program." Atherosclerosis. 2014;235(1):84-93.
"Obesity, subclinical myocardial injury, and incident heart failure." JACC Heart Fail. 2014;2(6):600-7.
"Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins." Nat Commun. 2014;5:5068.
"Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study." Arterioscler Thromb Vasc Biol. 2014;34(5):1069-77.
"Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol." Am J Hum Genet. 2014;94(2):233-45.
"Common variants associated with plasma triglycerides and risk for coronary artery disease." Nat Genet. 2013;45(11):1345-52.
"Elevated high-sensitivity C-reactive protein as a risk marker of the attenuated relationship between serum cholesterol and cardiovascular events at older age. The ARIC Study." Am J Epidemiol. 2013;178(7):1076-84.
"Lipoprotein-associated phospholipase A2 and venous thromboembolism: a prospective study." Thromb Res. 2013;132(1):44-6.
"No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population." Hum Genet. 2013;132(12):1427-31.
" "Associations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study." Circ Cardiovasc Genet. 2012;5(2):210-6.
"Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study." PLoS One. 2012;7(4):e35651.
"Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations." PLoS Genet. 2012;8(5):e1002714.
"Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci." Am J Hum Genet. 2012;91(5):823-38.
"Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project." PLoS One. 2012;7(5):e36473.
"Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study." Lancet. 2012;380(9841):572-80.
" "Association of high-density lipoprotein cholesterol with coronary heart disease risk across categories of low-density lipoprotein cholesterol: the atherosclerosis risk in communities study." Am J Med Sci. 2011;341(3):173-80.
"Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes." Diabetes. 2011;60(1):298-305.
" "Biological, clinical and population relevance of 95 loci for blood lipids." Nature. 2010;466(7307):707-13.
"Clinical implications of JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) in a U.S. population insights from the ARIC (Atherosclerosis Risk in Communities) study." J Am Coll Cardiol. 2009;54(25):2388-95.
"Correlates of carotid plaque presence and composition as measured by MRI: the Atherosclerosis Risk in Communities Study." Circ Cardiovasc Imaging. 2009;2(4):314-22.
"Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study." J Lipid Res. 2009;50(8):1685-91.
"Risk factor correlates of platelet and leukocyte markers assessed by flow cytometry in a population-based sample." Atherosclerosis. 2009;205(1):272-8.
"Variation in PCSK9, low LDL cholesterol, and risk of peripheral arterial disease." Atherosclerosis. 2009;202(1):211-5.
"APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels." Hum Mol Genet. 2008;17(13):2039-46.
"HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study." Transl Res. 2008;152(1):3-10.
" " "Risk factors for intracerebral hemorrhage in a pooled prospective study." Stroke. 2007;38(10):2718-25.
"Sequence variation in proprotein convertase subtilisin/kexin type 9 serine protease gene, low LDL cholesterol, and cancer incidence." Cancer Epidemiol Biomarkers Prev. 2007;16(11):2455-8.
"Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants." Am J Epidemiol. 2006;164(4):342-8.
"Does the impact of smoking on coronary heart disease differ by low-density lipoprotein cholesterol level?: the Atherosclerosis Risk in Communities (ARIC) Study." Circ J. 2006;70(9):1105-10.
"Multiple lipid scoring system for prediction of coronary heart disease risk: application to African Americans." J Natl Med Assoc. 2006;98(11):1740-5.
"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease." N Engl J Med. 2006;354(12):1264-72.
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Smoking and diabetes differ in their associations with subclinical atherosclerosis and coronary heart disease-the ARIC Study." Atherosclerosis. 2004;172(1):143-9.
"Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2003;34(3):623-31.
"The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes : the atherosclerosis risk in communities study." Ophthalmology. 2002;109(7):1225-34.
"Occurrence of unrecognized myocardial infarction in subjects aged 45 to 65 years (the ARIC study)." Am J Cardiol. 2002;90(9):927-31.
"SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study." Diabetes. 2002;51(1):231-7.
"Multi-country comparison of plasma lipid relationship to years of schooling in men and women." Int J Epidemiol. 2001;30(2):371-9.
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Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study." Int J Epidemiol. 1996;25(5):953-8.
"Can postmenopausal hormone replacement improve plasma lipids in women with diabetes? The Atherosclerosis Risk in Communities Study Investigators." Diabetes Care. 1996;19(5):480-5.
"Changes in plasma lipids and lipoproteins associated with starting or stopping postmenopausal hormone replacement therapy. Atherosclerosis Risk in Communities Study." Am Heart J. 1996;132(5):952-8.
"Race and gender differences in the association of Lp(a) with carotid artery wall thickness. The Atherosclerosis Risk in Communities (ARIC) Study." Arterioscler Thromb Vasc Biol. 1996;16(3):471-8.
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