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ARIC Publications

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Hyacinth HI, Franceschini N, Seals SR, et al. "Association of Sickle Cell Trait With Incidence of Coronary Heart Disease Among African American Individuals." JAMA Netw Open. 2021;4(1):e2030435.
DeBoer MD, Filipp SL. "Associations of a metabolic syndrome severity score with coronary heart disease and diabetes in fasting vs. non-fasting individuals." Nutr Metab Cardiovasc Dis. 2020;30(1):92-98.
Cowan LT, Lakshminarayan K, Lutsey PL, Beck J, Offenbacher S. "Endodontic therapy and incident cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) study." J Public Health Dent. 2020;80(1):79-91.
Oliver-Williams C, Vladutiu CJ, Loehr LR, Rosamond WD. "The Association Between Parity and Subsequent Cardiovascular Disease in Women: The Atherosclerosis Risk in Communities Study." J Womens Health (Larchmt). 2019;28(5):721-727.
Porter AK, Schilsky S, Evenson KR, Florido R, Palta P, Holliday KM. "The Association of Sport and Exercise Activities With Cardiovascular Disease Risk: The Atherosclerosis Risk in Communities (ARIC) Study." J Phys Act Health. 2019;16(9):698-705.
Cuthbertson CC, Tan X, Heiss G, Kucharska-Newton AMaria, Nichols HB, Kubota Y. "Associations of Leisure-Time Physical Activity and Television Viewing With Life Expectancy Free of Nonfatal Cardiovascular Disease: The ARIC Study." J Am Heart Assoc. 2019;8(18):e012657.
Agha G, Mendelson MM, Ward-Caviness CK, et al. "Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease." Circulation. 2019;140(8):645-657.
Gregson J, Kaptoge S, Bolton T, et al. "Cardiovascular Risk Factors Associated With Venous Thromboembolism." JAMA Cardiol. 2019;4(2):163-173.
Ding N, Sang Y, Chen J, et al. "Cigarette Smoking, Smoking Cessation, and Long-Term Risk of 3 Major Atherosclerotic Diseases." J Am Coll Cardiol. 2019;74(4):498-507.
Jia X, Sun W, Hoogeveen RC, et al. "High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study." Circulation. 2019;139(23):2642-2653.
Wang Z, Zhu C, Nambi V, et al. "Metabolomic Pattern Predicts Incident Coronary Heart Disease." Arterioscler Thromb Vasc Biol. 2019;39(7):1475-1482.
Parikh RR, Folsom AR, Misialek JR, Rosamond WD, Chang PP, Tang W. "Prospective study of plasma high molecular weight kininogen and prekallikrein and incidence of coronary heart disease, ischemic stroke and heart failure." Thromb Res. 2019;182:89-94.
Pokharel Y, Sun W, Villareal DT, et al. "Association between high-sensitivity troponin T and cardiovascular risk in individuals with and without metabolic syndrome: The ARIC study." Eur J Prev Cardiol. 2017;24(6):628-638.
van Capelleveen JC, Bochem AE, S Boekholdt M, et al. "Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and ." J Am Heart Assoc. 2017;6(8).
Ashar FN, Zhang Y, Longchamps RJ, et al. "Association of Mitochondrial DNA Copy Number With Cardiovascular Disease." JAMA Cardiol. 2017;2(11):1247-1255.
Gregson JM, Freitag DF, Surendran P, et al. "Genetic invalidation of Lp-PLA as a therapeutic target: Large-scale study of five functional Lp-PLA-lowering alleles." Eur J Prev Cardiol. 2017;24(5):492-504.
Joshi PK, Pirastu N, Kentistou KA, et al. "Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity." Nat Commun. 2017;8(1):910.
Maheshwari A, Norby FL, Soliman EZ, et al. "Relation of Prolonged P-Wave Duration to Risk of Sudden Cardiac Death in the General Population (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2017;119(9):1302-1306.
Zewinger S, Kleber ME, Tragante V, et al. "Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study." Lancet Diabetes Endocrinol. 2017;5(7):534-543.
Kubota Y, Alonso A. "β-Thromboglobulin and incident cardiovascular disease risk: The Atherosclerosis Risk in Communities study." Thromb Res. 2017;155:116-120.
Selvin E, Rawlings A, Lutsey PL, Maruthur N, Pankow JS, Steffes M. "Association of 1,5-Anhydroglucitol With Cardiovascular Disease and Mortality." Diabetes. 2016;65(1):201-8.
Fretz A, Schneider ALC, McEvoy JW, Hoogeveen RC, Ballantyne CM, Coresh JJ. "The Association of Socioeconomic Status With Subclinical Myocardial Damage, Incident Cardiovascular Events, and Mortality in the ARIC Study." Am J Epidemiol. 2016;183(5):452-61.
Konety S, Koene RJ, Norby FL, et al. "Echocardiographic Predictors of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study and Cardiovascular Health Study." Circ Cardiovasc Imaging. 2016;9(8).
O'Neal WT, Wang YGrace, Wu H-T, et al. "Electrocardiographic J Wave and Cardiovascular Outcomes in the General Population (from the Atherosclerosis Risk In Communities Study)." Am J Cardiol. 2016;118(6):811-815.
Khera AV, Emdin CA, Drake I, et al. "Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease." N Engl J Med. 2016;375(24):2349-2358.
Scott RA, Freitag DF, Li L, et al. "A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease." Sci Transl Med. 2016;8(341):341ra76.
Kim S, Cai J. "Improving the efficiency of estimation in the additive hazards model for stratified case-cohort design with multiple diseases." Stat Med. 2016;35(2):282-93.
Ndumele CE, Matsushita K, Lazo M, et al. "Obesity and Subtypes of Incident Cardiovascular Disease." J Am Heart Assoc. 2016;5(8).
Florido R, Zhao D, Ndumele CE, et al. "Physical Activity, Parental History of Premature Coronary Heart Disease, and Incident Atherosclerotic Cardiovascular Disease in the Atherosclerosis Risk in Communities (ARIC) Study." J Am Heart Assoc. 2016;5(9).
Campbell W, Ganna A, Ingelsson E. "Prediction impact curve is a new measure integrating intervention effects in the evaluation of risk models." J Clin Epidemiol. 2016;69:89-95.
Zanoni P, Khetarpal SA, Larach DB, et al. "Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease." Science. 2016;351(6278):1166-71.
Seidelmann SB, Claggett B, Bravo PE, et al. "Retinal Vessel Calibers in Predicting Long-Term Cardiovascular Outcomes: The Atherosclerosis Risk in Communities Study." Circulation. 2016;134(18):1328-1338.
Parrinello CM, Matsushita K, Woodward M, Wagenknecht LE, Coresh JJ. "Risk prediction of major complications in individuals with diabetes: the Atherosclerosis Risk in Communities Study." Diabetes Obes Metab. 2016;18(9):899-906.
McEvoy JW, Chen Y, Ndumele CE, et al. "Six-Year Change in High-Sensitivity Cardiac Troponin T and Risk of Subsequent Coronary Heart Disease, Heart Failure, and Death." JAMA Cardiol. 2016;1(5):519-28.
Michos ED, Misialek JR, Selvin E, Folsom AR, Pankow JS, Post WS. "25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study." Atherosclerosis. 2015;241(1):12-7.
Appiah D, Schreiner PJ, Maclehose RF. "Association of Plasma γ' Fibrinogen With Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study." Arterioscler Thromb Vasc Biol. 2015;35(12):2700-6.
Yu B, Li AH, Muzny D, et al. "Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine: Levels and Incident Coronary Heart Disease." Circ Cardiovasc Genet. 2015;8(2):351-5.
Skali H, Shah A, Gupta DK, et al. "Cardiac structure and function across the glycemic spectrum in elderly men and women free of prevalent heart disease: the Atherosclerosis Risk In the Community study." Circ Heart Fail. 2015;8(3):448-54.
"Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis." Lancet Diabetes Endocrinol. 2015;3(4):243-53.
Polfus LM, Gibbs RA. "Coronary heart disease and genetic variants with low phospholipase A2 activity." N Engl J Med. 2015;372(3):295-6.
Matsushita K, Coresh JJ, Sang Y, et al. "Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data." Lancet Diabetes Endocrinol. 2015;3(7):514-25.
Selvin E, Rawlings AM, Lutsey PL, Maruthur N, Pankow JS, Steffes M. "Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death." Circulation. 2015;132(4):269-77.
Alexander N, Matsushita K, Sang Y, Ballew S, Mahmoodi BK, Astor BC. "Kidney measures with diabetes and hypertension on cardiovascular disease: the Atherosclerosis Risk in Communities Study." Am J Nephrol. 2015;41(4-5):409-17.
Folsom AR, George KM. "Lack of association of plasma factor XI with incident stroke and coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2015;243(1):181-5.
Okwuosa TM, Soliman EZ, Norby FL, Williams KA, Alonso A. "Left ventricular hypertrophy and cardiovascular disease risk prediction and reclassification in blacks and whites: the Atherosclerosis Risk in Communities Study." Am Heart J. 2015;169(1):155-61.e5.
Hardy ST, Loehr LR, Butler KR, et al. "Reducing the Blood Pressure-Related Burden of Cardiovascular Disease: Impact of Achievable Improvements in Blood Pressure Prevention and Control." J Am Heart Assoc. 2015;4(10):e002276.
Bressler J, Franceschini N, Demerath EW, Mosley TH, Folsom AR. "Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study." BMC Med Genet. 2015;16:52.
Mongraw-Chaffin ML, Peters SAE, Huxley RR. "The sex-specific association between BMI and coronary heart disease: a systematic review and meta-analysis of 95 cohorts with 1·2 million participants." Lancet Diabetes Endocrinol. 2015;3(6):437-449.
Roca GQuerejeta, Redline S, Claggett B, Bello N, Ballantyne CM, Solomon SD. "Sex-Specific Association of Sleep Apnea Severity With Subclinical Myocardial Injury, Ventricular Hypertrophy, and Heart Failure Risk in a Community-Dwelling Cohort: The Atherosclerosis Risk in Communities-Sleep Heart Health Study." Circulation. 2015;132(14):1329-37.
Ndumele CE, Matsushita K, Astor B, et al. "Apolipoproteins do not add prognostic information beyond lipoprotein cholesterol measures among individuals with obesity and insulin resistance syndromes: the ARIC study." Eur J Prev Cardiol. 2014;21(7):866-75.
Holmes MV, Dale CE, Zuccolo L, et al. "Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data." BMJ. 2014;349:g4164.
Peloso GM, Auer PL, Bis JC, et al. "Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks." Am J Hum Genet. 2014;94(2):223-32.
Holmes MV, Lange LA, Palmer T, et al. "Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis." Am J Hum Genet. 2014;94(2):198-208.
Lamprea-Montealegre JA, Sharrett ARichey, Matsushita K, Selvin E, Szklo M. "Chronic kidney disease, lipids and apolipoproteins, and coronary heart disease: the ARIC study." Atherosclerosis. 2014;234(1):42-6.
Haring B, Gronroos N, Nettleton JA, von Ballmoos MCWyler, Selvin E. "Dietary protein intake and coronary heart disease in a large community based cohort: results from the Atherosclerosis Risk in Communities (ARIC) study [corrected]." PLoS One. 2014;9(10):e109552.
Lutsey PL, Alonso A, Selvin E, et al. "Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the Atherosclerosis Risk in Communities study." J Am Heart Assoc. 2014;3(3):e000936.
Di Angelantonio E, Gao P, Khan H, et al. "Glycated hemoglobin measurement and prediction of cardiovascular disease." JAMA. 2014;311(12):1225-33.
Simino J, Kume R, Kraja AT, et al. "Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program." Atherosclerosis. 2014;235(1):84-93.
Crosby J, Peloso GM, Auer PL, et al. "Loss-of-function mutations in APOC3, triglycerides, and coronary disease." N Engl J Med. 2014;371(1):22-31.
Holmes MV, Exeter HJ, Folkersen L, et al. "Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels." Circ Cardiovasc Genet. 2014;7(2):144-50.
Franceschini N, Hu Y, Reiner AP, et al. "Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study." PLoS One. 2014;9(12):e113203.
Hoogeveen RC, Gaubatz JW, Sun W, et al. "Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study." Arterioscler Thromb Vasc Biol. 2014;34(5):1069-77.
Rodriguez CJ, Swett K, Agarwal SK, et al. "Systolic blood pressure levels among adults with hypertension and incident cardiovascular events: the atherosclerosis risk in communities study." JAMA Intern Med. 2014;174(8):1252-61.
Maxwell TJ, Ballantyne CM, Cheverud JM, Guild CS, Ndumele CE. "APOE modulates the correlation between triglycerides, cholesterol, and CHD through pleiotropy, and gene-by-gene interactions." Genetics. 2013;195(4):1397-405.
Ogagarue ER, Lutsey PL, Klein R, Klein BE. "Association of ideal cardiovascular health metrics and retinal microvascular findings: the Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2013;2(6):e000430.
Matsushita K, Williams EK, Mongraw-Chaffin ML, et al. "The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study." Am J Epidemiol. 2013;178(3):401-9.
Rautaharju PM, Zhang Z-M, Warren J, et al. "Electrocardiographic predictors of coronary heart disease and sudden cardiac deaths in men and women free from cardiovascular disease in the Atherosclerosis Risk in Communities study." J Am Heart Assoc. 2013;2(3):e000061.
Whelton SP, Roy P, Astor BC, Zhang L, Hoogeveen RC, Ballantyne CM. "Elevated high-sensitivity C-reactive protein as a risk marker of the attenuated relationship between serum cholesterol and cardiovascular events at older age. The ARIC Study." Am J Epidemiol. 2013;178(7):1076-84.
H Y Wu J, Lemaitre RN, Manichaikul A, et al. "Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu." Circ Cardiovasc Genet. 2013;6(2):171-83.
Zhang L, Bůžková P, Wassel CL, et al. "Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study." Atherosclerosis. 2013;228(2):390-9.
Stevens J, Erber E, Truesdale KP, Wang C-H. "Long- and short-term weight change and incident coronary heart disease and ischemic stroke: the Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2013;178(2):239-48.
Kang S, Cai J. "Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study." Biostatistics. 2013;14(1):28-41.
Selvin E, Rawlings AM, Bergenstal RM, Coresh JJ. "No racial differences in the association of glycated hemoglobin with kidney disease and cardiovascular outcomes." Diabetes Care. 2013;36(10):2995-3001.