ARIC Publications
Filters: Keyword is Models, Genetic [Clear All Filters]
Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest." PLoS One. 2010;5(3):e9879.
"Genome-wide meta-analysis of common variant differences between men and women." Hum Mol Genet. 2012;21(21):4805-15.
" "Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies." Am J Hum Genet. 2019;104(2):260-274.
"Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair." Nat Genet. 2015;47(11):1294-1303.
"New Algorithm and Software (BNOmics) for Inferring and Visualizing Bayesian Networks from Heterogeneous Big Biological and Genetic Data." J Comput Biol. 2017;24(4):340-356.
"Meta-analysis of gene-level associations for rare variants based on single-variant statistics." Am J Hum Genet. 2013;93(2):236-48.
"FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics." Genetics. 2016;202(3):919-29.
"Gene-based tests of association." PLoS Genet. 2011;7(7):e1002177.
"Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
"New loci associated with kidney function and chronic kidney disease." Nat Genet. 2010;42(5):376-84.
"Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies." Am J Hum Genet. 2019;104(5):802-814.
"Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale." Nat Genet. 2020;52(9):969-983.
"A general framework for integrative analysis of incomplete multiomics data." Genet Epidemiol. 2020;44(7):646-664.
"ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies." Am J Hum Genet. 2019;104(3):410-421.
"A variational Bayes discrete mixture test for rare variant association." Genet Epidemiol. 2014;38(1):21-30.
"Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes." Nat Genet. 2018;50(4):524-537.
"Deep-coverage whole genome sequences and blood lipids among 16,324 individuals." Nat Commun. 2018;9(1):3391.
"The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery." Genet Epidemiol. 2011;35(5):410-22.
"A Bayesian Partitioning Model for the Detection of Multilocus Effects in Case-Control Studies." Hum Hered. 2015;79(2):69-79.
"USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis." Genet Epidemiol. 2016;40(1):20-34.
"A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape." Nat Commun. 2016;7:13357.
"Epigenetic Age and the Risk of Incident Atrial Fibrillation." Circulation. 2021;144(24):1899-1911.
"Use of wrapper algorithms coupled with a random forests classifier for variable selection in large-scale genomic association studies." J Comput Biol. 2009;16(12):1705-18.
"Genetic loci for retinal arteriolar microcirculation." PLoS One. 2013;8(6):e65804.
"Generalized estimating equations for genome-wide association studies using longitudinal phenotype data." Stat Med. 2015;34(1):118-30.
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Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI." Circ Cardiovasc Genet. 2015;8(2):398-409.
"On Robust Association Testing for Quantitative Traits and Rare Variants." G3 (Bethesda). 2016;6(12):3941-3950.
"Sequence Kernel Association Test of Multiple Continuous Phenotypes." Genet Epidemiol. 2016;40(2):91-100.
"Fast and Accurate Genome-Wide Association Test of Multiple Quantitative Traits." Comput Math Methods Med. 2018;2018:2564531.
"Sequence Kernel Association Analysis of Rare Variant Set Based on the Marginal Regression Model for Binary Traits." Genet Epidemiol. 2015;39(6):399-405.
"On Efficient and Accurate Calculation of Significance P-Values for Sequence Kernel Association Testing of Variant Set." Ann Hum Genet. 2016;80(2):123-35.
"Pathway analysis with next-generation sequencing data." Eur J Hum Genet. 2015;23(4):507-15.
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