ARIC Publications
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Midlife Cardiovascular Health and Robust Versus Frail Late-Life Status: The Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2022;77(6):1222-1229.
"Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes." Clin Epigenetics. 2021;13(1):230.
"Association of Changes in Cardiovascular Health Metrics and Risk of Subsequent Cardiovascular Disease and Mortality." J Am Heart Assoc. 2020;9(19):e017458.
"Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium." BMJ. 2019;364:k5301.
"Association of Undifferentiated Dyspnea in Late Life With Cardiovascular and Noncardiovascular Dysfunction: A Cross-sectional Analysis From the ARIC Study." JAMA Netw Open. 2019;2(6):e195321.
"Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits." Am J Hum Genet. 2019;104(1):112-138.
"Cardiovascular Risk Factors Associated With Venous Thromboembolism." JAMA Cardiol. 2019;4(2):163-173.
"The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies." Am J Epidemiol. 2019;188(6):991-1012.
"Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample." Hum Mol Genet. 2019;28(7):1212-1224.
"Joint Associations of Obesity and NT-proBNP With the Incidence of Atrial Fibrillation in the ARIC Study." J Am Heart Assoc. 2019;8(19):e013294.
"Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities Study." JAMA Cardiol. 2019;4(12):1203-1212.
"Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution." Nat Genet. 2019;51(3):452-469.
"Adiposity, body composition and ventricular-arterial stiffness in the elderly: the Atherosclerosis Risk in Communities Study." Eur J Heart Fail. 2018;20(8):1191-1201.
"American Heart Association's Life's Simple 7 at Middle Age and Prognosis After Myocardial Infarction in Later Life." J Am Heart Assoc. 2018;7(4).
"The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes." Diabetes Care. 2018;41(1):104-111.
"Associations of Obesity With Incident Hospitalization Related to Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study." J Am Heart Assoc. 2018;7(16):e008644.
"A comprehensive evaluation of the genetic architecture of sudden cardiac arrest." Eur Heart J. 2018;39(44):3961-3969.
""Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies." Clin Chem. 2018;64(1):183-191.
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders." Am J Hum Genet. 2018;103(5):691-706.
"Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
"Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent." Mol Nutr Food Res. 2018;62(3).
"Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients." J Am Heart Assoc. 2018;7(3).
"Novel associations between blood DNA methylation and body mass index in middle-aged and older adults." Int J Obes (Lond). 2018;42(4):887-896.
"Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity." Nat Genet. 2018;50(1):26-41.
"Relation of Lifestyle Factors and Life's Simple 7 Score to Temporal Reduction in Troponin Levels Measured by a High-Sensitivity Assay (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2018;121(4):430-436.
"Television Watching as Sedentary Behavior and Atrial Fibrillation: The Atherosclerosis Risk in Communities Study." J Phys Act Health. 2018;15(12):895-899.
"Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI." Int J Obes (Lond). 2018;42(3):384-390.
"Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations." J Clin Endocrinol Metab. 2018;103(4):1380-1392.
"Weight History and Subclinical Myocardial Damage." Clin Chem. 2018;64(1):201-209.
"Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study." Hum Genet. 2017;136(7):897-902.
"Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition." JAMA. 2017;317(14):1443-1450.
"Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach." PLoS Med. 2017;14(1):e1002215.
"Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies." Circulation. 2017;135(1):7-16.
"BNP and obesity in acute decompensated heart failure with preserved vs. reduced ejection fraction: The Atherosclerosis Risk in Communities Surveillance Study." Int J Cardiol. 2017;233:61-66.
"Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study." Clin Epigenetics. 2017;9:21.
"Diet Soda Consumption and Risk of Incident End Stage Renal Disease." Clin J Am Soc Nephrol. 2017;12(1):79-86.
"Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium." PLoS Genet. 2017;13(4):e1006719.
"Evaluation of the modified FINDRISC to identify individuals at high risk for diabetes among middle-aged white and black ARIC study participants." Diabetes Obes Metab. 2017;19(9):1260-1266.
"Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index." Mol Psychiatry. 2017;22(2):192-201.
"Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization." Circulation. 2017;135(8):741-754.
"Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity." Nat Commun. 2017;8(1):910.
"Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Nat Commun. 2017;8:14977.
"Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults." PLoS Genet. 2017;13(4):e1006528.
"Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk." Nat Genet. 2017;49(6):834-841.
"Impact of dietary fat composition on prediabetes: a 12-year follow-up study." Public Health Nutr. 2017;20(9):1617-1626.
"The Importance of Mid-to-Late-Life Body Mass Index Trajectories on Late-Life Gait Speed." J Gerontol A Biol Sci Med Sci. 2017;72(8):1130-1136.
"Independent associations between a metabolic syndrome severity score and future diabetes by sex and race: the Atherosclerosis Risk In Communities Study and Jackson Heart Study." Diabetologia. 2017;60(7):1261-1270.
"Kidney function, bone-mineral metabolism markers, and future risk of peripheral artery disease." Atherosclerosis. 2017;267:167-174.
"Physical Activity, Obesity, and Subclinical Myocardial Damage." JACC Heart Fail. 2017;5(5):377-384.
"Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study." Nicotine Tob Res. 2017;19(7):826-835.
"Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis." J Thromb Haemost. 2017;15(7):1334-1343.
" "Assessing the genetic overlap between BMI and cognitive function." Mol Psychiatry. 2016;21(10):1477-82.
"Association of Weight and Body Composition on Cardiac Structure and Function in the ARIC Study (Atherosclerosis Risk in Communities)." Circ Heart Fail. 2016;9(8).
"Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents." Lancet. 2016;388(10046):776-86.
"Changes in Body Mass Index and Obesity Risk in Married Couples Over 25 Years: The ARIC Cohort Study." Am J Epidemiol. 2016;183(5):435-43.
"Factors Associated With Change in 25-Hydroxyvitamin D Levels Over Longitudinal Follow-Up in the ARIC Study." J Clin Endocrinol Metab. 2016;101(1):33-43.
"Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array." Eur J Hum Genet. 2016;24(1):106-12.
"Obesity and Subtypes of Incident Cardiovascular Disease." J Am Heart Assoc. 2016;5(8).
"Obstructive sleep apnea and incident type 2 diabetes." Sleep Med. 2016;25:156-161.
"Racial Differences in and Prognostic Value of Biomarkers of Hyperglycemia." Diabetes Care. 2016;39(4):589-95.
"American Heart Association's Life's Simple 7 and incidence of venous thromboembolism." Am J Hematol. 2015;90(5):E92.
"American Heart Association's Life's Simple 7: Avoiding Heart Failure and Preserving Cardiac Structure and Function." Am J Med. 2015;128(9):970-6.e2.
"Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci." Hum Mol Genet. 2015;24(15):4464-79.
"Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference." Obesity (Silver Spring). 2015;23(7):1493-501.
"Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry." Hum Mol Genet. 2015;24(16):4728-38.
"Genetic studies of body mass index yield new insights for obesity biology." Nature. 2015;518(7538):197-206.
"HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials." Lancet. 2015;385(9965):351-61.
"Ideal Cardiovascular Health During Adult Life and Cardiovascular Structure and Function Among the Elderly." Circulation. 2015;132(21):1979-89.
"The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study." PLoS Genet. 2015;11(10):e1005378.
"Modulation of genetic associations with serum urate levels by body-mass-index in humans." PLoS One. 2015;10(3):e0119752.
"New genetic loci link adipose and insulin biology to body fat distribution." Nature. 2015;518(7538):187-196.
"Obesity related risk of sudden cardiac death in the atherosclerosis risk in communities study." Heart. 2015;101(3):215-21.
"Race, vitamin D-binding protein gene polymorphisms, 25-hydroxyvitamin D, and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Clin Nutr. 2015;101(6):1232-40.
"The sex-specific association between BMI and coronary heart disease: a systematic review and meta-analysis of 95 cohorts with 1·2 million participants." Lancet Diabetes Endocrinol. 2015;3(6):437-449.
" " "Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis." Am J Hum Genet. 2014;94(2):198-208.
"A comparative analysis of risk factors for stroke in blacks and whites: the Atherosclerosis Risk in Communities study." Ethn Health. 2014;19(6):601-16.
"Elevated hepatic enzymes and incidence of venous thromboembolism: a prospective study." Ann Epidemiol. 2014;24(11):817-821.e2.
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