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ARIC Publications

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2021
Goodrich JK, Singer-Berk M, Son R, et al. "Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes." Nat Commun. 2021;12(1):3505.
Segar MW, Jaeger BC, Patel KV, et al. "Development and Validation of Machine Learning-Based Race-Specific Models to Predict 10-Year Risk of Heart Failure: A Multicohort Analysis." Circulation. 2021;143(24):2370-2383.
Fang M, Ishigami J, Echouffo-Tcheugui JB, Lutsey PL, Pankow JS, Selvin E. "Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study." Diabetologia. 2021.
Graff M, Justice AE, Young KL, et al. "Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry." Am J Hum Genet. 2021;108(4):564-582.
Marchesan JT, Moss K, Morelli T, et al. "Distinct Microbial Signatures between Periodontal Profile Classes." J Dent Res. 2021:220345211009767.
Echouffo-Tcheugui JB, Zhang S, Florido R, et al. "Duration of Diabetes and Incident Heart Failure: The ARIC (Atherosclerosis Risk In Communities) Study." JACC Heart Fail. 2021;9(8):594-603.
2020
Li C, Mou C, Swartz MD, Yu B, Bai Y, Tu Y. "dbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions." Hum Mutat. 2020;41(6):1123-1130.
Kessler MD, Loesch DP, Perry JA, et al. "De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population." Proc Natl Acad Sci U S A. 2020;117(5):2560-2569.
Gigliotti JC, Tin A, Pourafshar S, et al. " Deletion Exaggerates Kidney Injury in Experimental Mouse Models and Confers the Protective Effect of Cruciferous Vegetables in Mice and Humans." J Am Soc Nephrol. 2020;31(1):102-116.
Johnson EL, Krauss GL, Kucharska-Newton AMaria, et al. "Dementia in late-onset epilepsy: The Atherosclerosis Risk in Communities study." Neurology. 2020;95(24):e3248-e3256.
Ning X, Ding N, Ballew SH, et al. "Diabetes, its duration, and the long-term risk of abdominal aortic aneurysm: The Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2020;313:137-143.
Dighe S, Zhao J, Steffen L, et al. "Diet patterns and the incidence of age-related macular degeneration in the Atherosclerosis Risk in Communities (ARIC) study." Br J Ophthalmol. 2020;104(8):1070-1076.
Xu Z, Steffen LM, Selvin E. "Diet quality, change in diet quality and risk of incident CVD and diabetes." Public Health Nutr. 2020;23(2):329-338.
Surendran P, Feofanova EV, Lahrouchi N, et al. "Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals." Nat Genet. 2020;52(12):1314-1332.
Kim J, Wang W, Zhang M, et al. "Diurnal circadian variations in paroxysmal atrial fibrillation: The atherosclerosis risk in communities (ARIC) study." J Electrocardiol. 2020;63:98-103.
Howell SJ, German D, Bender A, et al. "Does Sex Modify an Association of Electrophysiological Substrate with Sudden Cardiac Death? The Atherosclerosis Risk in Communities (ARIC) Study." Cardiovasc Digit Health J. 2020;1(2):80-88.
Li X, Li Z, Zhou H, et al. "Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale." Nat Genet. 2020;52(9):969-983.
2019
Han P, Bidulescu A, Barber JR, et al. "Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study." Cancer Causes Control. 2019;30(4):343-354.
Hu EA, Steffen LM, Grams ME, Crews DC, Coresh JJ, Appel LJ. "Dietary patterns and risk of incident chronic kidney disease: the Atherosclerosis Risk in Communities study." Am J Clin Nutr. 2019;110(3):713-721.
George KM, Folsom AR, Steffen LM, Wagenknecht LE. "Differences in Cardiovascular Mortality Risk among African Americans in the Minnesota Heart Survey: 1985-2015 vs The Atherosclerosis Risk in Communities Study Cohort: 1987-2015." Ethn Dis. 2019;29(1):47-52.
Bhatt SP, Balte PP, Schwartz JE, et al. "Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality." JAMA. 2019;321(24):2438-2447.
Perez-Alday EA, Bender A, German D, et al. "Dynamic predictive accuracy of electrocardiographic biomarkers of sudden cardiac death within a survival framework: the Atherosclerosis Risk in Communities (ARIC) study." BMC Cardiovasc Disord. 2019;19(1):255.
Li Z, Li X, Liu Y, et al. "Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies." Am J Hum Genet. 2019;104(5):802-814.
2018
"Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies." Clin Chem. 2018;64(1):183-191.
Silvestre OM, Nadruz W, Roca GQuerejeta, et al. "Declining Lung Function and Cardiovascular Risk: The ARIC Study." J Am Coll Cardiol. 2018;72(10):1109-1122.
Natarajan P, Peloso GM, Zekavat SMaryam, et al. "Deep-coverage whole genome sequences and blood lipids among 16,324 individuals." Nat Commun. 2018;9(1):3391.
Warren B, Rebholz CM, Sang Y, Lee AK, Coresh JJ, Selvin E. "Diabetes and Trajectories of Estimated Glomerular Filtration Rate: A Prospective Cohort Analysis of the Atherosclerosis Risk in Communities Study." Diabetes Care. 2018;41(8):1646-1653.
Kubota Y, Folsom AR, Pankow JS, Wagenknecht LE. "Diabetes-related factors and abdominal aortic aneurysm events: the Atherosclerotic Risk in Communities Study." Ann Epidemiol. 2018;28(2):102-106.e1.
Wang Y, Yang H, Huynh Q, Nolan M, Negishi K. "Diagnosis of Nonischemic Stage B Heart Failure in Type 2 Diabetes Mellitus: Optimal Parameters for Prediction of Heart Failure." JACC Cardiovasc Imaging. 2018;11(10):1390-1400.
Warren B, Lee AK, Ballantyne CM, et al. "Diagnostic Performance of 1,5-Anhydroglucitol Compared to 2-H Glucose in the Atherosclerosis Risk in Communities Study." Clin Chem. 2018;64(10):1536-1537.
Brigham EP, Steffen LM, London SJ, et al. "Diet Pattern and Respiratory Morbidity in the Atherosclerosis Risk in Communities Study." Ann Am Thorac Soc. 2018;15(6):675-682.
Seidelmann SB, Claggett B, Cheng S, et al. "Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis." Lancet Public Health. 2018;3(9):e419-e428.
Kocarnik JM, Richard M, Graff M, et al. "Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study." Hum Mol Genet. 2018;27(16):2940-2953.
Ward-Caviness CK, Huffman JE, Everett K, et al. "DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis." Blood. 2018;132(17):1842-1850.
Liu C, Marioni RE, Hedman ÅK, et al. "A DNA methylation biomarker of alcohol consumption." Mol Psychiatry. 2018;23(2):422-433.
Jovanova OStory, Nedeljkovic I, Spieler D, et al. "DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies." JAMA Psychiatry. 2018;75(9):949-959.
2017
Morelli T, Moss KL, Beck J, Preisser JS, Wu D, Divaris K. "Derivation and Validation of the Periodontal and Tooth Profile Classification System for Patient Stratification." J Periodontol. 2017;88(2):153-165.
Jensen MK, Jensen RA, Mukamal KJ, et al. "Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium." Hum Mol Genet. 2017;26(11):2156-2163.
Godino JG, Appel LJ, Gross AL, et al. "Diabetes, hyperglycemia, and the burden of functional disability among older adults in a community-based study." J Diabetes. 2017;9(1):76-84.
Schneider ALC, Selvin E, Sharrett ARichey, et al. "Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)." Diabetes Care. 2017;40(11):1514-1521.
Effoe VS, McClendon EE, Rodriguez CJ, Wagenknecht LE, Evans GW, Chang PP. "Diabetes status modifies the association between carotid intima-media thickness and incident heart failure: The Atherosclerosis Risk in Communities study." Diabetes Res Clin Pract. 2017;128:58-66.
Rebholz CM, Grams ME, Steffen LM, et al. "Diet Soda Consumption and Risk of Incident End Stage Renal Disease." Clin J Am Soc Nephrol. 2017;12(1):79-86.
Ogilvie RP, Lutsey PL, Heiss G, Folsom AR. "Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Clin Nutr. 2017;105(3):651-659.
Haring B, Selvin E, Liang M, et al. "Dietary Protein Sources and Risk for Incident Chronic Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study." J Ren Nutr. 2017;27(4):233-242.
C Y Ng M, Graff M, Lu Y, et al. "Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium." PLoS Genet. 2017;13(4):e1006719.
van den Berg ME, Warren HR, Cabrera CP, et al. "Discovery of novel heart rate-associated loci using the Exome Chip." Hum Mol Genet. 2017;26(12):2346-2363.
Richard MA, Huan T, Ligthart S, et al. "DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation." Am J Hum Genet. 2017;101(6):888-902.
2016
Rebholz CM, Crews DC, Grams ME, et al. "DASH (Dietary Approaches to Stop Hypertension) Diet and Risk of Subsequent Kidney Disease." Am J Kidney Dis. 2016;68(6):853-861.
Liu X, Wu C, Li C. "dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs." Hum Mutat. 2016;37(3):235-41.
Rubin J, Matsushita K, Lazo M, et al. "Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population." Clin Biochem. 2016;49(9):657-662.
Deo R, Norby FL, Katz R, et al. "Development and Validation of a Sudden Cardiac Death Prediction Model for the General Population." Circulation. 2016;134(11):806-16.
Fox ER, Samdarshi TE, Musani SK, et al. "Development and Validation of Risk Prediction Models for Cardiovascular Events in Black Adults: The Jackson Heart Study Cohort." JAMA Cardiol. 2016;1(1):15-25.
Schneider ALC, Kalyani RR, Golden S, et al. "Diabetes and Prediabetes and Risk of Hospitalization: The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2016;39(5):772-9.
Bell EJ, Folsom AR, Lutsey PL, Selvin E, Zakai NA, Cushman M. "Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis." Diabetes Res Clin Pract. 2016;111:10-8.
Khera AV, Won H-H, Peloso GM, et al. "Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia." J Am Coll Cardiol. 2016;67(22):2578-89.
McEvoy JW, Chen Y, Rawlings A, et al. "Diastolic Blood Pressure, Subclinical Myocardial Damage, and Cardiac Events: Implications for Blood Pressure Control." J Am Coll Cardiol. 2016;68(16):1713-1722.
Sahli MW, Mares JA, Meyers KJ, et al. "Dietary Intake of Lutein and Diabetic Retinopathy in the Atherosclerosis Risk in Communities Study (ARIC)." Ophthalmic Epidemiol. 2016;23(2):99-108.
J Smith G, Felix JF, Morrison AC, et al. "Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure." PLoS Genet. 2016;12(5):e1006034.
Ligthart S, Marzi C, Aslibekyan S, et al. "DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases." Genome Biol. 2016;17(1):255.
Chen BH, Marioni RE, Colicino E, et al. "DNA methylation-based measures of biological age: meta-analysis predicting time to death." Aging (Albany NY). 2016;8(9):1844-1865.
2015
Butler KR, Penman AD, Minor DS. "Determinants of pulse pressure and annual rates of change in the Atherosclerosis Risk in Communities study." J Hypertens. 2015;33(12):2463-70.
Rebholz CM, Coresh JJ, Grams ME, Steffen LM, Anderson CAM, Appel LJ. "Dietary Acid Load and Incident Chronic Kidney Disease: Results from the ARIC Study." Am J Nephrol. 2015;42(6):427-35.
Smith CE, Follis JL, Nettleton JA, et al. "Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium." Mol Nutr Food Res. 2015;59(7):1373-83.
Salfati E, Morrison AC, Boerwinkle E. "Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC)." PLoS One. 2015;10(7):e0133031.
Joshi PK, Esko T, Mattsson H, et al. "Directional dominance on stature and cognition in diverse human populations." Nature. 2015;523(7561):459-462.
Bis JC, Sitlani C, Irvin R, et al. "Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium." PLoS One. 2015;10(10):e0140496.
Wei GS, Coady SA, Reis JP, et al. "Duration and Degree of Weight Gain and Incident Diabetes in Younger Versus Middle-Aged Black and White Adults: ARIC, CARDIA, and the Framingham Heart Study." Diabetes Care. 2015;38(11):2042-9.
2014
Coresh JJ, Turin TChowdhury, Matsushita K, et al. "Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality." JAMA. 2014;311(24):2518-2531.
Wood AR, Esko T, Yang J, et al. "Defining the role of common variation in the genomic and biological architecture of adult human height." Nat Genet. 2014;46(11):1173-86.
Fowkes FGR, Murray GD, Butcher I, et al. "Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events." Eur J Prev Cardiol. 2014;21(3):310-20.
Rawlings AM, Sharrett ARichey, Schneider ALC, et al. "Diabetes in midlife and cognitive change over 20 years: a cohort study." Ann Intern Med. 2014;161(11):785-93.
Selvin E, Lazo M, Chen Y, et al. "Diabetes mellitus, prediabetes, and incidence of subclinical myocardial damage." Circulation. 2014;130(16):1374-82.
Haring B, Gronroos N, Nettleton JA, von Ballmoos MCWyler, Selvin E. "Dietary protein intake and coronary heart disease in a large community based cohort: results from the Atherosclerosis Risk in Communities (ARIC) study [corrected]." PLoS One. 2014;9(10):e109552.
Avery CL, Sitlani CM, Arking DE, et al. "Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval." Pharmacogenomics J. 2014;14(1):6-13.
2013
Schneider ALC, Williams EK, Brancati FL, Blecker S, Coresh JJ. "Diabetes and risk of fracture-related hospitalization: the Atherosclerosis Risk in Communities Study." Diabetes Care. 2013;36(5):1153-8.
Weng L-C, Steffen LM, Szklo M, Nettleton J, Chambless L. "A diet pattern with more dairy and nuts, but less meat is related to lower risk of developing hypertension in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) study." Nutrients. 2013;5(5):1719-33.
Cheng S, Gupta DK, Claggett B, et al. "Differential influence of distinct components of increased blood pressure on cardiovascular outcomes: from the atherosclerosis risk in communities study." Hypertension. 2013;62(3):492-8.
Erdmann J, Stark K, Esslinger UB, et al. "Dysfunctional nitric oxide signalling increases risk of myocardial infarction." Nature. 2013;504(7480):432-6.
2012
Mongraw-Chaffin ML, Matsushita K, Brancati FL, et al. "Diabetes medication use and blood lactate level among participants with type 2 diabetes: the atherosclerosis risk in communities carotid MRI study." PLoS One. 2012;7(12):e51237.
Franceschini N, van Rooij FJA, Prins BP, et al. "Discovery and fine mapping of serum protein loci through transethnic meta-analysis." Am J Hum Genet. 2012;91(4):744-53.

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