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ARIC Publications

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2021
Ishigami J, Mathews L, Hishida M, et al. "Echocardiographic measures and subsequent decline in kidney function in older adults: the Atherosclerosis Risk in Communities Study." Eur Heart J Cardiovasc Imaging. 2021.
Saadati HMozafar, Sabour S, Mansournia MAli, Mehrabi Y, Nazari SSaeed Hash. "Effect modification of general and central obesity by sex and age on cardiovascular outcomes: Targeted maximum likelihood estimation in the atherosclerosis risk in communities study." Diabetes Metab Syndr. 2021;15(2):479-485.
Johnson JA, Haq KT, Lutz KJ, et al. "Electrophysiological ventricular substrate of stroke: a prospective cohort study in the Atherosclerosis Risk in Communities (ARIC) study." BMJ Open. 2021;11(9):e048542.
Sun P, Kumar N, Tin A, et al. "Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease." Hypertension. 2021:HYPERTENSIONAHA12117597.
Vasan RS, Musani SK, Matsushita K, et al. "Epidemiology of Heart Failure Stages in Middle-Aged Black People in the Community: Prevalence and Prognosis in the Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2021;10(9):e016524.
Gondalia R, Baldassari A, Holliday KM, et al. "Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study." Environ Res. 2021;198:111211.
Wang P, Castellani CA, Yao J, et al. "Epigenome-wide association study of mitochondrial genome copy number." Hum Mol Genet. 2021.
Feofanova EV, Lim E, Chen H, et al. "Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Study." Genet Epidemiol. 2021;45(6):651-663.
2020
Alonso A, Chen LYee, Rudser KD, Norby FL, Rooney MR. "Effect of Magnesium Supplementation on Circulating Biomarkers of Cardiovascular Disease." Nutrients. 2020;12(6).
Cowan LT, Lakshminarayan K, Lutsey PL, Beck J, Offenbacher S. "Endodontic therapy and incident cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) study." J Public Health Dent. 2020;80(1):79-91.
Bressler J, Marioni RE, Walker RM, et al. "Epigenetic Age Acceleration and Cognitive Function in African American Adults in Midlife: The Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2020;75(3):473-480.
Longchamps RJ, Castellani CA, Yang SY, et al. "Evaluation of mitochondrial DNA copy number estimation techniques." PLoS One. 2020;15(1):e0228166.
2019
Mitchell RN, Ashar FN, Jarvelin M-R, et al. "Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death." J Am Heart Assoc. 2019;8(23):e013751.
Chen H, Huffman JE, Brody JA, et al. "Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies." Am J Hum Genet. 2019;104(2):260-274.
Syme C, Shin J, Richer L, Gaudet D, Fornage M, Paus T. "Epigenetic Loci of Blood Pressure." Circ Genom Precis Med. 2019;12(1):e002341.
Barrett JK, Huille R, Parker R, Yano Y. "Estimating the association between blood pressure variability and cardiovascular disease: An application using the ARIC Study." Stat Med. 2019;38(10):1855-1868.
Flannick J, Mercader JM, Fuchsberger C, et al. "Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls." Nature. 2019;570(7759):71-76.
Spracklen CN, Karaderi T, Yaghootkar H, et al. "Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology." Am J Hum Genet. 2019;105(1):15-28.
2018
Arora S, Matsushita K, Qamar A, R Stacey B. "Early versus late percutaneous revascularization in patients hospitalized with non ST-segment elevation myocardial infarction: The atherosclerosis risk in communities surveillance study." Catheter Cardiovasc Interv. 2018;91(2):253-259.
Joshu CE, Barber JR, Coresh JJ, et al. "Enhancing the Infrastructure of the Atherosclerosis Risk in Communities (ARIC) Study for Cancer Epidemiology Research: ARIC Cancer." Cancer Epidemiol Biomarkers Prev. 2018;27(3):295-305.
Dhana K, Braun KVE, Nano J, et al. "An Epigenome-Wide Association Study of Obesity-Related Traits." Am J Epidemiol. 2018;187(8):1662-1669.
Wang X, Pan Y, Zhu H, et al. "An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression." Clin Epigenetics. 2018;10:3.
Selvin E, Warren B, He X, Sacks DB. "Establishment of Community-Based Reference Intervals for Fructosamine, Glycated Albumin, and 1,5-Anhydroglucitol." Clin Chem. 2018;64(5):843-850.
Weng L-C, Roetker NS, Lutsey PL, et al. "Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study." PLoS One. 2018;13(4):e0195719.
Jian X, Satizabal CL, Smith AV, et al. "Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging." Stroke. 2018;49(8):1812-1819.
Prins BP, Mead TJ, Brody JA, et al. "Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6." Genome Biol. 2018;19(1):87.
Bihlmeyer NA, Brody JA, Smith A V, et al. "ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals." Circ Genom Precis Med. 2018;11(1):e001758.
2017
Nguyen KT, Vittinghoff E, Dewland TA, et al. "Ectopy on a Single 12-Lead ECG, Incident Cardiac Myopathy, and Death in the Community." J Am Heart Assoc. 2017;6(8).
B Windham G, Griswold ME, Lirette S, et al. "Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study." J Gerontol A Biol Sci Med Sci. 2017;72(1):89-94.
Aro AL, Reinier K, Rusinaru C, et al. "Electrical risk score beyond the left ventricular ejection fraction: prediction of sudden cardiac death in the Oregon Sudden Unexpected Death Study and the Atherosclerosis Risk in Communities Study." Eur Heart J. 2017;38(40):3017-3025.
Roberts JD, Soliman EZ, Alonso A, Vittinghoff E, Chen LYee, Loehr LR. "Electrocardiographic intervals associated with incident atrial fibrillation: Dissecting the QT interval." Heart Rhythm. 2017;14(5):654-660.
Zhang Z-M, Rautaharju PM, Prineas RJ, Tereshchenko L. "Electrocardiographic QRS-T angle and the risk of incident silent myocardial infarction in the Atherosclerosis Risk in Communities study." J Electrocardiol. 2017;50(5):661-666.
Chu AY, Tin A, Schlosser P, et al. "Epigenome-wide association studies identify DNA methylation associated with kidney function." Nat Commun. 2017;8(1):1286.
Kulkarni M, Foraker RE, McNeill AM, et al. "Evaluation of the modified FINDRISC to identify individuals at high risk for diabetes among middle-aged white and black ARIC study participants." Diabetes Obes Metab. 2017;19(9):1260-1266.
Hinney A, Kesselmeier M, Jall S, et al. "Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index." Mol Psychiatry. 2017;22(2):192-201.
Liu DJ, Peloso GM, Yu H, et al. "Exome-wide association study of plasma lipids in >300,000 individuals." Nat Genet. 2017;49(12):1758-1766.
Scott RA, Scott LJ, Mägi R, et al. "An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans." Diabetes. 2017;66(11):2888-2902.
2016
Konety S, Koene RJ, Norby FL, et al. "Echocardiographic Predictors of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study and Cardiovascular Health Study." Circ Cardiovasc Imaging. 2016;9(8).
Wu B, Guan W. "On Efficient and Accurate Calculation of Significance P-Values for Sequence Kernel Association Testing of Variant Set." Ann Hum Genet. 2016;80(2):123-35.
O'Neal WT, Zhang Z-M, Loehr LR, Chen LYee, Alonso A. "Electrocardiographic Advanced Interatrial Block and Atrial Fibrillation Risk in the General Population." Am J Cardiol. 2016;117(11):1755-9.
O'Neal WT, Wang YGrace, Wu H-T, et al. "Electrocardiographic J Wave and Cardiovascular Outcomes in the General Population (from the Atherosclerosis Risk In Communities Study)." Am J Cardiol. 2016;118(6):811-815.
Sung YJu, Winkler TW, Manning AK, et al. "An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group." Genet Epidemiol. 2016;40(5):404-15.
Joehanes R, Just AC, Marioni RE, et al. "Epigenetic Signatures of Cigarette Smoking." Circ Cardiovasc Genet. 2016;9(5):436-447.
Banack HR. "Estimating the Time-Varying Joint Effects of Obesity and Smoking on All-Cause Mortality Using Marginal Structural Models." Am J Epidemiol. 2016;183(2):122-9.
Rhee EP, Yang Q, Yu B, et al. "An exome array study of the plasma metabolome." Nat Commun. 2016;7:12360.
Chami N, Chen M-H, Slater AJ, et al. "Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits." Am J Hum Genet. 2016;99(1):8-21.
2015
Kamel H, O'Neal WT, Okin PM, Loehr LR, Alonso A. "Electrocardiographic left atrial abnormality and stroke subtype in the atherosclerosis risk in communities study." Ann Neurol. 2015;78(5):670-8.
Rautaharju PM, Zhang Z-M, Haisty WK, Kucharska-Newton AMaria, Rosamond WD. "Electrocardiographic repolarization-related predictors of coronary heart disease and sudden cardiac deaths in men and women with cardiovascular disease in the Atherosclerosis Risk in Communities (ARIC) study." J Electrocardiol. 2015;48(1):101-11.
Miedema MD, Norby FL, Blaha MJ, Virani SS, Coresh JJ, Ballantyne CM. "Eligibility for statin therapy according to new cholesterol guidelines and prevalent use of medication to lower lipid levels in an older US Cohort: the Atherosclerosis Risk in Communities Study Cohort." JAMA Intern Med. 2015;175(1):138-40.
Srinath R, Golden SHill, Carson KA. "Endogenous testosterone and its relationship to preclinical and clinical measures of cardiovascular disease in the atherosclerosis risk in communities study." J Clin Endocrinol Metab. 2015;100(4):1602-8.
Demerath EW, Guan W, Grove ML, et al. "Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci." Hum Mol Genet. 2015;24(15):4464-79.
Aslibekyan S, Demerath EW, Mendelson M, et al. "Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference." Obesity (Silver Spring). 2015;23(7):1493-501.
Matsushita K, Coresh JJ, Sang Y, et al. "Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data." Lancet Diabetes Endocrinol. 2015;3(7):514-25.
Gonzaga-Jauregui C, Harel T, Gambin T, et al. "Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy." Cell Rep. 2015;12(7):1169-83.
Do R, Stitziel NO, Won H-H, et al. "Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature. 2015;518(7537):102-6.
2014
Bekwelem W, Misialek JR, Konety S, et al. "Echocardiographic measures of cardiac structure and function are associated with risk of atrial fibrillation in blacks: the Atherosclerosis Risk in Communities (ARIC) study." PLoS One. 2014;9(10):e110111.
Cotlarciuc I, Malik R, Holliday EG, et al. "Effect of genetic variants associated with plasma homocysteine levels on stroke risk." Stroke. 2014;45(7):1920-4.
Ganesh SK, Chasman DI, Larson MG, et al. "Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations." Am J Hum Genet. 2014;95(1):49-65.
Tereshchenko LG, Henrikson CA, Sotoodehnia N, et al. "Electrocardiographic deep terminal negativity of the P wave in V(1) and risk of sudden cardiac death: the Atherosclerosis Risk in Communities (ARIC) study." J Am Heart Assoc. 2014;3(6):e001387.
Folsom AR, Lutsey PL, Roetker NS, et al. "Elevated hepatic enzymes and incidence of venous thromboembolism: a prospective study." Ann Epidemiol. 2014;24(11):817-821.e2.
Sung YJu, Schwander K, Arnett DK, et al. "An empirical comparison of meta-analysis and mega-analysis of individual participant data for identifying gene-environment interactions." Genet Epidemiol. 2014;38(4):369-78.
Kapoor A, Sekar RB, Hansen NF, et al. "An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval." Am J Hum Genet. 2014;94(6):854-69.
Bose M, Wu C, Pankow JS, et al. "Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study." BMC Bioinformatics. 2014;15:312.
2013
Nguyen K-DH, Pihur V, Ganesh SK, et al. "Effects of rare and common blood pressure gene variants on essential hypertension: results from the Family Blood Pressure Program, CLUE, and Atherosclerosis Risk in Communities studies." Circ Res. 2013;112(2):318-26.
Fesinmeyer MD, North KE, Lim U, et al. "Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study." BMC Med Genet. 2013;14:6.
Rautaharju PM, Zhang Z-M, Warren J, et al. "Electrocardiographic predictors of coronary heart disease and sudden cardiac deaths in men and women free from cardiovascular disease in the Atherosclerosis Risk in Communities study." J Am Heart Assoc. 2013;2(3):e000061.
Rautaharju PM, Zhang Z-M, Haisty WK, Prineas RJ, Kucharska-Newton AMaria, Rosamond WD. "Electrocardiographic predictors of incident heart failure in men and women free from manifest cardiovascular disease (from the Atherosclerosis Risk in Communities [ARIC] study)." Am J Cardiol. 2013;112(6):843-9.
Whelton SP, Roy P, Astor BC, Zhang L, Hoogeveen RC, Ballantyne CM. "Elevated high-sensitivity C-reactive protein as a risk marker of the attenuated relationship between serum cholesterol and cardiovascular events at older age. The ARIC Study." Am J Epidemiol. 2013;178(7):1076-84.
Yende S, Alvarez K, Loehr LR, et al. "Epidemiology and long-term clinical and biologic risk factors for pneumonia in community-dwelling older Americans: analysis of three cohorts." Chest. 2013;144(3):1008-1017.
Chow LS, Li S, Eberly LE, et al. "Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study." Metabolism. 2013;62(1):100-8.
Shinohara RT, Narayan AK, Hong K, Kim HS, Coresh JJ, Streiff MB. "Estimating parsimonious models of longitudinal causal effects using regressions on propensity scores." Stat Med. 2013;32(22):3829-37.
Divaris K, Monda KL, North KE, et al. "Exploring the genetic basis of chronic periodontitis: a genome-wide association study." Hum Mol Genet. 2013;22(11):2312-24.
2012
Schneider ALC, Sharrett ARichey, Patel MD, et al. "Education and cognitive change over 15 years: the atherosclerosis risk in communities study." J Am Geriatr Soc. 2012;60(10):1847-53.
Folsom AR, Nambi V, Pankow JS, Tang W, Farbakhsh K, Yamagishi K. "Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2012;224(2):435-9.
Paynter NP, Crainiceanu CM, Sharrett ARichey, Chambless LE. "Effect of correcting for long-term variation in major coronary heart disease risk factors: relative hazard estimation and risk prediction in the Atherosclerosis Risk in Communities Study." Ann Epidemiol. 2012;22(3):191-7.
Grallert H, Dupuis J, Bis JC, et al. "Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies." Eur Heart J. 2012;33(2):238-51.
Buyske S, Wu Y, Carty CL, et al. "Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study." PLoS One. 2012;7(4):e35651.
Tennessen JA, Bigham AW, O'Connor TD, et al. "Evolution and functional impact of rare coding variation from deep sequencing of human exomes." Science. 2012;337(6090):64-9.
2011
Soliman EZ, Prineas RJ, Case DL, et al. "Electrocardiographic and clinical predictors separating atherosclerotic sudden cardiac death from incident coronary heart disease." Heart. 2011;97(19):1597-601.
2010
Yeung EH, Saudek CD, Jahren HA, et al. "Evaluation of a novel isotope biomarker for dietary consumption of sweets." Am J Epidemiol. 2010;172(9):1045-52.

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