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ARIC Publications

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2020
Fuentes Lde Las, Sung YJu, Noordam R, et al. "Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci." Mol Psychiatry. 2020.
Weng L-C, Hall AWeber, Choi SHoan, et al. "Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation." Circ Genom Precis Med. 2020;13(5):387-395.
Shah S, Henry A, Roselli C, et al. "Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure." Nat Commun. 2020;11(1):163.
Qian H, Kowalski MH, Kramer HJ, et al. "Genome-Wide Association of Kidney Traits in Hispanics/Latinos Using Dense Imputed Whole-Genome Sequencing Data: The Hispanic Community Health Study/Study of Latinos." Circ Genom Precis Med. 2020;13(4):e002891.
Feofanova EV, Chen H, Dai Y, et al. "A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos." Am J Hum Genet. 2020;107(5):849-863.
Keene KL, Hyacinth HI, Bis JC, et al. "Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke." Stroke. 2020;51(8):2454-2463.
Jian X, Sofer T, Tarraf W, et al. "Genome-wide association study of cognitive function in diverse Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos." Transl Psychiatry. 2020;10(1):245.
Rooney MR, Tang O, Pankow JS. "Glycaemic markers and all-cause mortality in older adults with and without diabetes: the Atherosclerosis Risk in Communities (ARIC) study." Diabetologia. 2020.
2019
Wojcik GL, Graff M, Nishimura KK, et al. "Genetic analyses of diverse populations improves discovery for complex traits." Nature. 2019;570(7762):514-518.
Chauhan G, Adams HHH, Satizabal CL, et al. "Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting." Neurology. 2019.
Sakornsakolpat P, Prokopenko D, Lamontagne M, et al. "Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations." Nat Genet. 2019;51(3):494-505.
Kunkle BW, Grenier-Boley B, Sims R, et al. "Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing." Nat Genet. 2019;51(3):414-430.
Lin BM, Nadkarni GN, Tao R, et al. "Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study." Front Genet. 2019;10:494.
Shungin D, Haworth S, Divaris K, et al. "Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data." Nat Commun. 2019;10(1):2773.
Teumer A, Li Y, Ghasemi S, et al. "Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria." Nat Commun. 2019;10(1):4130.
van Setten J, Verweij N, Mbarek H, et al. "Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits." Eur J Hum Genet. 2019;27(6):952-962.
de Vries PS, Sabater-Lleal M, Huffman JE, et al. "A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology." Blood. 2019;133(9):967-977.
Guan M, Keaton JM, Dimitrov L, et al. "Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans." Hum Genomics. 2019;13(1):21.
Irvin MR, Sitlani CM, Floyd JS, et al. "Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group." Am J Hypertens. 2019;32(12):1146-1153.
Sabater-Lleal M, Huffman JE, de Vries PS, et al. "Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels." Circulation. 2019;139(5):620-635.
Huan T, Joehanes R, Song C, et al. "Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease." Nat Commun. 2019;10(1):4267.
Merino J, Dashti HS, Li SX, et al. "Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium." Mol Psychiatry. 2019;24(12):1920-1932.
Irvin MR, Sitlani CM, Noordam R, et al. "Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry." Pharmacogenomics J. 2019;19(1):97-108.
Lindström S, Wang L, Smith EN, et al. "Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism." Blood. 2019;134(19):1645-1657.
Oyenuga AO, Folsom AR, Cheng S, Tanaka H. "Greater Adherence to Life's Simple 7 Is Associated With Less Arterial Stiffness: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Hypertens. 2019;32(8):769-776.
2018
Hodonsky CJo, Schurmann C, Schick UM, et al. "Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study." Am J Hematol. 2018.
Evangelou E, Warren HR, Mosen-Ansorena D, et al. "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits." Nat Genet. 2018;50(10):1412-1425.
Fernández-Rhodes L, Malinowski JR, Wang Y, et al. "The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis." PLoS One. 2018;13(7):e0200486.
Robinson-Cohen C, Bartz TM, Lai D, et al. "Genetic Variants Associated with Circulating Fibroblast Growth Factor 23." J Am Soc Nephrol. 2018;29(10):2583-2592.
Li C, Grove ML, Yu B, Jones BC, Morrison A, Boerwinkle E. "Genetic variants in microRNA genes and targets associated with cardiovascular disease risk factors in the African-American population." Hum Genet. 2018;137(1):85-94.
Seidelmann SB, Feofanova E, Yu B, et al. "Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk." J Am Coll Cardiol. 2018;72(15):1763-1773.
Blue EE, Bis JC, Dorschner MO, et al. "Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project." Dement Geriatr Cogn Disord. 2018;45(1-2):1-17.
Young KL, Graff M, Fernández-Rhodes L. "Genetics of Obesity in Diverse Populations." Curr Diab Rep. 2018;18(12):145.
Ligthart S, Vaez A, Võsa U, et al. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders." Am J Hum Genet. 2018;103(5):691-706.
Teumer A, Chaker L, Groeneweg S, et al. "Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation." Nat Commun. 2018;9(1):4455.
Otto MC de Olive, Lemaitre RN, Sun Q, et al. "Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium." PLoS One. 2018;13(5):e0196951.
Napier MD, Franceschini N, Gondalia R, et al. "Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy." Sci Rep. 2018;8(1):5675.
Jiang X, O'Reilly PF, Aschard H, et al. "Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels." Nat Commun. 2018;9(1):260.
Vojinovic D, Adams HH, Jian X, et al. "Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume." Nat Commun. 2018;9(1):3945.
Klimentidis YC, Raichlen DA, Bea J, et al. "Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE." Int J Obes (Lond). 2018;42(6):1161-1176.
Loomis SJ, Li M, Maruthur NM, et al. "Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study." Diabetes. 2018;67(8):1684-1696.
Tereshchenko LG, Sotoodehnia N, Sitlani CM, et al. "Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study)." J Am Heart Assoc. 2018;7(8).
Keaton JM, Gao C, Guan M, et al. "Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
Smith CE, Follis JL, Dashti HS, et al. "Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent." Mol Nutr Food Res. 2018;62(3).
Biering-Sørensen T, Kabir M, Waks JW, et al. "Global ECG Measures and Cardiac Structure and Function: The ARIC Study (Atherosclerosis Risk in Communities)." Circ Arrhythm Electrophysiol. 2018;11(3):e005961.
"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017." Lancet. 2018;392(10159):1789-1858.
Franceschini N, Giambartolomei C, de Vries PS, et al. "GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes." Nat Commun. 2018;9(1):5141.
Offenbacher S, Jiao Y, Kim SJ, et al. "GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation." Nat Commun. 2018;9(1):3686.
2017
Fashanu OE, Norby FL, Aguilar D, et al. "Galectin-3 and incidence of atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study." Am Heart J. 2017;192:19-25.
Fashanu OE, Folsom AR, Oyenuga A, Ballantyne CM, Lutsey PL. "Galectin-3 and the incidence of abdominal aortic aneurysm: the atherosclerosis risk in communities (ARIC) study." Am J Cardiovasc Dis. 2017;7(6):114-121.
Fashanu OE, Heckbert SR, Aguilar D, et al. "Galectin-3 and Venous Thromboembolism Incidence: the Atherosclerosis Risk in Communities (ARIC) Study." Res Pract Thromb Haemost. 2017;1(2):223-230.
Schreiner PJ, Appiah D. "Gamma prime (γ') fibrinogen and carotid intima-media thickness: the Atherosclerosis Risk in Communities study." Blood Coagul Fibrinolysis. 2017;28(8):665-669.
Smith JA, Zhao W, Yasutake K, et al. "Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies." Int J Environ Res Public Health. 2017;14(12).
Yoneyama S, Yao J, Guo X, et al. "Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations." Int J Obes (Lond). 2017;41(2):324-331.
Gregson JM, Freitag DF, Surendran P, et al. "Genetic invalidation of Lp-PLA as a therapeutic target: Large-scale study of five functional Lp-PLA-lowering alleles." Eur J Prev Cardiol. 2017;24(5):492-504.
Hobbs BD, de Jong K, Lamontagne M, et al. "Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis." Nat Genet. 2017;49(3):426-432.
Chatterjee NA, Giulianini F, Geelhoed B, et al. "Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization." Circulation. 2017;135(8):741-754.
Robinson-Cohen C, Lutsey PL, Kleber ME, et al. "Genetic Variants Associated with Circulating Parathyroid Hormone." J Am Soc Nephrol. 2017;28(5):1553-1565.
Bressler J, Mosley TH, Penman A, et al. "Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study." Am J Med Genet B Neuropsychiatr Genet. 2017;174(3):269-282.
Traylor M, Malik R, Nalls MA, et al. "Genetic variation at 16q24.2 is associated with small vessel stroke." Ann Neurol. 2017;81(3):383-394.
Dong J, Wyss A, Yang J, et al. "Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans." Mol Neurobiol. 2017;54(10):8021-8032.
Mozaffarian D, Dashti HS, Wojczynski MK, et al. "Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts." PLoS One. 2017;12(12):e0186456.
Li M, Carey J, Cristiano S, et al. "Genome-Wide Association of Copy Number Polymorphisms and Kidney Function." PLoS One. 2017;12(1):e0170815.
Li M, Maruthur NM, Loomis SJ, et al. "Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism." Sci Rep. 2017;7(1):2812.
Gondalia R, Avery CL, Napier MD, et al. "Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation." Environ Health Perspect. 2017;125(6):067002.
Sennblad B, Basu S, Mazur J, et al. "Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels." Hum Mol Genet. 2017;26(3):637-649.
Wu B. "Genome-wide association test of multiple continuous traits using imputed SNPs." Stat Interface. 2017;10(3):379-386.
Keaton JM, Hellwege JN, C Y Ng M, et al. "GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS." Pac Symp Biocomput. 2017;22:242-253.
Joshi PK, Pirastu N, Kentistou KA, et al. "Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity." Nat Commun. 2017;8(1):910.
Justice AE, Winkler TW, Feitosa MF, et al. "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Nat Commun. 2017;8:14977.
Graff M, Scott RA, Justice AE, et al. "Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults." PLoS Genet. 2017;13(4):e1006528.
van Rooij FJA, Qayyum R, Smith AV, et al. "Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis." Am J Hum Genet. 2017;100(1):51-63.
Day FR, Thompson DJ, Helgason H, et al. "Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk." Nat Genet. 2017;49(6):834-841.
Rawlings AM, Sharrett ARichey, Mosley TH, Ballew SH, Deal JA. "Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline." Diabetes Care. 2017;40(7):879-886.
Pirastu N, Joshi PK, de Vries PS, et al. "GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk." Nat Commun. 2017;8(1):1584.
2016
McEvoy JW, Chen Y, Halushka MK, et al. "Galectin-3 and Risk of Heart Failure and Death in Blacks and Whites." J Am Heart Assoc. 2016;5(5).
Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen RC, Young JH. "GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study." Diabet Med. 2016;33(7):968-75.
Lin H, Mueller-Nurasyid M, Smith AV, et al. "Gene-gene Interaction Analyses for Atrial Fibrillation." Sci Rep. 2016;6:35371.

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