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ARIC Publications

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Gorski M, Jung B, Li Y, et al. "Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline." Kidney Int. 2021;99(4):926-939.
He WJ, Chen J, Razavi AC, et al. "Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease." Clin J Am Soc Nephrol. 2021;16(11):1620-1629.
Tariq A, Chen J, Yu B, et al. "Metabolomics of Dietary Acid Load and Incident Chronic Kidney Disease." J Ren Nutr. 2021.
Cohen AJ, Teramoto K, Claggett B, et al. "Mid- to Late-Life Inflammation and Risk of Cardiac Dysfunction, HFpEF and HFrEF in Late Life." J Card Fail. 2021.
Johnson EL, Krauss GL, Kucharska-Newton A, Lam AD, Sarkis R, Gottesman RF. "Mortality in Patients With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study." Neurology. 2021.
Wang H, Noordam R, Cade BE, et al. "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure." Mol Psychiatry. 2021.
Jhun M-A, Mendelson M, Wilson R, et al. "A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids." Nat Commun. 2021;12(1):3987.
Madrid L, Moreno-Grau S, Ahmad S, et al. "Multiomics integrative analysis identifies allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis." Aging (Albany NY). 2021;13(7):9277-9329.
Bae SSharon, L Chang C, Merkin S S, Elashoff D, Ishigami J, Matsushita K. "Major Lipids and Future Risk of Pneumonia: 20-Year Observation of the Atherosclerosis Risk in Communities (ARIC) Study Cohort." Am J Med. 2020.
Maners J, Gill D, Pankratz N, et al. "A Mendelian randomization of γ' and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke." Blood. 2020;136(26):3062-3069.
Justice AE, Chittoor G, Gondalia R, et al. "Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems." Epigenomics. 2020;12(17):1483-1499.
Koton S, Schneider ALC, B Windham G, Mosley TH, Gottesman RF. "Microvascular Brain Disease Progression and Risk of Stroke: The ARIC Study." Stroke. 2020;51(11):3264-3270.
Palta P, Heiss G, Sharrett ARichey, et al. "Mid- and Late-Life Leisure-Time Physical Activity and Global Brain Amyloid Burden: The Atherosclerosis Risk in Communities (ARIC)-PET Study." J Alzheimers Dis. 2020;76(1):139-147.
Teramoto K, Junior WNadruz, Matsushita K, et al. "Mid- to Late-Life Time-Averaged Cumulative Blood Pressure and Late-Life Cardiac Structure, Function, and Heart Failure." Hypertension. 2020;76(3):808-818.
George KM, Folsom AR, Sharrett ARichey, Mosley TH, Gottesman RF, Hamedani AG. "Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study." Headache. 2020;60(5):946-953.
DeBarmore B, Longchamps RJ, Zhang Y, et al. "Mitochondrial DNA copy number and diabetes: the Atherosclerosis Risk in Communities (ARIC) study." BMJ Open Diabetes Res Care. 2020;8(1).
Zhao D, Bartz TM, Sotoodehnia N, et al. "Mitochondrial DNA copy number and incident atrial fibrillation." BMC Med. 2020;18(1):246.
Hong YSoo, Longchamps RJ, Zhao D, et al. "Mitochondrial DNA Copy Number and Incident Heart Failure: The Atherosclerosis Risk in Communities (ARIC) Study." Circulation. 2020;141(22):1823-1825.
Castellani CA, Longchamps RJ, Sumpter JA, et al. "Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs." Genome Med. 2020;12(1):84.
Murthy VL, Yu B, Wang W, et al. "Molecular Signature of Multisystem Cardiometabolic Stress and Its Association With Prognosis." JAMA Cardiol. 2020.
Tang O, Matsushita K, Coresh JJ, et al. "Mortality Implications of Prediabetes and Diabetes in Older Adults." Diabetes Care. 2020;43(2):382-388.
Ntalla I, Weng L-C, Cartwright JH, et al. "Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction." Nat Commun. 2020;11(1):2542.
Baldassari AR, Sitlani CM, Highland HM, et al. "Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits." Circ Genom Precis Med. 2020;13(4):e002680.
Decker JJ, Norby FL, Rooney MR, et al. "Metabolic Syndrome and Risk of Ischemic Stroke in Atrial Fibrillation: ARIC Study." Stroke. 2019;50(11):3045-3050.
Wang Z, Zhu C, Nambi V, et al. "Metabolomic Pattern Predicts Incident Coronary Heart Disease." Arterioscler Thromb Vasc Biol. 2019;39(7):1475-1482.
Yu B, Flexeder C, McGarrah RW, et al. "Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population." Metabolites. 2019;9(4).
Gondalia R, Baldassari A, Holliday KM, et al. "Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation." Environ Int. 2019;132:104723.
Fashanu OE, Zhao D, Schneider ALC, et al. "Mid-life serum Vitamin D concentrations were associated with incident dementia but not late-life neuropsychological performance in the Atherosclerosis Risk in Communities (ARIC) Study." BMC Neurol. 2019;19(1):244.
B Windham G, Griswold ME, Wilkening SR, et al. "Midlife Smaller and Larger Infarctions, White Matter Hyperintensities, and 20-Year Cognitive Decline: A Cohort Study." Ann Intern Med. 2019;171(6):389-396.
Walker KA, Walston J, Gottesman RF, Kucharska-Newton AMaria, Palta P. "Midlife Systemic Inflammation Is Associated With Frailty in Later Life: The ARIC Study." J Gerontol A Biol Sci Med Sci. 2019;74(3):343-349.
X Androulakis M, Sen S, Kodumuri N, et al. "Migraine Age of Onset and Association With Ischemic Stroke in Late Life: 20 Years Follow-Up in ARIC." Headache. 2019;59(4):556-566.
de Vries PS, Brown MR, Bentley AR, et al. "Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions." Am J Epidemiol. 2019;188(6):1033-1054.
Bentley AR, Sung YJ, Brown MR, et al. "Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids." Nat Genet. 2019;51(4):636-648.
Sung YJu, Fuentes Lde Las, Winkler TW, et al. "A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure." Hum Mol Genet. 2019;28(15):2615-2633.
Noordam R, Bos MM, Wang H, et al. "Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration." Nat Commun. 2019;10(1):5121.
Kilpeläinen TO, Bentley AR, Noordam R, et al. "Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity." Nat Commun. 2019;10(1):376.
Kapoor A, Lee D, Zhu L, et al. "Multiple variant enhancers modulate its cardiac gene expression and the QT interval." Proc Natl Acad Sci U S A. 2019;116(22):10636-10645.
Lutsey PL, Rooney MR, Folsom AR, Michos ED, Alonso A. "Markers of vitamin D metabolism and incidence of clinically diagnosed abdominal aortic aneurysm: The Atherosclerosis Risk in Communities Study." Vasc Med. 2018;23(3):253-260.
Xu J, Bartz TM, Chittoor G, et al. "Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function." Br J Nutr. 2018;120(10):1159-1170.
Marioni RE, McRae AF, Bressler J, et al. "Meta-analysis of epigenome-wide association studies of cognitive abilities." Mol Psychiatry. 2018;23(11):2133-2144.
Jackson VE, Latourelle JC, Wain LV, et al. "Meta-analysis of exome array data identifies six novel genetic loci for lung function." Wellcome Open Res. 2018;3:4.
Gurka MJ, Guo Y, Filipp SL. "Metabolic syndrome severity is significantly associated with future coronary heart disease in Type 2 diabetes." Cardiovasc Diabetol. 2018;17(1):17.
González HM, Tarraf W, Harrison K, et al. "Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results." Alzheimers Dement. 2018;14(5):579-589.
Knopman DS, Gottesman RF, Sharrett ARichey, et al. "Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study." Alzheimers Dement. 2018;14(11):1406-1415.
Sen S, X Androulakis M, Duda V, et al. "Migraine with visual aura is a risk factor for incident atrial fibrillation: A cohort study." Neurology. 2018;91(24):e2202-e2210.
Malik R, Chauhan G, Traylor M, et al. "Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes." Nat Genet. 2018;50(4):524-537.
Roselli C, Chaffin MD, Weng L-C, et al. "Multi-ethnic genome-wide association study for atrial fibrillation." Nat Genet. 2018;50(9):1225-1233.
Wyss AB, Sofer T, Lee MKyeong, et al. "Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function." Nat Commun. 2018;9(1):2976.
Keogh RH, Seaman SR, Bartlett JW. "Multiple imputation of missing data in nested case-control and case-cohort studies." Biometrics. 2018;74(4):1438-1449.
Zeng D, Gao F. "Maximum likelihood estimation for semiparametric regression models with multivariate interval-censored data." Biometrika. 2017;104(3):505-525.
Yong F, Heiss G, Couper DJ, Meyer ML, Cheng S. "Measurement Repeatability of Central and Peripheral Blood Pressures: The ARIC Study." Am J Hypertens. 2017;30(10):978-984.
Matsushita K, Ballew SH, Coresh JJ, et al. "Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data." Lancet Diabetes Endocrinol. 2017;5(9):718-728.
Hess PL, Al-Khalidi HR, Friedman DJ, et al. "The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2017;6(8).
Bressler J, Yu B, Mosley TH, et al. "Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study." Transl Psychiatry. 2017;7(7):e1173.
Balakrishnan P, Beaty T, Young HJ, Colantuoni E. "Methods to estimate underlying blood pressure: The Atherosclerosis Risk in Communities (ARIC) Study." PLoS One. 2017;12(7):e0179234.
Nandakumar P, Tin A, Grove ML, Ma J, Boerwinkle E, Coresh JJ. "MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension." PLoS One. 2017;12(8):e0176734.
Power MC, Tingle JV, Reid RI, et al. "Midlife and Late-Life Vascular Risk Factors and White Matter Microstructural Integrity: The Atherosclerosis Risk in Communities Neurocognitive Study." J Am Heart Assoc. 2017;6(5).
Walker KA, Power MC, Hoogeveen RC, et al. "Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study." Stroke. 2017;48(12):3196-3202.
Walker KA, Hoogeveen RC, Folsom AR, et al. "Midlife systemic inflammatory markers are associated with late-life brain volume: The ARIC study." Neurology. 2017;89(22):2262-2270.
Petruski-Ivleva N, Kucharska-Newton AMaria, Palta P, et al. "Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC) Study." Nutrients. 2017;9(10).
Savitz ST, Stearns SC, Groves JS, Kucharska-Newton AMaria, Bengtson LGS. "Mind the Gap: Hospitalizations from Multiple Sources in a Longitudinal Study." Value Health. 2017;20(6):777-784.
Camplain R, Kucharska-Newton AMaria, Cuthbertson CC, Wright JD, Alonso A. "Misclassification of incident hospitalized and outpatient heart failure in administrative claims data: the Atherosclerosis Risk in Communities (ARIC) study." Pharmacoepidemiol Drug Saf. 2017;26(4):421-428.
Harris SE, Hagenaars SP, Davies G, et al. "Molecular genetic contributions to self-rated health." Int J Epidemiol. 2017;46(3):994-1009.
Rawlings AMonica, Sang Y, Sharrett ARichey, et al. "Multiple imputation of cognitive performance as a repeatedly measured outcome." Eur J Epidemiol. 2017;32(1):55-66.
Pokharel Y, Sun W, Virani SS, et al. "Myocardial Injury, Obesity, and the Obesity Paradox: The ARIC Study." JACC Heart Fail. 2017;5(1):56-63.
Henderson CM, Lutsey PL, Misialek JR, Laha TJ, Selvin E, Eckfeldt JH. "Measurement by a Novel LC-MS/MS Methodology Reveals Similar Serum Concentrations of Vitamin D-Binding Protein in Blacks and Whites." Clin Chem. 2016;62(1):179-87.
Liu C, Kraja AT, Smith JA, et al. "Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci." Nat Genet. 2016;48(10):1162-70.
de Vries PS, Chasman DI, Sabater-Lleal M, et al. "A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration." Hum Mol Genet. 2016;25(2):358-70.
van Leeuwen EM, Sabo A, Bis JC, et al. "Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels." J Med Genet. 2016;53(7):441-9.
Postmus I, Warren HR, Trompet S, et al. "Meta-analysis of genome-wide association studies of HDL cholesterol response to statins." J Med Genet. 2016;53(12):835-845.
"Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits." Nat Genet. 2016;48(8):867-76.
Knopman DS, Gottesman RF, Sharrett ARichey, et al. "Mild Cognitive Impairment and Dementia Prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)." Alzheimers Dement (Amst). 2016;2:1-11.
Bayram Y, Karaca E, Akdemir ZCoban, et al. "Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin." J Clin Invest. 2016;126(2):762-78.
Hill WD, Davies G, Harris SE, et al. "Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions." Transl Psychiatry. 2016;6(12):e980.
Harel T, Yesil G, Bayram Y, et al. "Monoallelic and Biallelic Variants in EMC1 Identified in Individuals with Global Developmental Delay, Hypotonia, Scoliosis, and Cerebellar Atrophy." Am J Hum Genet. 2016;98(3):562-570.
Qiao Y, Guallar E, Suri FK, et al. "MR Imaging Measures of Intracranial Atherosclerosis in a Population-based Study." Radiology. 2016;280(3):860-8.
Natarajan P, Bis JC, Bielak LF, et al. "Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis." Circ Cardiovasc Genet. 2016;9(6):511-520.