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ARIC Publications

2021
Qi Q, Li J, Yu B, et al. "Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies." Gut. 2021.
Zhao Y, Malik S, Budoff MJ, et al. "Identification and Predictors for Cardiovascular Disease Risk Equivalents among Adults With Diabetes Mellitus." Diabetes Care. 2021.
Sarnowski C, Chen H, Biggs ML, et al. "Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program." PLoS One. 2021;16(7):e0253611.
Sullivan KJ, Ranadive R, Su D, et al. "Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study." Brain Imaging Behav. 2021.
Narayan KMVenkat, Kondal D, Daya N, et al. "Incidence and pathophysiology of diabetes in South Asian adults living in India and Pakistan compared with US blacks and whites." BMJ Open Diabetes Res Care. 2021;9(1).
Narayan KMVenkat, Kondal D, Kobes S, et al. "Incidence of diabetes in South Asian young adults compared to Pima Indians." BMJ Open Diabetes Res Care. 2021;9(1).
Sarnowski C, Cousminer DL, Franceschini N, et al. "Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche." Hum Reprod. 2021;36(7):1999-2010.
Minamisawa M, Inciardi RM, Claggett B, et al. "Left atrial structure and function of the amyloidogenic V122I transthyretin variant in elderly African Americans." Eur J Heart Fail. 2021;23(8):1290-1295.
Krishnappa D, Wang W, Rooney MR, et al. "Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study." Int J Cardiol. 2021.
Xu H, Schwander K, Brown MR, et al. "Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions." Eur J Hum Genet. 2021;29(5):839-850.
Metcalf PA, Meyer ML, Tanaka H, et al. "Longitudinal associations of blood pressure with aortic stiffness and pulsatility: the Atherosclerosis Risk in Communities Study." J Hypertens. 2021;39(5):987-993.
Ting J, Jiang K, Du S, et al. "Longitudinal Blood Pressure Patterns from Mid-to-Late Life and Late-life Hearing Loss in the Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2021.
Harding BN, Norby FL, Heckbert SR, et al. "Longitudinal Measures of Blood Pressure and Subclinical Atrial Arrhythmias: The MESA and the ARIC Study." J Am Heart Assoc. 2021;10(11):e020260.
Lu Y, Pike JR, Selvin E, et al. "Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study." J Alzheimers Dis. 2021;79(4):1775-1784.
Gorski M, Jung B, Li Y, et al. "Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline." Kidney Int. 2021;99(4):926-939.
Tariq A, Chen J, Yu B, et al. "Metabolomics of Dietary Acid Load and Incident Chronic Kidney Disease." J Ren Nutr. 2021.
Cohen AJ, Teramoto K, Claggett B, et al. "Mid- to Late-Life Inflammation and Risk of Cardiac Dysfunction, HFpEF and HFrEF in Late Life." J Card Fail. 2021.
Johnson EL, Krauss GL, Kucharska-Newton A, Lam AD, Sarkis R, Gottesman RF. "Mortality in Patients With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study." Neurology. 2021.
Wang H, Noordam R, Cade BE, et al. "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure." Mol Psychiatry. 2021.
Jhun M-A, Mendelson M, Wilson R, et al. "A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids." Nat Commun. 2021;12(1):3987.
Madrid L, Moreno-Grau S, Ahmad S, et al. "Multiomics integrative analysis identifies allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis." Aging (Albany NY). 2021;13(7):9277-9329.
Walker KA, Chawla S, Nogueras-Ortiz C, et al. "Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study." Neurobiol Aging. 2021;97:65-72.
Folsom AR, de Vries PS, Cushman M. "No prospective association of a polygenic risk score for coronary artery disease with venous thromboembolism incidence." J Thromb Haemost. 2021.
Kahali B, Chen Y, Feitosa MF, et al. "A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction." J Clin Endocrinol Metab. 2021;106(2):372-387.
Fang M, Tcheugui JBEchouffo, Pankow JS, B Windham G, Selvin E. "Patient-reported preventive care practices in older adults with diabetes." Diabet Med. 2021;38(3):e14508.
Pandey A, Mehta A, Paluch A, et al. "Performance of the American Heart Association/American College of Cardiology Pooled Cohort Equations to Estimate Atherosclerotic Cardiovascular Disease Risk by Self-reported Physical Activity Levels." JAMA Cardiol. 2021;6(6):690-696.
Sen S, Redd K, Trivedi T, et al. "Periodontal Disease, Atrial Fibrillation and Stroke." Am Heart J. 2021;235:36-43.
Philips KH, Zhang S, Moss K, Ciarrocca K, Beck JD. "Periodontal disease, undiagnosed diabetes, and body mass index: Implications for diabetes screening by dentists." J Am Dent Assoc. 2021;152(1):25-35.
Zhang S, Philips KH, Moss K, et al. "Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-modified Association." J Clin Endocrinol Metab. 2021.
Xu J, Liu G, Hegde SM, et al. "Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study." Metabolites. 2021;11(1).
Damotte V, van der Lee SJ, Chouraki V, et al. "Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants." Alzheimers Dement. 2021.
Lindbohm JV, Mars N, Walker KA, et al. "Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies." Alzheimers Dement. 2021.
Seplyarskiy VB, Soldatov RA, Koch E, et al. "Population sequencing data reveal a compendium of mutational processes in the human germ line." Science. 2021;373(6558):1030-1035.
Briceño EM, Gross AL, Giordani BJ, et al. "Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS." J Alzheimers Dis. 2021.
Mediano MFF, Mok Y, Coresh J, et al. "Prestroke Physical Activity and Adverse Health Outcomes After Stroke in the Atherosclerosis Risk in Communities Study." Stroke. 2021:STROKEAHA120032695.
Schneider ALC, Wang D, Gottesman RF, Selvin E. "Prevalence of Disability Associated With Head Injury With Loss of Consciousness in Adults in the United States: A Population-Based Study." Neurology. 2021;97(2):e124-e135.
Hicks CW, Wang D, B Windham G, Matsushita K, Selvin E. "Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts." Sci Rep. 2021;11(1):19159.
Chunawala ZS, Hall ME, Arora S, et al. "Prognostic value of shock index in patients admitted with non-ST-segment elevation myocardial infarction: the ARIC study community surveillance." Eur Heart J Acute Cardiovasc Care. 2021.
Filshtein TJ, Li X, Zimmerman SC, Ackley SF, M Glymour M, Power MC. "Proof of Concept Example for Use of Simulation to Allow Data Pooling Despite Privacy Restrictions." Epidemiology. 2021;32(5):638-647.
Palta P, A Sharrett R, Gabriel KPettee, et al. "Prospective Analysis of Leisure-Time Physical Activity in Midlife and Beyond and Brain Damage on MRI in Older Adults." Neurology. 2021;96(7):e964-e974.
Prizment AE, McSweeney S, Pankratz N, et al. "Prostate Cancer Mortality Associated with Aggregate Polymorphisms in Androgen-Regulating Genes: The Atherosclerosis Risk in the Communities (ARIC) Study." Cancers (Basel). 2021;13(8).
Grams ME, Surapaneni A, Chen J, et al. "Proteins Associated with Risk of Kidney Function Decline in the General Population." J Am Soc Nephrol. 2021;32(9):2291-2302.
Rooney MR, Bell EJ, Alonso A, et al. "Proton Pump Inhibitor Use, Hypomagnesemia and Risk of Cardiovascular Diseases: The Atherosclerosis Risk in Communities (ARIC) Study." J Clin Gastroenterol. 2021;55(8):677-683.
Honda Y, Mok Y, Mathews L, et al. "Psychosocial factors and subsequent risk of hospitalizations with peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2021;329:36-43.
Caughey MC, Vaduganathan M, Arora S, et al. "Racial Differences and Temporal Obesity Trends in Heart Failure with Preserved Ejection Fraction." J Am Geriatr Soc. 2021.
Choi SHoan, Jurgens SJ, Haggerty CM, et al. "Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis." Circ Genom Precis Med. 2021;14(4):e003300.
Griswold ME, Talluri R, Zhu X, et al. "Reflection on modern methods: shared-parameter models for longitudinal studies with missing data." Int J Epidemiol. 2021;50(4):1384-1393.
Caughey MC, Qiao Y, Meyer ML, et al. "Relationship Between Central Artery Stiffness, Brain Arterial Dilation, and White Matter Hyperintensities in Older Adults: The ARIC Study-Brief Report." Arterioscler Thromb Vasc Biol. 2021;41(6):2109-2116.
Quispe R, Martin SS, Michos ED, et al. "Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study." Eur Heart J. 2021.
Hicks CW, Ding N, Kwak L, et al. "Risk of peripheral artery disease according to race and sex: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2021;324:52-57.
Rooney MR, Rawlings AM, Pankow JS, et al. "Risk of Progression to Diabetes Among Older Adults With Prediabetes." JAMA Intern Med. 2021;181(4):511-519.
Kwong AM, Blackwell TW, LeFaive J, et al. "Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries." Genetics. 2021;218(1).
"SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe." Eur Heart J. 2021;42(25):2439-2454.
"SCORE2-OP risk prediction algorithms: estimating incident cardiovascular event risk in older persons in four geographical risk regions." Eur Heart J. 2021;42(25):2455-2467.
Taliun D, Harris DN, Kessler MD, et al. "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program." Nature. 2021;590(7845):290-299.
Shannon CM, Ballew SH, Daya N, et al. "Serum albumin and risks of hospitalization and death: Findings from the Atherosclerosis Risk in Communities study." J Am Geriatr Soc. 2021.
Kim H, Hu EA, Wong KE, et al. "Serum Metabolites Associated with Healthy Diets in African Americans and European Americans." J Nutr. 2021;151(1):40-49.
Levine DA, Gross AL, Briceño EM, et al. "Sex Differences in Cognitive Decline Among US Adults." JAMA Netw Open. 2021;4(2):e210169.
Lagou V, Mägi R, Hottenga J-Jan, et al. "Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability." Nat Commun. 2021;12(1):24.
da Silva MSbaraini, Lazo M, Daya NR, et al. "Six-year changes in N-terminal pro-brain natriuretic peptide and changes in weight and risk of obesity." Obesity (Silver Spring). 2021;29(7):1215-1222.
Hussain A, Tang O, Sun C, et al. "Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2021;146:15-21.
Li D, Alam AB, Yu F, Kucharska-Newton A, B Windham G, Alonso A. "Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study." Sci Rep. 2021;11(1):1169.
Wu C, Zhang K, Odden MC, et al. "Subclinical Vascular Disease Burden and Premature Mortality Among Middle-aged Adults: the Atherosclerosis Risk in Communities Study." J Gen Intern Med. 2021.
Yu B, Roberts MB, Raffield LM, et al. "Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure." J Am Coll Cardiol. 2021;78(1):42-52.
Hicks CW, Al-Qunaibet A, Ding N, et al. "Symptomatic and asymptomatic peripheral artery disease and the risk of abdominal aortic aneurysm: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2021;333:32-38.
Stilp AM, Emery LS, Broome JG, et al. "A System for Phenotype Harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Program." Am J Epidemiol. 2021;190(10):1977-1992.
Lye WKit, Paterson E, Patterson CC, et al. "A systematic review and participant-level meta-analysis found little association of retinal microvascular caliber with reduced kidney function." Kidney Int. 2021;99(3):696-706.
Chen J, Spracklen CN, Marenne G, et al. "The trans-ancestral genomic architecture of glycemic traits." Nat Genet. 2021;53(6):840-860.
Caughey MC, Arora S, Qamar A, et al. "Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In-Hospital-Onset Versus Out-of-Hospital Onset: The ARIC Study." J Am Heart Assoc. 2021;10(2):e018414.
Hussain A, Sun C, Selvin E, et al. "Triglyceride-rich lipoproteins, apolipoprotein C-III, angiopoietin-like protein 3, and cardiovascular events in older adults: Atherosclerosis Risk in Communities (ARIC) study." Eur J Prev Cardiol. 2021.
Kim ED, Soliman EZ, Coresh J, Matsushita K, Chen LYee. "Two-Week Burden of Arrhythmias across CKD Severity in a Large Community-Based Cohort: The ARIC Study." J Am Soc Nephrol. 2021;32(3):629-638.
Lin BM, Grinde KE, Brody JA, et al. "Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium." EBioMedicine. 2021;63:103157.
Little A, Hu Y, Sun Q, et al. "Whole genome sequence analysis of platelet traits in the NHLBI trans-omics for precision medicine initiative." Hum Mol Genet. 2021.
Cade BE, Lee J, Sofer T, et al. "Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program." Genome Med. 2021;13(1):136.
Hu Y, Stilp AM, McHugh CP, et al. "Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program." Am J Hum Genet. 2021;108(6):1165.
Mikhaylova AV, McHugh CP, Polfus LM, et al. "Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program." Am J Hum Genet. 2021.

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