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ARIC Publications

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Ramalho SHR, Santos M, Claggett B, et al. "Association of Undifferentiated Dyspnea in Late Life With Cardiovascular and Noncardiovascular Dysfunction: A Cross-sectional Analysis From the ARIC Study." JAMA Netw Open. 2019;2(6):e195321.
Mishra A, Chauhan G, Violleau M-H, et al. "Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects." Brain. 2019;142(4):1009-1023.
Power MC, Su D, Wu A, et al. "Association of white matter microstructural integrity with cognition and dementia." Neurobiol Aging. 2019;83:63-72.
Johansen MC, Mosley TH, Knopman DS, et al. "Associations Between Left Ventricular Structure, Function, and Cerebral Amyloid: The ARIC-PET Study." Stroke. 2019;50(12):3622-3624.
Clark DW, Okada Y, Moore KHS, et al. "Associations of autozygosity with a broad range of human phenotypes." Nat Commun. 2019;10(1):4957.
Zhang Y, Vittinghoff E, Pletcher MJ, et al. "Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events." J Am Coll Cardiol. 2019;74(3):330-341.
Ishigami J, Hoogeveen RC, Ballantyne CM, Folsom AR, Coresh JJ, Selvin E. "Associations of High-Sensitivity Cardiac Troponin and Natriuretic Peptide With Subsequent Risk of Infection in Persons Without Cardiovascular Disease: The Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2019;188(12):2146-2155.
Cuthbertson CC, Tan X, Heiss G, Kucharska-Newton AMaria, Nichols HB, Kubota Y. "Associations of Leisure-Time Physical Activity and Television Viewing With Life Expectancy Free of Nonfatal Cardiovascular Disease: The ARIC Study." J Am Heart Assoc. 2019;8(18):e012657.
Kraja AT, Liu C, Fetterman JL, et al. "Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits." Am J Hum Genet. 2019;104(1):112-138.
Berman JP, Norby FL, Mosley T, et al. "Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities." Stroke. 2019;50(4):783-788.
Agha G, Mendelson MM, Ward-Caviness CK, et al. "Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease." Circulation. 2019;140(8):645-657.
Florido R, Lee AK, McEvoy JW, et al. "Cancer Survivorship and Subclinical Myocardial Damage." Am J Epidemiol. 2019;188(12):2188-2195.
Gregson J, Kaptoge S, Bolton T, et al. "Cardiovascular Risk Factors Associated With Venous Thromboembolism." JAMA Cardiol. 2019;4(2):163-173.
Wuttke M, Li Y, Li M, et al. "A catalog of genetic loci associated with kidney function from analyses of a million individuals." Nat Genet. 2019;51(6):957-972.
Liu S, Kim ED, Wu A, et al. "Central and peripheral pulse wave velocity and subclinical myocardial stress and damage in older adults." PLoS One. 2019;14(2):e0212892.
Palta P, Sharrett ARichey, Wei J, et al. "Central Arterial Stiffness Is Associated With Structural Brain Damage and Poorer Cognitive Performance: The ARIC Study." J Am Heart Assoc. 2019;8(2):e011045.
Coresh JJ, Heerspink HJL, Sang Y, et al. "Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies." Lancet Diabetes Endocrinol. 2019;7(2):115-127.
Ding N, Sang Y, Chen J, et al. "Cigarette Smoking, Smoking Cessation, and Long-Term Risk of 3 Major Atherosclerotic Diseases." J Am Coll Cardiol. 2019;74(4):498-507.
de Larriva APArenas, Alonso A, Norby FL, Roetker NS. "Circulating ceruloplasmin, ceruloplasmin-associated genes and the incidence of venous thromboembolism in the Atherosclerosis Risk in Communities study." J Thromb Haemost. 2019;17(5):818-826.
Georgakis MK, Malik R, Björkbacka H, et al. "Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals." Circ Res. 2019;125(8):773-782.
Hu EA, Lazo M, Selvin E, et al. "Coffee consumption and liver-related hospitalizations and deaths in the ARIC study." Eur J Clin Nutr. 2019;73(8):1133-1140.
Rawlings AM, Sharrett ARichey, Mosley TH, Wong DF, Knopman DS. "Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life." J Alzheimers Dis. 2019;68(2):517-521.
Travis RC, Perez-Cornago A, Appleby PN, et al. "A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk." Cancer Res. 2019;79(1):274-285.
Wang H, Nandakumar P, Tekola-Ayele F, et al. "Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31." Eur J Hum Genet. 2019;27(2):269-277.
Lee CMan Ying, Colagiuri S, Woodward M, et al. "Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes." BMJ Open Diabetes Res Care. 2019;7(1):e000794.
Sikdar S, Joehanes R, Joubert BR, et al. "Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking." Epigenomics. 2019;11(13):1487-1500.
Yu B, Zanetti KA, Temprosa M, et al. "The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies." Am J Epidemiol. 2019;188(6):991-1012.
Ishigami J, Padula WV, Grams ME, et al. "Cost-effectiveness of Pneumococcal Vaccination Among Patients With CKD in the United States." Am J Kidney Dis. 2019;74(1):23-35.
Han P, Bidulescu A, Barber JR, et al. "Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study." Cancer Causes Control. 2019;30(4):343-354.
Hu EA, Steffen LM, Grams ME, Crews DC, Coresh JJ, Appel LJ. "Dietary patterns and risk of incident chronic kidney disease: the Atherosclerosis Risk in Communities study." Am J Clin Nutr. 2019;110(3):713-721.
George KM, Folsom AR, Steffen LM, Wagenknecht LE. "Differences in Cardiovascular Mortality Risk among African Americans in the Minnesota Heart Survey: 1985-2015 vs The Atherosclerosis Risk in Communities Study Cohort: 1987-2015." Ethn Dis. 2019;29(1):47-52.
Bhatt SP, Balte PP, Schwartz JE, et al. "Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality." JAMA. 2019;321(24):2438-2447.
Perez-Alday EA, Bender A, German D, et al. "Dynamic predictive accuracy of electrocardiographic biomarkers of sudden cardiac death within a survival framework: the Atherosclerosis Risk in Communities (ARIC) study." BMC Cardiovasc Disord. 2019;19(1):255.
Li Z, Li X, Liu Y, et al. "Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies." Am J Hum Genet. 2019;104(5):802-814.
Chen H, Huffman JE, Brody JA, et al. "Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies." Am J Hum Genet. 2019;104(2):260-274.
Syme C, Shin J, Richer L, Gaudet D, Fornage M, Paus T. "Epigenetic Loci of Blood Pressure." Circ Genom Precis Med. 2019;12(1):e002341.
Barrett JK, Huille R, Parker R, Yano Y. "Estimating the association between blood pressure variability and cardiovascular disease: An application using the ARIC Study." Stat Med. 2019;38(10):1855-1868.
Flannick J, Mercader JM, Fuchsberger C, et al. "Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls." Nature. 2019;570(7759):71-76.
Spracklen CN, Karaderi T, Yaghootkar H, et al. "Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology." Am J Hum Genet. 2019;105(1):15-28.
Petty LE, Highland HM, Gamazon ER, et al. "Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample." Hum Mol Genet. 2019;28(7):1212-1224.
Bien SA, Wojcik GL, Hodonsky CJ, et al. "The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE." Annu Rev Genomics Hum Genet. 2019;20:181-200.
Wojcik GL, Graff M, Nishimura KK, et al. "Genetic analyses of diverse populations improves discovery for complex traits." Nature. 2019;570(7762):514-518.
Sakornsakolpat P, Prokopenko D, Lamontagne M, et al. "Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations." Nat Genet. 2019;51(3):494-505.
Kunkle BW, Grenier-Boley B, Sims R, et al. "Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing." Nat Genet. 2019;51(3):414-430.
Shungin D, Haworth S, Divaris K, et al. "Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data." Nat Commun. 2019;10(1):2773.
Teumer A, Li Y, Ghasemi S, et al. "Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria." Nat Commun. 2019;10(1):4130.
van Setten J, Verweij N, Mbarek H, et al. "Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits." Eur J Hum Genet. 2019;27(6):952-962.
de Vries PS, Sabater-Lleal M, Huffman JE, et al. "A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology." Blood. 2019;133(9):967-977.
Irvin MR, Sitlani CM, Floyd JS, et al. "Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group." Am J Hypertens. 2019;32(12):1146-1153.
Sabater-Lleal M, Huffman JE, de Vries PS, et al. "Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels." Circulation. 2019;139(5):620-635.
Huan T, Joehanes R, Song C, et al. "Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease." Nat Commun. 2019;10(1):4267.
Merino J, Dashti HS, Li SX, et al. "Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium." Mol Psychiatry. 2019;24(12):1920-1932.
Irvin MR, Sitlani CM, Noordam R, et al. "Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry." Pharmacogenomics J. 2019;19(1):97-108.
Lindström S, Wang L, Smith EN, et al. "Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism." Blood. 2019;134(19):1645-1657.
Oyenuga AO, Folsom AR, Cheng S, Tanaka H. "Greater Adherence to Life's Simple 7 Is Associated With Less Arterial Stiffness: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Hypertens. 2019;32(8):769-776.
Reed NS, Betz JF, Kucharska-Newton AMaria, Lin FR. "Hearing loss and satisfaction with healthcare: An unexplored relationship." J Am Geriatr Soc. 2019;67(3):624-626.
Loomis SJ, Tin A, Coresh JJ, et al. "Heritability analysis of nontraditional glycemic biomarkers in the Atherosclerosis Risk in Communities Study." Genet Epidemiol. 2019;43(7):776-785.
Selvaraj S, Seidelmann S, Silvestre OM, et al. "HFE H63D Polymorphism and the Risk for Systemic Hypertension, Myocardial Remodeling, and Adverse Cardiovascular Events in the ARIC Study." Hypertension. 2019;73(1):68-74.
Pokharel Y, Mouhanna F, Schneider ALC, et al. "High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change." J Am Geriatr Soc. 2019;67(11):2353-2361.
Jia X, Sun W, Hoogeveen RC, et al. "High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study." Circulation. 2019;139(23):2642-2653.
Kubota Y, Alonso A, Heckbert SR, Norby FL. "Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis." Heart Lung Circ. 2019;28(4):615-622.
Wong E, Ballew SH, Daya N, et al. "Hospitalization Risk among Older Adults with Chronic Kidney Disease." Am J Nephrol. 2019;50(3):212-220.
Marrone MT, Selvin E, Barber JR, Platz EA. "Hyperglycemia, Classified with Multiple Biomarkers Simultaneously in Men without Diabetes, and Risk of Fatal Prostate Cancer." Cancer Prev Res (Phila). 2019;12(2):103-112.
Sarnowski C, Leong A, Raffield LM, et al. "Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program." Am J Hum Genet. 2019;105(4):706-718.
Lutsey PL, Chen N, Mirabelli MC, et al. "Impaired Lung Function, Lung Disease, and Risk of Incident Dementia." Am J Respir Crit Care Med. 2019;199(11):1385-1396.
Perez-Alday EAndres, Li-Pershing Y, Bender A, et al. "Importance of the heart vector origin point definition for an ECG analysis: The Atherosclerosis Risk in Communities (ARIC) study." Comput Biol Med. 2019;104:127-138.
Pandey A, Patel KV, Vongpatanasin W, et al. "Incorporation of Biomarkers Into Risk Assessment for Allocation of Antihypertensive Medication According to the 2017 ACC/AHA High Blood Pressure Guideline: A Pooled Cohort Analysis." Circulation. 2019;140(25):2076-2088.
Liu J, Carnero-Montoro E, van Dongen J, et al. "An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis." Nat Commun. 2019;10(1):2581.
Almuwaqqat Z, O'Neal WT, Norby FL, et al. "Joint Associations of Obesity and NT-proBNP With the Incidence of Atrial Fibrillation in the ARIC Study." J Am Heart Assoc. 2019;8(19):e013294.
Grams ME, Surapaneni A, Ballew SH, et al. " Kidney Risk Variants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis." J Am Soc Nephrol. 2019;30(10):2027-2036.
Lindström S, Brody JA, Turman C, et al. "A large-scale exome array analysis of venous thromboembolism." Genet Epidemiol. 2019;43(4):449-457.
Palta P, Sharrett ARichey, Deal JA, et al. "Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study." Alzheimers Dement. 2019;15(2):273-281.
He KY, Li X, Kelly TN, et al. "Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data." Hum Genet. 2019;138(2):199-210.
Matsushita K, Sang Y, Ning H, et al. "Lifetime Risk of Lower-Extremity Peripheral Artery Disease Defined by Ankle-Brachial Index in the United States." J Am Heart Assoc. 2019;8(18):e012177.
Saeed A, Sun W, Agarwala A, et al. "Lipoprotein(a) levels and risk of cardiovascular disease events in individuals with diabetes mellitus or prediabetes: The Atherosclerosis Risk in Communities study." Atherosclerosis. 2019;282:52-56.
Wang SY, Tan ASL, Claggett B, et al. "Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities Study." JAMA Cardiol. 2019;4(12):1203-1212.
Decker JJ, Norby FL, Rooney MR, et al. "Metabolic Syndrome and Risk of Ischemic Stroke in Atrial Fibrillation: ARIC Study." Stroke. 2019;50(11):3045-3050.
Wang Z, Zhu C, Nambi V, et al. "Metabolomic Pattern Predicts Incident Coronary Heart Disease." Arterioscler Thromb Vasc Biol. 2019;39(7):1475-1482.
Gondalia R, Baldassari A, Holliday KM, et al. "Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation." Environ Int. 2019;132:104723.
Fashanu OE, Zhao D, Schneider ALC, et al. "Mid-life serum Vitamin D concentrations were associated with incident dementia but not late-life neuropsychological performance in the Atherosclerosis Risk in Communities (ARIC) Study." BMC Neurol. 2019;19(1):244.