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ARIC Publications

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Journal Article
Hibar DP, Adams HHH, Jahanshad N, et al. "Novel genetic loci associated with hippocampal volume." Nat Commun. 2017;8:13624.
Feitosa MF, Kraja AT, Chasman DI, et al. "Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries." PLoS One. 2018;13(6):e0198166.
Schneider ALC, Sharrett ARichey, Gottesman RF, et al. "Normative data for 8 neuropsychological tests in older blacks and whites from the atherosclerosis risk in communities (ARIC) study." Alzheimer Dis Assoc Disord. 2015;29(1):32-44.
Selvin E, Francis LMA, Ballantyne CM, et al. "Nontraditional markers of glycemia: associations with microvascular conditions." Diabetes Care. 2011;34(4):960-7.
Love S-AM, North KE, Zeng D, et al. "Nine-Year Ethanol Intake Trajectories and Their Association With 15-Year Cognitive Decline Among Black and White Adults." Am J Epidemiol. 2020;189(8):788-800.
West NA, B Windham G, Knopman DS, Shibata DK, Coker LH. "Neuroimaging findings in midlife and risk of late-life dementia over 20 years of follow-up." Neurology. 2019;92(9):e917-e923.
Graff-Radford J, Simino J, Kantarci K, et al. "Neuroimaging Correlates of Cerebral Microbleeds: The ARIC Study (Atherosclerosis Risk in Communities)." Stroke. 2017;48(11):2964-2972.
Sabater-Lleal M, Huang J, Chasman D, et al. "Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease." Circulation. 2013;128(12):1310-24.
Verhaaren BFJ, Debette S, Bis JC, et al. "Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI." Circ Cardiovasc Genet. 2015;8(2):398-409.
Kilpeläinen TO, Bentley AR, Noordam R, et al. "Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity." Nat Commun. 2019;10(1):376.
Noordam R, Bos MM, Wang H, et al. "Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration." Nat Commun. 2019;10(1):5121.
Bentley AR, Sung YJ, Brown MR, et al. "Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids." Nat Genet. 2019;51(4):636-648.
Tang O, Matsushita K, Coresh JJ, et al. "Mortality Implications of Prediabetes and Diabetes in Older Adults." Diabetes Care. 2020;43(2):382-388.
Knopman DS, Gottesman RF, Sharrett ARichey, et al. "Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study." Alzheimers Dement. 2018;14(11):1406-1415.
Walker KA, Power MC, Hoogeveen RC, et al. "Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study." Stroke. 2017;48(12):3196-3202.
Jia X, Sun C, Nambi V, et al. "Midlife determinants of healthy cardiovascular aging: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2022;350:82-89.
Marioni RE, McRae AF, Bressler J, et al. "Meta-analysis of epigenome-wide association studies of cognitive abilities." Mol Psychiatry. 2018;23(11):2133-2144.
de Vries PS, Chasman DI, Sabater-Lleal M, et al. "A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration." Hum Mol Genet. 2016;25(2):358-70.
Ellinor PT, Lunetta KL, Albert CM, et al. "Meta-analysis identifies six new susceptibility loci for atrial fibrillation." Nat Genet. 2012;44(6):670-5.
Yong F, Heiss G, Couper DJ, Meyer ML, Cheng S. "Measurement Repeatability of Central and Peripheral Blood Pressures: The ARIC Study." Am J Hypertens. 2017;30(10):978-984.
Wu A, Coresh JJ, Selvin E, et al. "Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community." J Am Heart Assoc. 2017;6(1).
Imamura F, Lemaitre RN, King IB, et al. "Long-chain monounsaturated Fatty acids and incidence of congestive heart failure in 2 prospective cohorts." Circulation. 2013;127(14):1512-21, 1521e1-18.
Kucharska-Newton A, Matsushita K, Mok Y, et al. "Loneliness and its predictors among older adults prior to and during the COVID-19 pandemic: cross-sectional and longitudinal survey findings from participants of the Atherosclerosis Risk in Communities (ARIC) Study cohort in the USA." BMJ Open. 2021;11(12):e053542.
"Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study." Lancet Neurol. 2016;15(2):174-184.
Ma Y, Tucker KL, Smith CE, et al. "Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: replication in two populations." Nutr Metab Cardiovasc Dis. 2014;24(12):1323-9.
Barral S, Cheng R, Reitz C, et al. "Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease." Alzheimers Dement. 2015;11(12):1397-1406.
Matsushita K, Sang Y, Ning H, et al. "Lifetime Risk of Lower-Extremity Peripheral Artery Disease Defined by Ankle-Brachial Index in the United States." J Am Heart Assoc. 2019;8(18):e012177.
Mou L, Norby FL, Chen LYee, et al. "Lifetime Risk of Atrial Fibrillation by Race and Socioeconomic Status: ARIC Study (Atherosclerosis Risk in Communities)." Circ Arrhythm Electrophysiol. 2018;11(7):e006350.
Tang W, Yao L, Roetker NS, et al. "Lifetime Risk and Risk Factors for Abdominal Aortic Aneurysm in a 24-Year Prospective Study: The ARIC Study (Atherosclerosis Risk in Communities)." Arterioscler Thromb Vasc Biol. 2016;36(12):2468-2477.
Power MC, Schneider ALC, Wruck L, et al. "Life-course blood pressure in relation to brain volumes." Alzheimers Dement. 2016;12(8):890-9.
Gonçalves A, Hung C-L, Claggett B, et al. "Left Atrial Structure and Function Across the Spectrum of Cardiovascular Risk in the Elderly: The Atherosclerosis Risk in Communities Study." Circ Cardiovasc Imaging. 2016;9(2):e004010.
Bianco F, De Caterina R, Chandra A, et al. "Left Atrial Remodeling and Stroke in Patients With Sinus Rhythm and Normal Ejection Fraction: ARIC-NCS." J Am Heart Assoc. 2022;11(9):e024292.
Secora A, G Alexander C, Ballew SH, Coresh JJ. "Kidney Function, Polypharmacy, and Potentially Inappropriate Medication Use in a Community-Based Cohort of Older Adults." Drugs Aging. 2018;35(8):735-750.
Matsushita K, Kwak L, Sang Y, et al. "Kidney Disease Measures and Left Ventricular Structure and Function: The Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2017;6(9).
Rosenthal EA, Ranchalis J, Crosslin DR, et al. "Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia." Am J Hum Genet. 2013;93(6):1035-45.
Liu J, Carnero-Montoro E, van Dongen J, et al. "An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis." Nat Commun. 2019;10(1):2581.
Bick AG, Weinstock JS, Nandakumar SK, et al. "Inherited causes of clonal haematopoiesis in 97,691 whole genomes." Nature. 2020;586(7831):763-768.
Graff M, Gordon-Larsen P, Lim U, et al. "The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study." Diabetes. 2013;62(5):1763-7.
Yi JS, Morales EEGarcia, Betz JF, et al. "Individual Life-Course Socioeconomic Position and Hearing Aid Use in the Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2022;77(3):645-653.
Lubitz SA, Sinner MF, Lunetta KL, et al. "Independent susceptibility markers for atrial fibrillation on chromosome 4q25." Circulation. 2010;122(10):976-84.
Gurka MJ, Golden SH, Musani SK, et al. "Independent associations between a metabolic syndrome severity score and future diabetes by sex and race: the Atherosclerosis Risk In Communities Study and Jackson Heart Study." Diabetologia. 2017;60(7):1261-1270.
Jensen PN, Gronroos NN, Chen LYee, Folsom AR, deFilippi C, Heckbert SR. "Incidence of and risk factors for sick sinus syndrome in the general population." J Am Coll Cardiol. 2014;64(6):531-8.
Miedema MD, Norby FL, Blaha MJ, Virani SS, Coresh JJ, Ballantyne CM. "Implications of the Eighth Joint National Committee Guidelines for the Management of High Blood Pressure for Aging Adults: Atherosclerosis Risk in Communities Study." Hypertension. 2015;66(3):474-80.
Gottesman RF, Rawlings AM, Sharrett ARichey, et al. "Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC neurocognitive study." Am J Epidemiol. 2014;179(8):956-66.
Corona G, Rastrelli G, Silverii A, et al. "The identification of prediabetes condition with ARIC algorithm predicts long-term CV events in patients with erectile dysfunction." J Sex Med. 2013;10(4):1114-23.
"Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies." Lancet Neurol. 2016;15(7):695-707.
Shah AM, Claggett B, Folsom AR, Lutsey PL, Ballantyne CM, Heiss G. "Ideal Cardiovascular Health During Adult Life and Cardiovascular Structure and Function Among the Elderly." Circulation. 2015;132(21):1979-89.
Sengeløv M, Cheng S, Biering-Sørensen T, et al. "Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients." J Am Heart Assoc. 2018;7(3).
Ong Y-T, Wong TY, Klein R, et al. "Hypertensive retinopathy and risk of stroke." Hypertension. 2013;62(4):706-11.
Cowan LT, Alonso A, Pankow JS, Folsom AR, Rosamond WD, Gottesman RF. "Hospitalized Infection as a Trigger for Acute Ischemic Stroke: The Atherosclerosis Risk in Communities Study." Stroke. 2016;47(6):1612-7.
Wong E, Ballew SH, Daya N, et al. "Hospitalization Risk among Older Adults with Chronic Kidney Disease." Am J Nephrol. 2019;50(3):212-220.
Kubota Y, Alonso A, Heckbert SR, Norby FL. "Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis." Heart Lung Circ. 2019;28(4):615-622.
Ebong IA, Wilson MD, Bertoni AG, et al. "High-sensitivity cardiac troponin T and the risk of heart failure in postmenopausal women of the ARIC Study." Menopause. 2021;28(3):284-291.
Tanaka H, Heiss G, McCabe EL, et al. "Hemodynamic Correlates of Blood Pressure in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study." J Clin Hypertens (Greenwich). 2016;18(12):1222-1227.
Fyfe-Johnson AL, Muller CJ, Alonso A, et al. "Heart Rate Variability and Incident Stroke: The Atherosclerosis Risk in Communities Study." Stroke. 2016;47(6):1452-8.
Shah AM, Claggett B, Loehr LR, et al. "Heart Failure Stages Among Older Adults in the Community: The Atherosclerosis Risk in Communities Study." Circulation. 2017;135(3):224-240.
Witt LS, Rotter J, Stearns SC, et al. "Heart Failure and Cognitive Impairment in the Atherosclerosis Risk in Communities (ARIC) Study." J Gen Intern Med. 2018;33(10):1721-1728.
Deal JA, Sharrett ARichey, Bandeen-Roche K, Kritchevsky SB, Pompeii LA, B Windham G. "Hearing Impairment and Physical Function and Falls in the Atherosclerosis Risk in Communities Hearing Pilot Study." J Am Geriatr Soc. 2016;64(4):906-8.
Deal JA, Sharrett ARichey, Albert MS, et al. "Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study." Am J Epidemiol. 2015;181(9):680-90.
Oelsner EC, Balte PP, Cassano PA, et al. "Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study." Am J Epidemiol. 2018;187(11):2265-2278.
Tanaka H, Palta P, Folsom AR, et al. "Habitual physical activity and central artery stiffening in older adults: the Atherosclerosis Risk in Communities study." J Hypertens. 2018;36(9):1889-1894.
Bell EJ, Selvin E, Lutsey PL, Nambi V, Cushman M. "Glycemia (hemoglobin A1c) and incident venous thromboembolism in the Atherosclerosis Risk in Communities cohort study." Vasc Med. 2013;18(5):245-50.
"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017." Lancet. 2018;392(10159):1789-1858.
Waks JW, Sitlani CM, Soliman EZ, et al. "Global Electric Heterogeneity Risk Score for Prediction of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies." Circulation. 2016;133(23):2222-34.
R Lumbers T, Shah S, Lin H, et al. "The genomics of heart failure: design and rationale of the HERMES consortium." ESC Heart Fail. 2021;8(6):5531-5541.
Morrison AC, Felix JF, L Cupples A, et al. "Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2010;3(3):248-55.
Debette S, Verbaas CAIbrahim, Bressler J, et al. "Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium." Biol Psychiatry. 2015;77(8):749-63.
Jones G, Trajanoska K, Santanasto AJ, et al. "Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women." Nat Commun. 2021;12(1):654.
Jensen RA, Sim X, Li X, et al. "Genome-wide association study of retinopathy in individuals without diabetes." PLoS One. 2013;8(2):e54232.
Guan W, Steffen BT, Lemaitre RN, et al. "Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2014;7(3):321-331.
Hek K, Demirkan A, Lahti J, et al. "A genome-wide association study of depressive symptoms." Biol Psychiatry. 2013;73(7):667-78.
Fornage M, Debette S, Bis JC, et al. "Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium." Ann Neurol. 2011;69(6):928-39.
van Loon J, Dehghan A, Weihong T, et al. "Genome-wide association studies identify genetic loci for low von Willebrand factor levels." Eur J Hum Genet. 2016;24(7):1035-40.
Ligthart S, Vaez A, Võsa U, et al. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders." Am J Hum Genet. 2018;103(5):691-706.
Blue EE, Bis JC, Dorschner MO, et al. "Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project." Dement Geriatr Cogn Disord. 2018;45(1-2):1-17.
Traylor M, Malik R, Nalls MA, et al. "Genetic variation at 16q24.2 is associated with small vessel stroke." Ann Neurol. 2017;81(3):383-394.
Sim X, Jensen RA, M Ikram K, et al. "Genetic loci for retinal arteriolar microcirculation." PLoS One. 2013;8(6):e65804.
Hobbs BD, de Jong K, Lamontagne M, et al. "Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis." Nat Genet. 2017;49(3):426-432.
Hofer E, Roshchupkin GV, Adams HHH, et al. "Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults." Nat Commun. 2020;11(1):4796.
Davies G, Armstrong N, Bis JC, et al. "Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949)." Mol Psychiatry. 2015;20(2):183-92.

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