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ARIC Publications

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Journal Article
Nambi V, Hoogeveen RC, Chambless L, et al. "Lipoprotein-associated phospholipase A2 and high-sensitivity C-reactive protein improve the stratification of ischemic stroke risk in the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2009;40(2):376-81.
Ohira T, Schreiner PJ, Morrisett JD, Chambless LE, Rosamond WD, Folsom AR. "Lipoprotein(a) and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2006;37(6):1407-12.
Pokharel Y, Sun W, Polfus LM, et al. "Lipoprotein associated phospholipase A2 activity, apolipoprotein C3 loss-of-function variants and cardiovascular disease: The Atherosclerosis Risk In Communities Study." Atherosclerosis. 2015;241(2):641-8.
Folsom AR, George KM. "Lack of association of plasma factor XI with incident stroke and coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2015;243(1):181-5.
Alexander N, Matsushita K, Sang Y, Ballew S, Mahmoodi BK, Astor BC. "Kidney measures with diabetes and hypertension on cardiovascular disease: the Atherosclerosis Risk in Communities Study." Am J Nephrol. 2015;41(4-5):409-17.
X Androulakis M, Kodumuri N, Giamberardino LD, Rosamond WD, Gottesman RF, Yim E. "Ischemic stroke subtypes and migraine with visual aura in the ARIC study." Neurology. 2016;87(24):2527-2532.
Mok Y, Ballew SH, Bash LD, et al. "International Validation of the Thrombolysis in Myocardial Infarction (TIMI) Risk Score for Secondary Prevention in Post-MI Patients: A Collaborative Analysis of the Chronic Kidney Disease Prognosis Consortium and the Risk Validation Scientific Committee." J Am Heart Assoc. 2018;7(14).
Volcik KA, Ballantyne CM, Hoogeveen R, Folsom AR, Boerwinkle E. "Intercellular adhesion molecule-1 G241R polymorphism predicts risk of incident ischemic stroke: Atherosclerosis Risk in Communities study." Stroke. 2010;41(5):1038-40.
Cowan LT, Lutsey PL, Pankow JS, Matsushita K, Ishigami J. "Inpatient and Outpatient Infection as a Trigger of Cardiovascular Disease: The ARIC Study." J Am Heart Assoc. 2018;7(22):e009683.
Kohsaka S, Volcik KA, Folsom AR, et al. "Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities Study." Atherosclerosis. 2008;196(2):926-30.
Kim S, Cai J. "Improving the efficiency of estimation in the additive hazards model for stratified case-cohort design with multiple diseases." Stat Med. 2016;35(2):282-93.
"Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies." Lancet Neurol. 2016;15(7):695-707.
Ong Y-T, Wong TY, Klein R, et al. "Hypertensive retinopathy and risk of stroke." Hypertension. 2013;62(4):706-11.
Cowan LT, Alonso A, Pankow JS, Folsom AR, Rosamond WD, Gottesman RF. "Hospitalized Infection as a Trigger for Acute Ischemic Stroke: The Atherosclerosis Risk in Communities Study." Stroke. 2016;47(6):1612-7.
Jia X, Sun W, Hoogeveen RC, et al. "High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study." Circulation. 2019;139(23):2642-2653.
Alonso A, Tang W, Agarwal SK, Soliman EZ, Chamberlain AM, Folsom AR. "Hemostatic markers are associated with the risk and prognosis of atrial fibrillation: the ARIC study." Int J Cardiol. 2012;155(2):217-22.
Sturgeon JD, Folsom AR, Longstreth WT, Shahar E, Rosamond WD, Cushman M. "Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort." Stroke. 2008;39(8):2268-73.
Kubota Y, Chen LYee, Whitsel EA. "Heart rate variability and lifetime risk of cardiovascular disease: the Atherosclerosis Risk in Communities Study." Ann Epidemiol. 2017;27(10):619-625.e2.
Fyfe-Johnson AL, Muller CJ, Alonso A, et al. "Heart Rate Variability and Incident Stroke: The Atherosclerosis Risk in Communities Study." Stroke. 2016;47(6):1452-8.
Stang PE, Carson AP, Rose KM, et al. "Headache, cerebrovascular symptoms, and stroke: the Atherosclerosis Risk in Communities Study." Neurology. 2005;64(9):1573-7.
Offenbacher S, Jiao Y, Kim SJ, et al. "GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation." Nat Commun. 2018;9(1):3686.
Morrison AC, Doris PA, Folsom AR, Nieto FJ, Boerwinkle E. "G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical stroke." Stroke. 2001;32(4):822-9.
Di Angelantonio E, Gao P, Khan H, et al. "Glycated hemoglobin measurement and prediction of cardiovascular disease." JAMA. 2014;311(12):1225-33.
Bower JK, Appel LJ, Matsushita K, et al. "Glycated hemoglobin and risk of hypertension in the atherosclerosis risk in communities study." Diabetes Care. 2012;35(5):1031-7.
Selvin E, Coresh J, Shahar E, Zhang L, Steffes M, A Sharrett R. "Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study." Lancet Neurol. 2005;4(12):821-6.
Keene KL, Hyacinth HI, Bis JC, et al. "Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke." Stroke. 2020;51(8):2454-2463.
de Vries PS, Sabater-Lleal M, Huffman JE, et al. "A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology." Blood. 2019;133(9):967-977.
Huang J, Huffman JE, Yamakuchi M, et al. "Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2." Arterioscler Thromb Vasc Biol. 2014;34(5):1093-101.
M Ikram A, Seshadri S, Bis JC, et al. "Genomewide association studies of stroke." N Engl J Med. 2009;360(17):1718-28.
Cheng Y-C, Stanne TM, Giese A-K, et al. "Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2." Stroke. 2016;47(2):307-16.
Traylor M, Malik R, Nalls MA, et al. "Genetic variation at 16q24.2 is associated with small vessel stroke." Ann Neurol. 2017;81(3):383-394.
Ehret GB, Munroe PB, Rice KM, et al. "Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk." Nature. 2011;478(7367):103-9.
Yamagishi K, Folsom AR, Rosamond WD, Boerwinkle E. "A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study." Eur Heart J. 2009;30(10):1222-8.
Traylor M, Farrall M, Holliday EG, et al. "Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies." Lancet Neurol. 2012;11(11):951-62.
Holliday EG, Traylor M, Malik R, et al. "Genetic overlap between diagnostic subtypes of ischemic stroke." Stroke. 2015;46(3):615-9.
Selvin E, Rawlings AM, Lutsey PL, Maruthur N, Pankow JS, Steffes M. "Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death." Circulation. 2015;132(4):269-77.
Knopman DS, Mosley TH, Catellier DJ, Coker LH. "Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI Study." Alzheimers Dement. 2009;5(3):207-14.
Soliman EZ, Prineas RJ, Case DL, Zhang Z-M, Goff DC. "Ethnic distribution of ECG predictors of atrial fibrillation and its impact on understanding the ethnic distribution of ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2009;40(4):1204-11.
Matsushita K, Coresh JJ, Sang Y, et al. "Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data." Lancet Diabetes Endocrinol. 2015;3(7):514-25.
Johnson JA, Haq KT, Lutz KJ, et al. "Electrophysiological ventricular substrate of stroke: a prospective cohort study in the Atherosclerosis Risk in Communities (ARIC) study." BMJ Open. 2021;11(9):e048542.
Kamel H, O'Neal WT, Okin PM, Loehr LR, Alonso A. "Electrocardiographic left atrial abnormality and stroke subtype in the atherosclerosis risk in communities study." Ann Neurol. 2015;78(5):670-8.
Cotlarciuc I, Malik R, Holliday EG, et al. "Effect of genetic variants associated with plasma homocysteine levels on stroke risk." Stroke. 2014;45(7):1920-4.
Fox ER, Alnabhan N, Penman AD, et al. "Echocardiographic left ventricular mass index predicts incident stroke in African Americans: Atherosclerosis Risk in Communities (ARIC) Study." Stroke. 2007;38(10):2686-91.
McEvoy JW, Chen Y, Rawlings A, et al. "Diastolic Blood Pressure, Subclinical Myocardial Damage, and Cardiac Events: Implications for Blood Pressure Control." J Am Coll Cardiol. 2016;68(16):1713-1722.
Rasmussen-Torvik LJ, Yatsuya H, Selvin E, Alonso A, Folsom AR. "Demographic and cardiovascular risk factors modify association of fasting insulin with incident coronary heart disease and ischemic stroke (from the Atherosclerosis Risk In Communities Study)." Am J Cardiol. 2010;105(10):1420-5.
Silvestre OM, Nadruz W, Roca GQuerejeta, et al. "Declining Lung Function and Cardiovascular Risk: The ARIC Study." J Am Coll Cardiol. 2018;72(10):1109-1122.
Lee CR, North KE, Bray MS, Couper DJ, Heiss G, Zeldin DC. "Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study." Clin Pharmacol Ther. 2008;83(1):52-60.
Sood SL, Cheng D, Ragni M, et al. "A cross-sectional analysis of cardiovascular disease in the hemophilia population." Blood Adv. 2018;2(11):1325-1333.
Alonso A, Knopman DS, Gottesman RF, et al. "Correlates of Dementia and Mild Cognitive Impairment in Patients With Atrial Fibrillation: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)." J Am Heart Assoc. 2017;6(7).
Huxley RR, Bell EJ, Lutsey PL, et al. "A comparative analysis of risk factors for stroke in blacks and whites: the Atherosclerosis Risk in Communities study." Ethn Health. 2014;19(6):601-16.
Yang EY, Nambi V, Tang Z, et al. "Clinical implications of JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) in a U.S. population insights from the ARIC (Atherosclerosis Risk in Communities) study." J Am Coll Cardiol. 2009;54(25):2388-95.
Georgakis MK, Malik R, Björkbacka H, et al. "Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals." Circ Res. 2019;125(8):773-782.
Ding N, Sang Y, Chen J, et al. "Cigarette Smoking, Smoking Cessation, and Long-Term Risk of 3 Major Atherosclerotic Diseases." J Am Coll Cardiol. 2019;74(4):498-507.
Rathore SS, Hinn AR, Cooper LS, Tyroler HA, Rosamond WD. "Characterization of incident stroke signs and symptoms: findings from the atherosclerosis risk in communities study." Stroke. 2002;33(11):2718-21.
Wong T Y, Klein R, A Sharrett R, et al. "Cerebral white matter lesions, retinopathy, and incident clinical stroke." JAMA. 2002;288(1):67-74.
Sargurupremraj M, Suzuki H, Jian X, et al. "Cerebral small vessel disease genomics and its implications across the lifespan." Nat Commun. 2020;11(1):6285.
Holmes MV, Lange LA, Palmer T, et al. "Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis." Am J Hum Genet. 2014;94(2):198-208.
Chambless LE, Folsom AR, Clegg LX, et al. "Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study." Am J Epidemiol. 2000;151(5):478-87.
Bekwelem W, Jensen PN, Norby FL, et al. "Carotid Atherosclerosis and Stroke in Atrial Fibrillation: The Atherosclerosis Risk in Communities Study." Stroke. 2016;47(6):1643-6.
Ohira T, Shahar E, Iso H, et al. "Carotid artery wall thickness and risk of stroke subtypes: the atherosclerosis risk in communities study." Stroke. 2011;42(2):397-403.
Yang EY, Chambless L, A Sharrett R, et al. "Carotid arterial wall characteristics are associated with incident ischemic stroke but not coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2012;43(1):103-8.
Lee C D, Folsom AR, Pankow JS, Brancati FL. "Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction." Circulation. 2004;109(7):855-60.
"Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis." Lancet Diabetes Endocrinol. 2015;3(4):243-53.
Kshirsagar AV, Carpenter M, Bang H, Wyatt SB, Colindres RE. "Blood pressure usually considered normal is associated with an elevated risk of cardiovascular disease." Am J Med. 2006;119(2):133-41.
Schanen JG, Iribarren C, Shahar E, et al. "Asthma and incident cardiovascular disease: the Atherosclerosis Risk in Communities Study." Thorax. 2005;60(8):633-8.
Steffen LM, Jacobs DR, Stevens J, Shahar E, Carithers T, Folsom AR. "Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Clin Nutr. 2003;78(3):383-90.
Yatsuya H, Yamagishi K, North KE, Brancati FL, Stevens J, Folsom AR. "Associations of obesity measures with subtypes of ischemic stroke in the ARIC Study." J Epidemiol. 2010;20(5):347-54.
Cuthbertson CC, Tan X, Heiss G, Kucharska-Newton AMaria, Nichols HB, Kubota Y. "Associations of Leisure-Time Physical Activity and Television Viewing With Life Expectancy Free of Nonfatal Cardiovascular Disease: The ARIC Study." J Am Heart Assoc. 2019;8(18):e012657.
Virani SS, Brautbar A, Davis BC, et al. "Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects: the Atherosclerosis Risk in Communities (ARIC) Study." Circulation. 2012;125(2):241-9.
Carty CL, Bůžková P, Fornage M, et al. "Associations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study." Circ Cardiovasc Genet. 2012;5(2):210-6.
Mishra A, Chauhan G, Violleau M-H, et al. "Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects." Brain. 2019;142(4):1009-1023.
Volcik KA, Ballantyne CM, Braun MC, Coresh J, Mosley TH, Boerwinkle E. "Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study." Am J Hypertens. 2008;21(5):533-8.
Kwon Y, Norby FL, Jensen PN, et al. "Association of Smoking, Alcohol, and Obesity with Cardiovascular Death and Ischemic Stroke in Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study and Cardiovascular Health Study (CHS)." PLoS One. 2016;11(1):e0147065.
Appiah D, Schreiner PJ, Maclehose RF. "Association of Plasma γ' Fibrinogen With Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study." Arterioscler Thromb Vasc Biol. 2015;35(12):2700-6.
Matsushita K, Williams EK, Mongraw-Chaffin ML, et al. "The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study." Am J Epidemiol. 2013;178(3):401-9.
Rawlings AM, Juraschek SP, Heiss G, et al. "Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline." Neurology. 2018;91(8):e759-e768.
Mahmoodi BK, Yatsuya H, Matsushita K, et al. "Association of kidney disease measures with ischemic versus hemorrhagic strokes: pooled analyses of 4 prospective community-based cohorts." Stroke. 2014;45(7):1925-31.
Ogagarue ER, Lutsey PL, Klein R, Klein BE. "Association of ideal cardiovascular health metrics and retinal microvascular findings: the Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2013;2(6):e000430.
Haring B, Misialek JR, Rebholz CM, Petruski-Ivleva N, Gottesman RF, Mosley TH. "Association of Dietary Protein Consumption With Incident Silent Cerebral Infarcts and Stroke: The Atherosclerosis Risk in Communities (ARIC) Study." Stroke. 2015;46(12):3443-50.
Di Angelantonio E, Kaptoge S, Wormser D, et al. "Association of Cardiometabolic Multimorbidity With Mortality." JAMA. 2015;314(1):52-60.

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