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ARIC Publications

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Nadruz W, Claggett B, Henglin M, et al. "Racial Disparities in Risks of Stroke." N Engl J Med. 2017;376(21):2089-2090.
Maheshwari A, Norby FL, Soliman EZ, et al. "Relation of Prolonged P-Wave Duration to Risk of Sudden Cardiac Death in the General Population (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2017;119(9):1302-1306.
Rapson IR, Michos ED, Alonso A, Hirsch AT, Matsushita K, Reis JP. "Serum 25-hydroxyvitamin D is associated with incident peripheral artery disease among white and black adults in the ARIC study cohort." Atherosclerosis. 2017;257:123-129.
Bello NA, Hyacinth HI, Roetker NS, et al. "Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function." Blood. 2017;129(6):799-801.
Liang J, Le TH, Edwards DRVelez, et al. "Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations." PLoS Genet. 2017;13(5):e1006728.
Millen AE, Nie J, Sahli MW, et al. "Vitamin D Status and Prevalent Early Age-Related Macular Degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study." J Nutr Health Aging. 2017;21(7):772-780.
Simino J, Wang Z, Bressler J, et al. "Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study." PLoS One. 2017;12(7):e0180046.
de Vries PS, Yu B, Feofanova EV, et al. "Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study." Hum Mol Genet. 2017;26(17):3442-3450.
Millen AE, Sahli MW, Nie J, et al. "Adequate vitamin D status is associated with the reduced odds of prevalent diabetic retinopathy in African Americans and Caucasians." Cardiovasc Diabetol. 2016;15(1):128.
O'Neal WT, Kamel H, Zhang Z-M, Chen LYee, Alonso A. "Advanced interatrial block and ischemic stroke: The Atherosclerosis Risk in Communities Study." Neurology. 2016;87(4):352-6.
"Are There Clinical Implications of Racial Differences in HbA1c? A Difference, to Be a Difference, Must Make a Difference." Diabetes Care. 2016;39(8):1462-7.
Gottesman RF, Schneider ALC, Zhou Y, et al. "The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE." Neurology. 2016;87(5):473-80.
Peloso GM, Lange LA, Varga TV, et al. "Association of Exome Sequences With Cardiovascular Traits Among Blacks in the Jackson Heart Study." Circ Cardiovasc Genet. 2016;9(4):368-74.
Bello NA, Cheng S, Claggett B, et al. "Association of Weight and Body Composition on Cardiac Structure and Function in the ARIC Study (Atherosclerosis Risk in Communities)." Circ Heart Fail. 2016;9(8).
Yu B, Heiss G, Alexander D, Grams ME. "Associations Between the Serum Metabolome and All-Cause Mortality Among African Americans in the Atherosclerosis Risk in Communities (ARIC) Study." Am J Epidemiol. 2016;183(7):650-6.
Yazdani A, Yazdani A. "A Causal Network Analysis of the Fatty Acid Metabolome in African-Americans Reveals a Critical Role for Palmitoleate and Margarate." OMICS. 2016;20(8):480-4.
Meyer ML, Tanaka H, Palta P, Cheng S, Gouskova N, Aguilar D. "Correlates of Segmental Pulse Wave Velocity in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study." Am J Hypertens. 2016;29(1):114-22.
Sahli MW, Mares JA, Meyers KJ, et al. "Dietary Intake of Lutein and Diabetic Retinopathy in the Atherosclerosis Risk in Communities Study (ARIC)." Ophthalmic Epidemiol. 2016;23(2):99-108.
J Smith G, Felix JF, Morrison AC, et al. "Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure." PLoS Genet. 2016;12(5):e1006034.
Ligthart S, Marzi C, Aslibekyan S, et al. "DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases." Genome Biol. 2016;17(1):255.
Konety S, Koene RJ, Norby FL, et al. "Echocardiographic Predictors of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study and Cardiovascular Health Study." Circ Cardiovasc Imaging. 2016;9(8).
O'Neal WT, Wang YGrace, Wu H-T, et al. "Electrocardiographic J Wave and Cardiovascular Outcomes in the General Population (from the Atherosclerosis Risk In Communities Study)." Am J Cardiol. 2016;118(6):811-815.
Chami N, Chen M-H, Slater AJ, et al. "Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits." Am J Hum Genet. 2016;99(1):8-21.
Evans DS, Avery CL, Nalls MA, et al. "Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans." Hum Mol Genet. 2016;25(19):4350-4368.
Zubair N, Graff M, Ambite JLuis, et al. "Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci." Hum Mol Genet. 2016;25(24):5500-5512.
Joshi AD, Andersson C, Buch S, et al. "Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies." Gastroenterology. 2016;151(2):351-363.e28.
McEvoy JW, Chen Y, Halushka MK, et al. "Galectin-3 and Risk of Heart Failure and Death in Blacks and Whites." J Am Heart Assoc. 2016;5(5).
Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen RC, Young JH. "GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study." Diabet Med. 2016;33(7):968-75.
Keaton JM, Hellwege JN, C Y Ng M, et al. "Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans." PLoS One. 2016;11(7):e0159977.
Begum F, Ruczinski I, Li S, et al. "Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort." Genet Epidemiol. 2016;40(1):81-8.
Yu B, Li AH, Metcalf GA, et al. "Loss-of-function variants influence the human serum metabolome." Sci Adv. 2016;2(8):e1600800.
Mirabelli MC, Preisser JS, Loehr LR, et al. "Lung function decline over 25 years of follow-up among black and white adults in the ARIC study cohort." Respir Med. 2016;113:57-64.
Yao L, Folsom AR, Pankow JS, et al. "Parathyroid hormone and the risk of incident hypertension: the Atherosclerosis Risk in Communities study." J Hypertens. 2016;34(2):196-203.
Reis JP, Selvin E, Pankow JS, Michos ED, Rebholz CM. "Parathyroid hormone is associated with incident diabetes in white, but not black adults: The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Metab. 2016;42(3):162-9.
Lacy ME, Wellenius GA, Carnethon MR, et al. "Racial Differences in the Performance of Existing Risk Prediction Models for Incident Type 2 Diabetes: The CARDIA Study." Diabetes Care. 2016;39(2):285-91.
Kapoor A, Bakshy K, Xu L, et al. "Rare coding TTN variants are associated with electrocardiographic QT interval in the general population." Sci Rep. 2016;6:28356.
Olfson E, Saccone NL, Johnson EO, et al. "Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans." Mol Psychiatry. 2016;21(5):601-7.
Kan M, Auer PL, Wang GT, et al. "Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project." Eur J Hum Genet. 2016;24(8):1181-7.
Folsom AR, Tang W, Weng L-C, Roetker NS, Cushman M, Basu S. "Replication of a genetic risk score for venous thromboembolism in whites but not in African Americans." J Thromb Haemost. 2016;14(1):83-8.
Kats D, Patel MD, Palta P, et al. "Social support and cognition in a community-based cohort: the Atherosclerosis Risk in Communities (ARIC) study." Age Ageing. 2016;45(4):475-80.
Michos ED, Misialek JR, Selvin E, Folsom AR, Pankow JS, Post WS. "25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study." Atherosclerosis. 2015;241(1):12-7.
Tandon A, Chen CJ, Penman A, et al. "African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans." Invest Ophthalmol Vis Sci. 2015;56(6):3999-4005.
C Quarta C, Buxbaum JN, Shah AM, et al. "The amyloidogenic V122I transthyretin variant in elderly black Americans." N Engl J Med. 2015;372(1):21-9.
Grubbs V, Vittinghoff E, Beck JD, et al. "Association Between Periodontal Disease and Kidney Function Decline in African Americans: The Jackson Heart Study." J Periodontol. 2015;86(10):1126-32.
Schick UM, Auer PL, Bis JC, et al. "Association of exome sequences with plasma C-reactive protein levels in >9000 participants." Hum Mol Genet. 2015;24(2):559-71.
Ashar FN, Moes A, Moore AZ, et al. "Association of mitochondrial DNA levels with frailty and all-cause mortality." J Mol Med (Berl). 2015;93(2):177-186.
Yu B, Li AH, Muzny D, et al. "Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine: Levels and Incident Coronary Heart Disease." Circ Cardiovasc Genet. 2015;8(2):351-5.
Caughey MC, Loehr LR, Cheng S, Solomon SD, Avery C. "Associations between echocardiographic arterial compliance and incident cardiovascular disease in blacks: the ARIC study." Am J Hypertens. 2015;28(1):81-8.
Akinkugbe AA, Saraiya VM, Preisser JS, Offenbacher S. "Bias in estimating the cross-sectional smoking, alcohol, obesity and diabetes associations with moderate-severe periodontitis in the Atherosclerosis Risk in Communities study: comparison of full versus partial-mouth estimates." J Clin Periodontol. 2015;42(7):609-21.
Gottesman RF, Fornage M, Knopman DS. "Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience." Curr Alzheimer Res. 2015;12(7):607-13.
Polfus LM, Gibbs RA. "Coronary heart disease and genetic variants with low phospholipase A2 activity." N Engl J Med. 2015;372(3):295-6.
Butler KR, Penman AD, Minor DS. "Determinants of pulse pressure and annual rates of change in the Atherosclerosis Risk in Communities study." J Hypertens. 2015;33(12):2463-70.
Bis JC, Sitlani C, Irvin R, et al. "Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium." PLoS One. 2015;10(10):e0140496.
Demerath EW, Guan W, Grove ML, et al. "Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci." Hum Mol Genet. 2015;24(15):4464-79.
Tang W, Cushman M, Green D, et al. "Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans." Am J Hematol. 2015;90(6):534-40.
Weng L-C, Cushman M, Pankow JS, Basu S, Boerwinkle E, Folsom AR. "A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study." Hum Mol Genet. 2015;24(8):2401-8.
Tin A, Köttgen A, Folsom AR, et al. "Genetic loci for serum magnesium among African-Americans and gene-environment interaction at MUC1 and TRPM6 in European-Americans: the Atherosclerosis Risk in Communities (ARIC) study." BMC Genet. 2015;16:56.
Maruthur NM, Li M, Halushka MK, et al. "Genetics of Plasma Soluble Receptor for Advanced Glycation End-Products and Cardiovascular Outcomes in a Community-based Population: Results from the Atherosclerosis Risk in Communities Study." PLoS One. 2015;10(6):e0128452.
Tin A, Grams ME, Maruthur NM, et al. "Hemostatic Factors, APOL1 Risk Variants, and the Risk of ESRD in the Atherosclerosis Risk in Communities Study." Clin J Am Soc Nephrol. 2015;10(5):784-90.
Miedema MD, Norby FL, Blaha MJ, Virani SS, Coresh JJ, Ballantyne CM. "Implications of the Eighth Joint National Committee Guidelines for the Management of High Blood Pressure for Aging Adults: Atherosclerosis Risk in Communities Study." Hypertension. 2015;66(3):474-80.
Okwuosa TM, Soliman EZ, Norby FL, Williams KA, Alonso A. "Left ventricular hypertrophy and cardiovascular disease risk prediction and reclassification in blacks and whites: the Atherosclerosis Risk in Communities Study." Am Heart J. 2015;169(1):155-61.e5.
Carty CL, Keene KL, Cheng Y-C, et al. "Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans." Stroke. 2015;46(8):2063-8.
Grams ME, Sang Y, Ballew SH, et al. "A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury." Am J Kidney Dis. 2015;66(4):591-601.
Alonso A, Yu B, Qureshi WT, et al. "Metabolomics and Incidence of Atrial Fibrillation in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study." PLoS One. 2015;10(11):e0142610.
Schneider ALC, Sharrett ARichey, Gottesman RF, et al. "Normative data for 8 neuropsychological tests in older blacks and whites from the atherosclerosis risk in communities (ARIC) study." Alzheimer Dis Assoc Disord. 2015;29(1):32-44.
Zhao J, Zhu Y, Boerwinkle E. "Pathway analysis with next-generation sequencing data." Eur J Hum Genet. 2015;23(4):507-15.
Parrinello CM, Rastegar I, Godino JG, Miedema MD, Matsushita K. "Prevalence of and Racial Disparities in Risk Factor Control in Older Adults With Diabetes: The Atherosclerosis Risk in Communities Study." Diabetes Care. 2015;38(7):1290-8.
Folsom AR, Tang W, Roetker NS, Heckbert SR, Cushman M. "Prospective study of circulating factor XI and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE)." Am J Hematol. 2015;90(11):1047-51.
Folsom AR, Tang W, Roetker NS, et al. "Prospective study of sickle cell trait and venous thromboembolism incidence." J Thromb Haemost. 2015;13(1):2-9.
Gupta DK, Claggett B, Wells Q, et al. "Racial differences in circulating natriuretic peptide levels: the atherosclerosis risk in communities study." J Am Heart Assoc. 2015;4(5).
Hardy ST, Loehr LR, Butler KR, et al. "Reducing the Blood Pressure-Related Burden of Cardiovascular Disease: Impact of Achievable Improvements in Blood Pressure Prevention and Control." J Am Heart Assoc. 2015;4(10):e002276.
Bressler J, Franceschini N, Demerath EW, Mosley TH, Folsom AR. "Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study." BMC Med Genet. 2015;16:52.
Vishnu A, Gurka MJ. "The severity of the metabolic syndrome increases over time within individuals, independent of baseline metabolic syndrome status and medication use: The Atherosclerosis Risk in Communities Study." Atherosclerosis. 2015;243(1):278-85.
Sanders AE, Divaris K, Naorungroj S, Heiss G. "Telomere length attrition and chronic periodontitis: an ARIC Study nested case-control study." J Clin Periodontol. 2015;42(1):12-20.
Shetty PB, Tang H, Feng T, et al. "Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families." Circ Cardiovasc Genet. 2015;8(1):106-13.
Carty CL, Bhattacharjee S, Haessler J, et al. "Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study." Circ Cardiovasc Genet. 2014;7(4):505-13.
Kucharska-Newton AMaria, Williams JE, Chang PP, Stearns SC, Sueta CA, Blecker SB. "Anger proneness, gender, and the risk of heart failure." J Card Fail. 2014;20(12):1020-6.
Naik RP, Derebail VK, Grams ME, et al. "Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans." JAMA. 2014;312(20):2115-25.
Lawani SO, Demerath EW, Norby FL, Soliman EZ, Huxley RR, Rose KM. "Birth weight and the risk of atrial fibrillation in whites and African Americans: the Atherosclerosis Risk In Communities (ARIC) study." BMC Cardiovasc Disord. 2014;14:69.
Effoe VS, Rodriguez CJ, Wagenknecht LE, Evans GW, Chang PP, Mirabelli MC. "Carotid intima-media thickness is associated with incident heart failure among middle-aged whites and blacks: the Atherosclerosis Risk in Communities study." J Am Heart Assoc. 2014;3(3):e000797.