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ARIC Publications

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Avery CL, Wassel CL, Richard MA, et al. "Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations." Heart Rhythm. 2017;14(4):572-580.
Yoneyama S, Yao J, Guo X, et al. "Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations." Int J Obes (Lond). 2017;41(2):324-331.
Gregson JM, Freitag DF, Surendran P, et al. "Genetic invalidation of Lp-PLA as a therapeutic target: Large-scale study of five functional Lp-PLA-lowering alleles." Eur J Prev Cardiol. 2017;24(5):492-504.
Hobbs BD, de Jong K, Lamontagne M, et al. "Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis." Nat Genet. 2017;49(3):426-432.
Chatterjee NA, Giulianini F, Geelhoed B, et al. "Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization." Circulation. 2017;135(8):741-754.
Robinson-Cohen C, Lutsey PL, Kleber ME, et al. "Genetic Variants Associated with Circulating Parathyroid Hormone." J Am Soc Nephrol. 2017;28(5):1553-1565.
Bressler J, Mosley TH, Penman A, et al. "Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study." Am J Med Genet B Neuropsychiatr Genet. 2017;174(3):269-282.
Dong J, Wyss A, Yang J, et al. "Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans." Mol Neurobiol. 2017;54(10):8021-8032.
Li M, Carey J, Cristiano S, et al. "Genome-Wide Association of Copy Number Polymorphisms and Kidney Function." PLoS One. 2017;12(1):e0170815.
Sennblad B, Basu S, Mazur J, et al. "Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels." Hum Mol Genet. 2017;26(3):637-649.
Joshi PK, Pirastu N, Kentistou KA, et al. "Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity." Nat Commun. 2017;8(1):910.
Justice AE, Winkler TW, Feitosa MF, et al. "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Nat Commun. 2017;8:14977.
Day FR, Thompson DJ, Helgason H, et al. "Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk." Nat Genet. 2017;49(6):834-841.
Pirastu N, Joshi PK, de Vries PS, et al. "GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk." Nat Commun. 2017;8(1):1584.
Pankow JS, Tang W, Pankratz N, et al. "Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities)." Arterioscler Thromb Vasc Biol. 2017;37(3):589-597.
Wild PS, Felix JF, Schillert A, et al. "Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function." J Clin Invest. 2017;127(5):1798-1812.
Eldomery MK, Coban-Akdemir Z, Harel T, et al. "Lessons learned from additional research analyses of unsolved clinical exome cases." Genome Med. 2017;9(1):26.
Harris SE, Hagenaars SP, Davies G, et al. "Molecular genetic contributions to self-rated health." Int J Epidemiol. 2017;46(3):994-1009.
Kraja AT, Cook JP, Warren HR, et al. "New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals." Circ Cardiovasc Genet. 2017;10(5).
Liu X, Li C. "The performance of deleteriousness prediction scores for rare non-protein-changing single nucleotide variants in human genes." J Med Genet. 2017;54(2):134-144.
Morrison AC, Huang Z, Yu B, et al. "Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood-Related Traits." Am J Hum Genet. 2017;100(2):205-215.
Seidelmann SB, Vardeny O, Claggett B, et al. "An Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality." J Am Heart Assoc. 2017;6(4).
Sims R, van der Lee SJ, Naj AC, et al. "Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease." Nat Genet. 2017;49(9):1373-1384.
Zewinger S, Kleber ME, Tragante V, et al. "Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study." Lancet Diabetes Endocrinol. 2017;5(7):534-543.
Jansen H, Willenborg C, Lieb W, et al. "Rheumatoid Arthritis and Coronary Artery Disease: Genetic Analyses Do Not Support a Causal Relation." J Rheumatol. 2017;44(1):4-10.
Liang J, Le TH, Edwards DRVelez, et al. "Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations." PLoS Genet. 2017;13(5):e1006728.
Roetker NS, Armasu SM, Pankow JS, et al. "Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis." J Thromb Haemost. 2017;15(7):1334-1343.
Bien SA, Pankow JS, Haessler J, et al. "Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium." Diabetologia. 2017;60(12):2384-2398.
McMahon GM, Hwang S-J, Clish CB, et al. "Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease." Kidney Int. 2017;91(6):1426-1435.
Simino J, Wang Z, Bressler J, et al. "Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study." PLoS One. 2017;12(7):e0180046.
de Vries PS, Yu B, Feofanova EV, et al. "Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study." Hum Mol Genet. 2017;26(17):3442-3450.
Marioni RE, Yang J, Dykiert D, et al. "Assessing the genetic overlap between BMI and cognitive function." Mol Psychiatry. 2016;21(10):1477-82.
Song J, Xue C, Preisser JS, et al. "Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity." PLoS One. 2016;11(9):e0160757.
Willems SM, Cornes BK, Brody JA, et al. "Association of the IGF1 gene with fasting insulin levels." Eur J Hum Genet. 2016;24(9):1337-43.
Yazdani A, Yazdani A. "A Causal Network Analysis of the Fatty Acid Metabolome in African-Americans Reveals a Critical Role for Palmitoleate and Margarate." OMICS. 2016;20(8):480-4.
van der Laan SW, Fall T, Soumaré A, et al. "Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study." J Am Coll Cardiol. 2016;68(9):934-45.
Liu X, Wu C, Li C. "dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs." Hum Mutat. 2016;37(3):235-41.
J Smith G, Felix JF, Morrison AC, et al. "Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure." PLoS Genet. 2016;12(5):e1006034.
Rhee EP, Yang Q, Yu B, et al. "An exome array study of the plasma metabolome." Nat Commun. 2016;7:12360.
Evans DS, Avery CL, Nalls MA, et al. "Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans." Hum Mol Genet. 2016;25(19):4350-4368.
Huang J, Wang K, Wei P, et al. "FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics." Genetics. 2016;202(3):919-29.
Joshi AD, Andersson C, Buch S, et al. "Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies." Gastroenterology. 2016;151(2):351-363.e28.
Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen RC, Young JH. "GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study." Diabet Med. 2016;33(7):968-75.
Lin H, Mueller-Nurasyid M, Smith AV, et al. "Gene-gene Interaction Analyses for Atrial Fibrillation." Sci Rep. 2016;6:35371.
Yazdani A, Yazdani A, Samiei A. "Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data." J Biomed Inform. 2016;60:114-9.
Roberts JD, Hu D, Heckbert SR, et al. "Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals." JAMA Cardiol. 2016;1(4):442-50.
Guo D-C, Grove ML, Prakash SK, et al. "Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections." Am J Hum Genet. 2016;99(3):762-769.
Ehret GB, Ferreira T, Chasman DI, et al. "The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals." Nat Genet. 2016;48(10):1171-1184.
Cheng Y-C, Stanne TM, Giese A-K, et al. "Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2." Stroke. 2016;47(2):307-16.
Teumer A, Tin A, Sorice R, et al. "Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes." Diabetes. 2016;65(3):803-17.
van Loon J, Dehghan A, Weihong T, et al. "Genome-wide association studies identify genetic loci for low von Willebrand factor levels." Eur J Hum Genet. 2016;24(7):1035-40.
Dehghan A, Bis JC, White CC, et al. "Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium." PLoS One. 2016;11(3):e0144997.
Keaton JM, Hellwege JN, C Y Ng M, et al. "Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans." PLoS One. 2016;11(7):e0159977.
Burke BTeevan, Köttgen A, Law A, Grams M, Baer AN, Coresh JJ. "Gout in Older Adults: The Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2016;71(4):536-42.
Matteini AM, Tanaka T, Karasik D, et al. "GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium." Aging Cell. 2016;15(5):792-800.
Yazdani A, Yazdani A, Liu X. "Identification of Rare Variants in Metabolites of the Carnitine Pathway by Whole Genome Sequencing Analysis." Genet Epidemiol. 2016;40(6):486-91.
Roberts JD, Dewland TA, Glidden DV, et al. "Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation." Am Heart J. 2016;175:9-17.
Ma Y, Follis JL, Smith CE, et al. "Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium." Am J Clin Nutr. 2016;103(2):567-78.
Rodriguez S, Gaunt TR, Guo Y, et al. "Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array." Eur J Hum Genet. 2016;24(1):106-12.
Liu C, Kraja AT, Smith JA, et al. "Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci." Nat Genet. 2016;48(10):1162-70.
de Vries PS, Chasman DI, Sabater-Lleal M, et al. "A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration." Hum Mol Genet. 2016;25(2):358-70.
van Leeuwen EM, Sabo A, Bis JC, et al. "Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels." J Med Genet. 2016;53(7):441-9.
Postmus I, Warren HR, Trompet S, et al. "Meta-analysis of genome-wide association studies of HDL cholesterol response to statins." J Med Genet. 2016;53(12):835-845.
Hill WD, Davies G, Harris SE, et al. "Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions." Transl Psychiatry. 2016;6(12):e980.
Jun G, Ibrahim-Verbaas CA, Vronskaya M, et al. "A novel Alzheimer disease locus located near the gene encoding tau protein." Mol Psychiatry. 2016;21(1):108-17.
Jensen RA, Sim X, Smith A V, et al. "Novel Genetic Loci Associated With Retinal Microvascular Diameter." Circ Cardiovasc Genet. 2016;9(1):45-54.
Adams HHH, Hibar DP, Chouraki V, et al. "Novel genetic loci underlying human intracranial volume identified through genome-wide association." Nat Neurosci. 2016;19(12):1569-1582.
Folsom AR, Tang W, George KM, Heckbert SR, Maclehose RF, Cushman M. "Prospective study of γ' fibrinogen and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE)." Thromb Res. 2016;139:44-9.
Kapoor A, Bakshy K, Xu L, et al. "Rare coding TTN variants are associated with electrocardiographic QT interval in the general population." Sci Rep. 2016;6:28356.
Folsom AR, Tang W, Weng L-C, Roetker NS, Cushman M, Basu S. "Replication of a genetic risk score for venous thromboembolism in whites but not in African Americans." J Thromb Haemost. 2016;14(1):83-8.
Wei P, Cao Y, Zhang Y, Xu Z, Kwak I-Y, Boerwinkle E. "On Robust Association Testing for Quantitative Traits and Rare Variants." G3 (Bethesda). 2016;6(12):3941-3950.
Rooney MR, Pankow JS, Sibley SD, Selvin E, Reis JP, Michos ED. "Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study." Am J Clin Nutr. 2016;104(4):1023-1029.
Demirkan A, Lahti J, Direk N, et al. "Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies." Psychol Med. 2016;46(8):1613-23.
Liu C-T, Raghavan S, Maruthur N, et al. "Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin." Am J Hum Genet. 2016;99(1):56-75.
Verweij N, Mateo Leach I, Isaacs A, et al. "Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram." Hum Mol Genet. 2016;25(10):2093-2103.
Ray D, Pankow JS. "USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis." Genet Epidemiol. 2016;40(1):20-34.
Lubitz SA, Brody JA, Bihlmeyer NA, et al. "Whole Exome Sequencing in Atrial Fibrillation." PLoS Genet. 2016;12(9):e1006284.
Yu B, de Vries PS, Metcalf GA, et al. "Whole genome sequence analysis of serum amino acid levels." Genome Biol. 2016;17(1):237.
Michos ED, Misialek JR, Selvin E, Folsom AR, Pankow JS, Post WS. "25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study." Atherosclerosis. 2015;241(1):12-7.