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ARIC Publications

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Pokharel Y, Sun W, Virani SS, et al. "Myocardial Injury, Obesity, and the Obesity Paradox: The ARIC Study." JACC Heart Fail. 2017;5(1):56-63.
Henderson CM, Lutsey PL, Misialek JR, Laha TJ, Selvin E, Eckfeldt JH. "Measurement by a Novel LC-MS/MS Methodology Reveals Similar Serum Concentrations of Vitamin D-Binding Protein in Blacks and Whites." Clin Chem. 2016;62(1):179-87.
Liu C, Kraja AT, Smith JA, et al. "Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci." Nat Genet. 2016;48(10):1162-70.
de Vries PS, Chasman DI, Sabater-Lleal M, et al. "A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration." Hum Mol Genet. 2016;25(2):358-70.
van Leeuwen EM, Sabo A, Bis JC, et al. "Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels." J Med Genet. 2016;53(7):441-9.
Postmus I, Warren HR, Trompet S, et al. "Meta-analysis of genome-wide association studies of HDL cholesterol response to statins." J Med Genet. 2016;53(12):835-845.
"Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits." Nat Genet. 2016;48(8):867-76.
Knopman DS, Gottesman RF, Sharrett ARichey, et al. "Mild Cognitive Impairment and Dementia Prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)." Alzheimers Dement (Amst). 2016;2:1-11.
Bayram Y, Karaca E, Akdemir ZCoban, et al. "Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin." J Clin Invest. 2016;126(2):762-78.
Hill WD, Davies G, Harris SE, et al. "Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions." Transl Psychiatry. 2016;6(12):e980.
Harel T, Yesil G, Bayram Y, et al. "Monoallelic and Biallelic Variants in EMC1 Identified in Individuals with Global Developmental Delay, Hypotonia, Scoliosis, and Cerebellar Atrophy." Am J Hum Genet. 2016;98(3):562-570.
Qiao Y, Guallar E, Suri FK, et al. "MR Imaging Measures of Intracranial Atherosclerosis in a Population-based Study." Radiology. 2016;280(3):860-8.
Natarajan P, Bis JC, Bielak LF, et al. "Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis." Circ Cardiovasc Genet. 2016;9(6):511-520.
Tangri N, Grams ME, Levey AS, et al. "Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis." JAMA. 2016;315(2):164-74.
Sueta CA, Rodgers JE, Chang PP, Zhou L, Thudium EM, Kucharska-Newton AMaria. "Medication Adherence Based on Part D Claims for Patients With Heart Failure After Hospitalization (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2015;116(3):413-9.
Holmes MV, Asselbergs FW, Palmer TM, et al. "Mendelian randomization of blood lipids for coronary heart disease." Eur Heart J. 2015;36(9):539-50.
Germain M, Chasman DI, de Haan H, et al. "Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism." Am J Hum Genet. 2015;96(4):532-42.
Carty CL, Keene KL, Cheng Y-C, et al. "Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans." Stroke. 2015;46(8):2063-8.
Grams ME, Sang Y, Ballew SH, et al. "A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury." Am J Kidney Dis. 2015;66(4):591-601.
James MT, Grams ME, Woodward M, et al. "A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury." Am J Kidney Dis. 2015;66(4):602-12.
Alonso A, Yu B, Qureshi WT, et al. "Metabolomics and Incidence of Atrial Fibrillation in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study." PLoS One. 2015;10(11):e0142610.
Jones SB, Loehr LR, Avery CL, Gottesman RF, Wruck L, Shahar E. "Midlife Alcohol Consumption and the Risk of Stroke in the Atherosclerosis Risk in Communities Study." Stroke. 2015;46(11):3124-30.
Huffman JE, Albrecht E, Teumer A, et al. "Modulation of genetic associations with serum urate levels by body-mass-index in humans." PLoS One. 2015;10(3):e0119752.
Obeidat M'en, Hao K, Bossé Y, et al. "Molecular mechanisms underlying variations in lung function: a systems genetics analysis." Lancet Respir Med. 2015;3(10):782-95.
Verhaaren BFJ, Debette S, Bis JC, et al. "Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI." Circ Cardiovasc Genet. 2015;8(2):398-409.
Hardy DS, Racette SB. "Macronutrient intake as a mediator with FTO to increase body mass index." J Am Coll Nutr. 2014;33(4):256-66.
Zheng Y, Yu B, Alexander D, Couper DJ. "Medium-term variability of the human serum metabolome in the Atherosclerosis Risk in Communities (ARIC) study." OMICS. 2014;18(6):364-73.
Kilarski LL, Achterberg S, Devan WJ, et al. "Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12." Neurology. 2014;83(8):678-85.
C Y Ng M, Shriner D, Chen BH, et al. "Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes." PLoS Genet. 2014;10(8):e1004517.
Chen CTL, Liu C-T, Chen GK, et al. "Meta-analysis of loci associated with age at natural menopause in African-American women." Hum Mol Genet. 2014;23(12):3327-42.
Dearborn JL, Knopman D, Sharrett ARichey, et al. "The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities study (ARIC)." Dement Geriatr Cogn Disord. 2014;38(5-6):337-46.
Zheng Y, Yu B, Alexander D, Steffen LM, Nettleton JA. "Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study." Am J Clin Nutr. 2014;99(6):1470-8.
Gottesman RF, Schneider ALC, Albert M, et al. "Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study." JAMA Neurol. 2014;71(10):1218-27.
Kocarnik JM, Pendergrass SA, Carty CL, et al. "Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study." Circ Cardiovasc Genet. 2014;7(2):178-88.
Liu C-T, Buchkovich ML, Winkler TW, et al. "Multi-ethnic fine-mapping of 14 central adiposity loci." Hum Mol Genet. 2014;23(17):4738-44.
Kang S, Cai J, Chambless L. "Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study." Biostatistics. 2013;14(1):28-41.
O'Brien EC, Rose KM, Suchindran CM, et al. "Medication, reperfusion therapy and survival in a community-based setting of hospitalised myocardial infarction." Heart. 2013;99(11):767-73.
Yaghootkar H, Lamina C, Scott RA, et al. "Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes." Diabetes. 2013;62(10):3589-98.
Monda KL, Chen GK, Taylor KC, et al. "A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry." Nat Genet. 2013;45(6):690-6.
Nettleton JA, Hivert M-F, Lemaitre RN, et al. "Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts." Am J Epidemiol. 2013;177(2):103-15.
Hu Y-J, Berndt SI, Gustafsson S, et al. "Meta-analysis of gene-level associations for rare variants based on single-variant statistics." Am J Hum Genet. 2013;93(2):236-48.
Bradshaw PT, Monda KL, Stevens J. "Metabolic syndrome in healthy obese, overweight, and normal weight individuals: the Atherosclerosis Risk in Communities Study." Obesity (Silver Spring). 2013;21(1):203-9.
Hamedani AG, Rose KM, B Peterlin L, et al. "Migraine and white matter hyperintensities: the ARIC MRI study." Neurology. 2013;81(15):1308-13.
Evans DM, Brion MJo A, Paternoster L, et al. "Mining the human phenome using allelic scores that index biological intermediates." PLoS Genet. 2013;9(10):e1003919.
Sabater-Lleal M, Huang J, Chasman D, et al. "Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease." Circulation. 2013;128(12):1310-24.
Stolk L, Perry JRB, Chasman DI, et al. "Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways." Nat Genet. 2012;44(3):260-8.
Qayyum R, Snively BM, Ziv E, et al. "A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans." PLoS Genet. 2012;8(3):e1002491.
Ellinor PT, Lunetta KL, Albert CM, et al. "Meta-analysis identifies six new susceptibility loci for atrial fibrillation." Nat Genet. 2012;44(6):670-5.
Musunuru K, Romaine SPR, Lettre G, et al. "Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project." PLoS One. 2012;7(5):e36473.
Bis JC, Kavousi M, Franceschini N, et al. "Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque." Nat Genet. 2011;43(10):940-7.
Dehghan A, Dupuis J, Barbalic M, et al. "Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels." Circulation. 2011;123(7):731-8.
Shi G, Boerwinkle E, Morrison AC, Gu CC, Chakravarti A, Rao DC. "Mining gold dust under the genome wide significance level: a two-stage approach to analysis of GWAS." Genet Epidemiol. 2011;35(2):111-8.
Nalls MA, Couper DJ, Tanaka T, et al. "Multiple loci are associated with white blood cell phenotypes." PLoS Genet. 2011;7(6):e1002113.
O'Seaghdha CM, Parekh RS, Hwang S-J, et al. "The MYH9/APOL1 region and chronic kidney disease in European-Americans." Hum Mol Genet. 2011;20(12):2450-6.
Selvin E, Coresh J, Zhu H, Folsom A, Steffes MW. "Measurement of HbA1c from stored whole blood samples in the Atherosclerosis Risk in Communities study." J Diabetes. 2010;2(2):118-24.
Hancock DB, Eijgelsheim M, Wilk JB, et al. "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function." Nat Genet. 2010;42(1):45-52.
Heid IM, Jackson AU, Randall JC, et al. "Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution." Nat Genet. 2010;42(11):949-60.
Chamberlain AM, Agarwal SK, Ambrose M, Folsom AR, Soliman EZ, Alonso A. "Metabolic syndrome and incidence of atrial fibrillation among blacks and whites in the Atherosclerosis Risk in Communities (ARIC) Study." Am Heart J. 2010;159(5):850-6.
Johnson AM, Rose KM, Elder GH, Chambless LE, Kaufman JS, Heiss G. "Military combat and burden of subclinical atherosclerosis in middle aged men: the ARIC study." Prev Med. 2010;50(5-6):277-81.
Johnson AM, Rose KM, Elder GH, Chambless LE, Kaufman JS, Heiss G. "Military combat and risk of coronary heart disease and ischemic stroke in aging men: The Atherosclerosis Risk in Communities (ARIC) study." Ann Epidemiol. 2010;20(2):143-50.
Volcik KA, Campbell S, Chambless LE, et al. "MMP2 genetic variation is associated with measures of fibrous cap thickness: The Atherosclerosis Risk in Communities Carotid MRI Study." Atherosclerosis. 2010;210(1):188-93.
Wasserman BA, Astor BC, A Sharrett R, Swingen C, Catellier D. "MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: methods, reliability and descriptive statistics." J Magn Reson Imaging. 2010;31(2):406-15.
Perry JRB, Stolk L, Franceschini N, et al. "Meta-analysis of genome-wide association data identifies two loci influencing age at menarche." Nat Genet. 2009;41(6):648-50.
McGeechan K, Liew G, Macaskill P, et al. "Meta-analysis: retinal vessel caliber and risk for coronary heart disease." Ann Intern Med. 2009;151(6):404-13.
Arking DE, Khera A, Xing C, et al. "Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population." PLoS One. 2009;4(1):e4333.
Köttgen A, Glazer NL, Dehghan A, et al. "Multiple loci associated with indices of renal function and chronic kidney disease." Nat Genet. 2009;41(6):712-7.
Ganesh SK, Zakai NA, van Rooij FJA, et al. "Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium." Nat Genet. 2009;41(11):1191-8.
Nambi V, Morrison AC, Hoogeveen RC, et al. "Matrix metalloproteinase-1 and tissue inhibitors do not predict incident coronary artery disease in the atherosclerosis risk in communities (ARIC) study." Tex Heart Inst J. 2008;35(4):388-94.
Ballantyne CM, Hoogeveen RC, McNeill AM, et al. "Metabolic syndrome risk for cardiovascular disease and diabetes in the ARIC study." Int J Obes (Lond). 2008;32 Suppl 2(Suppl 2):S21-4.
Rose KM, Wong TY, Carson AP, Couper DJ, Klein R, Sharrett AR. "Migraine and retinal microvascular abnormalities: the Atherosclerosis Risk in Communities Study." Neurology. 2007;68(20):1694-700.
Ahmed RL, Schmitz KH, Anderson KE, Rosamond WD, Folsom AR. "The metabolic syndrome and risk of incident colorectal cancer." Cancer. 2006;107(1):28-36.
Tande AJ, Platz EA, Folsom AR. "The metabolic syndrome is associated with reduced risk of prostate cancer." Am J Epidemiol. 2006;164(11):1094-102.
Everett CJ, Mainous AG, Koopman RJ, Diaz VA. "Multiple lipid scoring system for prediction of coronary heart disease risk: application to African Americans." J Natl Med Assoc. 2006;98(11):1740-5.
Rose KM, Carson AP, Sanford CP, et al. "Migraine and other headaches: associations with Rose angina and coronary heart disease." Neurology. 2004;63(12):2233-9.
Boland LL, Shahar E, Iber C, Knopman DS, Kuo TF, Nieto JF. "Measures of cognitive function in persons with varying degrees of sleep-disordered breathing: the Sleep Heart Health Study." J Sleep Res. 2002;11(3):265-72.