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ARIC Publications

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Lin H, Mueller-Nurasyid M, Smith AV, et al. "Gene-gene Interaction Analyses for Atrial Fibrillation." Sci Rep. 2016;6:35371.
Lin BM, Nadkarni GN, Tao R, et al. "Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study." Front Genet. 2019;10:494.
Lin H, Wang M, Brody JA, et al. "Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):335-43.
Lin H, Mares JA, Lamonte MJ, et al. "Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study." Ophthalmic Epidemiol. 2017;24(5):311-322.
Lin BM, Grinde KE, Brody JA, et al. "Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium." EBioMedicine. 2021;63:103157.
Ligthart S, Marzi C, Aslibekyan S, et al. "DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases." Genome Biol. 2016;17(1):255.
Ligthart S, de Vries PS, Uitterlinden AG, Hofman A, Franco OH, Chasman DI. "Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein." PLoS One. 2015;10(3):e0118859.
Ligthart S, Hasbani NR, Ahmadizar F, et al. "Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study." Diabet Med. 2021;38(10):e14639.
Ligthart S, Vaez A, Võsa U, et al. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders." Am J Hum Genet. 2018;103(5):691-706.
Liew G, A Sharrett R, Wang J J, et al. "Relative importance of systemic determinants of retinal arteriolar and venular caliber: the atherosclerosis risk in communities study." Arch Ophthalmol. 2008;126(10):1404-10.
Liew G, Shankar A, Wang J J, et al. "Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study." Arch Ophthalmol. 2007;125(6):813-8.
Liew G, Campbell S, Klein R, et al. "Ten-year longitudinal changes in retinal microvascular lesions: the atherosclerosis risk in communities study." Ophthalmology. 2011;118(8):1612-8.
Liew G, Wang J J, Klein R, et al. "The relationship between birthweight and early age-related maculopathy: the atherosclerosis risk in communities study." Ophthalmic Epidemiol. 2008;15(1):56-61.
Liew G, Wang J J, Duncan BB, et al. "Low birthweight is associated with narrower arterioles in adults." Hypertension. 2008;51(4):933-8.
Liese AD, Mayer-Davis EJ, Chambless LE, et al. "Elevated fasting insulin predicts incident hypertension: the ARIC study. Atherosclerosis Risk in Communities Study Investigators." J Hypertens. 1999;17(8):1169-77.
Liese AD, Mayer-Davis EJ, Tyroler HA, et al. "Development of the multiple metabolic syndrome in the ARIC cohort: joint contribution of insulin, BMI, and WHR. Atherosclerosis risk in communities." Ann Epidemiol. 1997;7(6):407-16.
Liese AD, Mayer-Davis EJ, Tyroler HA, et al. "Familial components of the multiple metabolic syndrome: the ARIC study." Diabetologia. 1997;40(8):963-70.
Lieb W, Jansen H, Loley C, et al. "Genetic predisposition to higher blood pressure increases coronary artery disease risk." Hypertension. 2013;61(5):995-1001.
Liao D, Carnethon M, Evans GW, Cascio WE, Heiss G. "Lower heart rate variability is associated with the development of coronary heart disease in individuals with diabetes: the atherosclerosis risk in communities (ARIC) study." Diabetes. 2002;51(12):3524-31.
Liao F, Folsom AR, Brancati FL. "Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study." Am Heart J. 1998;136(3):480-90.
Liao D, Barnes RW, Chambless LE, Simpson RJ, Sorlie P, Heiss G. "Age, race, and sex differences in autonomic cardiac function measured by spectral analysis of heart rate variability--the ARIC study. Atherosclerosis Risk in Communities." Am J Cardiol. 1995;76(12):906-12.
Liao D, Cai J, Brancati FL, et al. "Association of vagal tone with serum insulin, glucose, and diabetes mellitus--The ARIC Study." Diabetes Res Clin Pract. 1995;30(3):211-21.
Liao D, Heiss G, Chinchilli VM, et al. "Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study." J Expo Anal Environ Epidemiol. 2005;15(4):319-28.
Liao D, Cai J, Rosamond WD, et al. "Cardiac autonomic function and incident coronary heart disease: a population-based case-cohort study. The ARIC Study. Atherosclerosis Risk in Communities Study." Am J Epidemiol. 1997;145(8):696-706.
Liao D, Arnett DK, Tyroler HA, et al. "Arterial stiffness and the development of hypertension. The ARIC study." Hypertension. 1999;34(2):201-6.
Liao D, Evans GW, Chambless LE, et al. "Population-based study of heart rate variability and prevalent myocardial infarction. The Atherosclerosis Risk in Communities Study." J Electrocardiol. 1996;29(3):189-98.
Liao D, Duan Y, Whitsel EA, et al. "Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: a population-based study." Am J Epidemiol. 2004;159(8):768-77.
Liao D, Cai J, Barnes RW, et al. "Association of cardiac autonomic function and the development of hypertension: the ARIC study." Am J Hypertens. 1996;9(12 Pt 1):1147-56.
Liao D, Higgins M, Bryan NR, et al. "Lower pulmonary function and cerebral subclinical abnormalities detected by MRI: the Atherosclerosis Risk in Communities study." Chest. 1999;116(1):150-6.
Liao D, Barnes RW, Chambless LE, Heiss G. "A computer algorithm to impute interrupted heart rate data for the spectral analysis of heart rate variability--the ARIC study." Comput Biomed Res. 1996;29(2):140-51.
Liao D, Cooper L, Cai J, et al. "Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control. The ARIC Study. Atherosclerosis Risk in Communities Study." Stroke. 1996;27(12):2262-70.
Liao D, Sloan RP, Cascio WE, et al. "Multiple metabolic syndrome is associated with lower heart rate variability. The Atherosclerosis Risk in Communities Study." Diabetes Care. 1998;21(12):2116-22.
Liao D, Cooper L, Cai J, et al. "The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study." Neuroepidemiology. 1997;16(3):149-62.
Liang J, Cade BE, He KY, et al. "Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level." Am J Hum Genet. 2019;105(5):1057-1068.
Liang J, Le TH, Edwards DRVelez, et al. "Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations." PLoS Genet. 2017;13(5):e1006728.
Liang M, McEvoy JWilliam, Chen Y, Sharrett ARichey. "Association of a Biomarker of Glucose Peaks, 1,5-Anhydroglucitol, With Subclinical Cardiovascular Disease." Diabetes Care. 2016;39(10):1752-9.
Liang J, Le TH, Edwards DRVelez, et al. "Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations." PLoS Genet. 2018;14(5):e1007345.
Li M, Maruthur NM, Loomis SJ, et al. "Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism." Sci Rep. 2017;7(1):2812.
Li R, Cai J, Tegeler C, Sorlie P, Metcalf PA, Heiss G. "Reproducibility of extracranial carotid atherosclerotic lesions assessed by B-mode ultrasound: the Atherosclerosis Risk in Communities Study." Ultrasound Med Biol. 1996;22(7):791-9.
Li D, Misialek JR, Boerwinkle E, et al. "Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study." Alzheimers Dement (Amst). 2017;6:1-10.
Li R, Boerwinkle E, Olshan AF, et al. "Glutathione S-transferase genotype as a susceptibility factor in smoking-related coronary heart disease." Atherosclerosis. 2000;149(2):451-62.
Li D, Misialek JR, Jing M, et al. "Plasma phospholipid very-long-chain SFAs in midlife and 20-year cognitive change in the Atherosclerosis Risk in Communities (ARIC): a cohort study." Am J Clin Nutr. 2020;111(6):1252-1258.
Li D, Misialek JR, Boerwinkle E, et al. "Plasma phospholipids and prevalence of mild cognitive impairment and/or dementia in the ARIC Neurocognitive Study (ARIC-NCS)." Alzheimers Dement (Amst). 2016;3:73-82.
Li D, Misialek JR, Huang F, Windham GB, Yu F. "Independent Association of Plasma Hydroxysphingomyelins With Physical Function in the Atherosclerosis Risk in Communities (ARIC) Study." J Gerontol A Biol Sci Med Sci. 2018;73(8):1103-1110.
Li R, Bensen JT, Hutchinson RG, et al. "Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI family heart study." Genet Epidemiol. 2000;18(3):236-50.
Li AH, Morrison AC, Kovar C, et al. "Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease." Nat Genet. 2015;47(6):640-2.
Li X, Li Z, Zhou H, et al. "Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale." Nat Genet. 2020;52(9):969-983.
Li Z, Li X, Liu Y, et al. "Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies." Am J Hum Genet. 2019;104(5):802-814.
Li H, Sisoudiya SD, Martin-Giacalone BA, et al. "Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group." J Natl Cancer Inst. 2021;113(7):875-883.
Li C, Grove ML, Yu B, Jones BC, Morrison A, Boerwinkle E. "Genetic variants in microRNA genes and targets associated with cardiovascular disease risk factors in the African-American population." Hum Genet. 2018;137(1):85-94.
Li R, Folsom AR, Sharrett AR, Couper D, Bray M, Tyroler HA. "Interaction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease: the Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2001;154(3):729-38.
Li D, Alam AB, Yu F, Kucharska-Newton A, B Windham G, Alonso A. "Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study." Sci Rep. 2021;11(1):1169.
Li M, Li Y, Weeks O, et al. " and Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function." J Am Soc Nephrol. 2017;28(3):981-994.
Li J, Agarwal SK, Alonso A, et al. "Airflow obstruction, lung function, and incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study." Circulation. 2014;129(9):971-80.
Li M, Carey J, Cristiano S, et al. "Genome-Wide Association of Copy Number Polymorphisms and Kidney Function." PLoS One. 2017;12(1):e0170815.
Li L, Selvin E, Lutsey PL, et al. "Association of N-terminal pro B-type natriuretic peptide (NT-proBNP) change with the risk of atrial fibrillation in the ARIC cohort." Am Heart J. 2018;204:119-127.
Li C, Mou C, Swartz MD, Yu B, Bai Y, Tu Y. "dbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions." Hum Mutat. 2020;41(6):1123-1130.
Li R, Duncan BB, Metcalf PA, et al. "B-mode-detected carotid artery plaque in a general population. Atherosclerosis Risk in Communities (ARIC) Study Investigators." Stroke. 1994;25(12):2377-83.
Li D, Misialek JR, Jack CR, et al. "Plasma Metabolites Associated with Brain MRI Measures of Neurodegeneration in Older Adults in the Atherosclerosis Risk in Communities⁻Neurocognitive Study (ARIC-NCS)." Int J Mol Sci. 2019;20(7).
Lewis AA, Ayers CR, Selvin E, et al. "Racial Differences in Malignant Left Ventricular Hypertrophy and Incidence of Heart Failure: A Multicohort Study." Circulation. 2020;141(12):957-967.
Levy D, Ehret GB, Rice K, et al. "Genome-wide association study of blood pressure and hypertension." Nat Genet. 2009;41(6):677-87.
Levine DA, Gross AL, Briceño EM, et al. "Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals." JAMA Neurol. 2020;77(7):810-819.
Levine DA, Gross AL, Briceño EM, et al. "Sex Differences in Cognitive Decline Among US Adults." JAMA Netw Open. 2021;4(2):e210169.
Lesage SR, Mosley TH, Wong TY, et al. "Retinal microvascular abnormalities and cognitive decline: the ARIC 14-year follow-up study." Neurology. 2009;73(11):862-8.
van Lenthe FJ, Borrell LN, Costa G, et al. "Neighbourhood unemployment and all cause mortality: a comparison of six countries." J Epidemiol Community Health. 2005;59(3):231-7.
Lemaitre RN, Tanaka T, Tang W, et al. "Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium." PLoS Genet. 2011;7(7):e1002193.
Lemaitre RN, Johnson CO, Hesselson S, et al. "Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest." Heart Rhythm. 2014;11(3):471-7.
Lei HH, Coresh J, Shuldiner AR, Boerwinkle E, Brancati FL. "Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study." Diabetes. 1999;48(9):1868-72.
Lee AK, Rawlings AM, Lee CJ, et al. "Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study." Diabetologia. 2018;61(9):1956-1965.
Lee CD, Folsom AR, Nieto FJ, Chambless LE, Shahar E, Wolfe DA. "White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women: atherosclerosis risk in communities study." Am J Epidemiol. 2001;154(8):758-64.
Lee MJeong, Deal JA, Ramulu PY, Sharrett ARichey. "Prevalence of Retinal Signs and Association With Cognitive Status: The ARIC Neurocognitive Study." J Am Geriatr Soc. 2019;67(6):1197-1203.
Lee CR, North KE, Bray MS, Couper DJ, Heiss G, Zeldin DC. "Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study." Clin Pharmacol Ther. 2008;83(1):52-60.
Lee AK, Lee CJ, Huang ES, Sharrett ARichey, Coresh JJ. "Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2017;40(12):1661-1667.
Lee CMan Ying, Colagiuri S, Woodward M, et al. "Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes." BMJ Open Diabetes Res Care. 2019;7(1):e000794.
Lee AK, Woodward M, Wang D, et al. "The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE." J Clin Endocrinol Metab. 2020;105(1).
Lee CR, North KE, Bray MS, et al. "NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: the Atherosclerosis Risk in Communities study." Pharmacogenet Genomics. 2006;16(12):891-9.
Lee AK, Juraschek SP, B Windham G, Lee CJ, Sharrett ARichey, Coresh JJ. "Severe Hypoglycemia and Risk of Falls in Type 2 Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2020;43(9):2060-2065.
Lee C D, Folsom AR, Pankow JS, Brancati FL. "Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction." Circulation. 2004;109(7):855-60.
Lee AK, McEvoy JW, Hoogeveen RC, Ballantyne CM. "Severe Hypoglycemia and Elevated High-Sensitivity Cardiac Troponin T in Older Adults With Diabetes: The ARIC Study." J Am Coll Cardiol. 2016;68(12):1370-1.
Lee AK, Warren B, Lee CJ, et al. "The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes." Diabetes Care. 2018;41(1):104-111.

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