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ARIC Publications

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Rusu V, Hoch E, Mercader JM, et al. "Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms." Cell. 2017;170(1):199-212.e20.
Huxley RR, Alonso A, Lopez FL, et al. "Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: the Atherosclerosis Risk in Communities study." Heart. 2012;98(2):133-8.
Mayeda ER, Haan MN, Neuhaus J, et al. "Type 2 diabetes and cognitive decline over 14 years in middle-aged African Americans and whites: the ARIC Brain MRI Study." Neuroepidemiology. 2014;43(3-4):220-7.
Kim ED, Soliman EZ, Coresh J, Matsushita K, Chen LYee. "Two-Week Burden of Arrhythmias across CKD Severity in a Large Community-Based Cohort: The ARIC Study." J Am Soc Nephrol. 2021;32(3):629-638.
Rosamond WD, Chambless LE, Heiss G, et al. "Twenty-two-year trends in incidence of myocardial infarction, coronary heart disease mortality, and case fatality in 4 US communities, 1987-2008." Circulation. 2012;125(15):1848-57.
Verweij N, Mateo Leach I, Isaacs A, et al. "Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram." Hum Mol Genet. 2016;25(10):2093-2103.
Arora S, Stouffer GA, Kucharska-Newton AMaria, et al. "Twenty Year Trends and Sex Differences in Young Adults Hospitalized With Acute Myocardial Infarction." Circulation. 2019;139(8):1047-1056.
Voight BF, Scott LJ, Steinthorsdottir V, et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010;42(7):579-89.
Kubota Y, Cushman M, Zakai N, Rosamond WD. "TV viewing and incident venous thromboembolism: the Atherosclerotic Risk in Communities Study." J Thromb Thrombolysis. 2018;45(3):353-359.
Folsom AR, Lutsey PL, Nambi V, Defilippi CR, Heckbert SR, Cushman M. "Troponin T, NT-proBNP, and venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)." Vasc Med. 2014;19(1):33-41.
Folsom AR, Nambi V, Bell EJ, et al. "Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: the atherosclerosis risk in communities study." Stroke. 2013;44(4):961-7.
Oluleye OW, Folsom AR, Nambi V, Lutsey PL, Ballantyne CM. "Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality." Ann Epidemiol. 2013;23(2):66-73.
Nambi V, Liu X, Chambless LE, et al. "Troponin T and N-terminal pro-B-type natriuretic peptide: a biomarker approach to predict heart failure risk--the atherosclerosis risk in communities study." Clin Chem. 2013;59(12):1802-10.
Hussain A, Sun C, Selvin E, et al. "Triglyceride-rich lipoproteins, apolipoprotein C-III, angiopoietin-like protein 3, and cardiovascular events in older adults: Atherosclerosis Risk in Communities (ARIC) study." Eur J Prev Cardiol. 2021.
Cowan LT, Buck B, Schwind JS, et al. "Triggering of cardiovascular disease by infection type: The atherosclerosis risk in communities study (ARIC)." Int J Cardiol. 2020.
Caughey MC, Arora S, Qamar A, et al. "Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In-Hospital-Onset Versus Out-of-Hospital Onset: The ARIC Study." J Am Heart Assoc. 2021;10(2):e018414.
Rosamond WD, Chambless LE, Sorlie PD, et al. "Trends in the sensitivity, positive predictive value, false-positive rate, and comparability ratio of hospital discharge diagnosis codes for acute myocardial infarction in four US communities, 1987-2000." Am J Epidemiol. 2004;160(12):1137-46.
Rosamond WD, Chambless LE, Folsom AR, et al. "Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994." N Engl J Med. 1998;339(13):861-7.
Koton S, Sang Y, Schneider ALC, Rosamond WD, Gottesman RF. "Trends in Stroke Incidence Rates in Older US Adults: An Update From the Atherosclerosis Risk in Communities (ARIC) Cohort Study." JAMA Neurol. 2020;77(1):109-113.
Goff DC, Howard G, Wang CH, et al. "Trends in severity of hospitalized myocardial infarction: the atherosclerosis risk in communities (ARIC) study, 1987-1994." Am Heart J. 2000;139(5):874-80.
McGinn AP, Rosamond WD, Goff DC, Taylor HA, Miles SJ, Chambless L. "Trends in prehospital delay time and use of emergency medical services for acute myocardial infarction: experience in 4 US communities from 1987-2000." Am Heart J. 2005;150(3):392-400.
Szklo M, Chambless LE, Folsom AR, et al. "Trends in plasma cholesterol levels in the atherosclerosis risk in communities (ARIC) study." Prev Med. 2000;30(3):252-9.
Newman JD, Shimbo D, Baggett C, et al. "Trends in myocardial infarction rates and case fatality by anatomical location in four United States communities, 1987 to 2008 (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2013;112(11):1714-9.
Chang PP, Wruck LM, Shahar E, et al. "Trends in Hospitalizations and Survival of Acute Decompensated Heart Failure in Four US Communities (2005-2014): ARIC Study Community Surveillance." Circulation. 2018;138(1):12-24.
Ni H, Coady S, Rosamond W, et al. "Trends from 1987 to 2004 in sudden death due to coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study." Am Heart J. 2009;157(1):46-52.
Astor BC, Köttgen A, Hwang S-J, Bhavsar N, Fox CS, Coresh J. "Trefoil factor 3 predicts incident chronic kidney disease: a case-control study nested within the Atherosclerosis Risk in Communities (ARIC) study." Am J Nephrol. 2011;34(4):291-7.
Bozorgmanesh M, Hadaegh F, Azizi F. "Transportability of the updated diabetes prediction model from Atherosclerosis Risk in Communities Study to a Middle Eastern adult population: community-based cohort study." Acta Diabetol. 2013;50(2):175-81.
Liu C-T, C Y Ng M, Rybin D, et al. "Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource." Diabetologia. 2012;55(11):2970-84.
C Y Ng M, Saxena R, Li J, et al. "Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study." Diabetes. 2013;62(3):965-76.
Keller MF, Reiner AP, Okada Y, et al. "Trans-ethnic meta-analysis of white blood cell phenotypes." Hum Mol Genet. 2014;23(25):6944-60.
Liu C-T, Raghavan S, Maruthur N, et al. "Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin." Am J Hum Genet. 2016;99(1):56-75.
Morris AP, Le TH, Wu H, et al. "Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies." Nat Commun. 2019;10(1):29.
Bien SA, Pankow JS, Haessler J, et al. "Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium." Diabetologia. 2017;60(12):2384-2398.
Wu Y, Waite LL, Jackson AU, et al. "Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained." PLoS Genet. 2013;9(3):e1003379.
Fernández-Rhodes L, Gong J, Haessler J, et al. "Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci." Hum Genet. 2017;136(6):771-800.
Hong J, Hatchell KE, Bradfield JP, et al. "Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations." J Clin Endocrinol Metab. 2018;103(4):1380-1392.
Gong J, Nishimura KK, Fernández-Rhodes L, et al. "Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI." Int J Obes (Lond). 2018;42(3):384-390.
Yan Y, Klein R, Heiss G, et al. "The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study." BMC Endocr Disord. 2010;10:9.
Yan Y, North KE, Ballantyne CM, et al. "Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study." Diabetes. 2009;58(1):285-9.
Chen J, Spracklen CN, Marenne G, et al. "The trans-ancestral genomic architecture of glycemic traits." Nat Genet. 2021;53(6):840-860.
Norby FL, Soliman EZ, Chen LYee, Bengtson LGS, Loehr LR, Agarwal SK. "Trajectories of Cardiovascular Risk Factors and Incidence of Atrial Fibrillation Over a 25-Year Follow-Up: The ARIC Study (Atherosclerosis Risk in Communities)." Circulation. 2016;134(8):599-610.
Williams JE, Din-Dzietham R, Szklo M. "Trait anger and arterial stiffness: results from the Atherosclerosis Risk in Communities (ARIC) study." Prev Cardiol. 2006;9(1):14-20.
Kan H, Heiss G, Rose KM, Whitsel E, Lurmann F, London SJ. "Traffic exposure and lung function in adults: the Atherosclerosis Risk in Communities study." Thorax. 2007;62(10):873-9.
Kan H, Folsom AR, Cushman M, et al. "Traffic exposure and incident venous thromboembolism in the Atherosclerosis Risk in Communities (ARIC) Study." J Thromb Haemost. 2011;9(4):672-8.
Muntner P, He J, Astor BC, Folsom AR, Coresh J. "Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease: results from the atherosclerosis risk in communities study." J Am Soc Nephrol. 2005;16(2):529-38.
Ding N, Kwak L, Ballew SH, et al. "Traditional and nontraditional glycemic markers and risk of peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2018;274:86-93.
Kanoni S, Nettleton JA, Hivert M-F, et al. "Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis." Diabetes. 2011;60(9):2407-16.
Zakai NA, Lutsey PL, Folsom AR, Heckbert SR, Cushman M. "Total tissue factor pathway inhibitor and venous thrombosis. The Longitudinal Investigation of Thromboembolism Etiology." Thromb Haemost. 2010;104(2):207-12.
Quispe R, Elshazly MB, Zhao D, et al. "Total cholesterol/HDL-cholesterol ratio discordance with LDL-cholesterol and non-HDL-cholesterol and incidence of atherosclerotic cardiovascular disease in primary prevention: The ARIC study." Eur J Prev Cardiol. 2020;27(15):1597-1605.
Naorungroj S, Schoenbach VJ, Wruck L, et al. "Tooth loss, periodontal disease, and cognitive decline in the Atherosclerosis Risk in Communities (ARIC) study." Community Dent Oral Epidemiol. 2015;43(1):47-57.
Schultheiss UT, Daya N, Grams ME, et al. "Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study." Nephrol Dial Transplant. 2017;32(11):1874-1881.
Martin SS, Daya N, Lutsey PL, et al. "Thyroid Function, Cardiovascular Risk Factors, and Incident Atherosclerotic Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study." J Clin Endocrinol Metab. 2017;102(9):3306-3315.
Wu KK, Aleksic N, Ahn C, Boerwinkle E, Folsom AR, Juneja H. "Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease." Circulation. 2001;103(10):1386-9.
Cui Z, Truesdale KP, Bradshaw PT, Cai J. "Three-year weight change and cardiometabolic risk factors in obese and normal weight adults who are metabolically healthy: the atherosclerosis risk in communities study." Int J Obes (Lond). 2015;39(8):1203-8.
Bower JK, Pankow JS, Lazo M, et al. "Three-year variability in plasma concentrations of the soluble receptor for advanced glycation end products (sRAGE)." Clin Biochem. 2014;47(1-2):132-4.
Wong TY, Klein R, Amirul Islam FM, et al. "Three-year incidence and cumulative prevalence of retinopathy: the atherosclerosis risk in communities study." Am J Ophthalmol. 2007;143(6):970-6.
Ghelani KP, Chen LYee, Norby FL, Soliman EZ, Koton S, Alonso A. "Thirty-Year Trends in the Incidence of Atrial Fibrillation: The ARIC Study." J Am Heart Assoc. 2022;11(8):e023583.
Caughey MC, Derebail VK, Key NS, Reiner AP, Gottesman RF, Kshirsagar AV. "Thirty-year risk of ischemic stroke in individuals with sickle cell trait and modification by chronic kidney disease: The atherosclerosis risk in communities (ARIC) study." Am J Hematol. 2019;94(12):1306-1313.
Liew G, Campbell S, Klein R, et al. "Ten-year longitudinal changes in retinal microvascular lesions: the atherosclerosis risk in communities study." Ophthalmology. 2011;118(8):1612-8.
Koton S, Wruck L, Quibrera PMiguel, et al. "Temporal trends in validated ischaemic stroke hospitalizations in the USA." Int J Epidemiol. 2019;48(3):994-1003.
Cheng S, Claggett B, Correia AW, et al. "Temporal trends in the population attributable risk for cardiovascular disease: the Atherosclerosis Risk in Communities Study." Circulation. 2014;130(10):820-8.
Bengtson LGS, Chen LYee, Chamberlain AM, et al. "Temporal trends in the occurrence and outcomes of atrial fibrillation in patients with acute myocardial infarction (from the Atherosclerosis Risk in Communities Surveillance Study)." Am J Cardiol. 2014;114(5):692-7.
Pandey A, Vaduganathan M, Arora S, et al. "Temporal Trends in Prevalence and Prognostic Implications of Comorbidities Among Patients With Acute Decompensated Heart Failure: The ARIC Study Community Surveillance." Circulation. 2020;142(3):230-243.
O'Brien EC, Rose KM, Suchindran CM, et al. "Temporal trends in medical therapies for ST- and non-ST elevation myocardial infarction: (from the Atherosclerosis Risk in Communities [ARIC] Surveillance Study)." Am J Cardiol. 2013;111(3):305-11.
Agarwal SK, Wruck L, Quibrera M, et al. "Temporal Trends in Hospitalization for Acute Decompensated Heart Failure in the United States, 1998-2011." Am J Epidemiol. 2016;183(5):462-70.
Juraschek SP, McAdams-DeMarco M, Miller ER, et al. "Temporal relationship between uric acid concentration and risk of diabetes in a community-based study population." Am J Epidemiol. 2014;179(6):684-91.
Sanders AE, Divaris K, Naorungroj S, Heiss G. "Telomere length attrition and chronic periodontitis: an ARIC Study nested case-control study." J Clin Periodontol. 2015;42(1):12-20.
Kubota Y, Alonso A, Shah AM, Chen LYee. "Television Watching as Sedentary Behavior and Atrial Fibrillation: The Atherosclerosis Risk in Communities Study." J Phys Act Health. 2018;15(12):895-899.
Meyer A-M, Evenson KR, Couper DJ, Stevens J, Pereria MA, Heiss G. "Television, physical activity, diet, and body weight status: the ARIC cohort." Int J Behav Nutr Phys Act. 2008;5:68.
Köttgen A, Hwang S-J, Rampersaud E, et al. "TCF7L2 variants associate with CKD progression and renal function in population-based cohorts." J Am Soc Nephrol. 2008;19(10):1989-99.
Bielinski SJ, Pankow JS, Folsom AR, North KE, Boerwinkle E. "TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study." Diabetologia. 2008;51(6):968-70.
de Haan HG, A Vlieg vanHylckama, Lotta LA, et al. "Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes." J Thromb Haemost. 2018;16(12):2432-2441.
Lin H, Sinner MF, Brody JA, et al. "Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study." Heart Rhythm. 2014;11(3):452-7.
Tin A, Marten J, Kuhns VLHalperin, et al. "Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels." Nat Genet. 2019;51(10):1459-1474.
Roetker NS, Armasu SM, Pankow JS, et al. "Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis." J Thromb Haemost. 2017;15(7):1334-1343.