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ARIC Publications

Ruth KS, Day FR, Hussain J, et al. "Genetic insights into biological mechanisms governing human ovarian ageing." Nature. 2021;596(7872):393-397.
Ligthart S, Hasbani NR, Ahmadizar F, et al. "Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study." Diabet Med. 2021;38(10):e14639.
Schunk SJ, Kleber ME, März W, et al. "Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality." Eur Heart J. 2021;42(18):1742-1756.
McCartney DL, Min JL, Richmond RC, et al. "Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging." Genome Biol. 2021;22(1):194.
Ahluwalia TS, Prins BP, Abdollahi M, et al. "Genome-wide association study of circulating interleukin 6 levels identifies novel loci." Hum Mol Genet. 2021;30(5):393-409.
Luo S, Feofanova EV, Tin A, et al. "Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension." Kidney Int. 2021;100(2):430-439.
Jones G, Trajanoska K, Santanasto AJ, et al. "Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women." Nat Commun. 2021;12(1):654.
Li H, Sisoudiya SD, Martin-Giacalone BA, et al. "Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group." J Natl Cancer Inst. 2021;113(7):875-883.
Selvin E, Wang D, Tang O, Minotti M, Echouffo-Tcheugui JB, Coresh J. "Glucose Patterns in Very Old Adults: A Pilot Study in a Community-Based Population." Diabetes Technol Ther. 2021.
Echouffo-Tcheugui JB, Daya N, Matsushita K, et al. "Growth Differentiation Factor (GDF)-15 and Cardiometabolic Outcomes among Older Adults: The Atherosclerosis Risk in Communities Study." Clin Chem. 2021;67(4):653-661.
Schneider ALC, Selvin E, Latour L, et al. "Head injury and 25-year risk of dementia." Alzheimers Dement. 2021.
Deal JA, Gross AL, A Sharrett R, et al. "Hearing impairment and missing cognitive test scores in a population-based study of older adults: The Atherosclerosis Risk in Communities neurocognitive study." Alzheimers Dement. 2021.
Commodore-Mensah Y, Lazo M, Tang O, et al. "High Burden of Subclinical and Cardiovascular Disease Risk in Adults with Metabolically Healthy Obesity: The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2021.
Du S, Kim H, Rebholz CM. "Higher Ultra-Processed Food Consumption Is Associated with Increased Risk of Incident Coronary Artery Disease in the Atherosclerosis Risk in Communities Study." J Nutr. 2021.
Ishigami J, Kim Y, Sang Y, et al. "High-Sensitivity Cardiac Troponin, Natriuretic Peptide, and Long-Term Risk of Acute Kidney Injury: The Atherosclerosis Risk in Communities (ARIC) Study." Clin Chem. 2021;67(1):298-307.
Ebong IA, Wilson MD, Bertoni AG, et al. "High-sensitivity cardiac troponin T and the risk of heart failure in postmenopausal women of the ARIC Study." Menopause. 2021;28(3):284-291.
Qi Q, Li J, Yu B, et al. "Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies." Gut. 2021.
Zhao Y, Malik S, Budoff MJ, et al. "Identification and Predictors for Cardiovascular Disease Risk Equivalents among Adults With Diabetes Mellitus." Diabetes Care. 2021.
Sarnowski C, Chen H, Biggs ML, et al. "Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program." PLoS One. 2021;16(7):e0253611.
Sullivan KJ, Ranadive R, Su D, et al. "Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study." Brain Imaging Behav. 2021.
Narayan KMVenkat, Kondal D, Daya N, et al. "Incidence and pathophysiology of diabetes in South Asian adults living in India and Pakistan compared with US blacks and whites." BMJ Open Diabetes Res Care. 2021;9(1).
Narayan KMVenkat, Kondal D, Kobes S, et al. "Incidence of diabetes in South Asian young adults compared to Pima Indians." BMJ Open Diabetes Res Care. 2021;9(1).
Sarnowski C, Cousminer DL, Franceschini N, et al. "Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche." Hum Reprod. 2021;36(7):1999-2010.
Minamisawa M, Inciardi RM, Claggett B, et al. "Left atrial structure and function of the amyloidogenic V122I transthyretin variant in elderly African Americans." Eur J Heart Fail. 2021;23(8):1290-1295.
Krishnappa D, Wang W, Rooney MR, et al. "Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study." Int J Cardiol. 2021.
Xu H, Schwander K, Brown MR, et al. "Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions." Eur J Hum Genet. 2021;29(5):839-850.
Marrone MT, Mondul AM, Prizment AE, et al. "Lipid-Lowering Drug Use and Cancer Incidence and Mortality in the ARIC Study." JNCI Cancer Spectr. 2021;5(5).
Metcalf PA, Meyer ML, Tanaka H, et al. "Longitudinal associations of blood pressure with aortic stiffness and pulsatility: the Atherosclerosis Risk in Communities Study." J Hypertens. 2021;39(5):987-993.
Ting J, Jiang K, Du S, et al. "Longitudinal Blood Pressure Patterns from Mid-to-Late Life and Late-life Hearing Loss in the Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2021.
Harding BN, Norby FL, Heckbert SR, et al. "Longitudinal Measures of Blood Pressure and Subclinical Atrial Arrhythmias: The MESA and the ARIC Study." J Am Heart Assoc. 2021;10(11):e020260.
Lu Y, Pike JR, Selvin E, et al. "Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study." J Alzheimers Dis. 2021;79(4):1775-1784.
Gorski M, Jung B, Li Y, et al. "Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline." Kidney Int. 2021;99(4):926-939.
He WJ, Chen J, Razavi AC, et al. "Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease." Clin J Am Soc Nephrol. 2021;16(11):1620-1629.
Tariq A, Chen J, Yu B, et al. "Metabolomics of Dietary Acid Load and Incident Chronic Kidney Disease." J Ren Nutr. 2021.
Cohen AJ, Teramoto K, Claggett B, et al. "Mid- to Late-Life Inflammation and Risk of Cardiac Dysfunction, HFpEF and HFrEF in Late Life." J Card Fail. 2021.
Palta P, Griswold M, Ranadive R, et al. "Midlife Cardiovascular Health and Robust versus Frail Late-Life Status: The Atherosclerosis Risk in Communities (ARIC) Study." J Gerontol A Biol Sci Med Sci. 2021.
Johnson EL, Krauss GL, Kucharska-Newton A, Lam AD, Sarkis R, Gottesman RF. "Mortality in Patients With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study." Neurology. 2021.
Wang H, Noordam R, Cade BE, et al. "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure." Mol Psychiatry. 2021.
Jhun M-A, Mendelson M, Wilson R, et al. "A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids." Nat Commun. 2021;12(1):3987.
Madrid L, Moreno-Grau S, Ahmad S, et al. "Multiomics integrative analysis identifies allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis." Aging (Albany NY). 2021;13(7):9277-9329.
Walker KA, Chawla S, Nogueras-Ortiz C, et al. "Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study." Neurobiol Aging. 2021;97:65-72.
Folsom AR, de Vries PS, Cushman M. "No prospective association of a polygenic risk score for coronary artery disease with venous thromboembolism incidence." J Thromb Haemost. 2021.
Kahali B, Chen Y, Feitosa MF, et al. "A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction." J Clin Endocrinol Metab. 2021;106(2):372-387.
Raffield LM, Howard AGreen, Graff M, et al. "Obesity Duration, Severity, and Distribution Trajectories and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2021;10(24):e019946.
Fang M, Tcheugui JBEchouffo, Pankow JS, B Windham G, Selvin E. "Patient-reported preventive care practices in older adults with diabetes." Diabet Med. 2021;38(3):e14508.
Armstrong NM, Wang H, E J-Y, et al. "Patterns of Prevalence of Multiple Sensory Impairments among Community-Dwelling Older Adults." J Gerontol A Biol Sci Med Sci. 2021.
Pandey A, Mehta A, Paluch A, et al. "Performance of the American Heart Association/American College of Cardiology Pooled Cohort Equations to Estimate Atherosclerotic Cardiovascular Disease Risk by Self-reported Physical Activity Levels." JAMA Cardiol. 2021;6(6):690-696.
Sen S, Redd K, Trivedi T, et al. "Periodontal Disease, Atrial Fibrillation and Stroke." Am Heart J. 2021;235:36-43.
Arsiwala LT, Mok Y, Yang C, et al. "Periodontal disease measures and risk of incident peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study." J Periodontol. 2021.
Philips KH, Zhang S, Moss K, Ciarrocca K, Beck JD. "Periodontal disease, undiagnosed diabetes, and body mass index: Implications for diabetes screening by dentists." J Am Dent Assoc. 2021;152(1):25-35.
Zhang S, Philips KH, Moss K, et al. "Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-modified Association." J Clin Endocrinol Metab. 2021.
Xu J, Liu G, Hegde SM, et al. "Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study." Metabolites. 2021;11(1).
Damotte V, van der Lee SJ, Chouraki V, et al. "Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants." Alzheimers Dement. 2021.
Lindbohm JV, Mars N, Walker KA, et al. "Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies." Alzheimers Dement. 2021.
Yu Z, Jin J, Tin A, et al. "Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases." J Am Soc Nephrol. 2021.
Seplyarskiy VB, Soldatov RA, Koch E, et al. "Population sequencing data reveal a compendium of mutational processes in the human germ line." Science. 2021;373(6558):1030-1035.
Briceño EM, Gross AL, Giordani BJ, et al. "Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS." J Alzheimers Dis. 2021.
Mediano MFF, Mok Y, Coresh J, et al. "Prestroke Physical Activity and Adverse Health Outcomes After Stroke in the Atherosclerosis Risk in Communities Study." Stroke. 2021:STROKEAHA120032695.
Schneider ALC, Wang D, Gottesman RF, Selvin E. "Prevalence of Disability Associated With Head Injury With Loss of Consciousness in Adults in the United States: A Population-Based Study." Neurology. 2021;97(2):e124-e135.
Hicks CW, Wang D, B Windham G, Matsushita K, Selvin E. "Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts." Sci Rep. 2021;11(1):19159.
Chunawala ZS, Hall ME, Arora S, et al. "Prognostic value of shock index in patients admitted with non-ST-segment elevation myocardial infarction: the ARIC study community surveillance." Eur Heart J Acute Cardiovasc Care. 2021.
Filshtein TJ, Li X, Zimmerman SC, Ackley SF, M Glymour M, Power MC. "Proof of Concept Example for Use of Simulation to Allow Data Pooling Despite Privacy Restrictions." Epidemiology. 2021;32(5):638-647.
Palta P, A Sharrett R, Gabriel KPettee, et al. "Prospective Analysis of Leisure-Time Physical Activity in Midlife and Beyond and Brain Damage on MRI in Older Adults." Neurology. 2021;96(7):e964-e974.
Prizment AE, McSweeney S, Pankratz N, et al. "Prostate Cancer Mortality Associated with Aggregate Polymorphisms in Androgen-Regulating Genes: The Atherosclerosis Risk in the Communities (ARIC) Study." Cancers (Basel). 2021;13(8).
Grams ME, Surapaneni A, Chen J, et al. "Proteins Associated with Risk of Kidney Function Decline in the General Population." J Am Soc Nephrol. 2021;32(9):2291-2302.
Norby FL, Tang W, Pankow JS, et al. "Proteomics and Risk of Atrial Fibrillation in Older Adults (From the Atherosclerosis Risk in Communities [ARIC] Study)." Am J Cardiol. 2021;161:42-50.
Rooney MR, Bell EJ, Alonso A, et al. "Proton Pump Inhibitor Use, Hypomagnesemia and Risk of Cardiovascular Diseases: The Atherosclerosis Risk in Communities (ARIC) Study." J Clin Gastroenterol. 2021;55(8):677-683.
Honda Y, Mok Y, Mathews L, et al. "Psychosocial factors and subsequent risk of hospitalizations with peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2021;329:36-43.
Caughey MC, Vaduganathan M, Arora S, et al. "Racial Differences and Temporal Obesity Trends in Heart Failure with Preserved Ejection Fraction." J Am Geriatr Soc. 2021.
Choi SHoan, Jurgens SJ, Haggerty CM, et al. "Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis." Circ Genom Precis Med. 2021;14(4):e003300.
Griswold ME, Talluri R, Zhu X, et al. "Reflection on modern methods: shared-parameter models for longitudinal studies with missing data." Int J Epidemiol. 2021;50(4):1384-1393.
Caughey MC, Qiao Y, Meyer ML, et al. "Relationship Between Central Artery Stiffness, Brain Arterial Dilation, and White Matter Hyperintensities in Older Adults: The ARIC Study-Brief Report." Arterioscler Thromb Vasc Biol. 2021;41(6):2109-2116.
Powell DS, Kuo P-L, Qureshi R, et al. "The Relationship of ε4, Race, and Sex on the Age of Onset and Risk of Dementia." Front Neurol. 2021;12:735036.
Quispe R, Martin SS, Michos ED, et al. "Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study." Eur Heart J. 2021.
Wijkman MO, Malachias MVB, Claggett BL, et al. "Resistance to antihypertensive treatment and long-term risk: The Atherosclerosis Risk in Communities study." J Clin Hypertens (Greenwich). 2021;23(10):1887-1896.
Hong J, Surapaneni A, Daya N, et al. "Retinopathy and Risk of Kidney Disease in Persons With Diabetes." Kidney Med. 2021;3(5):808-815.e1.
Hicks CW, Ding N, Kwak L, et al. "Risk of peripheral artery disease according to race and sex: The Atherosclerosis Risk in Communities (ARIC) study." Atherosclerosis. 2021;324:52-57.
Rooney MR, Rawlings AM, Pankow JS, et al. "Risk of Progression to Diabetes Among Older Adults With Prediabetes." JAMA Intern Med. 2021;181(4):511-519.
Kwong AM, Blackwell TW, LeFaive J, et al. "Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries." Genetics. 2021;218(1).
"SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe." Eur Heart J. 2021;42(25):2439-2454.