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ARIC Publications

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Chami N, Chen M-H, Slater AJ, et al. "Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits." Am J Hum Genet. 2016;99(1):8-21.
Gonzaga-Jauregui C, Harel T, Gambin T, et al. "Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy." Cell Rep. 2015;12(7):1169-83.
Feofanova EV, Lim E, Chen H, et al. "Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Study." Genet Epidemiol. 2021;45(6):651-663.
Do R, Stitziel NO, Won H-H, et al. "Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature. 2015;518(7537):102-6.
Flannick J, Mercader JM, Fuchsberger C, et al. "Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls." Nature. 2019;570(7759):71-76.
Prins BP, Mead TJ, Brody JA, et al. "Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6." Genome Biol. 2018;19(1):87.
Bihlmeyer NA, Brody JA, Smith A V, et al. "ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals." Circ Genom Precis Med. 2018;11(1):e001758.
Spracklen CN, Karaderi T, Yaghootkar H, et al. "Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology." Am J Hum Genet. 2019;105(1):15-28.
Liu DJ, Peloso GM, Yu H, et al. "Exome-wide association study of plasma lipids in >300,000 individuals." Nat Genet. 2017;49(12):1758-1766.
Riveros-Mckay F, Roberts D, Di Angelantonio E, et al. "An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript." Diabetes. 2022;71(2):359-364.
Scott RA, Scott LJ, Mägi R, et al. "An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans." Diabetes. 2017;66(11):2888-2902.
Divaris K, Monda KL, North KE, et al. "Exploring the genetic basis of chronic periodontitis: a genome-wide association study." Hum Mol Genet. 2013;22(11):2312-24.
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Rawlings AM, Bandeen-Roche K, Gross AL, et al. "Factor structure of the ARIC-NCS Neuropsychological Battery: An evaluation of invariance across vascular factors and demographic characteristics." Psychol Assess. 2016;28(12):1674-1683.
Folsom AR, Cushman M, Heckbert SR, Ohira T, Rasmussen-Torvik L, Tsai MY. "Factor VII coagulant activity, factor VII -670A/C and -402G/A polymorphisms, and risk of venous thromboembolism." J Thromb Haemost. 2007;5(8):1674-8.
Duncan BB, Schmidt MI, Offenbacher S, Wu KK, Savage PJ, Heiss G. "Factor VIII and other hemostasis variables are related to incident diabetes in adults. The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 1999;22(5):767-72.
Aleksic N, Ahn C, Wang Y-W, et al. "Factor XIIIA Val34Leu polymorphism does not predict risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study." Arterioscler Thromb Vasc Biol. 2002;22(2):348-52.
McKibben RA, Zhao D, Lutsey PL, Schneider ALC, Guallar E, Mosley TH. "Factors Associated With Change in 25-Hydroxyvitamin D Levels Over Longitudinal Follow-Up in the ARIC Study." J Clin Endocrinol Metab. 2016;101(1):33-43.
Faulkner KM, Dickson VVaughan, Fletcher J, et al. "Factors Associated With Cognitive Impairment in Heart Failure With Preserved Ejection Fraction." J Cardiovasc Nurs. 2020.
George KM, Folsom AR, Kucharska-Newton AMaria, Mosley TH. "Factors Related to Differences in Retention among African American and White Participants in the Atherosclerosis Risk in Communities Study (ARIC) Prospective Cohort: 1987-2013." Ethn Dis. 2017;27(1):31-38.
Knowles JW, Assimes TL, Boerwinkle E, et al. "Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD." BMC Med Genet. 2008;9:23.
Folsom AR, Roetker NS, Kelley ST, Tang W. "Failure to replicate thrombomodulin genetic variant predictors of venous thromboembolism in African Americans." Blood. 2017;130(5):688-690.
Liese AD, Mayer-Davis EJ, Tyroler HA, et al. "Familial components of the multiple metabolic syndrome: the ARIC study." Diabetologia. 1997;40(8):963-70.
Pankow JS, Folsom AR, Province MA, et al. "Family history of coronary heart disease and hemostatic variables in middle-aged adults. Atherosclerosis Risk in Communities Investigators and Family Heart Study Research Group." Thromb Haemost. 1997;77(1):87-93.
Bensen JT, Li R, Hutchinson RG, Province MA, Tyroler HA. "Family history of coronary heart disease and pre-clinical carotid artery atherosclerosis in African-Americans and whites: the ARIC study: Atherosclerosis Risk in Communities." Genet Epidemiol. 1999;16(2):165-78.
Pereira MA, Schreiner PJ, Pankow JS, et al. "The Family Risk Score for coronary heart disease: associations with lipids, lipoproteins, and body habitus in a middle-aged bi-racial cohort: The ARIC study." Ann Epidemiol. 2000;10(4):239-45.
Li R, Bensen JT, Hutchinson RG, et al. "Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI family heart study." Genet Epidemiol. 2000;18(3):236-50.
Wu B. "Fast and Accurate Genome-Wide Association Test of Multiple Quantitative Traits." Comput Math Methods Med. 2018;2018:2564531.
Nabulsi AA, Folsom AR, Heiss G, et al. "Fasting hyperinsulinemia and cardiovascular disease risk factors in nondiabetic adults: stronger associations in lean versus obese subjects. Atherosclerosis Risk in Communities Study Investigators." Metabolism. 1995;44(7):914-22.
Folsom AR, Vitelli LL, Lewis CE, Schreiner PJ, Watson RL, Wagenknecht LE. "Is fasting insulin concentration inversely associated with rate of weight gain? Contrasting findings from the CARDIA and ARIC study cohorts." Int J Obes Relat Metab Disord. 1998;22(1):48-54.
Pankow JS, Duncan BB, Schmidt M I, et al. "Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study." Diabetes Care. 2004;27(1):77-82.
Bressler J, Fornage M, Demerath EW, et al. "Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study." Neurology. 2013;80(1):92-9.
Beck TF, Campeau PM, Jhangiani SN, et al. "FBN1 contributing to familial congenital diaphragmatic hernia." Am J Med Genet A. 2015;167A(4):831-6.
Silvestre OM, Gonçalves A, Nadruz W, et al. "Ferritin levels and risk of heart failure-the Atherosclerosis Risk in Communities Study." Eur J Heart Fail. 2017;19(3):340-347.
Thibord F, Song C, Pattee J, et al. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer.. Vol. 19.; 2021. J Thromb Haemost 19(8).
Cushman M, Folsom AR, Wang L, et al. "Fibrin fragment D-dimer and the risk of future venous thrombosis." Blood. 2003;101(4):1243-8.
Duncan BB, Schmidt MI, Chambless LE, Folsom AR, Carpenter M, Heiss G. "Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults--the ARIC study. Atherosclerosis Risk in Communities." Obes Res. 2000;8(4):279-86.
Lutsey PL, Alonso A, Selvin E, et al. "Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the Atherosclerosis Risk in Communities study." J Am Heart Assoc. 2014;3(3):e000936.
Ding N, Yang C, Ballew SH, et al. "Fibrosis and Inflammatory Markers and Long-Term Risk of Peripheral Artery Disease: The ARIC Study." Arterioscler Thromb Vasc Biol. 2020;40(9):2322-2331.
Howson JMM, Zhao W, Barnes DR, et al. "Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms." Nat Genet. 2017;49(7):1113-1119.
Arora S, Stouffer GA, Kucharska-Newton AMaria, et al. "Fifteen-Year Trends in Management and Outcomes of Non-ST-Segment-Elevation Myocardial Infarction Among Black and White Patients: The ARIC Community Surveillance Study, 2000-2014." J Am Heart Assoc. 2018;7(19):e010203.
Inker LA, Coresh JJ, Sang Y, et al. "Filtration Markers as Predictors of ESRD and Mortality: Individual Participant Data Meta-Analysis." Clin J Am Soc Nephrol. 2017;12(1):69-78.
Gong J, Schumacher F, Lim U, et al. "Fine Mapping and Identification of BMI Loci in African Americans." Am J Hum Genet. 2013;93(4):661-71.
Avery CL, Wassel CL, Richard MA, et al. "Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations." Heart Rhythm. 2017;14(4):572-580.
Avery CL, Sethupathy P, Buyske S, et al. "Fine-mapping and initial characterization of QT interval loci in African Americans." PLoS Genet. 2012;8(8):e1002870.
Evans DS, Avery CL, Nalls MA, et al. "Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans." Hum Mol Genet. 2016;25(19):4350-4368.
Zubair N, Graff M, Ambite JLuis, et al. "Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci." Hum Mol Genet. 2016;25(24):5500-5512.
Shahar E, Folsom A. "Fish consumption may limit the damage of smoking on the lung." Am J Respir Crit Care Med. 1995;151(5):1688-9.
Gronroos NN, Chamberlain AM, Folsom AR, et al. "Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study." PLoS One. 2012;7(5):e36686.
Bare LA, Morrison AC, Rowland CM, et al. "Five common gene variants identify elevated genetic risk for coronary heart disease." Genet Med. 2007;9(10):682-9.
Huang J, Wang K, Wei P, et al. "FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics." Genetics. 2016;202(3):919-29.
Ford MD, Xie YJ, Wasserman BA, Steinman DA. "Is flow in the common carotid artery fully developed?" Physiol Meas. 2008;29(11):1335-49.
Boerwinkle E. "Following-up genome-wide association study signals: lessons learned from Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):332-4.
Joshi AD, Andersson C, Buch S, et al. "Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies." Gastroenterology. 2016;151(2):351-363.e28.
Watkins S, Thiemann D, Coresh J, Powe N, Folsom AR, Rosamond W. "Fourteen-year (1987 to 2000) trends in the attack rates of, therapy for, and mortality from non-ST-elevation acute coronary syndromes in four United States communities." Am J Cardiol. 2005;96(10):1349-55.
Knopman DS, Mosley TH, Catellier DJ, Coker LH. "Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI Study." Alzheimers Dement. 2009;5(3):207-14.
Ballew SH, Chen Y, Daya NR, et al. "Frailty, Kidney Function, and Polypharmacy: The Atherosclerosis Risk in Communities (ARIC) Study." Am J Kidney Dis. 2017;69(2):228-236.
Rapsomaniki E, White IR, Wood AM, Thompson SG. "A framework for quantifying net benefits of alternative prognostic models." Stat Med. 2012;31(2):114-30.
Kalbaugh CA, Loehr LR, Wruck L, et al. "Frequency of Care and Mortality Following an Incident Diagnosis of Peripheral Artery Disease in the Inpatient or Outpatient Setting: The ARIC (Atherosclerosis Risk in Communities) Study." J Am Heart Assoc. 2018;7(8).
Rooney MR, Norby FL, Maheshwari A, et al. "Frequent Premature Atrial Contractions Are Associated With Poorer Cognitive Function in the Atherosclerosis Risk in Communities (ARIC) Study." Mayo Clin Proc. 2021;96(5):1147-1156.
Banack HR. "From bad to worse: collider stratification amplifies confounding bias in the "obesity paradox"." Eur J Epidemiol. 2015;30(10):1111-4.
Savoca MR, Steffen LM, Bertoni AG. "From Neighborhood to Genome: Three Decades of Nutrition-Related Research from the Atherosclerosis Risk in Communities Study." J Acad Nutr Diet. 2017;117(12):1881-1886.e10.
Selvin E, Rawlings AM, Lutsey PL, Maruthur N, Pankow JS, Steffes M. "Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death." Circulation. 2015;132(4):269-77.
Selvin E, Rawlings AM, Grams M, Klein R, Sharrett ARichey, Steffes M. "Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study." Lancet Diabetes Endocrinol. 2014;2(4):279-288.
Qi Q, Kilpeläinen TO, Downer MK, et al. "FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals." Hum Mol Genet. 2014;23(25):6961-72.
Yang J, Loos RJF, Powell JE, et al. "FTO genotype is associated with phenotypic variability of body mass index." Nature. 2012;490(7419):267-72.
Petrick JL, Reeve BB, Kucharska-Newton AMaria, et al. "Functional status declines among cancer survivors: trajectory and contributing factors." J Geriatr Oncol. 2014;5(4):359-67.
Petty LE, Highland HM, Gamazon ER, et al. "Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample." Hum Mol Genet. 2019;28(7):1212-1224.
Bien SA, Wojcik GL, Hodonsky CJ, et al. "The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE." Annu Rev Genomics Hum Genet. 2019;20:181-200.
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Richardson K, Nettleton JA, Rotllan N, et al. "Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site." Am J Hum Genet. 2013;92(1):5-14.
Fashanu OE, Norby FL, Aguilar D, et al. "Galectin-3 and incidence of atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study." Am Heart J. 2017;192:19-25.
McEvoy JW, Chen Y, Halushka MK, et al. "Galectin-3 and Risk of Heart Failure and Death in Blacks and Whites." J Am Heart Assoc. 2016;5(5).
Fashanu OE, Folsom AR, Oyenuga A, Ballantyne CM, Lutsey PL. "Galectin-3 and the incidence of abdominal aortic aneurysm: the atherosclerosis risk in communities (ARIC) study." Am J Cardiovasc Dis. 2017;7(6):114-121.
Fashanu OE, Heckbert SR, Aguilar D, et al. "Galectin-3 and Venous Thromboembolism Incidence: the Atherosclerosis Risk in Communities (ARIC) Study." Res Pract Thromb Haemost. 2017;1(2):223-230.
Schreiner PJ, Appiah D. "Gamma prime (γ') fibrinogen and carotid intima-media thickness: the Atherosclerosis Risk in Communities study." Blood Coagul Fibrinolysis. 2017;28(8):665-669.
Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen RC, Young JH. "GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study." Diabet Med. 2016;33(7):968-75.
Weitzman S, Cooper L, Chambless L, et al. "Gender, racial, and geographic differences in the performance of cardiac diagnostic and therapeutic procedures for hospitalized acute myocardial infarction in four states." Am J Cardiol. 1997;79(6):722-6.
Nettleton JA, Follis JL, Ngwa JS, et al. "Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry." Hum Mol Genet. 2015;24(16):4728-38.
Simino J, Shi G, Bis JC, et al. "Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia." Am J Hum Genet. 2014;95(1):24-38.
Huang H, Chanda P, Alonso A, Bader JS, Arking DE. "Gene-based tests of association." PLoS Genet. 2011;7(7):e1002177.
Smith JA, Zhao W, Yasutake K, et al. "Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies." Int J Environ Res Public Health. 2017;14(12).

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