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ARIC Publications

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Yoneyama S, Guo Y, Lanktree MB, et al. "Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations." Hum Mol Genet. 2014;23(9):2498-510.
Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ. "Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals." Hum Mol Genet. 2013;22(1):184-201.
Tragante V, Barnes MR, Ganesh SK, et al. "Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci." Am J Hum Genet. 2014;94(3):349-60.
Fuentes Lde Las, Sung YJu, Noordam R, et al. "Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci." Mol Psychiatry. 2020.
Grove ML, Morrison A, Folsom AR, Boerwinkle E, Hoelscher DM, Bray MS. "Gene-environment interaction and the GNB3 gene in the Atherosclerosis Risk in Communities study." Int J Obes (Lond). 2007;31(6):919-26.
Lin H, Mueller-Nurasyid M, Smith AV, et al. "Gene-gene Interaction Analyses for Atrial Fibrillation." Sci Rep. 2016;6:35371.
Mishra A, Duplaà C, Vojinovic D, et al. "Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate." Brain. 2022;145(6):1992-2007.
Lin D-Y, Zeng D, Couper D. "A general framework for integrative analysis of incomplete multiomics data." Genet Epidemiol. 2020;44(7):646-664.
Gianattasio KZ, Bennett EE, Wei J, et al. "Generalizability of findings from a clinical sample to a community-based sample: A comparison of ADNI and ARIC." Alzheimers Dement. 2021.
Carlson CS, Matise TC, North KE, et al. "Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study." PLoS Biol. 2013;11(9):e1001661.
Yoneyama S, Yao J, Guo X, et al. "Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations." Int J Obes (Lond). 2017;41(2):324-331.
Hodonsky CJo, Schurmann C, Schick UM, et al. "Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study." Am J Hematol. 2018.
Sitlani CM, Rice KM, Lumley T, et al. "Generalized estimating equations for genome-wide association studies using longitudinal phenotype data." Stat Med. 2015;34(1):118-30.
Yazdani A, Yazdani A, Samiei A. "Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data." J Biomed Inform. 2016;60:114-9.
Karaca E, Harel T, Pehlivan D, et al. "Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease." Neuron. 2015;88(3):499-513.
Wojcik GL, Graff M, Nishimura KK, et al. "Genetic analyses of diverse populations improves discovery for complex traits." Nature. 2019;570(7762):514-518.
Hamidovic A, Goodloe RJ, Young TR, et al. "Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites." J Clin Psychopharmacol. 2013;33(2):206-10.
Evangelou E, Warren HR, Mosen-Ansorena D, et al. "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits." Nat Genet. 2018;50(10):1412-1425.
Chauhan G, Adams HHH, Satizabal CL, et al. "Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting." Neurology. 2019.
Satizabal CL, Adams HHH, Hibar DP, et al. "Genetic architecture of subcortical brain structures in 38,851 individuals." Nat Genet. 2019;51(11):1624-1636.
Grasby KL, Jahanshad N, Painter JN, et al. "The genetic architecture of the human cerebral cortex." Science. 2020;367(6484).
Weng L-C, Cushman M, Pankow JS, Basu S, Boerwinkle E, Folsom AR. "A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study." Hum Mol Genet. 2015;24(8):2401-8.
Weng L-C, Tang W, Rich SS, et al. "A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups." Thromb Res. 2014;134(2):462-7.
Arking DE, Pulit SL, Crotti L, et al. "Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization." Nat Genet. 2014;46(8):826-36.
Pattaro C, Teumer A, Gorski M, et al. "Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function." Nat Commun. 2016;7:10023.
Tang W, Schwienbacher C, Lopez LM, et al. "Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease." Am J Hum Genet. 2012;91(1):152-62.
Klimentidis YC, Arora A, Zhou J, Kittles R. "The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies." Front Genet. 2016;7:89.
Davies G, Armstrong N, Bis JC, et al. "Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949)." Mol Psychiatry. 2015;20(2):183-92.
Hofer E, Roshchupkin GV, Adams HHH, et al. "Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults." Nat Commun. 2020;11(1):4796.
Yu B, Zheng Y, Alexander D, Morrison AC, Coresh JJ. "Genetic determinants influencing human serum metabolome among African Americans." PLoS Genet. 2014;10(3):e1004212.
Weng L-C, Hall AWeber, Choi SHoan, et al. "Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation." Circ Genom Precis Med. 2020;13(5):387-395.
Campos M, Sun W, Yu F, et al. "Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort." Blood. 2011;117(19):5224-30.
Taub MA, Conomos MP, Keener R, et al. "Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed." Cell Genom. 2022;2(1).
Wassel CL, Lamina C, Nambi V, et al. "Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium." Atherosclerosis. 2012;222(1):138-47.
Bihlmeyer NA, Brody JA, Smith A V, et al. "Genetic diversity is a predictor of mortality in humans." BMC Genet. 2014;15:159.
Yaghootkar H, Scott RA, White CC, et al. "Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes." Diabetes. 2014;63(12):4369-77.
Gaulton KJ, Ferreira T, Lee Y, et al. "Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci." Nat Genet. 2015;47(12):1415-25.
Ruth KS, Day FR, Hussain J, et al. "Genetic insights into biological mechanisms governing human ovarian ageing." Nature. 2021;596(7872):393-397.
Gregson JM, Freitag DF, Surendran P, et al. "Genetic invalidation of Lp-PLA as a therapeutic target: Large-scale study of five functional Lp-PLA-lowering alleles." Eur J Prev Cardiol. 2017;24(5):492-504.
Roberts JD, Hu D, Heckbert SR, et al. "Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals." JAMA Cardiol. 2016;1(4):442-50.
Sakornsakolpat P, Prokopenko D, Lamontagne M, et al. "Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations." Nat Genet. 2019;51(3):494-505.
Gorski M, Rasheed H, Teumer A, et al. "Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies." Kidney Int. 2022;102(3):624-639.
Hobbs BD, de Jong K, Lamontagne M, et al. "Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis." Nat Genet. 2017;49(3):426-432.
Allen NB, Lloyd-Jones D, Hwang S-J, et al. "Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies." Am Heart J. 2016;175:112-20.
Lemaitre RN, Tanaka T, Tang W, et al. "Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium." PLoS Genet. 2011;7(7):e1002193.
Hahn J, Fu Y-P, Brown MR, et al. "Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium." PLoS One. 2020;15(11):e0230035.
Sim X, Jensen RA, M Ikram K, et al. "Genetic loci for retinal arteriolar microcirculation." PLoS One. 2013;8(6):e65804.
Tin A, Köttgen A, Folsom AR, et al. "Genetic loci for serum magnesium among African-Americans and gene-environment interaction at MUC1 and TRPM6 in European-Americans: the Atherosclerosis Risk in Communities (ARIC) study." BMC Genet. 2015;16:56.
M Munir S, Weng L-C, Tang W, et al. "Genetic markers associated with plasma protein C level in African Americans: the atherosclerosis risk in communities (ARIC) study." Genet Epidemiol. 2014;38(8):709-13.
Kunkle BW, Grenier-Boley B, Sims R, et al. "Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing." Nat Genet. 2019;51(3):414-430.
Chatterjee NA, Giulianini F, Geelhoed B, et al. "Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization." Circulation. 2017;135(8):741-754.
Holliday EG, Traylor M, Malik R, et al. "Genetic overlap between diagnostic subtypes of ischemic stroke." Stroke. 2015;46(3):615-9.
Lieb W, Jansen H, Loley C, et al. "Genetic predisposition to higher blood pressure increases coronary artery disease risk." Hypertension. 2013;61(5):995-1001.
Khera AV, Emdin CA, Drake I, et al. "Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease." N Engl J Med. 2016;375(24):2349-2358.
Fesinmeyer MD, North KE, Ritchie MD, et al. "Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study." Obesity (Silver Spring). 2013;21(4):835-46.
Traylor M, Farrall M, Holliday EG, et al. "Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies." Lancet Neurol. 2012;11(11):951-62.