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ARIC Publications

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Vojinovic D, Adams HH, Jian X, et al. "Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume." Nat Commun. 2018;9(1):3945.
Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA. "Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study." Genet Epidemiol. 2013;37(8):840-5.
Demerath EW, Liu C-T, Franceschini N, et al. "Genome-wide association study of age at menarche in African-American women." Hum Mol Genet. 2013;22(16):3329-46.
Walter S, Atzmon G, Demerath EW, et al. "A genome-wide association study of aging." Neurobiol Aging. 2011;32(11):2109.e15-28.
Irvin MR, Sitlani CM, Floyd JS, et al. "Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group." Am J Hypertens. 2019;32(12):1146-1153.
Offenbacher S, Divaris K, Barros SP, et al. "Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease." Hum Mol Genet. 2016;25(10):2113-2129.
Levy D, Ehret GB, Rice K, et al. "Genome-wide association study of blood pressure and hypertension." Nat Genet. 2009;41(6):677-87.
Ahluwalia TS, Prins BP, Abdollahi M, et al. "Genome-wide association study of circulating interleukin 6 levels identifies novel loci." Hum Mol Genet. 2021;30(5):393-409.
Jian X, Sofer T, Tarraf W, et al. "Genome-wide association study of cognitive function in diverse Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos." Transl Psychiatry. 2020;10(1):245.
Hek K, Demirkan A, Lahti J, et al. "A genome-wide association study of depressive symptoms." Biol Psychiatry. 2013;73(7):667-78.
Klimentidis YC, Raichlen DA, Bea J, et al. "Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE." Int J Obes (Lond). 2018;42(6):1161-1176.
Foroud T, Lai D, Koller D, et al. "Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7." Stroke. 2014;45(11):3194-9.
Imboden M, Bouzigon E, Curjuric I, et al. "Genome-wide association study of lung function decline in adults with and without asthma." J Allergy Clin Immunol. 2012;129(5):1218-28.
Divaris K, Monda KL, North KE, et al. "Genome-wide association study of periodontal pathogen colonization." J Dent Res. 2012;91(7 Suppl):21S-28S.
Guan W, Steffen BT, Lemaitre RN, et al. "Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2014;7(3):321-331.
Pfeufer A, van Noord C, Marciante KD, et al. "Genome-wide association study of PR interval." Nat Genet. 2010;42(2):153-9.
Mick E, McGough J, Deutsch CK, Frazier JA, Kennedy D. "Genome-wide association study of proneness to anger." PLoS One. 2014;9(1):e87257.
Jensen RA, Sim X, Li X, et al. "Genome-wide association study of retinopathy in individuals without diabetes." PLoS One. 2013;8(2):e54232.
Loomis SJ, Li M, Maruthur NM, et al. "Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study." Diabetes. 2018;67(8):1684-1696.
Luo S, Feofanova EV, Tin A, et al. "Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension." Kidney Int. 2021;100(2):430-439.
Gondalia R, Avery CL, Napier MD, et al. "Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation." Environ Health Perspect. 2017;125(6):067002.
Reiner AP, Lettre G, Nalls MA, et al. "Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)." PLoS Genet. 2011;7(6):e1002108.
Sennblad B, Basu S, Mazur J, et al. "Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels." Hum Mol Genet. 2017;26(3):637-649.
Wu B. "Genome-wide association test of multiple continuous traits using imputed SNPs." Stat Interface. 2017;10(3):379-386.
Sabater-Lleal M, Huffman JE, de Vries PS, et al. "Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels." Circulation. 2019;139(5):620-635.
Tereshchenko LG, Sotoodehnia N, Sitlani CM, et al. "Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study)." J Am Heart Assoc. 2018;7(8).
Huan T, Joehanes R, Song C, et al. "Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease." Nat Commun. 2019;10(1):4267.
Keaton JM, Hellwege JN, C Y Ng M, et al. "Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans." PLoS One. 2016;11(7):e0159977.
Keaton JM, Gao C, Guan M, et al. "Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
Smith CE, Follis JL, Dashti HS, et al. "Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent." Mol Nutr Food Res. 2018;62(3).
David SP, Hamidovic A, Chen GK, et al. "Genome-wide meta-analyses of smoking behaviors in African Americans." Transl Psychiatry. 2012;2:e119.
Joshi PK, Pirastu N, Kentistou KA, et al. "Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity." Nat Commun. 2017;8(1):910.
Berndt SI, Gustafsson S, Mägi R, et al. "Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture." Nat Genet. 2013;45(5):501-12.
Cornelis MC, Monda KL, Yu K, et al. "Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption." PLoS Genet. 2011;7(4):e1002033.
Justice AE, Winkler TW, Feitosa MF, et al. "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Nat Commun. 2017;8:14977.
Boraska V, Jerončić A, Colonna V, et al. "Genome-wide meta-analysis of common variant differences between men and women." Hum Mol Genet. 2012;21(21):4805-15.
Merino J, Dashti HS, Li SX, et al. "Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium." Mol Psychiatry. 2019;24(12):1920-1932.
Jones G, Trajanoska K, Santanasto AJ, et al. "Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women." Nat Commun. 2021;12(1):654.
Irvin MR, Sitlani CM, Noordam R, et al. "Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry." Pharmacogenomics J. 2019;19(1):97-108.
Dong J, Yang J, Tranah G, et al. "Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults." Medicine (Baltimore). 2015;94(47):e1892.
Graff M, Scott RA, Justice AE, et al. "Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults." PLoS Genet. 2017;13(4):e1006528.
Tin A, Astor BC, Boerwinkle E, Hoogeveen RC, Coresh J, Kao LWH. "Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans." Nephrol Dial Transplant. 2013;28(6):1497-504.
Debette S, Verbaas CAIbrahim, Bressler J, et al. "Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium." Biol Psychiatry. 2015;77(8):749-63.
Mahajan A, Go MJin, Zhang W, et al. "Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility." Nat Genet. 2014;46(3):234-44.
van Rooij FJA, Qayyum R, Smith AV, et al. "Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis." Am J Hum Genet. 2017;100(1):51-63.
Day FR, Thompson DJ, Helgason H, et al. "Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk." Nat Genet. 2017;49(6):834-841.
Lindström S, Wang L, Smith EN, et al. "Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism." Blood. 2019;134(19):1645-1657.
Scott RA, Freitag DF, Li L, et al. "A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease." Sci Transl Med. 2016;8(341):341ra76.
Morrison AC, Felix JF, L Cupples A, et al. "Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2010;3(3):248-55.
Li H, Sisoudiya SD, Martin-Giacalone BA, et al. "Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group." J Natl Cancer Inst. 2021;113(7):875-883.
Zhong Y, Slade GD, Beck JD, Offenbacher S. "Gingival crevicular fluid interleukin-1beta, prostaglandin E2 and periodontal status in a community population." J Clin Periodontol. 2007;34(4):285-93.
Shin J, Ma S, Hofer E, et al. "Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes." Cereb Cortex. 2020;30(7):4121-4139.
Biering-Sørensen T, Kabir M, Waks JW, et al. "Global ECG Measures and Cardiac Structure and Function: The ARIC Study (Atherosclerosis Risk in Communities)." Circ Arrhythm Electrophysiol. 2018;11(3):e005961.
Waks JW, Sitlani CM, Soliman EZ, et al. "Global Electric Heterogeneity Risk Score for Prediction of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies." Circulation. 2016;133(23):2222-34.
W Y Yau J, Rogers SL, Kawasaki R, et al. "Global prevalence and major risk factors of diabetic retinopathy." Diabetes Care. 2012;35(3):556-64.
"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017." Lancet. 2018;392(10159):1789-1858.
Golden S H, Ding J, Szklo M, Schmidt M I, Duncan BB, Dobs A. "Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study." Am J Epidemiol. 2004;160(6):540-8.
Selvin E, Wang D, Tang O, Minotti M, Echouffo-Tcheugui JB, Coresh J. "Glucose Patterns in Very Old Adults: A Pilot Study in a Community-Based Population." Diabetes Technol Ther. 2021.
Rawlings AM, Sharrett ARichey, Mosley TH, Ballew SH, Deal JA. "Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline." Diabetes Care. 2017;40(7):879-886.
Vigo A, Duncan BB, Schmidt MI, et al. "Glutamic acid decarboxylase antibodies are indicators of the course, but not of the onset, of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities Study." Braz J Med Biol Res. 2007;40(7):933-41.
Li R, Boerwinkle E, Olshan AF, et al. "Glutathione S-transferase genotype as a susceptibility factor in smoking-related coronary heart disease." Atherosclerosis. 2000;149(2):451-62.
Miller EA, Pankow JS, Millikan RC, et al. "Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) study." Atherosclerosis. 2003;171(2):265-72.
Selvin E, Coresh J, Shahar E, Zhang L, Steffes M, A Sharrett R. "Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study." Lancet Neurol. 2005;4(12):821-6.
Rooney MR, Tang O, Pankow JS. "Glycaemic markers and all-cause mortality in older adults with and without diabetes: the Atherosclerosis Risk in Communities (ARIC) study." Diabetologia. 2020.
Christman AL, Matsushita K, Gottesman RF, et al. "Glycated haemoglobin and cognitive decline: the Atherosclerosis Risk in Communities (ARIC) study." Diabetologia. 2011;54(7):1645-52.
Joshu CE, Prizment AE, Dluzniewski PJ, et al. "Glycated hemoglobin and cancer incidence and mortality in the Atherosclerosis in Communities (ARIC) Study, 1990-2006." Int J Cancer. 2012;131(7):1667-77.
Bower JK, Appel LJ, Matsushita K, et al. "Glycated hemoglobin and risk of hypertension in the atherosclerosis risk in communities study." Diabetes Care. 2012;35(5):1031-7.
Selvin E, Ning Y, Steffes MW, et al. "Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes." Diabetes. 2011;60(1):298-305.
Selvin E, Steffes MW, Zhu H, et al. "Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults." N Engl J Med. 2010;362(9):800-11.
Di Angelantonio E, Gao P, Khan H, et al. "Glycated hemoglobin measurement and prediction of cardiovascular disease." JAMA. 2014;311(12):1225-33.
Bell EJ, Selvin E, Lutsey PL, Nambi V, Cushman M. "Glycemia (hemoglobin A1c) and incident venous thromboembolism in the Atherosclerosis Risk in Communities cohort study." Vasc Med. 2013;18(5):245-50.
Selvin E, Coresh J, Golden SH, Brancati FL, Folsom AR, Steffes MW. "Glycemic control and coronary heart disease risk in persons with and without diabetes: the atherosclerosis risk in communities study." Arch Intern Med. 2005;165(16):1910-6.
Selvin E, Coresh J, Golden SH, Boland LL, Brancati FL, Steffes MW. "Glycemic control, atherosclerosis, and risk factors for cardiovascular disease in individuals with diabetes: the atherosclerosis risk in communities study." Diabetes Care. 2005;28(8):1965-73.
Vitelli LL, Shahar E, Heiss G, et al. "Glycosylated hemoglobin level and carotid intimal-medial thickening in nondiabetic individuals. The Atherosclerosis Risk in Communities Study." Diabetes Care. 1997;20(9):1454-8.
Meyer TE, Shiffman D, Morrison AC, et al. "GOSR2 Lys67Arg is associated with hypertension in whites." Am J Hypertens. 2009;22(2):163-8.
Burke BTeevan, Köttgen A, Law A, Grams M, Baer AN, Coresh JJ. "Gout in Older Adults: The Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2016;71(4):536-42.
Morrison AC, Doris PA, Folsom AR, Nieto FJ, Boerwinkle E. "G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical stroke." Stroke. 2001;32(4):822-9.
Oyenuga AO, Folsom AR, Cheng S, Tanaka H. "Greater Adherence to Life's Simple 7 Is Associated With Less Arterial Stiffness: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Hypertens. 2019;32(8):769-776.
Steffen LM, Folsom AR, Cushman M, Jacobs DR, Rosamond WD. "Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology." Circulation. 2007;115(2):188-95.