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ARIC Publications

Poon AK, Juraschek SP, Ballantyne CM, Steffes MW. "Comparative associations of diabetes risk factors with five measures of hyperglycemia." BMJ Open Diabetes Res Care. 2014;2(1):e000002.
Scharpf RB, Mireles L, Yang Q, et al. "Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations." BMC Genet. 2014;15:81.
Coresh JJ, Turin TChowdhury, Matsushita K, et al. "Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality." JAMA. 2014;311(24):2518-2531.
Wood AR, Esko T, Yang J, et al. "Defining the role of common variation in the genomic and biological architecture of adult human height." Nat Genet. 2014;46(11):1173-86.
Fowkes FGR, Murray GD, Butcher I, et al. "Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events." Eur J Prev Cardiol. 2014;21(3):310-20.
Rawlings AM, Sharrett ARichey, Schneider ALC, et al. "Diabetes in midlife and cognitive change over 20 years: a cohort study." Ann Intern Med. 2014;161(11):785-93.
Selvin E, Lazo M, Chen Y, et al. "Diabetes mellitus, prediabetes, and incidence of subclinical myocardial damage." Circulation. 2014;130(16):1374-82.
Haring B, Gronroos N, Nettleton JA, von Ballmoos MCWyler, Selvin E. "Dietary protein intake and coronary heart disease in a large community based cohort: results from the Atherosclerosis Risk in Communities (ARIC) study [corrected]." PLoS One. 2014;9(10):e109552.
Avery CL, Sitlani CM, Arking DE, et al. "Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval." Pharmacogenomics J. 2014;14(1):6-13.
Bekwelem W, Misialek JR, Konety S, et al. "Echocardiographic measures of cardiac structure and function are associated with risk of atrial fibrillation in blacks: the Atherosclerosis Risk in Communities (ARIC) study." PLoS One. 2014;9(10):e110111.
Cotlarciuc I, Malik R, Holliday EG, et al. "Effect of genetic variants associated with plasma homocysteine levels on stroke risk." Stroke. 2014;45(7):1920-4.
Ganesh SK, Chasman DI, Larson MG, et al. "Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations." Am J Hum Genet. 2014;95(1):49-65.
Tereshchenko LG, Henrikson CA, Sotoodehnia N, et al. "Electrocardiographic deep terminal negativity of the P wave in V(1) and risk of sudden cardiac death: the Atherosclerosis Risk in Communities (ARIC) study." J Am Heart Assoc. 2014;3(6):e001387.
Folsom AR, Lutsey PL, Roetker NS, et al. "Elevated hepatic enzymes and incidence of venous thromboembolism: a prospective study." Ann Epidemiol. 2014;24(11):817-821.e2.
Sung YJu, Schwander K, Arnett DK, et al. "An empirical comparison of meta-analysis and mega-analysis of individual participant data for identifying gene-environment interactions." Genet Epidemiol. 2014;38(4):369-78.
Kapoor A, Sekar RB, Hansen NF, et al. "An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval." Am J Hum Genet. 2014;94(6):854-69.
Bose M, Wu C, Pankow JS, et al. "Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study." BMC Bioinformatics. 2014;15:312.
Lutsey PL, Alonso A, Selvin E, et al. "Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the Atherosclerosis Risk in Communities study." J Am Heart Assoc. 2014;3(3):e000936.
Boerwinkle E. "Following-up genome-wide association study signals: lessons learned from Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):332-4.
Selvin E, Rawlings AM, Grams M, Klein R, Sharrett ARichey, Steffes M. "Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study." Lancet Diabetes Endocrinol. 2014;2(4):279-288.
Qi Q, Kilpeläinen TO, Downer MK, et al. "FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals." Hum Mol Genet. 2014;23(25):6961-72.
Petrick JL, Reeve BB, Kucharska-Newton AMaria, et al. "Functional status declines among cancer survivors: trajectory and contributing factors." J Geriatr Oncol. 2014;5(4):359-67.
Simino J, Shi G, Bis JC, et al. "Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia." Am J Hum Genet. 2014;95(1):24-38.
Yoneyama S, Guo Y, Lanktree MB, et al. "Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations." Hum Mol Genet. 2014;23(9):2498-510.
Tragante V, Barnes MR, Ganesh SK, et al. "Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci." Am J Hum Genet. 2014;94(3):349-60.
Weng L-C, Tang W, Rich SS, et al. "A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups." Thromb Res. 2014;134(2):462-7.
Arking DE, Pulit SL, Crotti L, et al. "Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization." Nat Genet. 2014;46(8):826-36.
Yu B, Zheng Y, Alexander D, Morrison AC, Coresh JJ. "Genetic determinants influencing human serum metabolome among African Americans." PLoS Genet. 2014;10(3):e1004212.
Bihlmeyer NA, Brody JA, Smith A V, et al. "Genetic diversity is a predictor of mortality in humans." BMC Genet. 2014;15:159.
Yaghootkar H, Scott RA, White CC, et al. "Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes." Diabetes. 2014;63(12):4369-77.
M Munir S, Weng L-C, Tang W, et al. "Genetic markers associated with plasma protein C level in African Americans: the atherosclerosis risk in communities (ARIC) study." Genet Epidemiol. 2014;38(8):709-13.
Escott-Price V, Bellenguez C, San Wang L-, et al. "Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease." PLoS One. 2014;9(6):e94661.
Loth DW, Artigas MSoler, Gharib SA, et al. "Genome-wide association analysis identifies six new loci associated with forced vital capacity." Nat Genet. 2014;46(7):669-77.
Huang J, Huffman JE, Yamakuchi M, et al. "Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2." Arterioscler Thromb Vasc Biol. 2014;34(5):1093-101.
An P, Miljkovic I, Thyagarajan B, et al. "Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS)." Metabolism. 2014;63(4):461-8.
Hara K, Fujita H, Johnson TA, et al. "Genome-wide association study identifies three novel loci for type 2 diabetes." Hum Mol Genet. 2014;23(1):239-46.
Foroud T, Lai D, Koller D, et al. "Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7." Stroke. 2014;45(11):3194-9.
Guan W, Steffen BT, Lemaitre RN, et al. "Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2014;7(3):321-331.
Mick E, McGough J, Deutsch CK, Frazier JA, Kennedy D. "Genome-wide association study of proneness to anger." PLoS One. 2014;9(1):e87257.
Mahajan A, Go MJin, Zhang W, et al. "Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility." Nat Genet. 2014;46(3):234-44.
Di Angelantonio E, Gao P, Khan H, et al. "Glycated hemoglobin measurement and prediction of cardiovascular disease." JAMA. 2014;311(12):1225-33.
Gupta DK, Skali H, Claggett B, et al. "Heart failure risk across the spectrum of ankle-brachial index: the ARIC study (Atherosclerosis Risk In Communities)." JACC Heart Fail. 2014;2(5):447-54.
Schneider ALC, Rawlings AM, Sharrett ARichey, et al. "High-sensitivity cardiac troponin T and cognitive function and dementia risk: the atherosclerosis risk in communities study." Eur Heart J. 2014;35(27):1817-24.
Foraker RE, Rose KM, Chang PP, Suchindran CM, McNeill AM, Rosamond WD. "Hospital length of stay for incident heart failure: Atherosclerosis Risk in Communities (ARIC) cohort: 1987-2005." J Healthc Qual. 2014;36(1):45-51.
Zheng Y, Yu B, Alexander D, Steffen LM. "Human metabolome associates with dietary intake habits among African Americans in the atherosclerosis risk in communities study." Am J Epidemiol. 2014;179(12):1424-33.
Grams ME, Rebholz CM, McMahon B, et al. "Identification of incident CKD stage 3 in research studies." Am J Kidney Dis. 2014;64(2):214-21.
Gottesman RF, Rawlings AM, Sharrett ARichey, et al. "Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC neurocognitive study." Am J Epidemiol. 2014;179(8):956-66.
Chang PP, Chambless LE, Shahar E, et al. "Incidence and survival of hospitalized acute decompensated heart failure in four US communities (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2014;113(3):504-10.
Jensen PN, Gronroos NN, Chen LYee, Folsom AR, deFilippi C, Heckbert SR. "Incidence of and risk factors for sick sinus syndrome in the general population." J Am Coll Cardiol. 2014;64(6):531-8.
Ellis J, Lange EM, Li J, et al. "Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans." Hum Genet. 2014;133(8):985-95.
Tang W, Kowgier M, Loth DW, et al. "Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function." PLoS One. 2014;9(7):e100776.
Claussnitzer M, Dankel SN, Klocke B, et al. "Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms." Cell. 2014;156(1-2):343-58.
Simino J, Kume R, Kraja AT, et al. "Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program." Atherosclerosis. 2014;235(1):84-93.
Ma Y, Tucker KL, Smith CE, et al. "Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: replication in two populations." Nutr Metab Cardiovasc Dis. 2014;24(12):1323-9.
Crosby J, Peloso GM, Auer PL, et al. "Loss-of-function mutations in APOC3, triglycerides, and coronary disease." N Engl J Med. 2014;371(1):22-31.
Hardy DS, Racette SB. "Macronutrient intake as a mediator with FTO to increase body mass index." J Am Coll Nutr. 2014;33(4):256-66.
Zheng Y, Yu B, Alexander D, Couper DJ. "Medium-term variability of the human serum metabolome in the Atherosclerosis Risk in Communities (ARIC) study." OMICS. 2014;18(6):364-73.
Kilarski LL, Achterberg S, Devan WJ, et al. "Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12." Neurology. 2014;83(8):678-85.
C Y Ng M, Shriner D, Chen BH, et al. "Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes." PLoS Genet. 2014;10(8):e1004517.
Chen CTL, Liu C-T, Chen GK, et al. "Meta-analysis of loci associated with age at natural menopause in African-American women." Hum Mol Genet. 2014;23(12):3327-42.
Dearborn JL, Knopman D, Sharrett ARichey, et al. "The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities study (ARIC)." Dement Geriatr Cogn Disord. 2014;38(5-6):337-46.
Zheng Y, Yu B, Alexander D, Steffen LM, Nettleton JA. "Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study." Am J Clin Nutr. 2014;99(6):1470-8.
Gottesman RF, Schneider ALC, Albert M, et al. "Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study." JAMA Neurol. 2014;71(10):1218-27.
Kocarnik JM, Pendergrass SA, Carty CL, et al. "Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study." Circ Cardiovasc Genet. 2014;7(2):178-88.
Liu C-T, Buchkovich ML, Winkler TW, et al. "Multi-ethnic fine-mapping of 14 central adiposity loci." Hum Mol Genet. 2014;23(17):4738-44.
Chatterjee R, Brancati FL, Shafi T, et al. "Non-traditional risk factors are important contributors to the racial disparity in diabetes risk: the atherosclerosis risk in communities study." J Gen Intern Med. 2014;29(2):290-7.
Hoggart CJ, Venturini G, Mangino M, et al. "Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index." PLoS Genet. 2014;10(7):e1004508.
Holmes MV, Exeter HJ, Folkersen L, et al. "Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels." Circ Cardiovasc Genet. 2014;7(2):144-50.
Lubitz SA, Lunetta KL, Lin H, et al. "Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese." J Am Coll Cardiol. 2014;63(12):1200-1210.
Ndumele CE, Coresh JJ, Lazo M, et al. "Obesity, subclinical myocardial injury, and incident heart failure." JACC Heart Fail. 2014;2(6):600-7.
Caughey MC, Avery CL, Ni H, et al. "Outcomes of patients with anemia and acute decompensated heart failure with preserved versus reduced ejection fraction (from the ARIC study community surveillance)." Am J Cardiol. 2014;114(12):1850-4.
Folsom AR, Alonso A, Misialek JR, et al. "Parathyroid hormone concentration and risk of cardiovascular diseases: the Atherosclerosis Risk in Communities (ARIC) study." Am Heart J. 2014;168(3):296-302.
Perry JRb, Day F, Elks CE, et al. "Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche." Nature. 2014;514(7520):92-97.
Tabor HK, Auer PL, Jamal SM, et al. "Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results." Am J Hum Genet. 2014;95(2):183-93.
Grams ME, Waikar SS, MacMahon B, Whelton S, Ballew SH. "Performance and limitations of administrative data in the identification of AKI." Clin J Am Soc Nephrol. 2014;9(4):682-9.
Xing C, Dupuis J. "Performance of statistical methods on CHARGE targeted sequencing data." BMC Genet. 2014;15:104.
Postmus I, Trompet S, Deshmukh HA, et al. "Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins." Nat Commun. 2014;5:5068.
Huxley RR, Misialek JR, Agarwal SK, Loehr LR, Soliman EZ, Chen LYee. "Physical activity, obesity, weight change, and risk of atrial fibrillation: the Atherosclerosis Risk in Communities study." Circ Arrhythm Electrophysiol. 2014;7(4):620-5.
S Park L, Fesinmeyer MD, Timofeeva M, et al. "Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia." J Natl Cancer Inst. 2014;106(4):dju061.
Cheng I, Kocarnik JM, Dumitrescu L, et al. "Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia." Gut. 2014;63(5):800-7.