ARIC Publications
"Comparative associations of diabetes risk factors with five measures of hyperglycemia." BMJ Open Diabetes Res Care. 2014;2(1):e000002.
"Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations." BMC Genet. 2014;15:81.
"Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality." JAMA. 2014;311(24):2518-2531.
"Defining the role of common variation in the genomic and biological architecture of adult human height." Nat Genet. 2014;46(11):1173-86.
"Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events." Eur J Prev Cardiol. 2014;21(3):310-20.
"Diabetes in midlife and cognitive change over 20 years: a cohort study." Ann Intern Med. 2014;161(11):785-93.
"Diabetes mellitus, prediabetes, and incidence of subclinical myocardial damage." Circulation. 2014;130(16):1374-82.
"Dietary protein intake and coronary heart disease in a large community based cohort: results from the Atherosclerosis Risk in Communities (ARIC) study [corrected]." PLoS One. 2014;9(10):e109552.
"Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval." Pharmacogenomics J. 2014;14(1):6-13.
"Echocardiographic measures of cardiac structure and function are associated with risk of atrial fibrillation in blacks: the Atherosclerosis Risk in Communities (ARIC) study." PLoS One. 2014;9(10):e110111.
"Effect of genetic variants associated with plasma homocysteine levels on stroke risk." Stroke. 2014;45(7):1920-4.
"Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations." Am J Hum Genet. 2014;95(1):49-65.
"Electrocardiographic deep terminal negativity of the P wave in V(1) and risk of sudden cardiac death: the Atherosclerosis Risk in Communities (ARIC) study." J Am Heart Assoc. 2014;3(6):e001387.
"Elevated hepatic enzymes and incidence of venous thromboembolism: a prospective study." Ann Epidemiol. 2014;24(11):817-821.e2.
"An empirical comparison of meta-analysis and mega-analysis of individual participant data for identifying gene-environment interactions." Genet Epidemiol. 2014;38(4):369-78.
"An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval." Am J Hum Genet. 2014;94(6):854-69.
"Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study." BMC Bioinformatics. 2014;15:312.
"Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the Atherosclerosis Risk in Communities study." J Am Heart Assoc. 2014;3(3):e000936.
"Following-up genome-wide association study signals: lessons learned from Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study." Circ Cardiovasc Genet. 2014;7(3):332-4.
"Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study." Lancet Diabetes Endocrinol. 2014;2(4):279-288.
"FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals." Hum Mol Genet. 2014;23(25):6961-72.
"Functional status declines among cancer survivors: trajectory and contributing factors." J Geriatr Oncol. 2014;5(4):359-67.
"Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia." Am J Hum Genet. 2014;95(1):24-38.
"Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations." Hum Mol Genet. 2014;23(9):2498-510.
"Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci." Am J Hum Genet. 2014;94(3):349-60.
"A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups." Thromb Res. 2014;134(2):462-7.
"Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization." Nat Genet. 2014;46(8):826-36.
"Genetic determinants influencing human serum metabolome among African Americans." PLoS Genet. 2014;10(3):e1004212.
"Genetic diversity is a predictor of mortality in humans." BMC Genet. 2014;15:159.
"Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes." Diabetes. 2014;63(12):4369-77.
"Genetic markers associated with plasma protein C level in African Americans: the atherosclerosis risk in communities (ARIC) study." Genet Epidemiol. 2014;38(8):709-13.
"Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease." PLoS One. 2014;9(6):e94661.
"Genome-wide association analysis identifies six new loci associated with forced vital capacity." Nat Genet. 2014;46(7):669-77.
"Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2." Arterioscler Thromb Vasc Biol. 2014;34(5):1093-101.
"Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS)." Metabolism. 2014;63(4):461-8.
"Genome-wide association study identifies three novel loci for type 2 diabetes." Hum Mol Genet. 2014;23(1):239-46.
"Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7." Stroke. 2014;45(11):3194-9.
"Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2014;7(3):321-331.
"Genome-wide association study of proneness to anger." PLoS One. 2014;9(1):e87257.
"Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility." Nat Genet. 2014;46(3):234-44.
"Glycated hemoglobin measurement and prediction of cardiovascular disease." JAMA. 2014;311(12):1225-33.
"Heart failure risk across the spectrum of ankle-brachial index: the ARIC study (Atherosclerosis Risk In Communities)." JACC Heart Fail. 2014;2(5):447-54.
"High-sensitivity cardiac troponin T and cognitive function and dementia risk: the atherosclerosis risk in communities study." Eur Heart J. 2014;35(27):1817-24.
"Hospital length of stay for incident heart failure: Atherosclerosis Risk in Communities (ARIC) cohort: 1987-2005." J Healthc Qual. 2014;36(1):45-51.
"Human metabolome associates with dietary intake habits among African Americans in the atherosclerosis risk in communities study." Am J Epidemiol. 2014;179(12):1424-33.
"Identification of incident CKD stage 3 in research studies." Am J Kidney Dis. 2014;64(2):214-21.
"Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC neurocognitive study." Am J Epidemiol. 2014;179(8):956-66.
"Incidence and survival of hospitalized acute decompensated heart failure in four US communities (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2014;113(3):504-10.
"Incidence of and risk factors for sick sinus syndrome in the general population." J Am Coll Cardiol. 2014;64(6):531-8.
"Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans." Hum Genet. 2014;133(8):985-95.
"Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function." PLoS One. 2014;9(7):e100776.
"Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms." Cell. 2014;156(1-2):343-58.
"Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program." Atherosclerosis. 2014;235(1):84-93.
"Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: replication in two populations." Nutr Metab Cardiovasc Dis. 2014;24(12):1323-9.
"Loss-of-function mutations in APOC3, triglycerides, and coronary disease." N Engl J Med. 2014;371(1):22-31.
"Macronutrient intake as a mediator with FTO to increase body mass index." J Am Coll Nutr. 2014;33(4):256-66.
"Medium-term variability of the human serum metabolome in the Atherosclerosis Risk in Communities (ARIC) study." OMICS. 2014;18(6):364-73.
"Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12." Neurology. 2014;83(8):678-85.
"Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes." PLoS Genet. 2014;10(8):e1004517.
"Meta-analysis of loci associated with age at natural menopause in African-American women." Hum Mol Genet. 2014;23(12):3327-42.
"The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities study (ARIC)." Dement Geriatr Cogn Disord. 2014;38(5-6):337-46.
"Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study." Am J Clin Nutr. 2014;99(6):1470-8.
"Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study." JAMA Neurol. 2014;71(10):1218-27.
"Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study." Circ Cardiovasc Genet. 2014;7(2):178-88.
"Multi-ethnic fine-mapping of 14 central adiposity loci." Hum Mol Genet. 2014;23(17):4738-44.
"Non-traditional risk factors are important contributors to the racial disparity in diabetes risk: the atherosclerosis risk in communities study." J Gen Intern Med. 2014;29(2):290-7.
"Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index." PLoS Genet. 2014;10(7):e1004508.
"Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels." Circ Cardiovasc Genet. 2014;7(2):144-50.
"Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese." J Am Coll Cardiol. 2014;63(12):1200-1210.
"Obesity, subclinical myocardial injury, and incident heart failure." JACC Heart Fail. 2014;2(6):600-7.
"Outcomes of patients with anemia and acute decompensated heart failure with preserved versus reduced ejection fraction (from the ARIC study community surveillance)." Am J Cardiol. 2014;114(12):1850-4.
"Parathyroid hormone concentration and risk of cardiovascular diseases: the Atherosclerosis Risk in Communities (ARIC) study." Am Heart J. 2014;168(3):296-302.
"Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche." Nature. 2014;514(7520):92-97.
"Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results." Am J Hum Genet. 2014;95(2):183-93.
"Performance and limitations of administrative data in the identification of AKI." Clin J Am Soc Nephrol. 2014;9(4):682-9.
"Performance of statistical methods on CHARGE targeted sequencing data." BMC Genet. 2014;15:104.
"Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins." Nat Commun. 2014;5:5068.
"Physical activity, obesity, weight change, and risk of atrial fibrillation: the Atherosclerosis Risk in Communities study." Circ Arrhythm Electrophysiol. 2014;7(4):620-5.
"Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia." J Natl Cancer Inst. 2014;106(4):dju061.