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ARIC Publications

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Journal Article
Fesinmeyer MD, Meigs JB, North KE, et al. "Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study." BMC Med Genet. 2013;14:98.
Li C, Grove ML, Yu B, Jones BC, Morrison A, Boerwinkle E. "Genetic variants in microRNA genes and targets associated with cardiovascular disease risk factors in the African-American population." Hum Genet. 2018;137(1):85-94.
Crosslin DR, McDavid A, Weston N, et al. "Genetic variation associated with circulating monocyte count in the eMERGE Network." Hum Mol Genet. 2013;22(10):2119-27.
Traylor M, Malik R, Nalls MA, et al. "Genetic variation at 16q24.2 is associated with small vessel stroke." Ann Neurol. 2017;81(3):383-394.
Ligthart S, Vaez A, Võsa U, et al. "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders." Am J Hum Genet. 2018;103(5):691-706.
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, et al. "Genome-wide association analysis identifies multiple loci related to resting heart rate." Hum Mol Genet. 2010;19(19):3885-94.
Chen Z, Tang H, Qayyum R, et al. "Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network." Hum Mol Genet. 2013;22(12):2529-38.
Cheng Y-C, Stanne TM, Giese A-K, et al. "Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2." Stroke. 2016;47(2):307-16.
Mozaffarian D, Dashti HS, Wojczynski MK, et al. "Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts." PLoS One. 2017;12(12):e0186456.
Teumer A, Tin A, Sorice R, et al. "Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes." Diabetes. 2016;65(3):803-17.
Meyer TE, Verwoert GC, Hwang S-J, et al. "Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels." PLoS Genet. 2010;6(8).
Tin A, Woodward OM, Kao W H L, et al. "Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele." Hum Mol Genet. 2011;20(20):4056-68.
H Y Wu J, Lemaitre RN, Manichaikul A, et al. "Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu." Circ Cardiovasc Genet. 2013;6(2):171-83.
Klimentidis YC, Raichlen DA, Bea J, et al. "Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE." Int J Obes (Lond). 2018;42(6):1161-1176.
Foroud T, Lai D, Koller D, et al. "Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7." Stroke. 2014;45(11):3194-9.
Imboden M, Bouzigon E, Curjuric I, et al. "Genome-wide association study of lung function decline in adults with and without asthma." J Allergy Clin Immunol. 2012;129(5):1218-28.
Guan W, Steffen BT, Lemaitre RN, et al. "Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2014;7(3):321-331.
Loomis SJ, Li M, Maruthur NM, et al. "Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study." Diabetes. 2018;67(8):1684-1696.
Keaton JM, Hellwege JN, C Y Ng M, et al. "Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans." PLoS One. 2016;11(7):e0159977.
Keaton JM, Gao C, Guan M, et al. "Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
Smith CE, Follis JL, Dashti HS, et al. "Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent." Mol Nutr Food Res. 2018;62(3).
David SP, Hamidovic A, Chen GK, et al. "Genome-wide meta-analyses of smoking behaviors in African Americans." Transl Psychiatry. 2012;2:e119.
Cornelis MC, Monda KL, Yu K, et al. "Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption." PLoS Genet. 2011;7(4):e1002033.
Justice AE, Winkler TW, Feitosa MF, et al. "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Nat Commun. 2017;8:14977.
Dong J, Yang J, Tranah G, et al. "Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults." Medicine (Baltimore). 2015;94(47):e1892.
Waks JW, Sitlani CM, Soliman EZ, et al. "Global Electric Heterogeneity Risk Score for Prediction of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies." Circulation. 2016;133(23):2222-34.
W Y Yau J, Rogers SL, Kawasaki R, et al. "Global prevalence and major risk factors of diabetic retinopathy." Diabetes Care. 2012;35(3):556-64.
"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017." Lancet. 2018;392(10159):1789-1858.
Selvin E, Ning Y, Steffes MW, et al. "Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes." Diabetes. 2011;60(1):298-305.
Steffen LM, Folsom AR, Cushman M, Jacobs DR, Rosamond WD. "Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology." Circulation. 2007;115(2):188-95.
Matteini AM, Tanaka T, Karasik D, et al. "GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium." Aging Cell. 2016;15(5):792-800.
Oelsner EC, Balte PP, Cassano PA, et al. "Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study." Am J Epidemiol. 2018;187(11):2265-2278.
Eigenbrodt ML, Fuchs FD, Hutchinson RG, Paton CC, Goff DC, Couper DJ. "Health-associated changes in drinking: a period prevalence study of the Atherosclerosis Risk In Communities (ARIC) cohort (1987-1995)." Prev Med. 2000;31(1):81-9.
Chen L, Patsch W, Boerwinkle E. "HindIII DNA polymorphism in the lipoprotein lipase gene and plasma lipid phenotypes and carotid artery atherosclerosis." Hum Genet. 1996;98(5):551-6.
McAdams DeMarco M, Coresh J, Woodward M, et al. "Hypertension status, treatment, and control among spousal pairs in a middle-aged adult cohort." Am J Epidemiol. 2011;174(7):790-6.
Arking DE, M Junttila J, Goyette P, et al. "Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals." PLoS Genet. 2011;7(6):e1002158.
"Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies." Lancet Neurol. 2016;15(7):695-707.
Corona G, Rastrelli G, Silverii A, et al. "The identification of prediabetes condition with ARIC algorithm predicts long-term CV events in patients with erectile dysfunction." J Sex Med. 2013;10(4):1114-23.
J Smith G, Avery CL, Evans DS, et al. "Impact of ancestry and common genetic variants on QT interval in African Americans." Circ Cardiovasc Genet. 2012;5(6):647-55.
Billings LK, Hsu Y-H, Ackerman RJ, et al. "Impact of common variation in bone-related genes on type 2 diabetes and related traits." Diabetes. 2012;61(8):2176-86.
Lutsey PL, Chen N, Mirabelli MC, et al. "Impaired Lung Function, Lung Disease, and Risk of Incident Dementia." Am J Respir Crit Care Med. 2019;199(11):1385-1396.
Folsom AR, Burke GL, Byers CL, et al. "Implications of obesity for cardiovascular disease in blacks: the CARDIA and ARIC studies." Am J Clin Nutr. 1991;53(6 Suppl):1604S-1611S.
Bijari PB, Antiga L, Gallo D, Wasserman BA, Steinman DA. "Improved prediction of disturbed flow via hemodynamically-inspired geometric variables." J Biomech. 2012;45(9):1632-7.
Auer PL, Johnsen JM, Johnson AD, et al. "Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project." Am J Hum Genet. 2012;91(5):794-808.
Lin J, Sun J, Wang S, et al. "In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study." Psychoneuroendocrinology. 2018;96:179-187.
Rywik SL, Williams OD, Pajak A, et al. "Incidence and correlates of hypertension in the Atherosclerosis Risk in Communities (ARIC) study and the Monitoring Trends and Determinants of Cardiovascular Disease (POL-MONICA) project." J Hypertens. 2000;18(8):999-1006.
Narayan KMVenkat, Kondal D, Kobes S, et al. "Incidence of diabetes in South Asian young adults compared to Pima Indians." BMJ Open Diabetes Res Care. 2021;9(1).
Bressler J, Knopman DS, Sharrett ARichey, et al. "Incident Heart Failure and Cognitive Decline: The Atherosclerosis Risk in Communities Study." J Card Fail. 2017;23(1):47-55.
Pandey A, Patel KV, Vongpatanasin W, et al. "Incorporation of Biomarkers Into Risk Assessment for Allocation of Antihypertensive Medication According to the 2017 ACC/AHA High Blood Pressure Guideline: A Pooled Cohort Analysis." Circulation. 2019;140(25):2076-2088.
Hartz SM, Short SE, Saccone NL, et al. "Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers." Arch Gen Psychiatry. 2012;69(8):854-60.
Bick AG, Popadin K, Thorball CW, et al. "Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV." Sci Rep. 2022;12(1):577.
Gurka MJ, Golden SH, Musani SK, et al. "Independent associations between a metabolic syndrome severity score and future diabetes by sex and race: the Atherosclerosis Risk In Communities Study and Jackson Heart Study." Diabetologia. 2017;60(7):1261-1270.
Yi JS, Morales EEGarcia, Betz JF, et al. "Individual Life-Course Socioeconomic Position and Hearing Aid Use in the Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2022;77(3):645-653.
Winkler TW, Justice AE, Graff M, et al. "The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study." PLoS Genet. 2015;11(10):e1005378.
Graff M, Gordon-Larsen P, Lim U, et al. "The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study." Diabetes. 2013;62(5):1763-7.
Bick AG, Weinstock JS, Nandakumar SK, et al. "Inherited causes of clonal haematopoiesis in 97,691 whole genomes." Nature. 2020;586(7831):763-768.
Liu J, Carnero-Montoro E, van Dongen J, et al. "An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis." Nat Commun. 2019;10(1):2581.
Nettleton JA, McKeown NM, Kanoni S, et al. "Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies." Diabetes Care. 2010;33(12):2684-91.
Rosenthal EA, Ranchalis J, Crosslin DR, et al. "Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia." Am J Hum Genet. 2013;93(6):1035-45.
Grams ME, Sang Y, Levey AS, et al. "Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate." N Engl J Med. 2016;374(5):411-21.
Iribarren C, Sempos CT, Eckfeldt JH, Folsom AR. "Lack of association between ferritin level and measures of LDL oxidation: the ARIC study. Atherosclerosis Risk in Communities." Atherosclerosis. 1998;139(1):189-95.
Ellis J, Lange EM, Li J, et al. "Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans." Hum Genet. 2014;133(8):985-95.
Scott RA, Lagou V, Welch RP, et al. "Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways." Nat Genet. 2012;44(9):991-1005.
Tang W, Kowgier M, Loth DW, et al. "Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function." PLoS One. 2014;9(7):e100776.
Day FR, Ruth KS, Thompson DJ, et al. "Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair." Nat Genet. 2015;47(11):1294-1303.
Gondalia R, Holliday KM, Baldassari A, et al. "Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study." Environ Health Perspect. 2020;128(1):17004.
Xiao Q, Heiss G, Kucharska-Newton A, Bey G, Love S-AM, Whitsel EA. "Life-Course Neighborhood Socioeconomic Status and Cardiovascular Events in Black and White Adults in the Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2022;191(8):1470-1484.
Commodore-Mensah Y, Mok Y, Gottesman RF, et al. "Life's Simple 7 at Midlife and Risk of Recurrent Cardiovascular Disease and Mortality after Stroke: The ARIC study." J Stroke Cerebrovasc Dis. 2022;31(7):106486.
Matsushita K, Sang Y, Ning H, et al. "Lifetime Risk of Lower-Extremity Peripheral Artery Disease Defined by Ankle-Brachial Index in the United States." J Am Heart Assoc. 2019;8(18):e012177.
Simino J, Kume R, Kraja AT, et al. "Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program." Atherosclerosis. 2014;235(1):84-93.
Rodriguez S, Gaunt TR, Guo Y, et al. "Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array." Eur J Hum Genet. 2016;24(1):106-12.
Nambi V, Hoogeveen RC, Chambless L, et al. "Lipoprotein-associated phospholipase A2 and high-sensitivity C-reactive protein improve the stratification of ischemic stroke risk in the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2009;40(2):376-81.
Schneider ALC, Lazo M, Ndumele CE, et al. "Liver enzymes, race, gender and diabetes risk: the Atherosclerosis Risk in Communities (ARIC) Study." Diabet Med. 2013;30(8):926-33.
"Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study." Lancet Neurol. 2016;15(2):174-184.
Ganesh SK, Tragante V, Guo W, et al. "Loci influencing blood pressure identified using a cardiovascular gene-centric array." Hum Mol Genet. 2013;22(8):1663-78.
Stevens J, Erber E, Truesdale KP, Wang C-H, Cai J. "Long- and short-term weight change and incident coronary heart disease and ischemic stroke: the Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2013;178(2):239-48.
Lutsey PL, Cushman M, Heckbert SR, Tang W, Folsom AR. "Longer legs are associated with greater risk of incident venous thromboembolism independent of total body height. The Longitudinal Study of Thromboembolism Etiology (LITE)." Thromb Haemost. 2011;106(1):113-20.
Aggarwal V, Schneider ALC, Selvin E. "Low hemoglobin A(1c) in nondiabetic adults: an elevated risk state?" Diabetes Care. 2012;35(10):2055-60.
van der Velde M, Matsushita K, Coresh J, et al. "Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts." Kidney Int. 2011;79(12):1341-52.
Oelsner EC, Balte PP, Bhatt SP, et al. "Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study." Lancet Respir Med. 2020;8(1):34-44.