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ARIC Publications

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Journal Article
Liu J, Carnero-Montoro E, van Dongen J, et al. "An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis." Nat Commun. 2019;10(1):2581.
Chasman DI, Fuchsberger C, Pattaro C, et al. "Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function." Hum Mol Genet. 2012;21(24):5329-43.
Holliday EG, Smith AV, Cornes BK, et al. "Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis." PLoS One. 2013;8(1):e53830.
Bressler J, Fornage M, Hanis CL, et al. "The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts." BMC Med Genet. 2009;10:56.
Xu H, Zhang H, Yang W, et al. "Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children." Nat Commun. 2015;6:7553.
Winkler TW, Justice AE, Graff M, et al. "The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study." PLoS Genet. 2015;11(10):e1005378.
Auer PL, Johnsen JM, Johnson AD, et al. "Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project." Am J Hum Genet. 2012;91(5):794-808.
Duan Q, Liu EYi, Auer PL, et al. "Imputation of coding variants in African Americans: better performance using data from the exome sequencing project." Bioinformatics. 2013;29(21):2744-9.
Rasmussen-Torvik LJ, Alonso A, Li M, et al. "Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose." Genet Epidemiol. 2010;34(7):665-73.
Roberts JD, Dewland TA, Glidden DV, et al. "Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation." Am Heart J. 2016;175:9-17.
Billings LK, Hsu Y-H, Ackerman RJ, et al. "Impact of common variation in bone-related genes on type 2 diabetes and related traits." Diabetes. 2012;61(8):2176-86.
Wheeler E, Leong A, Liu C-T, et al. "Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis." PLoS Med. 2017;14(9):e1002383.
J Smith G, Avery CL, Evans DS, et al. "Impact of ancestry and common genetic variants on QT interval in African Americans." Circ Cardiovasc Genet. 2012;5(6):647-55.
Begum F, Ruczinski I, Li S, et al. "Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort." Genet Epidemiol. 2016;40(1):81-8.
Hoed Mden, Eijgelsheim M, Esko T, et al. "Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders." Nat Genet. 2013;45(6):621-31.
Pankow JS, Tang W, Pankratz N, et al. "Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities)." Arterioscler Thromb Vasc Biol. 2017;37(3):589-597.
"Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies." Lancet Neurol. 2016;15(7):695-707.
Arking DE, M Junttila J, Goyette P, et al. "Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals." PLoS Genet. 2011;7(6):e1002158.
Allen HLango, Estrada K, Lettre G, et al. "Hundreds of variants clustered in genomic loci and biological pathways affect human height." Nature. 2010;467(7317):832-8.
Pirastu N, Joshi PK, de Vries PS, et al. "GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk." Nat Commun. 2017;8(1):1584.
Offenbacher S, Jiao Y, Kim SJ, et al. "GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation." Nat Commun. 2018;9(1):3686.
Franceschini N, Giambartolomei C, de Vries PS, et al. "GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes." Nat Commun. 2018;9(1):5141.
Matteini AM, Tanaka T, Karasik D, et al. "GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium." Aging Cell. 2016;15(5):792-800.
Morrison AC, Felix JF, L Cupples A, et al. "Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2010;3(3):248-55.
Lindström S, Wang L, Smith EN, et al. "Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism." Blood. 2019;134(19):1645-1657.
Day FR, Thompson DJ, Helgason H, et al. "Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk." Nat Genet. 2017;49(6):834-841.
van Rooij FJA, Qayyum R, Smith AV, et al. "Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis." Am J Hum Genet. 2017;100(1):51-63.
Mahajan A, Go MJin, Zhang W, et al. "Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility." Nat Genet. 2014;46(3):234-44.
Debette S, Verbaas CAIbrahim, Bressler J, et al. "Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium." Biol Psychiatry. 2015;77(8):749-63.
Tin A, Astor BC, Boerwinkle E, Hoogeveen RC, Coresh J, Kao LWH. "Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans." Nephrol Dial Transplant. 2013;28(6):1497-504.
Graff M, Scott RA, Justice AE, et al. "Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults." PLoS Genet. 2017;13(4):e1006528.
Dong J, Yang J, Tranah G, et al. "Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults." Medicine (Baltimore). 2015;94(47):e1892.
Irvin MR, Sitlani CM, Noordam R, et al. "Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry." Pharmacogenomics J. 2019;19(1):97-108.
Jones G, Trajanoska K, Santanasto AJ, et al. "Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women." Nat Commun. 2021;12(1):654.
Merino J, Dashti HS, Li SX, et al. "Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium." Mol Psychiatry. 2019;24(12):1920-1932.
Boraska V, Jerončić A, Colonna V, et al. "Genome-wide meta-analysis of common variant differences between men and women." Hum Mol Genet. 2012;21(21):4805-15.
Justice AE, Winkler TW, Feitosa MF, et al. "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Nat Commun. 2017;8:14977.
Cornelis MC, Monda KL, Yu K, et al. "Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption." PLoS Genet. 2011;7(4):e1002033.
Berndt SI, Gustafsson S, Mägi R, et al. "Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture." Nat Genet. 2013;45(5):501-12.
Joshi PK, Pirastu N, Kentistou KA, et al. "Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity." Nat Commun. 2017;8(1):910.
David SP, Hamidovic A, Chen GK, et al. "Genome-wide meta-analyses of smoking behaviors in African Americans." Transl Psychiatry. 2012;2:e119.
Smith CE, Follis JL, Dashti HS, et al. "Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent." Mol Nutr Food Res. 2018;62(3).
Keaton JM, Gao C, Guan M, et al. "Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans." Genet Epidemiol. 2018;42(6):559-570.
Keaton JM, Hellwege JN, C Y Ng M, et al. "GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS." Pac Symp Biocomput. 2017;22:242-253.
Keaton JM, Hellwege JN, C Y Ng M, et al. "Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans." PLoS One. 2016;11(7):e0159977.
Huan T, Joehanes R, Song C, et al. "Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease." Nat Commun. 2019;10(1):4267.
Tereshchenko LG, Sotoodehnia N, Sitlani CM, et al. "Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study)." J Am Heart Assoc. 2018;7(8).
Sabater-Lleal M, Huffman JE, de Vries PS, et al. "Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels." Circulation. 2019;139(5):620-635.
Sennblad B, Basu S, Mazur J, et al. "Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels." Hum Mol Genet. 2017;26(3):637-649.
Reiner AP, Lettre G, Nalls MA, et al. "Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)." PLoS Genet. 2011;7(6):e1002108.
Gondalia R, Avery CL, Napier MD, et al. "Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation." Environ Health Perspect. 2017;125(6):067002.
Luo S, Feofanova EV, Tin A, et al. "Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension." Kidney Int. 2021;100(2):430-439.
Loomis SJ, Li M, Maruthur NM, et al. "Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study." Diabetes. 2018;67(8):1684-1696.
Jensen RA, Sim X, Li X, et al. "Genome-wide association study of retinopathy in individuals without diabetes." PLoS One. 2013;8(2):e54232.
Mick E, McGough J, Deutsch CK, Frazier JA, Kennedy D. "Genome-wide association study of proneness to anger." PLoS One. 2014;9(1):e87257.
Pfeufer A, van Noord C, Marciante KD, et al. "Genome-wide association study of PR interval." Nat Genet. 2010;42(2):153-9.
Guan W, Steffen BT, Lemaitre RN, et al. "Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium." Circ Cardiovasc Genet. 2014;7(3):321-331.
Divaris K, Monda KL, North KE, et al. "Genome-wide association study of periodontal pathogen colonization." J Dent Res. 2012;91(7 Suppl):21S-28S.
Imboden M, Bouzigon E, Curjuric I, et al. "Genome-wide association study of lung function decline in adults with and without asthma." J Allergy Clin Immunol. 2012;129(5):1218-28.
Foroud T, Lai D, Koller D, et al. "Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7." Stroke. 2014;45(11):3194-9.
Klimentidis YC, Raichlen DA, Bea J, et al. "Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE." Int J Obes (Lond). 2018;42(6):1161-1176.
Hek K, Demirkan A, Lahti J, et al. "A genome-wide association study of depressive symptoms." Biol Psychiatry. 2013;73(7):667-78.
Levy D, Ehret GB, Rice K, et al. "Genome-wide association study of blood pressure and hypertension." Nat Genet. 2009;41(6):677-87.
Offenbacher S, Divaris K, Barros SP, et al. "Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease." Hum Mol Genet. 2016;25(10):2113-2129.
Irvin MR, Sitlani CM, Floyd JS, et al. "Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group." Am J Hypertens. 2019;32(12):1146-1153.
Walter S, Atzmon G, Demerath EW, et al. "A genome-wide association study of aging." Neurobiol Aging. 2011;32(11):2109.e15-28.
Demerath EW, Liu C-T, Franceschini N, et al. "Genome-wide association study of age at menarche in African-American women." Hum Mol Genet. 2013;22(16):3329-46.
Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA. "Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study." Genet Epidemiol. 2013;37(8):840-5.
Vojinovic D, Adams HH, Jian X, et al. "Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume." Nat Commun. 2018;9(1):3945.
Li M, Maruthur NM, Loomis SJ, et al. "Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism." Sci Rep. 2017;7(1):2812.
Keene KL, Hyacinth HI, Bis JC, et al. "Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke." Stroke. 2020;51(8):2454-2463.
Jiang X, O'Reilly PF, Aschard H, et al. "Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels." Nat Commun. 2018;9(1):260.
Hara K, Fujita H, Johnson TA, et al. "Genome-wide association study identifies three novel loci for type 2 diabetes." Hum Mol Genet. 2014;23(1):239-46.
Wain LV, Verwoert GC, O'Reilly PF, et al. "Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure." Nat Genet. 2011;43(10):1005-11.
Tang W, Basu S, Kong X, et al. "Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study." Blood. 2010;116(23):5032-6.
H Y Wu J, Lemaitre RN, Manichaikul A, et al. "Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu." Circ Cardiovasc Genet. 2013;6(2):171-83.
de Vries PS, Sabater-Lleal M, Huffman JE, et al. "A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology." Blood. 2019;133(9):967-977.