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ARIC Publications

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2016
Evans DS, Avery CL, Nalls MA, et al. "Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans." Hum Mol Genet. 2016;25(19):4350-4368.
Zubair N, Graff M, Ambite JLuis, et al. "Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci." Hum Mol Genet. 2016;25(24):5500-5512.
Huang J, Wang K, Wei P, et al. "FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics." Genetics. 2016;202(3):919-29.
Joshi AD, Andersson C, Buch S, et al. "Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies." Gastroenterology. 2016;151(2):351-363.e28.
Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen RC, Young JH. "GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study." Diabet Med. 2016;33(7):968-75.
Lin H, Mueller-Nurasyid M, Smith AV, et al. "Gene-gene Interaction Analyses for Atrial Fibrillation." Sci Rep. 2016;6:35371.
Pattaro C, Teumer A, Gorski M, et al. "Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function." Nat Commun. 2016;7:10023.
Allen NB, Lloyd-Jones D, Hwang S-J, et al. "Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies." Am Heart J. 2016;175:112-20.
Ehret GB, Ferreira T, Chasman DI, et al. "The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals." Nat Genet. 2016;48(10):1171-1184.
Cheng Y-C, Stanne TM, Giese A-K, et al. "Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2." Stroke. 2016;47(2):307-16.
Teumer A, Tin A, Sorice R, et al. "Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes." Diabetes. 2016;65(3):803-17.
van Loon J, Dehghan A, Weihong T, et al. "Genome-wide association studies identify genetic loci for low von Willebrand factor levels." Eur J Hum Genet. 2016;24(7):1035-40.
Dehghan A, Bis JC, White CC, et al. "Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium." PLoS One. 2016;11(3):e0144997.
Offenbacher S, Divaris K, Barros SP, et al. "Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease." Hum Mol Genet. 2016;25(10):2113-2129.
Keaton JM, Hellwege JN, C Y Ng M, et al. "Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans." PLoS One. 2016;11(7):e0159977.
Matteini AM, Tanaka T, Karasik D, et al. "GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium." Aging Cell. 2016;15(5):792-800.
"Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies." Lancet Neurol. 2016;15(7):695-707.
Begum F, Ruczinski I, Li S, et al. "Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort." Genet Epidemiol. 2016;40(1):81-8.
Roberts JD, Dewland TA, Glidden DV, et al. "Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation." Am Heart J. 2016;175:9-17.
Tajuddin SM, Schick UM, Eicher JD, et al. "Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases." Am J Hum Genet. 2016;99(1):22-39.
Rodriguez S, Gaunt TR, Guo Y, et al. "Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array." Eur J Hum Genet. 2016;24(1):106-12.
"Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study." Lancet Neurol. 2016;15(2):174-184.
Liu C, Kraja AT, Smith JA, et al. "Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci." Nat Genet. 2016;48(10):1162-70.
de Vries PS, Chasman DI, Sabater-Lleal M, et al. "A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration." Hum Mol Genet. 2016;25(2):358-70.
van Leeuwen EM, Sabo A, Bis JC, et al. "Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels." J Med Genet. 2016;53(7):441-9.
Postmus I, Warren HR, Trompet S, et al. "Meta-analysis of genome-wide association studies of HDL cholesterol response to statins." J Med Genet. 2016;53(12):835-845.
"Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits." Nat Genet. 2016;48(8):867-76.
Bayram Y, Karaca E, Akdemir ZCoban, et al. "Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin." J Clin Invest. 2016;126(2):762-78.
Hill WD, Davies G, Harris SE, et al. "Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions." Transl Psychiatry. 2016;6(12):e980.
Natarajan P, Bis JC, Bielak LF, et al. "Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis." Circ Cardiovasc Genet. 2016;9(6):511-520.
Lu Y, Day FR, Gustafsson S, et al. "New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk." Nat Commun. 2016;7:10495.
Jun G, Ibrahim-Verbaas CA, Vronskaya M, et al. "A novel Alzheimer disease locus located near the gene encoding tau protein." Mol Psychiatry. 2016;21(1):108-17.
Adams HHH, Hibar DP, Chouraki V, et al. "Novel genetic loci underlying human intracranial volume identified through genome-wide association." Nat Neurosci. 2016;19(12):1569-1582.
Eicher JD, Chami N, Kacprowski T, et al. "Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals." Am J Hum Genet. 2016;99(1):40-55.
Ried JS, M JJeff, Chu AY, et al. "A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape." Nat Commun. 2016;7:13357.
Wei P, Cao Y, Zhang Y, Xu Z, Kwak I-Y, Boerwinkle E. "On Robust Association Testing for Quantitative Traits and Rare Variants." G3 (Bethesda). 2016;6(12):3941-3950.
Demirkan A, Lahti J, Direk N, et al. "Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies." Psychol Med. 2016;46(8):1613-23.
Liu C-T, Raghavan S, Maruthur N, et al. "Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin." Am J Hum Genet. 2016;99(1):56-75.
Verweij N, Mateo Leach I, Isaacs A, et al. "Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram." Hum Mol Genet. 2016;25(10):2093-2103.
Ray D, Pankow JS. "USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis." Genet Epidemiol. 2016;40(1):20-34.
Yu B, de Vries PS, Metcalf GA, et al. "Whole genome sequence analysis of serum amino acid levels." Genome Biol. 2016;17(1):237.
2017
Gorski M, van der Most PJ, Teumer A, et al. "1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function." Sci Rep. 2017;7:45040.
Direk N, Williams S, Smith JA, et al. "An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype." Biol Psychiatry. 2017;82(5):322-329.
Böger CA, Gorski M, McMahon GM, et al. " and Loci Associate with Plasma Osmolality." J Am Soc Nephrol. 2017;28(8):2311-2321.
Li M, Li Y, Weeks O, et al. " and Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function." J Am Soc Nephrol. 2017;28(3):981-994.
Lindström S, Germain M, Crous-Bou M, et al. "Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study." Hum Genet. 2017;136(7):897-902.
Haycock PC, Burgess S, Nounu A, et al. "Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study." JAMA Oncol. 2017;3(5):636-651.
Mendelson MM, Marioni RE, Joehanes R, et al. "Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach." PLoS Med. 2017;14(1):e1002215.
Raina A, Zhao X, Grove ML, et al. "Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study." Clin Epigenetics. 2017;9:21.
Sanders AE, Sofer T, Wong Q, et al. "Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos." J Dent Res. 2017;96(1):64-72.
de Vries PS, Sabater-Lleal M, Chasman DI, et al. "Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study." PLoS One. 2017;12(1):e0167742.
Ben-Avraham D, Karasik D, Verghese J, et al. "The complex genetics of gait speed: genome-wide meta-analysis approach." Aging (Albany NY). 2017;9(1):209-246.
Jensen MK, Jensen RA, Mukamal KJ, et al. "Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium." Hum Mol Genet. 2017;26(11):2156-2163.
C Y Ng M, Graff M, Lu Y, et al. "Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium." PLoS Genet. 2017;13(4):e1006719.
van den Berg ME, Warren HR, Cabrera CP, et al. "Discovery of novel heart rate-associated loci using the Exome Chip." Hum Mol Genet. 2017;26(12):2346-2363.
Richard MA, Huan T, Ligthart S, et al. "DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation." Am J Hum Genet. 2017;101(6):888-902.
Chu AY, Tin A, Schlosser P, et al. "Epigenome-wide association studies identify DNA methylation associated with kidney function." Nat Commun. 2017;8(1):1286.
Hinney A, Kesselmeier M, Jall S, et al. "Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index." Mol Psychiatry. 2017;22(2):192-201.
Scott RA, Scott LJ, Mägi R, et al. "An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans." Diabetes. 2017;66(11):2888-2902.
Howson JMM, Zhao W, Barnes DR, et al. "Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms." Nat Genet. 2017;49(7):1113-1119.
Avery CL, Wassel CL, Richard MA, et al. "Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations." Heart Rhythm. 2017;14(4):572-580.
Yoneyama S, Yao J, Guo X, et al. "Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations." Int J Obes (Lond). 2017;41(2):324-331.
Hobbs BD, de Jong K, Lamontagne M, et al. "Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis." Nat Genet. 2017;49(3):426-432.
Robinson-Cohen C, Lutsey PL, Kleber ME, et al. "Genetic Variants Associated with Circulating Parathyroid Hormone." J Am Soc Nephrol. 2017;28(5):1553-1565.
Bressler J, Mosley TH, Penman A, et al. "Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study." Am J Med Genet B Neuropsychiatr Genet. 2017;174(3):269-282.
Traylor M, Malik R, Nalls MA, et al. "Genetic variation at 16q24.2 is associated with small vessel stroke." Ann Neurol. 2017;81(3):383-394.
Dong J, Wyss A, Yang J, et al. "Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans." Mol Neurobiol. 2017;54(10):8021-8032.
Mozaffarian D, Dashti HS, Wojczynski MK, et al. "Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts." PLoS One. 2017;12(12):e0186456.
Li M, Carey J, Cristiano S, et al. "Genome-Wide Association of Copy Number Polymorphisms and Kidney Function." PLoS One. 2017;12(1):e0170815.
Li M, Maruthur NM, Loomis SJ, et al. "Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism." Sci Rep. 2017;7(1):2812.
Gondalia R, Avery CL, Napier MD, et al. "Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation." Environ Health Perspect. 2017;125(6):067002.
Sennblad B, Basu S, Mazur J, et al. "Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels." Hum Mol Genet. 2017;26(3):637-649.
Keaton JM, Hellwege JN, C Y Ng M, et al. "GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS." Pac Symp Biocomput. 2017;22:242-253.
Joshi PK, Pirastu N, Kentistou KA, et al. "Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity." Nat Commun. 2017;8(1):910.
Justice AE, Winkler TW, Feitosa MF, et al. "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits." Nat Commun. 2017;8:14977.
Graff M, Scott RA, Justice AE, et al. "Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults." PLoS Genet. 2017;13(4):e1006528.
van Rooij FJA, Qayyum R, Smith AV, et al. "Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis." Am J Hum Genet. 2017;100(1):51-63.