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ARIC Publications

2021
Graff M, Justice AE, Young KL, et al. "Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry." Am J Hum Genet. 2021;108(4):564-582.
Marchesan JT, Moss K, Morelli T, et al. "Distinct Microbial Signatures between Periodontal Profile Classes." J Dent Res. 2021;100(12):1405-1413.
Echouffo-Tcheugui JB, Zhang S, Florido R, et al. "Duration of Diabetes and Incident Heart Failure: The ARIC (Atherosclerosis Risk In Communities) Study." JACC Heart Fail. 2021;9(8):594-603.
Akbilgic O, Butler L, Karabayir I, et al. "ECG-AI: electrocardiographic artificial intelligence model for prediction of heart failure." Eur Heart J Digit Health. 2021;2(4):626-634.
Ishigami J, Mathews L, Hishida M, et al. "Echocardiographic measures and subsequent decline in kidney function in older adults: the Atherosclerosis Risk in Communities Study." Eur Heart J Cardiovasc Imaging. 2021.
Saadati HMozafar, Sabour S, Mansournia MAli, Mehrabi Y, Nazari SSaeed Hash. "Effect modification of general and central obesity by sex and age on cardiovascular outcomes: Targeted maximum likelihood estimation in the atherosclerosis risk in communities study." Diabetes Metab Syndr. 2021;15(2):479-485.
Johnson JA, Haq KT, Lutz KJ, et al. "Electrophysiological ventricular substrate of stroke: a prospective cohort study in the Atherosclerosis Risk in Communities (ARIC) study." BMJ Open. 2021;11(9):e048542.
Mao H, Li L, Fan Q, et al. "Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin." Nat Commun. 2021;12(1):5296.
Sun P, Kumar N, Tin A, et al. "Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease." Hypertension. 2021;78(5):1555-1566.
Vasan RS, Musani SK, Matsushita K, et al. "Epidemiology of Heart Failure Stages in Middle-Aged Black People in the Community: Prevalence and Prognosis in the Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2021;10(9):e016524.
Roberts JD, Vittinghoff E, Lu AT, et al. "Epigenetic Age and the Risk of Incident Atrial Fibrillation." Circulation. 2021;144(24):1899-1911.
Gondalia R, Baldassari A, Holliday KM, et al. "Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study." Environ Res. 2021;198:111211.
Wang P, Castellani CA, Yao J, et al. "Epigenome-wide association study of mitochondrial genome copy number." Hum Mol Genet. 2021.
Bellows BK, Zhang Y, Zhang Z, et al. "Estimating Systolic Blood Pressure Intervention Trial Participant Posttrial Survival Using Pooled Epidemiologic Cohort Data." J Am Heart Assoc. 2021;10(10):e020361.
Hu JK, Chan KCG, Couper DJ, Breslow NE. "Estimating the hazard rate difference from case-cohort studies." Eur J Epidemiol. 2021;36(11):1129-1142.
Feofanova EV, Lim E, Chen H, et al. "Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Study." Genet Epidemiol. 2021;45(6):651-663.
Thibord F, Song C, Pattee J, et al. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer.. Vol. 19.; 2021. J Thromb Haemost 19(8).
Honda Y, Mok Y, Ishigami J, et al. "The Fifth-Generation Cardiac Troponin T and Cardiovascular Disease in the Community." J Am Coll Cardiol. 2021;78(20):2019-2021.
Rooney MR, Norby FL, Maheshwari A, et al. "Frequent Premature Atrial Contractions Are Associated With Poorer Cognitive Function in the Atherosclerosis Risk in Communities (ARIC) Study." Mayo Clin Proc. 2021;96(5):1147-1156.
Gianattasio KZ, Bennett EE, Wei J, et al. "Generalizability of findings from a clinical sample to a community-based sample: A comparison of ADNI and ARIC." Alzheimers Dement. 2021.
Ruth KS, Day FR, Hussain J, et al. "Genetic insights into biological mechanisms governing human ovarian ageing." Nature. 2021;596(7872):393-397.
Ligthart S, Hasbani NR, Ahmadizar F, et al. "Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study." Diabet Med. 2021;38(10):e14639.
Schunk SJ, Kleber ME, März W, et al. "Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality." Eur Heart J. 2021;42(18):1742-1756.
McCartney DL, Min JL, Richmond RC, et al. "Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging." Genome Biol. 2021;22(1):194.
Ahluwalia TS, Prins BP, Abdollahi M, et al. "Genome-wide association study of circulating interleukin 6 levels identifies novel loci." Hum Mol Genet. 2021;30(5):393-409.
Luo S, Feofanova EV, Tin A, et al. "Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension." Kidney Int. 2021;100(2):430-439.
Jones G, Trajanoska K, Santanasto AJ, et al. "Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women." Nat Commun. 2021;12(1):654.
R Lumbers T, Shah S, Lin H, et al. "The genomics of heart failure: design and rationale of the HERMES consortium." ESC Heart Fail. 2021;8(6):5531-5541.
Li H, Sisoudiya SD, Martin-Giacalone BA, et al. "Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group." J Natl Cancer Inst. 2021;113(7):875-883.
Selvin E, Wang D, Tang O, Minotti M, Echouffo-Tcheugui JB, Coresh J. "Glucose Patterns in Very Old Adults: A Pilot Study in a Community-Based Population." Diabetes Technol Ther. 2021.
Echouffo-Tcheugui JB, Daya N, Matsushita K, et al. "Growth Differentiation Factor (GDF)-15 and Cardiometabolic Outcomes among Older Adults: The Atherosclerosis Risk in Communities Study." Clin Chem. 2021;67(4):653-661.
Schneider ALC, Selvin E, Latour L, et al. "Head injury and 25-year risk of dementia." Alzheimers Dement. 2021.
Deal JA, Gross AL, A Sharrett R, et al. "Hearing impairment and missing cognitive test scores in a population-based study of older adults: The Atherosclerosis Risk in Communities neurocognitive study." Alzheimers Dement. 2021.
Commodore-Mensah Y, Lazo M, Tang O, et al. "High Burden of Subclinical and Cardiovascular Disease Risk in Adults with Metabolically Healthy Obesity: The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2021.
Du S, Kim H, Rebholz CM. "Higher Ultra-Processed Food Consumption Is Associated with Increased Risk of Incident Coronary Artery Disease in the Atherosclerosis Risk in Communities Study." J Nutr. 2021.
Ishigami J, Kim Y, Sang Y, et al. "High-Sensitivity Cardiac Troponin, Natriuretic Peptide, and Long-Term Risk of Acute Kidney Injury: The Atherosclerosis Risk in Communities (ARIC) Study." Clin Chem. 2021;67(1):298-307.
Ebong IA, Wilson MD, Bertoni AG, et al. "High-sensitivity cardiac troponin T and the risk of heart failure in postmenopausal women of the ARIC Study." Menopause. 2021;28(3):284-291.
Fletcher-Lloyd N, Soreq E, Wilson D, Nilforooshan R, Sharp DJ, Barnaghi P. "Home monitoring of daily living activities and prediction of agitation risk in a cohort of people living with dementia." Alzheimers Dement. 2021;17 Suppl 12:e058614.
Qi Q, Li J, Yu B, et al. "Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies." Gut. 2021.
Zhao Y, Malik S, Budoff MJ, et al. "Identification and Predictors for Cardiovascular Disease Risk Equivalents among Adults With Diabetes Mellitus." Diabetes Care. 2021.
Yang Y, Bartz TM, Brown MR, et al. "Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation." Circ Genom Precis Med. 2021;14(6):e003460.
Sarnowski C, Chen H, Biggs ML, et al. "Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program." PLoS One. 2021;16(7):e0253611.
Sullivan KJ, Ranadive R, Su D, et al. "Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study." Brain Imaging Behav. 2021.
Narayan KMVenkat, Kondal D, Daya N, et al. "Incidence and pathophysiology of diabetes in South Asian adults living in India and Pakistan compared with US blacks and whites." BMJ Open Diabetes Res Care. 2021;9(1).
Narayan KMVenkat, Kondal D, Kobes S, et al. "Incidence of diabetes in South Asian young adults compared to Pima Indians." BMJ Open Diabetes Res Care. 2021;9(1).
Sarnowski C, Cousminer DL, Franceschini N, et al. "Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche." Hum Reprod. 2021;36(7):1999-2010.
Xue D, Bush WS, Renton AE, et al. "Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease." Alzheimers Dement (Amst). 2021;13(1):e12255.
Minamisawa M, Inciardi RM, Claggett B, et al. "Left atrial structure and function of the amyloidogenic V122I transthyretin variant in elderly African Americans." Eur J Heart Fail. 2021;23(8):1290-1295.
Krishnappa D, Wang W, Rooney MR, et al. "Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study." Int J Cardiol. 2021.
Xu H, Schwander K, Brown MR, et al. "Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions." Eur J Hum Genet. 2021;29(5):839-850.
Marrone MT, Mondul AM, Prizment AE, et al. "Lipid-Lowering Drug Use and Cancer Incidence and Mortality in the ARIC Study." JNCI Cancer Spectr. 2021;5(5).
Kucharska-Newton A, Matsushita K, Mok Y, et al. "Loneliness and its predictors among older adults prior to and during the COVID-19 pandemic: cross-sectional and longitudinal survey findings from participants of the Atherosclerosis Risk in Communities (ARIC) Study cohort in the USA." BMJ Open. 2021;11(12):e053542.
Metcalf PA, Meyer ML, Tanaka H, et al. "Longitudinal associations of blood pressure with aortic stiffness and pulsatility: the Atherosclerosis Risk in Communities Study." J Hypertens. 2021;39(5):987-993.
Ting J, Jiang K, Du S, et al. "Longitudinal Blood Pressure Patterns from Mid-to-Late Life and Late-life Hearing Loss in the Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2021.
Keshawarz A, Joehanes R, Guan W, et al. "Longitudinal change in blood DNA epigenetic signature after smoking cessation." Epigenetics. 2021:1-12.
Harding BN, Norby FL, Heckbert SR, et al. "Longitudinal Measures of Blood Pressure and Subclinical Atrial Arrhythmias: The MESA and the ARIC Study." J Am Heart Assoc. 2021;10(11):e020260.
Lu Y, Pike JR, Selvin E, et al. "Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study." J Alzheimers Dis. 2021;79(4):1775-1784.
Schlosser P, Tin A, Matias-Garcia PR, et al. "Meta-analyses identify DNA methylation associated with kidney function and damage." Nat Commun. 2021;12(1):7174.
Gorski M, Jung B, Li Y, et al. "Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline." Kidney Int. 2021;99(4):926-939.
He WJ, Chen J, Razavi AC, et al. "Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease." Clin J Am Soc Nephrol. 2021;16(11):1620-1629.
Tariq A, Chen J, Yu B, et al. "Metabolomics of Dietary Acid Load and Incident Chronic Kidney Disease." J Ren Nutr. 2021.
Cohen AJ, Teramoto K, Claggett B, et al. "Mid- to Late-Life Inflammation and Risk of Cardiac Dysfunction, HFpEF and HFrEF in Late Life." J Card Fail. 2021.
Johnson EL, Krauss GL, Kucharska-Newton A, Lam AD, Sarkis R, Gottesman RF. "Mortality in Patients With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study." Neurology. 2021.
Sun D, Richard M, Musani SK, et al. "Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits." HGG Adv. 2021;2(1).
Wang H, Noordam R, Cade BE, et al. "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure." Mol Psychiatry. 2021.
Jhun M-A, Mendelson M, Wilson R, et al. "A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids." Nat Commun. 2021;12(1):3987.
Madrid L, Moreno-Grau S, Ahmad S, et al. "Multiomics integrative analysis identifies allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis." Aging (Albany NY). 2021;13(7):9277-9329.
Walker KA, Chawla S, Nogueras-Ortiz C, et al. "Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study." Neurobiol Aging. 2021;97:65-72.
Folsom AR, de Vries PS, Cushman M. "No prospective association of a polygenic risk score for coronary artery disease with venous thromboembolism incidence." J Thromb Haemost. 2021.
Kahali B, Chen Y, Feitosa MF, et al. "A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction." J Clin Endocrinol Metab. 2021;106(2):372-387.
Raffield LM, Howard AGreen, Graff M, et al. "Obesity Duration, Severity, and Distribution Trajectories and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study." J Am Heart Assoc. 2021;10(24):e019946.
Fang M, Tcheugui JBEchouffo, Pankow JS, B Windham G, Selvin E. "Patient-reported preventive care practices in older adults with diabetes." Diabet Med. 2021;38(3):e14508.
Armstrong NM, Wang H, E J-Y, et al. "Patterns of Prevalence of Multiple Sensory Impairments among Community-Dwelling Older Adults." J Gerontol A Biol Sci Med Sci. 2021.
Pandey A, Mehta A, Paluch A, et al. "Performance of the American Heart Association/American College of Cardiology Pooled Cohort Equations to Estimate Atherosclerotic Cardiovascular Disease Risk by Self-reported Physical Activity Levels." JAMA Cardiol. 2021;6(6):690-696.
Sen S, Redd K, Trivedi T, et al. "Periodontal Disease, Atrial Fibrillation and Stroke." Am Heart J. 2021;235:36-43.
Philips KH, Zhang S, Moss K, Ciarrocca K, Beck JD. "Periodontal disease, undiagnosed diabetes, and body mass index: Implications for diabetes screening by dentists." J Am Dent Assoc. 2021;152(1):25-35.
Zhang S, Philips KH, Moss K, et al. "Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-modified Association." J Clin Endocrinol Metab. 2021.
Xu J, Liu G, Hegde SM, et al. "Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study." Metabolites. 2021;11(1).
Damotte V, van der Lee SJ, Chouraki V, et al. "Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants." Alzheimers Dement. 2021.
Lindbohm JV, Mars N, Walker KA, et al. "Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies." Alzheimers Dement. 2021.

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