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ARIC Publications

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Yan Y, North KE, Ballantyne CM, et al. "Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study." Diabetes. 2009;58(1):285-9.
Yan Y, Klein R, Heiss G, et al. "The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study." BMC Endocr Disord. 2010;10:9.
Gong J, Nishimura KK, Fernández-Rhodes L, et al. "Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI." Int J Obes (Lond). 2018;42(3):384-390.
Hong J, Hatchell KE, Bradfield JP, et al. "Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations." J Clin Endocrinol Metab. 2018;103(4):1380-1392.
Fernández-Rhodes L, Gong J, Haessler J, et al. "Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci." Hum Genet. 2017;136(6):771-800.
Wu Y, Waite LL, Jackson AU, et al. "Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained." PLoS Genet. 2013;9(3):e1003379.
Bien SA, Pankow JS, Haessler J, et al. "Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium." Diabetologia. 2017;60(12):2384-2398.
Morris AP, Le TH, Wu H, et al. "Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies." Nat Commun. 2019;10(1):29.
Liu C-T, Raghavan S, Maruthur N, et al. "Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin." Am J Hum Genet. 2016;99(1):56-75.
Keller MF, Reiner AP, Okada Y, et al. "Trans-ethnic meta-analysis of white blood cell phenotypes." Hum Mol Genet. 2014;23(25):6944-60.
C Y Ng M, Saxena R, Li J, et al. "Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study." Diabetes. 2013;62(3):965-76.
Liu C-T, C Y Ng M, Rybin D, et al. "Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource." Diabetologia. 2012;55(11):2970-84.
Bozorgmanesh M, Hadaegh F, Azizi F. "Transportability of the updated diabetes prediction model from Atherosclerosis Risk in Communities Study to a Middle Eastern adult population: community-based cohort study." Acta Diabetol. 2013;50(2):175-81.
Astor BC, Köttgen A, Hwang S-J, Bhavsar N, Fox CS, Coresh J. "Trefoil factor 3 predicts incident chronic kidney disease: a case-control study nested within the Atherosclerosis Risk in Communities (ARIC) study." Am J Nephrol. 2011;34(4):291-7.
Ni H, Coady S, Rosamond W, et al. "Trends from 1987 to 2004 in sudden death due to coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study." Am Heart J. 2009;157(1):46-52.
Chang PP, Wruck LM, Shahar E, et al. "Trends in Hospitalizations and Survival of Acute Decompensated Heart Failure in Four US Communities (2005-2014): ARIC Study Community Surveillance." Circulation. 2018;138(1):12-24.
Newman JD, Shimbo D, Baggett C, et al. "Trends in myocardial infarction rates and case fatality by anatomical location in four United States communities, 1987 to 2008 (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2013;112(11):1714-9.
Szklo M, Chambless LE, Folsom AR, et al. "Trends in plasma cholesterol levels in the atherosclerosis risk in communities (ARIC) study." Prev Med. 2000;30(3):252-9.
McGinn AP, Rosamond WD, Goff DC, Taylor HA, Miles SJ, Chambless L. "Trends in prehospital delay time and use of emergency medical services for acute myocardial infarction: experience in 4 US communities from 1987-2000." Am Heart J. 2005;150(3):392-400.
Goff DC, Howard G, Wang CH, et al. "Trends in severity of hospitalized myocardial infarction: the atherosclerosis risk in communities (ARIC) study, 1987-1994." Am Heart J. 2000;139(5):874-80.
Koton S, Sang Y, Schneider ALC, Rosamond WD, Gottesman RF. "Trends in Stroke Incidence Rates in Older US Adults: An Update From the Atherosclerosis Risk in Communities (ARIC) Cohort Study." JAMA Neurol. 2020;77(1):109-113.
Rosamond WD, Chambless LE, Folsom AR, et al. "Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994." N Engl J Med. 1998;339(13):861-7.
Rosamond WD, Chambless LE, Sorlie PD, et al. "Trends in the sensitivity, positive predictive value, false-positive rate, and comparability ratio of hospital discharge diagnosis codes for acute myocardial infarction in four US communities, 1987-2000." Am J Epidemiol. 2004;160(12):1137-46.
Caughey MC, Arora S, Qamar A, et al. "Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In-Hospital-Onset Versus Out-of-Hospital Onset: The ARIC Study." J Am Heart Assoc. 2021;10(2):e018414.
Cowan LT, Buck B, Schwind JS, et al. "Triggering of cardiovascular disease by infection type: The atherosclerosis risk in communities study (ARIC)." Int J Cardiol. 2020.
Hussain A, Sun C, Selvin E, et al. "Triglyceride-rich lipoproteins, apolipoprotein C-III, angiopoietin-like protein 3, and cardiovascular events in older adults: Atherosclerosis Risk in Communities (ARIC) study." Eur J Prev Cardiol. 2021.
Nambi V, Liu X, Chambless LE, et al. "Troponin T and N-terminal pro-B-type natriuretic peptide: a biomarker approach to predict heart failure risk--the atherosclerosis risk in communities study." Clin Chem. 2013;59(12):1802-10.
Oluleye OW, Folsom AR, Nambi V, Lutsey PL, Ballantyne CM. "Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality." Ann Epidemiol. 2013;23(2):66-73.
Folsom AR, Nambi V, Bell EJ, et al. "Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: the atherosclerosis risk in communities study." Stroke. 2013;44(4):961-7.
Folsom AR, Lutsey PL, Nambi V, Defilippi CR, Heckbert SR, Cushman M. "Troponin T, NT-proBNP, and venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)." Vasc Med. 2014;19(1):33-41.
Kubota Y, Cushman M, Zakai N, Rosamond WD. "TV viewing and incident venous thromboembolism: the Atherosclerotic Risk in Communities Study." J Thromb Thrombolysis. 2018;45(3):353-359.
Voight BF, Scott LJ, Steinthorsdottir V, et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010;42(7):579-89.
Arora S, Stouffer GA, Kucharska-Newton AMaria, et al. "Twenty Year Trends and Sex Differences in Young Adults Hospitalized With Acute Myocardial Infarction." Circulation. 2019;139(8):1047-1056.
Verweij N, Mateo Leach I, Isaacs A, et al. "Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram." Hum Mol Genet. 2016;25(10):2093-2103.
Rosamond WD, Chambless LE, Heiss G, et al. "Twenty-two-year trends in incidence of myocardial infarction, coronary heart disease mortality, and case fatality in 4 US communities, 1987-2008." Circulation. 2012;125(15):1848-57.
Kim ED, Soliman EZ, Coresh J, Matsushita K, Chen LYee. "Two-Week Burden of Arrhythmias across CKD Severity in a Large Community-Based Cohort: The ARIC Study." J Am Soc Nephrol. 2021;32(3):629-638.
Mayeda ER, Haan MN, Neuhaus J, et al. "Type 2 diabetes and cognitive decline over 14 years in middle-aged African Americans and whites: the ARIC Brain MRI Study." Neuroepidemiology. 2014;43(3-4):220-7.
Huxley RR, Alonso A, Lopez FL, et al. "Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: the Atherosclerosis Risk in Communities study." Heart. 2012;98(2):133-8.
Rusu V, Hoch E, Mercader JM, et al. "Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms." Cell. 2017;170(1):199-212.e20.
Chiang CWK, Liu C-T, Lettre G, et al. "Ultraconserved elements in the human genome: association and transmission analyses of highly constrained single-nucleotide polymorphisms." Genetics. 2012;192(1):253-66.
Riley WA, Barnes RW, Evans GW, Burke GL. "Ultrasonic measurement of the elastic modulus of the common carotid artery. The Atherosclerosis Risk in Communities (ARIC) Study." Stroke. 1992;23(7):952-6.
Yee SWah, Stecula A, Chien H-C, et al. "Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies." PLoS Genet. 2019;15(9):e1008208.
McAdams-Demarco MA, Maynard JW, Baer AN, Kao LW, Köttgen A, Coresh J. "A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study." Ann Rheum Dis. 2013;72(5):701-6.
Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. "Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?" Atherosclerosis. 2000;148(1):131-9.
Foster MC, Coresh JJ, Bonventre JV, et al. "Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study." Clin J Am Soc Nephrol. 2015;10(11):1956-63.
McMahon GM, Hwang S-J, Clish CB, et al. "Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease." Kidney Int. 2017;91(6):1426-1435.
Sekula P, Tin A, Schultheiss UT, et al. "Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease." Sci Rep. 2020;10(1):10018.
Köttgen A, Hwang S-J, Larson MG, et al. "Uromodulin levels associate with a common UMOD variant and risk for incident CKD." J Am Soc Nephrol. 2010;21(2):337-44.
Ray D, Pankow JS. "USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis." Genet Epidemiol. 2016;40(1):20-34.
Kowalski MH, Qian H, Hou Z, et al. "Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations." PLoS Genet. 2019;15(12):e1008500.
Pendergrass SA, Brown-Gentry K, Dudek SM, et al. "The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery." Genet Epidemiol. 2011;35(5):410-22.
Ozenberger K, G Alexander C, Shin J-I, Whitsel EA, Qato DM. "Use of prescription medications with cardiovascular adverse effects among older adults in the United States." Pharmacoepidemiol Drug Saf. 2022;31(10):1027-1038.
Kucharska-Newton AM, Loop MShane, Bullo M, et al. "Use of troponins in the classification of myocardial infarction from electronic health records. The Atherosclerosis Risk in Communities (ARIC) Study." Int J Cardiol. 2022;348:152-156.
Rodin AS, Litvinenko A, Klos K, et al. "Use of wrapper algorithms coupled with a random forests classifier for variable selection in large-scale genomic association studies." J Comput Biol. 2009;16(12):1705-18.
Zhang Z-M, Rautaharju PM, Prineas RJ, Loehr LR, Rosamond WD. "Usefulness of electrocardiographic QRS/T angles with versus without bundle branch blocks to predict heart failure (from the Atherosclerosis Risk in Communities Study)." Am J Cardiol. 2014;114(3):412-8.
Hermida J, Lopez FL, Montes R, Matsushita K, Astor BC, Alonso A. "Usefulness of high-sensitivity C-reactive protein to predict mortality in patients with atrial fibrillation (from the Atherosclerosis Risk In Communities [ARIC] Study)." Am J Cardiol. 2012;109(1):95-9.
Soliman EZ, Zhang Z-M, Chen LYee, Tereshchenko LG, Arking D. "Usefulness of Maintaining a Normal Electrocardiogram Over Time for Predicting Cardiovascular Health." Am J Cardiol. 2017;119(2):249-255.
Massing MW, Simpson RJ, Rautaharju PM, Schreiner PJ, Crow R, Heiss G. "Usefulness of ventricular premature complexes to predict coronary heart disease events and mortality (from the Atherosclerosis Risk In Communities cohort)." Am J Cardiol. 2006;98(12):1609-12.
Shungin D, Cornelis MC, Divaris K, et al. "Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium." Int J Epidemiol. 2015;44(2):638-50.
Tin A, Colantuoni E, Boerwinkle E, et al. "Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate." J Hum Genet. 2013;58(7):461-6.
Breslow NE, Lumley T, Ballantyne CM, Chambless LE, Kulich M. "Using the whole cohort in the analysis of case-cohort data." Am J Epidemiol. 2009;169(11):1398-405.
Bidulescu A, Chambless LE, Siega-Riz A M, Zeisel SH, Heiss G. "Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study." BMC Cardiovasc Disord. 2007;7:20.
Lusk CM, Dyson G, Clark AG, et al. "Validated context-dependent associations of coronary heart disease risk with genotype variation in the chromosome 9p21 region: the Atherosclerosis Risk in Communities study." Hum Genet. 2014;133(9):1105-16.
Coady SA, Sorlie PD, Cooper LS, Folsom AR, Rosamond WD, Conwill DE. "Validation of death certificate diagnosis for coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study." J Clin Epidemiol. 2001;54(1):40-50.
Wang HE, Donnelly JP, Yende S, et al. "Validation of the REGARDS Severe Sepsis Risk Score." J Clin Med. 2018;7(12).
Schneider ALC, Pankow JS, Heiss G, Selvin E. "Validity and reliability of self-reported diabetes in the Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2012;176(8):738-43.
Jones SA, Gottesman RF, Shahar E, Wruck L. "Validity of hospital discharge diagnosis codes for stroke: the Atherosclerosis Risk in Communities Study." Stroke. 2014;45(11):3219-25.
Bhaskara S, Whitsel EA, Ballantyne CM. "Validity of self-report of lipid medication use: the Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2015;242(2):625-9.
Chambless LE, Zhong MM, Arnett D, Folsom AR, Riley WA, Heiss G. "Variability in B-mode ultrasound measurements in the atherosclerosis risk in communities (ARIC) study." Ultrasound Med Biol. 1996;22(5):545-54.
Arnett DK, Chambless LE, Kim H, Evans GW, Riley W. "Variability in ultrasonic measurements of arterial stiffness in the Atherosclerosis Risk in Communities study." Ultrasound Med Biol. 1999;25(2):175-80.
Afshar-Kharghan V, Matijevic-Aleksic N, Ahn C, Boerwinkle E, Wu KK, López JA. "The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease." Blood. 2004;103(3):963-5.
Shetty PB, Tang H, Feng T, et al. "Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families." Circ Cardiovasc Genet. 2015;8(1):106-13.
Benjamin EJ, Rice KM, Arking DE, et al. "Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry." Nat Genet. 2009;41(8):879-81.
Luo S, Surapaneni A, Zheng Z, et al. "Variants, N-Acetylated Amino Acids, and Progression of CKD." Clin J Am Soc Nephrol. 2020;16(1):37-47.
Lei HH, Coresh J, Shuldiner AR, Boerwinkle E, Brancati FL. "Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study." Diabetes. 1999;48(9):1868-72.
Pearte CA, Myerson M, Coresh J, et al. "Variation and temporal trends in the use of diagnostic testing during hospitalization for acute myocardial infarction by age, gender, race, and geography (the Atherosclerosis Risk In Communities Study)." Am J Cardiol. 2008;101(9):1219-25.
Folsom AR, Peacock JM, Demerath E, Boerwinkle E. "Variation in ANGPTL4 and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study." Metabolism. 2008;57(11):1591-6.
Folsom AR, Peacock JM, Boerwinkle E. "Variation in PCSK9, low LDL cholesterol, and risk of peripheral arterial disease." Atherosclerosis. 2009;202(1):211-5.
Lee M, Whitsel E, Avery C, et al. "Variation in Population Attributable Fraction of Dementia Associated With Potentially Modifiable Risk Factors by Race and Ethnicity in the US." JAMA Netw Open. 2022;5(7):e2219672.
Foraker RE, Rose KM, Kucharska-Newton AM, Ni H, Suchindran CM, Whitsel EA. "Variation in rates of fatal coronary heart disease by neighborhood socioeconomic status: the atherosclerosis risk in communities surveillance (1992-2002)." Ann Epidemiol. 2011;21(8):580-8.