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ARIC Publications

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Wu Y, Waite LL, Jackson AU, et al. "Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained." PLoS Genet. 2013;9(3):e1003379.
Wu A, Coresh JJ, Selvin E, et al. "Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community." J Am Heart Assoc. 2017;6(1).
Wu KK, Aleksic N, Ballantyne CM, Ahn C, Juneja H, Boerwinkle E. "Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease." Circulation. 2003;107(13):1729-32.
Wu KK, Aleksic N, Ahn C, Boerwinkle E, Folsom AR, Juneja H. "Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease." Circulation. 2001;103(10):1386-9.
Wu B, Pankow JS. "Sequence Kernel Association Analysis of Rare Variant Set Based on the Marginal Regression Model for Binary Traits." Genet Epidemiol. 2015;39(6):399-405.
Wu KK, Folsom AR, Heiss G, Davis CE, Conlan MG, Barnes R. "Association of coagulation factors and inhibitors with carotid artery atherosclerosis. Early results of the Atherosclerosis Risk in Communities (ARIC) Study." Ann Epidemiol. 1992;2(4):471-80.
Wu B. "Statistical methods for association tests of multiple continuous traits in genome-wide association studies." Ann Hum Genet. 2015;79(4):282-93.
Wu KK, Papp AC, Patsch W, Rock R, Eckfeldt J, Sharrett R. "ARIC hemostasis study--II. Organizational plan and feasibility study." Thromb Haemost. 1990;64(4):521-5.
Wuttke M, Li Y, Li M, et al. "A catalog of genetic loci associated with kidney function from analyses of a million individuals." Nat Genet. 2019;51(6):957-972.
Wyss AB, Sofer T, Lee MKyeong, et al. "Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function." Nat Commun. 2018;9(1):2976.
Xiao Q, Heiss G, Kucharska-Newton A, Bey G, Love S-AM, Whitsel EA. "Life-Course Neighborhood Socioeconomic Status and Cardiovascular Events in Black and White Adults in the Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2022;191(8):1470-1484.
Xing C, Dupuis J. "Performance of statistical methods on CHARGE targeted sequencing data." BMC Genet. 2014;15:104.
Xu J, Bartz TM, Chittoor G, et al. "Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function." Br J Nutr. 2018;120(10):1159-1170.
Xu J, Liu G, Hegde SM, et al. "Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study." Metabolites. 2021;11(1).
Xu J, Gaddis NC, Bartz TM, et al. "Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association." Am J Respir Crit Care Med. 2019;199(5):631-642.
Xu Y, Kim S, Zhang M-J, Couper D, Ahn KWoo. "Competing risks regression models with covariates-adjusted censoring weight under the generalized case-cohort design." Lifetime Data Anal. 2022;28(2):241-262.
Xu H, Schwander K, Brown MR, et al. "Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions." Eur J Hum Genet. 2021;29(5):839-850.
Xu Z, Steffen LM, Selvin E. "Diet quality, change in diet quality and risk of incident CVD and diabetes." Public Health Nutr. 2020;23(2):329-338.
Xu H, Zhang H, Yang W, et al. "Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children." Nat Commun. 2015;6:7553.
Xue D, Bush WS, Renton AE, et al. "Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease." Alzheimers Dement (Amst). 2021;13(1):e12255.
Yaghootkar H, Scott RA, White CC, et al. "Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes." Diabetes. 2014;63(12):4369-77.
Yaghootkar H, Lamina C, Scott RA, et al. "Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes." Diabetes. 2013;62(10):3589-98.
Yamagishi K, Nettleton JA, Folsom AR. "Plasma fatty acid composition and incident heart failure in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study." Am Heart J. 2008;156(5):965-74.
Yamagishi K, Cushman M, Heckbert SR, Tsai MY, Folsom AR. "Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective study." Br J Haematol. 2009;145(2):221-6.
Yamagishi K, Aleksic N, Hannan PJ, Folsom AR. "Coagulation factors II, V, IX, X, XI, and XII, plasminogen, and alpha-2 antiplasmin and risk of coronary heart disease." J Atheroscler Thromb. 2010;17(4):402-9.
Yamagishi K, Folsom AR, Rosamond WD, Boerwinkle E. "A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study." Eur Heart J. 2009;30(10):1222-8.
Yamagishi K, Folsom AR. "Plasma fatty acid composition and incident ischemic stroke in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study." Cerebrovasc Dis. 2013;36(1):38-46.
Yan Y, Klein R, Heiss G, et al. "The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study." BMC Endocr Disord. 2010;10:9.
Yan Y, North KE, Ballantyne CM, et al. "Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study." Diabetes. 2009;58(1):285-9.
Yang EY, Chambless L, A Sharrett R, et al. "Carotid arterial wall characteristics are associated with incident ischemic stroke but not coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2012;43(1):103-8.
Yang Y, Knol MJ, Wang R, et al. "Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI." Brain. 2022.
Yang EY, Nambi V, Tang Z, et al. "Clinical implications of JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) in a U.S. population insights from the ARIC (Atherosclerosis Risk in Communities) study." J Am Coll Cardiol. 2009;54(25):2388-95.
Yang Y, Bartz TM, Brown MR, et al. "Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation." Circ Genom Precis Med. 2021;14(6):e003460.
Yang C, Kwak L, Ballew SH, et al. "Kidney function, bone-mineral metabolism markers, and future risk of peripheral artery disease." Atherosclerosis. 2017;267:167-174.
Yang J, Loos RJF, Powell JE, et al. "FTO genotype is associated with phenotypic variability of body mass index." Nature. 2012;490(7419):267-72.
Yang C, Kwak L, Ballew SH, et al. "Retinal microvascular findings and risk of incident peripheral artery disease: An analysis from the Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2020;294:62-71.
Yano Y, Griswold M, Wang W, et al. "Long-Term Blood Pressure Level and Variability From Midlife to Later Life and Subsequent Cognitive Change: The ARIC Neurocognitive Study." J Am Heart Assoc. 2018;7(15):e009578.
Yao L, Folsom AR, Pankow JS, et al. "Parathyroid hormone and the risk of incident hypertension: the Atherosclerosis Risk in Communities study." J Hypertens. 2016;34(2):196-203.
Yao L, Folsom AR, Alonso A, et al. "Association of carotid atherosclerosis and stiffness with abdominal aortic aneurysm: The atherosclerosis risk in communities (ARIC) study." Atherosclerosis. 2018;270:110-116.
Yatsuya H, Folsom AR, Yamagishi K, North KE, Brancati FL, Stevens J. "Race- and sex-specific associations of obesity measures with ischemic stroke incidence in the Atherosclerosis Risk in Communities (ARIC) study." Stroke. 2010;41(3):417-25.
Yatsuya H, Yamagishi K, North KE, Brancati FL, Stevens J, Folsom AR. "Associations of obesity measures with subtypes of ischemic stroke in the ARIC Study." J Epidemiol. 2010;20(5):347-54.
Yatsuya H, Folsom AR. "Risk of incident cardiovascular disease among users of smokeless tobacco in the Atherosclerosis Risk in Communities (ARIC) study." Am J Epidemiol. 2010;172(5):600-5.
Yatsuya H, Folsom AR, Wong TY, Klein R, Klein BEK, A Sharrett R. "Retinal microvascular abnormalities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study." Stroke. 2010;41(7):1349-55.
Yatsuya H, Folsom AR, Alonso A, Gottesman RF, Rose KM. "Postural changes in blood pressure and incidence of ischemic stroke subtypes: the ARIC study." Hypertension. 2011;57(2):167-73.
Yazdani A, Yazdani A, Liu X. "Identification of Rare Variants in Metabolites of the Carnitine Pathway by Whole Genome Sequencing Analysis." Genet Epidemiol. 2016;40(6):486-91.
Yazdani A, Yazdani A, Samiei A. "Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data." J Biomed Inform. 2016;60:114-9.
Yazdani A, Yazdani A. "A Causal Network Analysis of the Fatty Acid Metabolome in African-Americans Reveals a Critical Role for Palmitoleate and Margarate." OMICS. 2016;20(8):480-4.
Yazdani A, Yazdani A, Samiei A. "Identification, analysis, and interpretation of a human serum metabolomics causal network in an observational study." J Biomed Inform. 2016;63:337-343.
Yazdani A, Yazdani A, Saniei A. "A causal network analysis in an observational study identifies metabolomics pathways influencing plasma triglyceride levels." Metabolomics. 2016;12:104.
Yazdani A, Yazdani A. "Rare variants analysis using penalization methods for whole genome sequence data." BMC Bioinformatics. 2015;16:405.
Yeap BBeng, Marriott RJames, Adams RJ, et al. "Androgens In Men Study (AIMS): protocol for meta-analyses of individual participant data investigating associations of androgens with health outcomes in men." BMJ Open. 2020;10(5):e034777.
Yee SWah, Stecula A, Chien H-C, et al. "Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies." PLoS Genet. 2019;15(9):e1008208.
Yeh H-C, Duncan BB, Schmidt M I, Wang N-Y, Brancati FL. "Smoking, smoking cessation, and risk for type 2 diabetes mellitus: a cohort study." Ann Intern Med. 2010;152(1):10-7.
Yeh H-C, Punjabi NM, Wang N-Y, et al. "Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study." Diabetes Care. 2008;31(4):741-6.
Yeh H-C, Punjabi NM, Wang N-Y, Pankow JS, Duncan BB, Brancati FL. "Vital capacity as a predictor of incident type 2 diabetes: the Atherosclerosis Risk in Communities study." Diabetes Care. 2005;28(6):1472-9.
Yende S, Alvarez K, Loehr L, et al. "Epidemiology and long-term clinical and biologic risk factors for pneumonia in community-dwelling older Americans: analysis of three cohorts." Chest. 2013;144(3):1008-1017.
Yeung EH, Saudek CD, Jahren HA, et al. "Evaluation of a novel isotope biomarker for dietary consumption of sweets." Am J Epidemiol. 2010;172(9):1045-52.
Yeung EH, Pankow JS, Astor BC, Powe NR, Saudek CD, Kao LWH. "Increased risk of type 2 diabetes from a family history of coronary heart disease and type 2 diabetes." Diabetes Care. 2007;30(1):154-6.
Yi S-Y, Steffen LM, Haring B, Rebholz CM, Mosley TH, Shah AM. "Associations of the Dietary Approaches to Stop Hypertension dietary pattern with cardiac structure and function." Nutr Metab Cardiovasc Dis. 2021;31(12):3345-3351.
Yi S-Y, Steffen LM, Lutsey PL, Cushman M, Folsom AR. "Contrasting Associations of Prudent and Western Dietary Patterns with Risk of Developing Venous Thromboembolism." Am J Med. 2021.
Yi JS, Morales EEGarcia, Betz JF, et al. "Individual Life-Course Socioeconomic Position and Hearing Aid Use in the Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2022;77(3):645-653.
Yoneyama S, Yao J, Guo X, et al. "Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations." Int J Obes (Lond). 2017;41(2):324-331.
Yoneyama S, Guo Y, Lanktree MB, et al. "Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations." Hum Mol Genet. 2014;23(9):2498-510.
Yong F, Heiss G, Couper DJ, Meyer ML, Cheng S. "Measurement Repeatability of Central and Peripheral Blood Pressures: The ARIC Study." Am J Hypertens. 2017;30(10):978-984.
Yoshida Y, Chen Z, Baudier RL, et al. "Menopausal hormone therapy and risk of cardiovascular events in women with prediabetes or type 2 diabetes: A pooled analysis of 2917 postmenopausal women." Atherosclerosis. 2022;344:13-19.
Young KL, Graff M, Fernández-Rhodes L. "Genetics of Obesity in Diverse Populations." Curr Diab Rep. 2018;18(12):145.
Young SE, Mainous AG, Carnemolla M. "Hyperinsulinemia and cognitive decline in a middle-aged cohort." Diabetes Care. 2006;29(12):2688-93.
Yu B, Zheng Y, Alexander D, Morrison AC, Coresh JJ. "Genetic determinants influencing human serum metabolome among African Americans." PLoS Genet. 2014;10(3):e1004212.
Yu Z, Rebholz CM, Wong E, Chen Y, Matsushita K, Coresh JJ. "Association Between Hypertension and Kidney Function Decline: The Atherosclerosis Risk in Communities (ARIC) Study." Am J Kidney Dis. 2019;74(3):310-319.
Yu B, Zheng Y, Nettleton JA, Alexander D, Coresh JJ. "Serum metabolomic profiling and incident CKD among African Americans." Clin J Am Soc Nephrol. 2014;9(8):1410-7.
Yu F, Lu J, Liu X, et al. "Population genomic analysis of 962 whole genome sequences of humans reveals natural selection in non-coding regions." PLoS One. 2015;10(3):e0121644.
Yu B, Flexeder C, McGarrah RW, et al. "Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population." Metabolites. 2019;9(4).
Yu B, Pulit SL, Hwang S-J, et al. "Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk." Circ Cardiovasc Genet. 2016;9(1):64-70.
Yu B, Li AH, Muzny D, et al. "Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine: Levels and Incident Coronary Heart Disease." Circ Cardiovasc Genet. 2015;8(2):351-5.
Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA. "Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study." Genet Epidemiol. 2013;37(8):840-5.
Yu B, Heiss G, Alexander D, Grams ME. "Associations Between the Serum Metabolome and All-Cause Mortality Among African Americans in the Atherosclerosis Risk in Communities (ARIC) Study." Am J Epidemiol. 2016;183(7):650-6.
Yu B, Li AH, Metcalf GA, et al. "Loss-of-function variants influence the human serum metabolome." Sci Adv. 2016;2(8):e1600800.
Yu Z, Jin J, Tin A, et al. "Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases." J Am Soc Nephrol. 2021.
Yu Z, Grams ME, Ndumele CE, et al. "Association Between Midlife Obesity and Kidney Function Trajectories: The Atherosclerosis Risk in Communities (ARIC) Study." Am J Kidney Dis. 2020.
Yu B, Barbalic M, Brautbar A, et al. "Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies." Circ Cardiovasc Genet. 2013;6(1):82-8.