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ARIC Publications

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Musunuru K, Romaine SPR, Lettre G, et al. "Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project." PLoS One. 2012;7(5):e36473.
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Nalls MA, Couper DJ, Tanaka T, et al. "Multiple loci are associated with white blood cell phenotypes." PLoS Genet. 2011;7(6):e1002113.
Nambi V, Boerwinkle E, Lawson K, et al. "The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study." Atherosclerosis. 2012;222(1):135-7.
Napier MD, Franceschini N, Gondalia R, et al. "Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy." Sci Rep. 2018;8(1):5675.
Natarajan P, Pampana A, Graham SE, et al. "Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices." Nat Commun. 2021;12(1):2182.
Nettleton JA, Hivert M-F, Lemaitre RN, et al. "Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts." Am J Epidemiol. 2013;177(2):103-15.
Nettleton JA, Steffen LM, Ballantyne CM, Boerwinkle E, Folsom AR. "Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults." Atherosclerosis. 2007;194(2):e131-40.
Nettleton JA, McKeown NM, Kanoni S, et al. "Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies." Diabetes Care. 2010;33(12):2684-91.
Nettleton JA, Follis JL, Ngwa JS, et al. "Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry." Hum Mol Genet. 2015;24(16):4728-38.
Noordam R, Bos MM, Wang H, et al. "Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration." Nat Commun. 2019;10(1):5121.
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Pankow JS, Tang W, Pankratz N, et al. "Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities)." Arterioscler Thromb Vasc Biol. 2017;37(3):589-597.
Pankratz N, Wei P, Brody JA, et al. "Whole-exome sequencing of 14 389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors." Hum Mol Genet. 2022;31(18):3120-3132.
S Park L, Fesinmeyer MD, Timofeeva M, et al. "Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia." J Natl Cancer Inst. 2014;106(4):dju061.
Park SLani, Cheng I, Pendergrass SA, et al. "Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study." Am J Epidemiol. 2013;178(5):780-90.
Parsa A, Fuchsberger C, Köttgen A, et al. "Common variants in Mendelian kidney disease genes and their association with renal function." J Am Soc Nephrol. 2013;24(12):2105-17.
Pendergrass SA, Brown-Gentry K, Dudek SM, et al. "The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery." Genet Epidemiol. 2011;35(5):410-22.
Pendergrass SA, Buyske S, Jeff JM, et al. "A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans." PLoS One. 2019;14(12):e0226771.
Pendergrass SA, Brown-Gentry K, Dudek S, et al. "Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network." PLoS Genet. 2013;9(1):e1003087.
Perry JRb, Day F, Elks CE, et al. "Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche." Nature. 2014;514(7520):92-97.
Perry JRB, Voight BF, Yengo L, et al. "Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases." PLoS Genet. 2012;8(5):e1002741.
Perry JRB, Stolk L, Franceschini N, et al. "Meta-analysis of genome-wide association data identifies two loci influencing age at menarche." Nat Genet. 2009;41(6):648-50.
Petty LE, Highland HM, Gamazon ER, et al. "Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample." Hum Mol Genet. 2019;28(7):1212-1224.
Pirastu N, Joshi PK, de Vries PS, et al. "GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk." Nat Commun. 2017;8(1):1584.
Postmus I, Warren HR, Trompet S, et al. "Meta-analysis of genome-wide association studies of HDL cholesterol response to statins." J Med Genet. 2016;53(12):835-845.
Postmus I, Trompet S, Deshmukh HA, et al. "Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins." Nat Commun. 2014;5:5068.
Prins BP, Mead TJ, Brody JA, et al. "Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6." Genome Biol. 2018;19(1):87.
Prizment AE, Folsom AR, Dreyfus J, et al. "Plasma C-reactive protein, genetic risk score, and risk of common cancers in the Atherosclerosis Risk in Communities study." Cancer Causes Control. 2013;24(12):2077-87.
Prudente S, Copetti M, Morini E, et al. "The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry." Nutr Metab Cardiovasc Dis. 2013;23(11):1043-9.
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Qayyum R, Snively BM, Ziv E, et al. "A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans." PLoS Genet. 2012;8(3):e1002491.
Qi Q, Kilpeläinen TO, Downer MK, et al. "FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals." Hum Mol Genet. 2014;23(25):6961-72.
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Raffield LM, Iyengar AK, Wang B, et al. "Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts." Am J Hum Genet. 2020;106(1):112-120.
Rannikmae K, Sivakumaran V, Millar H, et al. " is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls." Neurology. 2017;89(17):1829-1839.
Rasmussen-Torvik LJ, Li M, Kao WH, et al. "Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study." Diabetes. 2011;60(1):331-5.
Rasmussen-Torvik LJ, Alonso A, Li M, et al. "Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose." Genet Epidemiol. 2010;34(7):665-73.
Ray D, Li X, Pan W, Pankow JS. "A Bayesian Partitioning Model for the Detection of Multilocus Effects in Case-Control Studies." Hum Hered. 2015;79(2):69-79.
Ray D, Pankow JS. "USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis." Genet Epidemiol. 2016;40(1):20-34.
Reich D, Nalls MA, Kao LWH, et al. "Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene." PLoS Genet. 2009;5(1):e1000360.
Reiner AP, Lettre G, Nalls MA, et al. "Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)." PLoS Genet. 2011;7(6):e1002108.
Reis JP, Michos ED, Selvin E, Pankow JS. "Race, vitamin D-binding protein gene polymorphisms, 25-hydroxyvitamin D, and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study." Am J Clin Nutr. 2015;101(6):1232-40.
Rhee EP, Yang Q, Yu B, et al. "An exome array study of the plasma metabolome." Nat Commun. 2016;7:12360.
Rhodin K, Divaris K, North KE, Barros SP, Moss K, Beck JD. "Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses." J Dent Res. 2014;93(9):882-90.
Richardson K, Nettleton JA, Rotllan N, et al. "Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site." Am J Hum Genet. 2013;92(1):5-14.
Riveros-Mckay F, Roberts D, Di Angelantonio E, et al. "An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript." Diabetes. 2022;71(2):359-364.
Roberts JD, Hu D, Heckbert SR, et al. "Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals." JAMA Cardiol. 2016;1(4):442-50.
Roberts JD, Dewland TA, Glidden DV, et al. "Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation." Am Heart J. 2016;175:9-17.
Robinson-Cohen C, Bartz TM, Lai D, et al. "Genetic Variants Associated with Circulating Fibroblast Growth Factor 23." J Am Soc Nephrol. 2018;29(10):2583-2592.
Robinson-Cohen C, Lutsey PL, Kleber ME, et al. "Genetic Variants Associated with Circulating Parathyroid Hormone." J Am Soc Nephrol. 2017;28(5):1553-1565.
Rodriguez S, Gaunt TR, Guo Y, et al. "Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array." Eur J Hum Genet. 2016;24(1):106-12.
Roetker NS, Armasu SM, Pankow JS, et al. "Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis." J Thromb Haemost. 2017;15(7):1334-1343.
Rooney MR, Pankow JS, Sibley SD, Selvin E, Reis JP, Michos ED. "Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study." Am J Clin Nutr. 2016;104(4):1023-1029.
Rosenthal EA, Ranchalis J, Crosslin DR, et al. "Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia." Am J Hum Genet. 2013;93(6):1035-45.
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Sabater-Lleal M, Huang J, Chasman D, et al. "Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease." Circulation. 2013;128(12):1310-24.
Sakornsakolpat P, Prokopenko D, Lamontagne M, et al. "Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations." Nat Genet. 2019;51(3):494-505.
Salfati E, Morrison AC, Boerwinkle E. "Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC)." PLoS One. 2015;10(7):e0133031.
Sanders AE, Sofer T, Wong Q, et al. "Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos." J Dent Res. 2017;96(1):64-72.
Sanna S, Jackson AU, Nagaraja R, et al. "Common variants in the GDF5-UQCC region are associated with variation in human height." Nat Genet. 2008;40(2):198-203.
Sarnowski C, Cousminer DL, Franceschini N, et al. "Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche." Hum Reprod. 2021;36(7):1999-2010.
Sarnowski C, Leong A, Raffield LM, et al. "Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program." Am J Hum Genet. 2019;105(4):706-718.
Scharpf RB, Mireles L, Yang Q, et al. "Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations." BMC Genet. 2014;15:81.
Schick UM, Auer PL, Bis JC, et al. "Association of exome sequences with plasma C-reactive protein levels in >9000 participants." Hum Mol Genet. 2015;24(2):559-71.
Schneider ALC, Lutsey PL, Selvin E, et al. "Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study." Eur J Neurol. 2015;22(8):1220-7.
Schultheiss UT, Teumer A, Medici M, et al. "A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations." J Clin Endocrinol Metab. 2015;100(5):E799-807.
Scott RA, Chu AY, Grarup N, et al. "No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels." Diabetes. 2012;61(5):1291-6.
Seidelmann SB, Vardeny O, Claggett B, et al. "An Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality." J Am Heart Assoc. 2017;6(4).
Selvaraj S, Claggett B, Minamisawa M, et al. "Atrial Fibrillation and Ischemic Stroke With the Amyloidogenic V122I Transthyretin Variant Among Black Americans." J Am Coll Cardiol. 2021;78(1):89-91.
Sennblad B, Basu S, Mazur J, et al. "Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels." Hum Mol Genet. 2017;26(3):637-649.
Seyerle AA, Sitlani CM, Noordam R, et al. "Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology." Pharmacogenomics J. 2018;18(2):215-226.
Shetty PB, Tang H, Feng T, et al. "Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families." Circ Cardiovasc Genet. 2015;8(1):106-13.
Shi G, Boerwinkle E, Morrison AC, Gu CC, Chakravarti A, Rao DC. "Mining gold dust under the genome wide significance level: a two-stage approach to analysis of GWAS." Genet Epidemiol. 2011;35(2):111-8.
Shungin D, Haworth S, Divaris K, et al. "Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data." Nat Commun. 2019;10(1):2773.
Shungin D, Winkler TW, Croteau-Chonka DC, et al. "New genetic loci link adipose and insulin biology to body fat distribution." Nature. 2015;518(7538):187-196.
Shungin D, Cornelis MC, Divaris K, et al. "Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium." Int J Epidemiol. 2015;44(2):638-50.
Simino J, Wang Z, Bressler J, et al. "Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study." PLoS One. 2017;12(7):e0180046.
Sims R, van der Lee SJ, Naj AC, et al. "Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease." Nat Genet. 2017;49(9):1373-1384.