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ARIC Publications

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2013
Sabater-Lleal M, Huang J, Chasman D, et al. "Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease." Circulation. 2013;128(12):1310-24.
Dumitrescu L, Carty CL, Franceschini N, et al. "No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population." Hum Genet. 2013;132(12):1427-31.
Olden M, Teumer A, Bochud M, et al. "Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium." Am J Kidney Dis. 2013;61(6):889-98.
Pendergrass SA, Brown-Gentry K, Dudek S, et al. "Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network." PLoS Genet. 2013;9(1):e1003087.
Prizment AE, Folsom AR, Dreyfus J, et al. "Plasma C-reactive protein, genetic risk score, and risk of common cancers in the Atherosclerosis Risk in Communities study." Cancer Causes Control. 2013;24(12):2077-87.
Dumitrescu L, Carty CL, Franceschini N, et al. "Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study." Ann Hum Genet. 2013;77(5):416-25.
Carty CL, Spencer KL, Setiawan VW, et al. "Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study." Hum Reprod. 2013;28(6):1695-706.
Dastani Z, Johnson T, Kronenberg F, Nelson CP, Assimes TL, März W. "The shared allelic architecture of adiponectin levels and coronary artery disease." Atherosclerosis. 2013;229(1):145-8.
Peters U, North KE, Sethupathy P, et al. "A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study." PLoS Genet. 2013;9(1):e1003171.
Wu Y, Waite LL, Jackson AU, et al. "Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained." PLoS Genet. 2013;9(3):e1003379.
C Y Ng M, Saxena R, Li J, et al. "Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study." Diabetes. 2013;62(3):965-76.
Morrison AC, Voorman A, Johnson AD, et al. "Whole-genome sequence-based analysis of high-density lipoprotein cholesterol." Nat Genet. 2013;45(8):899-901.
2012
Cheng C-Y, Reich D, Haiman CA, et al. "African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts." PLoS One. 2012;7(3):e32840.
Murabito JM, White CC, Kavousi M, et al. "Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies." Circ Cardiovasc Genet. 2012;5(1):100-12.
Köttgen A, Yang Q, Shimmin LC, et al. "Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing." PLoS One. 2012;7(5):e38311.
Carty CL, Bůžková P, Fornage M, et al. "Associations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study." Circ Cardiovasc Genet. 2012;5(2):210-6.
Bis JC, DeCarli C, Smith A V, et al. "Common variants at 12q14 and 12q24 are associated with hippocampal volume." Nat Genet. 2012;44(5):545-51.
Holliday EG, Maguire JM, Evans T-J, et al. "Common variants at 6p21.1 are associated with large artery atherosclerotic stroke." Nat Genet. 2012;44(10):1147-51.
Franceschini N, van Rooij FJA, Prins BP, et al. "Discovery and fine mapping of serum protein loci through transethnic meta-analysis." Am J Hum Genet. 2012;91(4):744-53.
Grallert H, Dupuis J, Bis JC, et al. "Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies." Eur Heart J. 2012;33(2):238-51.
Buyske S, Wu Y, Carty CL, et al. "Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study." PLoS One. 2012;7(4):e35651.
Avery CL, Sethupathy P, Buyske S, et al. "Fine-mapping and initial characterization of QT interval loci in African Americans." PLoS Genet. 2012;8(8):e1002870.
Yang J, Loos RJF, Powell JE, et al. "FTO genotype is associated with phenotypic variability of body mass index." Nature. 2012;490(7419):267-72.
Tang W, Schwienbacher C, Lopez LM, et al. "Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease." Am J Hum Genet. 2012;91(1):152-62.
Traylor M, Farrall M, Holliday EG, et al. "Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies." Lancet Neurol. 2012;11(11):951-62.
Manning AK, Hivert M-F, Scott RA, et al. "A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance." Nat Genet. 2012;44(6):659-69.
Pattaro C, Köttgen A, Teumer A, et al. "Genome-wide association and functional follow-up reveals new loci for kidney function." PLoS Genet. 2012;8(3):e1002584.
Huang J, Sabater-Lleal M, Asselbergs FW, et al. "Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation." Blood. 2012;120(24):4873-81.
Imboden M, Bouzigon E, Curjuric I, et al. "Genome-wide association study of lung function decline in adults with and without asthma." J Allergy Clin Immunol. 2012;129(5):1218-28.
Divaris K, Monda KL, North KE, et al. "Genome-wide association study of periodontal pathogen colonization." J Dent Res. 2012;91(7 Suppl):21S-28S.
David SP, Hamidovic A, Chen GK, et al. "Genome-wide meta-analyses of smoking behaviors in African Americans." Transl Psychiatry. 2012;2:e119.
Boraska V, Jerončić A, Colonna V, et al. "Genome-wide meta-analysis of common variant differences between men and women." Hum Mol Genet. 2012;21(21):4805-15.
J Smith G, Avery CL, Evans DS, et al. "Impact of ancestry and common genetic variants on QT interval in African Americans." Circ Cardiovasc Genet. 2012;5(6):647-55.
Billings LK, Hsu Y-H, Ackerman RJ, et al. "Impact of common variation in bone-related genes on type 2 diabetes and related traits." Diabetes. 2012;61(8):2176-86.
Auer PL, Johnsen JM, Johnson AD, et al. "Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project." Am J Hum Genet. 2012;91(5):794-808.
Chasman DI, Fuchsberger C, Pattaro C, et al. "Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function." Hum Mol Genet. 2012;21(24):5329-43.
Ma L, Brautbar A, Boerwinkle E, Sing CF, Clark AG. "Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations." PLoS Genet. 2012;8(5):e1002714.
Scott RA, Lagou V, Welch RP, et al. "Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways." Nat Genet. 2012;44(9):991-1005.
Morris AP, Voight BF, Teslovich TM, et al. "Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes." Nat Genet. 2012;44(9):981-90.
Asselbergs FW, Guo Y, van Iperen EPA, et al. "Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci." Am J Hum Genet. 2012;91(5):823-38.
Stolk L, Perry JRB, Chasman DI, et al. "Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways." Nat Genet. 2012;44(3):260-8.
Qayyum R, Snively BM, Ziv E, et al. "A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans." PLoS Genet. 2012;8(3):e1002491.
Ellinor PT, Lunetta KL, Albert CM, et al. "Meta-analysis identifies six new susceptibility loci for atrial fibrillation." Nat Genet. 2012;44(6):670-5.
Butler AM, Yin X, Evans DS, et al. "Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts." Circ Cardiovasc Genet. 2012;5(6):639-46.
Dastani Z, Hivert M-F, Timpson N, et al. "Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals." PLoS Genet. 2012;8(3):e1002607.
Perry JRB, Voight BF, Yengo L, et al. "Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases." PLoS Genet. 2012;8(5):e1002741.
2011
Rasmussen-Torvik LJ, Li M, Kao WH, et al. "Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study." Diabetes. 2011;60(1):331-5.
Kraja AT, Vaidya D, Pankow JS, et al. "A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium." Diabetes. 2011;60(4):1329-39.
Huang H, Chanda P, Alonso A, Bader JS, Arking DE. "Gene-based tests of association." PLoS Genet. 2011;7(7):e1002177.
Lemaitre RN, Tanaka T, Tang W, et al. "Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium." PLoS Genet. 2011;7(7):e1002193.
Ehret GB, Munroe PB, Rice KM, et al. "Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk." Nature. 2011;478(7367):103-9.
Hsu CC, Kao WL, Steffes MW, et al. "Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) study." BMC Med Genet. 2011;12:16.
Barbalic M, Reiner AP, Wu C, et al. "Genome-wide association analysis of incident coronary heart disease (CHD) in African Americans: a short report." PLoS Genet. 2011;7(8):e1002199.
Artigas MSoler, Loth DW, Wain LV, et al. "Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function." Nat Genet. 2011;43(11):1082-90.
Fornage M, Debette S, Bis JC, et al. "Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium." Ann Neurol. 2011;69(6):928-39.
Tin A, Woodward OM, Kao W H L, et al. "Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele." Hum Mol Genet. 2011;20(20):4056-68.
Wain LV, Verwoert GC, O'Reilly PF, et al. "Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure." Nat Genet. 2011;43(10):1005-11.
Walter S, Atzmon G, Demerath EW, et al. "A genome-wide association study of aging." Neurobiol Aging. 2011;32(11):2109.e15-28.
Reiner AP, Lettre G, Nalls MA, et al. "Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)." PLoS Genet. 2011;7(6):e1002108.
Cornelis MC, Monda KL, Yu K, et al. "Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption." PLoS Genet. 2011;7(4):e1002033.
Arking DE, M Junttila J, Goyette P, et al. "Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals." PLoS Genet. 2011;7(6):e1002158.
Bis JC, Kavousi M, Franceschini N, et al. "Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque." Nat Genet. 2011;43(10):940-7.
Dehghan A, Dupuis J, Barbalic M, et al. "Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels." Circulation. 2011;123(7):731-8.
Shi G, Boerwinkle E, Morrison AC, Gu CC, Chakravarti A, Rao DC. "Mining gold dust under the genome wide significance level: a two-stage approach to analysis of GWAS." Genet Epidemiol. 2011;35(2):111-8.
Nalls MA, Couper DJ, Tanaka T, et al. "Multiple loci are associated with white blood cell phenotypes." PLoS Genet. 2011;7(6):e1002113.
O'Seaghdha CM, Parekh RS, Hwang S-J, et al. "The MYH9/APOL1 region and chronic kidney disease in European-Americans." Hum Mol Genet. 2011;20(12):2450-6.
Pendergrass SA, Brown-Gentry K, Dudek SM, et al. "The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery." Genet Epidemiol. 2011;35(5):410-22.
2010
Speliotes EK, Willer CJ, Berndt SI, et al. "Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index." Nat Genet. 2010;42(11):937-48.
Smith NL, Felix JF, Morrison AC, et al. "Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium." Circ Cardiovasc Genet. 2010;3(3):256-66.
Teslovich TM, Musunuru K, Smith AV, et al. "Biological, clinical and population relevance of 95 loci for blood lipids." Nature. 2010;466(7307):707-13.
Soranzo N, Sanna S, Wheeler E, et al. "Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways." Diabetes. 2010;59(12):3229-39.
Sotoodehnia N, Isaacs A, de Bakker PIW, et al. "Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction." Nat Genet. 2010;42(12):1068-76.
Ellinor PT, Lunetta KL, Glazer NL, et al. "Common variants in KCNN3 are associated with lone atrial fibrillation." Nat Genet. 2010;42(3):240-4.
Meyer TE, Boerwinkle E, Morrison AC, et al. "Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study." Cancer Epidemiol Biomarkers Prev. 2010;19(2):558-65.
Bressler J, Folsom AR, Couper DJ, Volcik KA, Boerwinkle E. "Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study." Am J Epidemiol. 2010;171(1):14-23.
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, et al. "Genome-wide association analysis identifies multiple loci related to resting heart rate." Hum Mol Genet. 2010;19(19):3885-94.
Meyer TE, Verwoert GC, Hwang S-J, et al. "Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels." PLoS Genet. 2010;6(8).
Arking DE, Reinier K, Post W, et al. "Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest." PLoS One. 2010;5(3):e9879.
Tang W, Basu S, Kong X, et al. "Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study." Blood. 2010;116(23):5032-6.
Pfeufer A, van Noord C, Marciante KD, et al. "Genome-wide association study of PR interval." Nat Genet. 2010;42(2):153-9.

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