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ARIC Publications

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van der Laan SW, Fall T, Soumaré A, et al. "Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study." J Am Coll Cardiol. 2016;68(9):934-45.
Rebholz CM, Crews DC, Grams ME, et al. "DASH (Dietary Approaches to Stop Hypertension) Diet and Risk of Subsequent Kidney Disease." Am J Kidney Dis. 2016;68(6):853-861.
Liu X, Wu C, Li C. "dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs." Hum Mutat. 2016;37(3):235-41.
Rubin J, Matsushita K, Lazo M, et al. "Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population." Clin Biochem. 2016;49(9):657-662.
Deo R, Norby FL, Katz R, et al. "Development and Validation of a Sudden Cardiac Death Prediction Model for the General Population." Circulation. 2016;134(11):806-16.
Fox ER, Samdarshi TE, Musani SK, et al. "Development and Validation of Risk Prediction Models for Cardiovascular Events in Black Adults: The Jackson Heart Study Cohort." JAMA Cardiol. 2016;1(1):15-25.
Schneider ALC, Kalyani RR, Golden S, et al. "Diabetes and Prediabetes and Risk of Hospitalization: The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2016;39(5):772-9.
Bell EJ, Folsom AR, Lutsey PL, Selvin E, Zakai NA, Cushman M. "Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis." Diabetes Res Clin Pract. 2016;111:10-8.
Khera AV, Won H-H, Peloso GM, et al. "Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia." J Am Coll Cardiol. 2016;67(22):2578-89.
McEvoy JW, Chen Y, Rawlings A, et al. "Diastolic Blood Pressure, Subclinical Myocardial Damage, and Cardiac Events: Implications for Blood Pressure Control." J Am Coll Cardiol. 2016;68(16):1713-1722.
Sahli MW, Mares JA, Meyers KJ, et al. "Dietary Intake of Lutein and Diabetic Retinopathy in the Atherosclerosis Risk in Communities Study (ARIC)." Ophthalmic Epidemiol. 2016;23(2):99-108.
J Smith G, Felix JF, Morrison AC, et al. "Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure." PLoS Genet. 2016;12(5):e1006034.
Ligthart S, Marzi C, Aslibekyan S, et al. "DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases." Genome Biol. 2016;17(1):255.
Chen BH, Marioni RE, Colicino E, et al. "DNA methylation-based measures of biological age: meta-analysis predicting time to death." Aging (Albany NY). 2016;8(9):1844-1865.
Konety S, Koene RJ, Norby FL, et al. "Echocardiographic Predictors of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study and Cardiovascular Health Study." Circ Cardiovasc Imaging. 2016;9(8).
Wu B, Guan W. "On Efficient and Accurate Calculation of Significance P-Values for Sequence Kernel Association Testing of Variant Set." Ann Hum Genet. 2016;80(2):123-35.
O'Neal WT, Zhang Z-M, Loehr LR, Chen LYee, Alonso A. "Electrocardiographic Advanced Interatrial Block and Atrial Fibrillation Risk in the General Population." Am J Cardiol. 2016;117(11):1755-9.
O'Neal WT, Wang YGrace, Wu H-T, et al. "Electrocardiographic J Wave and Cardiovascular Outcomes in the General Population (from the Atherosclerosis Risk In Communities Study)." Am J Cardiol. 2016;118(6):811-815.
Sung YJu, Winkler TW, Manning AK, et al. "An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group." Genet Epidemiol. 2016;40(5):404-15.
Joehanes R, Just AC, Marioni RE, et al. "Epigenetic Signatures of Cigarette Smoking." Circ Cardiovasc Genet. 2016;9(5):436-447.
Banack HR. "Estimating the Time-Varying Joint Effects of Obesity and Smoking on All-Cause Mortality Using Marginal Structural Models." Am J Epidemiol. 2016;183(2):122-9.
Rhee EP, Yang Q, Yu B, et al. "An exome array study of the plasma metabolome." Nat Commun. 2016;7:12360.
Chami N, Chen M-H, Slater AJ, et al. "Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits." Am J Hum Genet. 2016;99(1):8-21.
Rawlings AM, Bandeen-Roche K, Gross AL, et al. "Factor structure of the ARIC-NCS Neuropsychological Battery: An evaluation of invariance across vascular factors and demographic characteristics." Psychol Assess. 2016;28(12):1674-1683.
McKibben RA, Zhao D, Lutsey PL, Schneider ALC, Guallar E, Mosley TH. "Factors Associated With Change in 25-Hydroxyvitamin D Levels Over Longitudinal Follow-Up in the ARIC Study." J Clin Endocrinol Metab. 2016;101(1):33-43.
Evans DS, Avery CL, Nalls MA, et al. "Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans." Hum Mol Genet. 2016;25(19):4350-4368.
Zubair N, Graff M, Ambite JLuis, et al. "Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci." Hum Mol Genet. 2016;25(24):5500-5512.
Huang J, Wang K, Wei P, et al. "FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics." Genetics. 2016;202(3):919-29.
Joshi AD, Andersson C, Buch S, et al. "Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies." Gastroenterology. 2016;151(2):351-363.e28.
McEvoy JW, Chen Y, Halushka MK, et al. "Galectin-3 and Risk of Heart Failure and Death in Blacks and Whites." J Am Heart Assoc. 2016;5(5).
Tin A, Balakrishnan P, Beaty TH, Boerwinkle E, Hoogeveen RC, Young JH. "GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study." Diabet Med. 2016;33(7):968-75.
Lin H, Mueller-Nurasyid M, Smith AV, et al. "Gene-gene Interaction Analyses for Atrial Fibrillation." Sci Rep. 2016;6:35371.
Yazdani A, Yazdani A, Samiei A. "Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data." J Biomed Inform. 2016;60:114-9.
Pattaro C, Teumer A, Gorski M, et al. "Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function." Nat Commun. 2016;7:10023.
Roberts JD, Hu D, Heckbert SR, et al. "Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals." JAMA Cardiol. 2016;1(4):442-50.
Allen NB, Lloyd-Jones D, Hwang S-J, et al. "Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies." Am Heart J. 2016;175:112-20.
Khera AV, Emdin CA, Drake I, et al. "Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease." N Engl J Med. 2016;375(24):2349-2358.
Guo D-C, Grove ML, Prakash SK, et al. "Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections." Am J Hum Genet. 2016;99(3):762-769.
Ehret GB, Ferreira T, Chasman DI, et al. "The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals." Nat Genet. 2016;48(10):1171-1184.
Cheng Y-C, Stanne TM, Giese A-K, et al. "Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2." Stroke. 2016;47(2):307-16.
Teumer A, Tin A, Sorice R, et al. "Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes." Diabetes. 2016;65(3):803-17.
van Loon J, Dehghan A, Weihong T, et al. "Genome-wide association studies identify genetic loci for low von Willebrand factor levels." Eur J Hum Genet. 2016;24(7):1035-40.
Dehghan A, Bis JC, White CC, et al. "Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium." PLoS One. 2016;11(3):e0144997.
Offenbacher S, Divaris K, Barros SP, et al. "Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease." Hum Mol Genet. 2016;25(10):2113-2129.
Keaton JM, Hellwege JN, C Y Ng M, et al. "Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans." PLoS One. 2016;11(7):e0159977.
Scott RA, Freitag DF, Li L, et al. "A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease." Sci Transl Med. 2016;8(341):341ra76.
Waks JW, Sitlani CM, Soliman EZ, et al. "Global Electric Heterogeneity Risk Score for Prediction of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies." Circulation. 2016;133(23):2222-34.
Burke BTeevan, Köttgen A, Law A, Grams M, Baer AN, Coresh JJ. "Gout in Older Adults: The Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2016;71(4):536-42.
Matteini AM, Tanaka T, Karasik D, et al. "GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium." Aging Cell. 2016;15(5):792-800.
Deal JA, Sharrett ARichey, Bandeen-Roche K, Kritchevsky SB, Pompeii LA, B Windham G. "Hearing Impairment and Physical Function and Falls in the Atherosclerosis Risk in Communities Hearing Pilot Study." J Am Geriatr Soc. 2016;64(4):906-8.
Fyfe-Johnson AL, Muller CJ, Alonso A, et al. "Heart Rate Variability and Incident Stroke: The Atherosclerosis Risk in Communities Study." Stroke. 2016;47(6):1452-8.
Tanaka H, Heiss G, McCabe EL, et al. "Hemodynamic Correlates of Blood Pressure in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study." J Clin Hypertens (Greenwich). 2016;18(12):1222-1227.
Schneider ALC, Jonassaint C, Sharrett ARichey, et al. "Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study." J Gerontol A Biol Sci Med Sci. 2016;71(6):772-9.
Cowan LT, Alonso A, Pankow JS, Folsom AR, Rosamond WD, Gottesman RF. "Hospitalized Infection as a Trigger for Acute Ischemic Stroke: The Atherosclerosis Risk in Communities Study." Stroke. 2016;47(6):1612-7.
Huang Z, Rustagi N, Veeraraghavan N, et al. "A hybrid computational strategy to address WGS variant analysis in >5000 samples." BMC Bioinformatics. 2016;17(1):361.
Yazdani A, Yazdani A, Samiei A. "Identification, analysis, and interpretation of a human serum metabolomics causal network in an observational study." J Biomed Inform. 2016;63:337-343.
"Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies." Lancet Neurol. 2016;15(7):695-707.
Kucharska-Newton AMaria, Heiss G, Ni H, Stearns SC, Puccinelli-Ortega N, Wruck LM. "Identification of Heart Failure Events in Medicare Claims: The Atherosclerosis Risk in Communities (ARIC) Study." J Card Fail. 2016;22(1):48-55.
Yazdani A, Yazdani A, Liu X. "Identification of Rare Variants in Metabolites of the Carnitine Pathway by Whole Genome Sequencing Analysis." Genet Epidemiol. 2016;40(6):486-91.
Begum F, Ruczinski I, Li S, et al. "Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort." Genet Epidemiol. 2016;40(1):81-8.
Roberts JD, Dewland TA, Glidden DV, et al. "Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation." Am Heart J. 2016;175:9-17.
Ogunwale AN, Morrison AC, Sun W, et al. "The impact of multiple single day blood pressure readings on cardiovascular risk estimation: The Atherosclerosis Risk in Communities study." Eur J Prev Cardiol. 2016;23(14):1529-36.
Kim S, Cai J. "Improving the efficiency of estimation in the additive hazards model for stratified case-cohort design with multiple diseases." Stat Med. 2016;35(2):282-93.
Wu C, Demerath EW, Pankow JS, et al. "Imputation of missing covariate values in epigenome-wide analysis of DNA methylation data." Epigenetics. 2016;11(2):132-9.
Nadruz W, Gonçalves A, Claggett B, et al. "Influence of cigarette smoking on cardiac biomarkers: the Atherosclerosis Risk in Communities (ARIC) Study." Eur J Heart Fail. 2016;18(6):629-37.
Ma Y, Follis JL, Smith CE, et al. "Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium." Am J Clin Nutr. 2016;103(2):567-78.
X Androulakis M, Kodumuri N, Giamberardino LD, Rosamond WD, Gottesman RF, Yim E. "Ischemic stroke subtypes and migraine with visual aura in the ARIC study." Neurology. 2016;87(24):2527-2532.
Parrinello CM, Grams ME, Sang Y, et al. "Iterative Outlier Removal: A Method for Identifying Outliers in Laboratory Recalibration Studies." Clin Chem. 2016;62(7):966-72.
Daya N, Voskertchian A, Schneider ALC, et al. "Kidney Function and Fracture Risk: The Atherosclerosis Risk in Communities (ARIC) Study." Am J Kidney Dis. 2016;67(2):218-226.
Suzuki T, Agarwal SK, Deo R, et al. "Kidney function and sudden cardiac death in the community: The Atherosclerosis Risk in Communities (ARIC) Study." Am Heart J. 2016;180:46-53.
Grams ME, Sang Y, Levey AS, et al. "Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate." N Engl J Med. 2016;374(5):411-21.
Tajuddin SM, Schick UM, Eicher JD, et al. "Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases." Am J Hum Genet. 2016;99(1):22-39.
Gonçalves A, Hung C-L, Claggett B, et al. "Left Atrial Structure and Function Across the Spectrum of Cardiovascular Risk in the Elderly: The Atherosclerosis Risk in Communities Study." Circ Cardiovasc Imaging. 2016;9(2):e004010.
Power MC, Schneider ALC, Wruck L, et al. "Life-course blood pressure in relation to brain volumes." Alzheimers Dement. 2016;12(8):890-9.
Tang W, Yao L, Roetker NS, et al. "Lifetime Risk and Risk Factors for Abdominal Aortic Aneurysm in a 24-Year Prospective Study: The ARIC Study (Atherosclerosis Risk in Communities)." Arterioscler Thromb Vasc Biol. 2016;36(12):2468-2477.
Bell EJ, Lutsey PL, Basu S, Cushman M, Heckbert SR, Lloyd-Jones DM. "Lifetime Risk of Venous Thromboembolism in Two Cohort Studies." Am J Med. 2016;129(3):339.e19-26.
Rodriguez S, Gaunt TR, Guo Y, et al. "Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array." Eur J Hum Genet. 2016;24(1):106-12.
"Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study." Lancet Neurol. 2016;15(2):174-184.
Petruski-Ivleva N, Viera AJ, Shimbo D, et al. "Longitudinal Patterns of Change in Systolic Blood Pressure and Incidence of Cardiovascular Disease: The Atherosclerosis Risk in Communities Study." Hypertension. 2016;67(6):1150-6.
Yu B, Li AH, Metcalf GA, et al. "Loss-of-function variants influence the human serum metabolome." Sci Adv. 2016;2(8):e1600800.