ARIC Publications
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Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function." Nat Commun. 2018;9(1):2976.
"A catalog of genetic loci associated with kidney function from analyses of a million individuals." Nat Genet. 2019;51(6):957-972.
"Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community." J Am Heart Assoc. 2017;6(1).
"ARIC hemostasis study--II. Organizational plan and feasibility study." Thromb Haemost. 1990;64(4):521-5.
"Statistical methods for association tests of multiple continuous traits in genome-wide association studies." Ann Hum Genet. 2015;79(4):282-93.
"Subclinical Vascular Disease Burden and Premature Mortality Among Middle-aged Adults: the Atherosclerosis Risk in Communities Study." J Gen Intern Med. 2021.
"Sequence Kernel Association Test of Multiple Continuous Phenotypes." Genet Epidemiol. 2016;40(2):91-100.
"Association of coagulation factors and inhibitors with carotid artery atherosclerosis. Early results of the Atherosclerosis Risk in Communities (ARIC) Study." Ann Epidemiol. 1992;2(4):471-80.
"Genome-wide association test of multiple continuous traits using imputed SNPs." Stat Interface. 2017;10(3):379-386.
"On Efficient and Accurate Calculation of Significance P-Values for Sequence Kernel Association Testing of Variant Set." Ann Hum Genet. 2016;80(2):123-35.
"Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease." Circulation. 2003;107(13):1729-32.
"Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment." JAMA Netw Open. 2019;2(5):e193359.
"Sequence Kernel Association Analysis of Rare Variant Set Based on the Marginal Regression Model for Binary Traits." Genet Epidemiol. 2015;39(6):399-405.
"Fast and Accurate Genome-Wide Association Test of Multiple Quantitative Traits." Comput Math Methods Med. 2018;2018:2564531.
"Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained." PLoS Genet. 2013;9(3):e1003379.
"Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease." Circulation. 2001;103(10):1386-9.
"Imputation of missing covariate values in epigenome-wide analysis of DNA methylation data." Epigenetics. 2016;11(2):132-9.
"The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8." J Am Coll Cardiol. 2021;77(23):2939-2959.
"Within-person variability in calculated risk factors: comparing the aetiological association of adiposity ratios with risk of coronary heart disease." Int J Epidemiol. 2013;42(3):849-59.
"Defining the role of common variation in the genomic and biological architecture of adult human height." Nat Genet. 2014;46(11):1173-86.
"Age-related macular degeneration and risk for stroke." Ann Intern Med. 2006;145(2):98-106.
"Cerebral white matter lesions, retinopathy, and incident clinical stroke." JAMA. 2002;288(1):67-74.
"Apolipoprotein E gene and early age-related maculopathy: the Atherosclerosis Risk in Communities Study." Ophthalmology. 2006;113(2):255-9.
"Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study." Lancet. 2001;358(9288):1134-40.
"Retinopathy and risk of congestive heart failure." JAMA. 2005;293(1):63-9.
"Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the Atherosclerosis Risk in Communities Study." Stroke. 2002;33(6):1487-92.
"Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons." JAMA. 2002;287(19):2528-33.
"Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes: A Pooling Project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study." Diabetes Care. 2016;39(5):668-76.
"Retinal arteriolar diameter and risk for hypertension." Ann Intern Med. 2004;140(4):248-55.
"Age-related macular degeneration and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study." Ophthalmology. 2007;114(1):86-91.
"Racial differences in the prevalence of hypertensive retinopathy." Hypertension. 2003;41(5):1086-91.
"Retinal microvascular abnormalities and renal dysfunction: the atherosclerosis risk in communities study." J Am Soc Nephrol. 2004;15(9):2469-76.
"Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study." JAMA. 2002;287(9):1153-9.
"Three-year incidence and cumulative prevalence of retinopathy: the atherosclerosis risk in communities study." Am J Ophthalmol. 2007;143(6):970-6.
"Hospitalization Risk among Older Adults with Chronic Kidney Disease." Am J Nephrol. 2019;50(3):212-220.
"Is early age-related maculopathy related to cognitive function? The Atherosclerosis Risk in Communities Study." Am J Ophthalmol. 2002;134(6):828-35.
"Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities study." Invest Ophthalmol Vis Sci. 2004;45(9):2949-54.
"Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people." Neurology. 2003;61(6):806-11.
"Genetic analyses of diverse populations improves discovery for complex traits." Nature. 2019;570(7762):514-518.
"Obesity Hypertension in the Atherosclerosis Risk in Communities Cohort: Implications of Obesity Guidelines." J Clin Hypertens (Greenwich). 1999;1(1):27-32.
"Heart Failure and Cognitive Impairment in the Atherosclerosis Risk in Communities (ARIC) Study." J Gen Intern Med. 2018;33(10):1721-1728.
"A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation." Circ Arrhythm Electrophysiol. 2011;4(1):87-93.
"Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study." PLoS Genet. 2016;12(6):e1006166.
"Quality control and conduct of genome-wide association meta-analyses." Nat Protoc. 2014;9(5):1192-212.
"The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study." PLoS Genet. 2015;11(10):e1005378.
"Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study." Sleep. 2009;32(6):772-8.
"Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study." Neurology. 2008;70(1):35-42.
"Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study." J Gerontol A Biol Sci Med Sci. 2017;72(1):89-94.
"Relationship Between Midlife Cardiovascular Health and Late-Life Physical Performance: The ARIC Study." J Am Geriatr Soc. 2017;65(5):1012-1018.
"Covert neurological symptoms associated with silent infarcts from midlife to older age: the Atherosclerosis Risk in Communities study." Stroke. 2012;43(5):1218-23.
"The Importance of Mid-to-Late-Life Body Mass Index Trajectories on Late-Life Gait Speed." J Gerontol A Biol Sci Med Sci. 2017;72(8):1130-1136.
"Small Brain Lesions and Incident Stroke and Mortality: A Cohort Study." Ann Intern Med. 2015;163(1):22-31.
"Midlife Smaller and Larger Infarctions, White Matter Hyperintensities, and 20-Year Cognitive Decline: A Cohort Study." Ann Intern Med. 2019;171(6):389-396.
"Anger proneness predicts coronary heart disease risk: prospective analysis from the atherosclerosis risk in communities (ARIC) study." Circulation. 2000;101(17):2034-9.
"Vital exhaustion as a risk factor for adverse cardiac events (from the Atherosclerosis Risk In Communities [ARIC] study)." Am J Cardiol. 2010;105(12):1661-5.
"Racial disparities in CHD mortality from 1968-1992 in the state economic areas surrounding the ARIC study communities. Atherosclerosis Risk in Communities." Ann Epidemiol. 1999;9(8):472-80.
"Effects of an angry temperament on coronary heart disease risk : The Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2001;154(3):230-5.
"Trait anger and arterial stiffness: results from the Atherosclerosis Risk in Communities (ARIC) study." Prev Cardiol. 2006;9(1):14-20.
"The association between trait anger and incident stroke risk: the Atherosclerosis Risk in Communities (ARIC) Study." Stroke. 2002;33(1):13-9.
"Race-gender differences in the association of trait anger with subclinical carotid artery atherosclerosis: the Atherosclerosis Risk in Communities Study." Am J Epidemiol. 2007;165(11):1296-304.
"Association between exposure to combat-related stress and psychological health in aging men: the Atherosclerosis Risk in Communities (ARIC) Study." J Trauma Stress. 2010;23(3):358-66.
"Association of the IGF1 gene with fasting insulin levels." Eur J Hum Genet. 2016;24(9):1337-43.
"Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis." Lancet Diabetes Endocrinol. 2016;4(10):840-9.
"Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function." J Clin Invest. 2017;127(5):1798-1812.
"Resistance to antihypertensive treatment and long-term risk: The Atherosclerosis Risk in Communities study." J Clin Hypertens (Greenwich). 2021;23(10):1887-1896.
"Accuracy and repeatability of commercial geocoding." Am J Epidemiol. 2004;160(10):1023-9.
"NT -pro BNP as a Mediator of the Racial Difference in Incident Atrial Fibrillation and Heart Failure." J Am Heart Assoc. 2019;8(7):e010868.
"Covariate-adjusted measures of discrimination for survival data." Biom J. 2015;57(4):592-613.
"Sex and race differences in short-term prognosis after acute coronary heart disease events: the Atherosclerosis Risk In Communities (ARIC) study." Am Heart J. 1999;138(3 Pt 1):540-8.
"POGZ truncating alleles cause syndromic intellectual disability." Genome Med. 2016;8(1):3.
"Community surveillance of coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) Study: methods and initial two years' experience." J Clin Epidemiol. 1996;49(2):223-33.
"Elevated high-sensitivity C-reactive protein as a risk marker of the attenuated relationship between serum cholesterol and cardiovascular events at older age. The ARIC Study." Am J Epidemiol. 2013;178(7):1076-84.
"High-Sensitivity Cardiac Troponin T (hs-cTnT) as a Predictor of Incident Diabetes in the Atherosclerosis Risk in Communities Study." Diabetes Care. 2017;40(2):261-269.
"Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis." PLoS Med. 2017;14(9):e1002383.
"Neuroimaging findings in midlife and risk of late-life dementia over 20 years of follow-up." Neurology. 2019;92(9):e917-e923.
"The PPARG Pro12Ala Polymorphism and 20-year Cognitive Decline: Race and Sex Heterogeneity." Alzheimer Dis Assoc Disord. 2018;32(2):131-136.
"Cognition and 20-year subsequent sleep disturbances." Sleep Health. 2021.
"Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility." Nat Commun. 2015;6:5897.
"Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables." Thromb Res. 2018;168:53-59.
"Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation." Circ Genom Precis Med. 2020;13(5):387-395.
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