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ARIC Publications

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2021
Palmer ND, Kahali B, Kuppa A, et al. "Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction." Hum Mol Genet. 2021;30(15):1443-1456.
Murthy SB, Zhang C, Diaz I, et al. "Association Between Intracerebral Hemorrhage and Subsequent Arterial Ischemic Events in Participants From 4 Population-Based Cohort Studies." JAMA Neurol. 2021;78(7):809-816.
Georgakis MK, de Lemos JA, Ayers C, et al. "Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies." JAMA Cardiol. 2021;6(5):587-592.
Georgakis MK, de Lemos JA, Ayers C, et al. "Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies." JAMA Cardiol. 2021;6(5):587-592.
Hyacinth HI, Franceschini N, Seals SR, et al. "Association of Sickle Cell Trait With Incidence of Coronary Heart Disease Among African American Individuals." JAMA Netw Open. 2021;4(1):e2030435.
Pandey A, Vaduganathan M, Patel KV, et al. "Biomarker-Based Risk Prediction of Incident Heart Failure in Pre-Diabetes and Diabetes." JACC Heart Fail. 2021;9(3):215-223.
Natarajan P, Pampana A, Graham SE, et al. "Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices." Nat Commun. 2021;12(1):2182.
Natarajan P, Pampana A, Graham SE, et al. "Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices." Nat Commun. 2021;12(1):2182.
Oelsner EC, Allen NBai, Ali T, et al. "Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design." medRxiv. 2021.
Goodrich JK, Singer-Berk M, Son R, et al. "Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes." Nat Commun. 2021;12(1):3505.
Fang M, Ishigami J, Echouffo-Tcheugui JB, Lutsey PL, Pankow JS, Selvin E. "Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study." Diabetologia. 2021.
Graff M, Justice AE, Young KL, et al. "Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry." Am J Hum Genet. 2021;108(4):564-582.
Echouffo-Tcheugui JB, Zhang S, Florido R, et al. "Duration of Diabetes and Incident Heart Failure: The ARIC (Atherosclerosis Risk In Communities) Study." JACC Heart Fail. 2021;9(8):594-603.
Gondalia R, Baldassari A, Holliday KM, et al. "Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study." Environ Res. 2021;198:111211.
Ruth KS, Day FR, Hussain J, et al. "Genetic insights into biological mechanisms governing human ovarian ageing." Nature. 2021;596(7872):393-397.
Ruth KS, Day FR, Hussain J, et al. "Genetic insights into biological mechanisms governing human ovarian ageing." Nature. 2021;596(7872):393-397.
Ruth KS, Day FR, Hussain J, et al. "Genetic insights into biological mechanisms governing human ovarian ageing." Nature. 2021;596(7872):393-397.
Ruth KS, Day FR, Hussain J, et al. "Genetic insights into biological mechanisms governing human ovarian ageing." Nature. 2021;596(7872):393-397.
Schunk SJ, Kleber ME, März W, et al. "Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality." Eur Heart J. 2021;42(18):1742-1756.
Schunk SJ, Kleber ME, März W, et al. "Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality." Eur Heart J. 2021;42(18):1742-1756.
Schunk SJ, Kleber ME, März W, et al. "Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality." Eur Heart J. 2021;42(18):1742-1756.
McCartney DL, Min JL, Richmond RC, et al. "Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging." Genome Biol. 2021;22(1):194.
McCartney DL, Min JL, Richmond RC, et al. "Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging." Genome Biol. 2021;22(1):194.
Ahluwalia TS, Prins BP, Abdollahi M, et al. "Genome-wide association study of circulating interleukin 6 levels identifies novel loci." Hum Mol Genet. 2021;30(5):393-409.
Ahluwalia TS, Prins BP, Abdollahi M, et al. "Genome-wide association study of circulating interleukin 6 levels identifies novel loci." Hum Mol Genet. 2021;30(5):393-409.
Ahluwalia TS, Prins BP, Abdollahi M, et al. "Genome-wide association study of circulating interleukin 6 levels identifies novel loci." Hum Mol Genet. 2021;30(5):393-409.
Ahluwalia TS, Prins BP, Abdollahi M, et al. "Genome-wide association study of circulating interleukin 6 levels identifies novel loci." Hum Mol Genet. 2021;30(5):393-409.
Selvin E, Wang D, Tang O, Minotti M, Echouffo-Tcheugui JB, Coresh J. "Glucose Patterns in Very Old Adults: A Pilot Study in a Community-Based Population." Diabetes Technol Ther. 2021.
Echouffo-Tcheugui JB, Daya N, Matsushita K, et al. "Growth Differentiation Factor (GDF)-15 and Cardiometabolic Outcomes among Older Adults: The Atherosclerosis Risk in Communities Study." Clin Chem. 2021;67(4):653-661.
Commodore-Mensah Y, Lazo M, Tang O, et al. "High Burden of Subclinical and Cardiovascular Disease Risk in Adults with Metabolically Healthy Obesity: The Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2021.
Ebong IA, Wilson MD, Bertoni AG, et al. "High-sensitivity cardiac troponin T and the risk of heart failure in postmenopausal women of the ARIC Study." Menopause. 2021;28(3):284-291.
Gorski M, Jung B, Li Y, et al. "Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline." Kidney Int. 2021;99(4):926-939.
Gorski M, Jung B, Li Y, et al. "Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline." Kidney Int. 2021;99(4):926-939.
Wang H, Noordam R, Cade BE, et al. "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure." Mol Psychiatry. 2021.
Wang H, Noordam R, Cade BE, et al. "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure." Mol Psychiatry. 2021.
Wang H, Noordam R, Cade BE, et al. "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure." Mol Psychiatry. 2021.
Madrid L, Moreno-Grau S, Ahmad S, et al. "Multiomics integrative analysis identifies allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis." Aging (Albany NY). 2021;13(7):9277-9329.
Kahali B, Chen Y, Feitosa MF, et al. "A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction." J Clin Endocrinol Metab. 2021;106(2):372-387.
Seplyarskiy VB, Soldatov RA, Koch E, et al. "Population sequencing data reveal a compendium of mutational processes in the human germ line." Science. 2021;373(6558):1030-1035.
Seplyarskiy VB, Soldatov RA, Koch E, et al. "Population sequencing data reveal a compendium of mutational processes in the human germ line." Science. 2021;373(6558):1030-1035.
Briceño EM, Gross AL, Giordani BJ, et al. "Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS." J Alzheimers Dis. 2021.
Palta P, A Sharrett R, Gabriel KPettee, et al. "Prospective Analysis of Leisure-Time Physical Activity in Midlife and Beyond and Brain Damage on MRI in Older Adults." Neurology. 2021;96(7):e964-e974.
Choi SHoan, Jurgens SJ, Haggerty CM, et al. "Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis." Circ Genom Precis Med. 2021;14(4):e003300.
Quispe R, Martin SS, Michos ED, et al. "Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study." Eur Heart J. 2021.
Kwong AM, Blackwell TW, LeFaive J, et al. "Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries." Genetics. 2021;218(1).
Kwong AM, Blackwell TW, LeFaive J, et al. "Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries." Genetics. 2021;218(1).
Taliun D, Harris DN, Kessler MD, et al. "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program." Nature. 2021;590(7845):290-299.
Taliun D, Harris DN, Kessler MD, et al. "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program." Nature. 2021;590(7845):290-299.
Taliun D, Harris DN, Kessler MD, et al. "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program." Nature. 2021;590(7845):290-299.
Taliun D, Harris DN, Kessler MD, et al. "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program." Nature. 2021;590(7845):290-299.
Levine DA, Gross AL, Briceño EM, et al. "Sex Differences in Cognitive Decline Among US Adults." JAMA Netw Open. 2021;4(2):e210169.
Lagou V, Mägi R, Hottenga J-Jan, et al. "Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability." Nat Commun. 2021;12(1):24.
Lagou V, Mägi R, Hottenga J-Jan, et al. "Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability." Nat Commun. 2021;12(1):24.
Lagou V, Mägi R, Hottenga J-Jan, et al. "Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability." Nat Commun. 2021;12(1):24.
Yu B, Roberts MB, Raffield LM, et al. "Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure." J Am Coll Cardiol. 2021;78(1):42-52.
Yu B, Roberts MB, Raffield LM, et al. "Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure." J Am Coll Cardiol. 2021;78(1):42-52.
Stilp AM, Emery LS, Broome JG, et al. "A System for Phenotype Harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Program." Am J Epidemiol. 2021;190(10):1977-1992.
Stilp AM, Emery LS, Broome JG, et al. "A System for Phenotype Harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Program." Am J Epidemiol. 2021;190(10):1977-1992.
Chen J, Spracklen CN, Marenne G, et al. "The trans-ancestral genomic architecture of glycemic traits." Nat Genet. 2021;53(6):840-860.
Chen J, Spracklen CN, Marenne G, et al. "The trans-ancestral genomic architecture of glycemic traits." Nat Genet. 2021;53(6):840-860.
Chen J, Spracklen CN, Marenne G, et al. "The trans-ancestral genomic architecture of glycemic traits." Nat Genet. 2021;53(6):840-860.