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Relations between hemostasis variables and cardiovascular risk factors in middle-aged adults. Atherosclerosis Risk in Communities (ARIC) Study Investigators.

TitleRelations between hemostasis variables and cardiovascular risk factors in middle-aged adults. Atherosclerosis Risk in Communities (ARIC) Study Investigators.
Publication TypeJournal Article
Year of Publication1992
AuthorsFolsom AR, Conlan MG, Davis CE, Wu KK
JournalAnn Epidemiol
Volume2
Issue4
Pagination481-94
Date Published1992 Jul
ISSN1047-2797
KeywordsAfrican Continental Ancestry Group, Antithrombin III, Blood Coagulation Factors, Cardiovascular Diseases, Factor VII, Factor VIII, Female, Fibrinogen, Hemostasis, Humans, Male, Middle Aged, Protein C, Risk Factors, von Willebrand Factor
Abstract

The relations between hemostatic variables and cardiovascular risk factors were examined in a biracial population sample of middle-aged adults. Fibrinogen, factor VII, factor VIII, von Willebrand factor, protein C, and antithrombin III levels varied considerably by age, sex, and race. Hemostatic variables also were associated with several life-style and biochemical risk factors. For the most part, higher levels of the risk factors were associated with higher levels of the hemostatic variables. The findings point to potential confounders that warrant consideration in cardiovascular disease studies, and/or mechanisms by which cardiovascular risk is conferred. They also suggest that modification of the cardiovascular risk factors may have the potential to alter the risk of thrombosis.

DOI10.1016/1047-2797(92)90098-b
Alternate JournalAnn Epidemiol
PubMed ID1342299
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States