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Distributions of hemostatic variables in blacks and whites: population reference values from the Atherosclerosis Risk in Communities (ARIC) Study.

TitleDistributions of hemostatic variables in blacks and whites: population reference values from the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication1992
AuthorsFolsom AR, Wu KK, Conlan MG, Finch A, Davis CE, Marcucci G, Sorlie PD, Szklo M
JournalEthn Dis
Volume2
Issue1
Pagination35-46
Date Published1992 Winter
ISSN1049-510X
KeywordsAfrican Continental Ancestry Group, Arteriosclerosis, Blood Coagulation Factors, Diet, European Continental Ancestry Group, Female, Humans, Male, Maryland, Middle Aged, Minnesota, Mississippi, North Carolina, Prospective Studies, Reference Values, Residence Characteristics, Seasons, Sex Factors
Abstract

The Atherosclerosis Risk in Communities Study measured hemostatic variables in nearly 16,000 men and women, aged 45 to 64 years, from four US communities. This report, based on the first 12,681 participants, presents distributions of fibrinogen concentration, factor VII activity, factor VIII activity, von Willebrand factor antigen, protein C antigen, antithrombin III activity, and activated partial thromboplastin time. Many of the hemostatic variables differed between blacks and whites, and by sex and age. For example, compared to whites, blacks had higher mean values of fibrinogen, factor VIII, von Willebrand factor, and antithrombin III, and lower mean values of protein C. Some seasonal fluctuations in hemostatic variables were noted; most notably, mean values of factor VII were lowest and protein C were highest in subjects examined in the summer compared to those examined during the other seasons. These results provide population-based reference values on blacks and whites for those interested in the relation of hemostasis to disease.

Alternate JournalEthn Dis
PubMed ID1458214
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States