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Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors.

TitlePopulation correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors.
Publication TypeJournal Article
Year of Publication1991
AuthorsFolsom AR, Wu KK, Davis CE, Conlan MG, Sorlie PD, Szklo M
JournalAtherosclerosis
Volume91
Issue3
Pagination191-205
Date Published1991 Dec
ISSN0021-9150
KeywordsBody Constitution, Cardiovascular Diseases, Continental Population Groups, Coronary Disease, Factor VII, Female, Fibrinogen, Humans, Life Style, Lipids, Male, Middle Aged, Prospective Studies, Risk Factors, Sex Factors, Smoking
Abstract

Recent prospective investigations have reported that higher plasma fibrinogen concentrations and higher factor VII coagulant activity are associated with greater risk of cardiovascular disease. To discover what characteristics may influence fibrinogen and factor VII, we analyzed data from the Atherosclerosis Risk in Communities Study obtained from over 12,000 men and women, aged 45-64 years, from four communities in December 1986 to June 1989. Fibrinogen was higher in blacks than whites and in women than men; in general, it increased with age, smoking, body size, diabetes, fasting serum insulin, LDL cholesterol, lipoprotein(a), leukocyte count, and menopause, and it decreased with ethanol intake, physical activity, HDL cholesterol, and female hormone use. Factor VII was higher in women than men and, in women, increased with age; in both sexes, it increased with body size, triglycerides, LDL cholesterol, and HDL cholesterol, and it decreased with ethanol intake. These findings indicate that elevations in fibrinogen and factor VII may be modifiable through appropriate lifestyle changes.

DOI10.1016/0021-9150(91)90167-2
Alternate JournalAtherosclerosis
PubMed ID1789804
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States