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Low serum albumin. Association with diabetes mellitus and other cardiovascular risk factors but not with prevalent cardiovascular disease or carotid artery intima-media thickness. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.

TitleLow serum albumin. Association with diabetes mellitus and other cardiovascular risk factors but not with prevalent cardiovascular disease or carotid artery intima-media thickness. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.
Publication TypeJournal Article
Year of Publication1995
AuthorsFolsom AR, Ma J, Eckfeldt JH, Nieto FJ, Metcalf PA, Barnes RW
JournalAnn Epidemiol
Volume5
Issue3
Pagination186-91
Date Published1995 May
ISSN1047-2797
KeywordsAfrican Continental Ancestry Group, Arteriosclerosis, Cardiovascular Diseases, Carotid Stenosis, Diabetes Mellitus, European Continental Ancestry Group, Female, Hemostasis, Humans, Male, Middle Aged, Prevalence, Risk Factors, Serum Albumin, Sex Factors, Tunica Intima, Tunica Media, Ultrasonography, United States
Abstract

We examined the association of serum albumin concentration with diabetes mellitus and other cardiovascular risk factors, prevalent cardiovascular disease, and ultrasonographically assessed carotid artery intima-media thickness using data from 45- to 64-year-old adults in the Atherosclerosis Risk in Communities (ARIC) Study. The mean albumin concentration was 0.04 to 0.12 g/L lower in participants with diabetes and 0.02 to 0.06 g/L lower in those with cardiovascular disease, compared to participants without these conditions. However, lower serum albumin level was also correlated with most traditional risk factors and hemostatic variables. On adjustment for these, there was essentially no association between serum albumin and prevalent cardiovascular disease. Likewise, there was no association between albumin and carotid intima-media thickness (a marker of atherosclerosis). While hypoalbuminemia may be a marker for chronic disease and perhaps renal loss of albumin, it seems unlikely that it is an important cause of atherosclerosis.

DOI10.1016/1047-2797(94)00105-3
Alternate JournalAnn Epidemiol
PubMed ID7606307
Grant ListN01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States