| Title | No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. |
| Publication Type | Journal Article |
| Year of Publication | 1995 |
| Authors | Moore M, Folsom AR, Barnes RW, Eckfeldt JH |
| Journal | Am J Epidemiol |
| Volume | 141 |
| Issue | 8 |
| Pagination | 719-23 |
| Date Published | 1995 Apr 15 |
| ISSN | 0002-9262 |
| Keywords | Arteriosclerosis, Carotid Artery Diseases, Case-Control Studies, Diet, Female, Ferritins, Humans, Iron, Male, Middle Aged, Odds Ratio, Risk Factors, Tunica Intima, Tunica Media |
| Abstract | A possible association between body iron stores, measured as serum ferritin, and carotid arterial intima-media thickening was investigated in the Atherosclerosis Risk in Communities Study during 1990-1992 using a matched case-control design. For a 143-micrograms/liter greater serum ferritin concentration (the interquartile range), the odds ratio for cases with carotid intima-media thickening versus controls was 1.12 (95% confidence interval 0.97-1.30). However, there was no association (odds ratio = 1.00) after adjusting for major cardiovascular risk factors. This analysis of carotid arterial intima-media thickening, a measure of early atherosclerosis, in relation to serum ferritin does not support the hypothesis that increased body iron stores increase the risk of atherosclerotic cardiovascular disease. |
| DOI | 10.1093/oxfordjournals.aje.a117493 |
| Alternate Journal | Am J Epidemiol |
| PubMed ID | 7709914 |
| Grant List | N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States |