|Title||Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities Study.|
|Publication Type||Journal Article|
|Year of Publication||1995|
|Authors||Salomaa V, Stinson V, Kark JD, Folsom AR, Davis CE, Wu KK|
|Date Published||1995 Jan 15|
|Keywords||Arteriosclerosis, Case-Control Studies, Dose-Response Relationship, Drug, Female, Fibrin Fibrinogen Degradation Products, Fibrinolysis, Humans, Male, Plasminogen Activator Inhibitor 1, Regression Analysis, Tissue Plasminogen Activator|
BACKGROUND: Thrombosis, provoked by a rupture of an atherosclerotic plaque, plays a crucial role in precipitating a coronary heart disease event. Its role at the early stage of atherosclerosis has, however, been unclear, but it has been hypothesized that thrombosis or defective fibrinolysis contributes to the progression of atherosclerotic lesions.
METHODS AND RESULTS: We studied the association of plasminogen activator inhibitor antigen (PAI-1), tissue-type plasminogen activator antigen (TPA), and D-dimer with early atherosclerosis in a cross-sectional case-control study involving 457 pairs chosen from the biracial cohort of the Atherosclerosis Risk in Communities (ARIC) Study. As examined by B-mode ultrasound, patients (cases) had intima-media thickness of carotid arteries above the 90th percentile and control subjects had thickness below the 75th percentile of the ARIC cohort. Persons with a history of heart disease, stroke, or claudication were excluded from the case-control selection. PAI-1, TPA, and D-dimer were higher in patients than in control subjects (P
CONCLUSIONS: The findings support the hypothesis that thrombosis and fibrinolysis play a role at the early stage of the atherosclerotic process.
|Grant List||N01-55015 / / PHS HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States