Pulse lineResearch With Heart Logo

Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities Study.

TitleAssociation of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication1995
AuthorsSalomaa V, Stinson V, Kark JD, Folsom AR, Davis CE, Wu KK
JournalCirculation
Volume91
Issue2
Pagination284-90
Date Published1995 Jan 15
ISSN0009-7322
KeywordsArteriosclerosis, Case-Control Studies, Dose-Response Relationship, Drug, Female, Fibrin Fibrinogen Degradation Products, Fibrinolysis, Humans, Male, Plasminogen Activator Inhibitor 1, Regression Analysis, Tissue Plasminogen Activator
Abstract

BACKGROUND: Thrombosis, provoked by a rupture of an atherosclerotic plaque, plays a crucial role in precipitating a coronary heart disease event. Its role at the early stage of atherosclerosis has, however, been unclear, but it has been hypothesized that thrombosis or defective fibrinolysis contributes to the progression of atherosclerotic lesions.

METHODS AND RESULTS: We studied the association of plasminogen activator inhibitor antigen (PAI-1), tissue-type plasminogen activator antigen (TPA), and D-dimer with early atherosclerosis in a cross-sectional case-control study involving 457 pairs chosen from the biracial cohort of the Atherosclerosis Risk in Communities (ARIC) Study. As examined by B-mode ultrasound, patients (cases) had intima-media thickness of carotid arteries above the 90th percentile and control subjects had thickness below the 75th percentile of the ARIC cohort. Persons with a history of heart disease, stroke, or claudication were excluded from the case-control selection. PAI-1, TPA, and D-dimer were higher in patients than in control subjects (P

CONCLUSIONS: The findings support the hypothesis that thrombosis and fibrinolysis play a role at the early stage of the atherosclerotic process.

DOI10.1161/01.cir.91.2.284
Alternate JournalCirculation
PubMed ID7805229
Grant ListN01-55015 / / PHS HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States