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Correlation of plasma protein C levels with cardiovascular risk factors in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleCorrelation of plasma protein C levels with cardiovascular risk factors in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication1993
AuthorsConlan MG, Folsom AR, Finch A, Davis CE, Sorlie P, Wu KK
JournalThromb Haemost
Volume70
Issue5
Pagination762-7
Date Published1993 Nov 15
ISSN0340-6245
KeywordsAge Factors, Alcohol Drinking, Arteriosclerosis, Blood Coagulation Factors, Body Mass Index, Cardiovascular Diseases, Cohort Studies, Continental Population Groups, Female, Gonadal Steroid Hormones, Humans, Lipids, Male, Middle Aged, Protein C, Reference Values, Risk Factors, Sex Factors, Smoking, United States
Abstract

To evaluate the association of plasma protein C levels with constitutional, socioeconomic, life-style and biochemical factors important in cardiovascular diseases, we measured protein C levels in 12,290 middle aged (45-64 years) subjects participating in the ARIC study. Protein C levels had a normal distribution with a mean value of 3.17 micrograms/ml. They were higher in women than men and in whites than blacks; higher in postmenopausal women and further increased by hormonal supplements. The age influence was inconsistent and was considered to be inconsequential. Protein C levels were positively correlated with body mass index, LDL-cholesterol, HDL-cholesterol, and triglycerides and negatively associated with cigarette smoking. These factors should be taken into consideration when establishing normal protein C levels and when analyzing the relation between protein C and arterial and venous thrombotic disorders.

Alternate JournalThromb Haemost
PubMed ID8128432
Grant ListN01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States