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Lipoprotein(a) as a risk factor for preclinical atherosclerotic disease in a biracial cohort: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleLipoprotein(a) as a risk factor for preclinical atherosclerotic disease in a biracial cohort: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication1994
AuthorsSchreiner PJ
JournalChem Phys Lipids
Volume67-68
Pagination405-10
Date Published1994 Jan
ISSN0009-3084
KeywordsAfrican Continental Ancestry Group, Arteriosclerosis, Cohort Studies, European Continental Ancestry Group, Female, Humans, Lipoprotein(a), Male, Middle Aged, Prospective Studies, Risk Factors, Sex Characteristics, United States
Abstract

Lipoprotein(a) (Lp(a)) is a risk factor for clinically manifest coronary heart disease (CHD) and cerebrovascular disease in Caucasian and in Asian populations. The role of Lp(a) as a risk factor in blacks has not been described, despite the markedly higher levels of Lp(a) and excess CHD and stroke prevalence observed in middle-aged blacks compared with whites. Further, little information exists on the association of Lp(a) and asymptomatic atherosclerosis in any race or gender group. In this report, 15,700 middle-aged black and white participants in the Atherosclerosis Risk in Communities (ARIC) Study had complete B-mode ultrasound scans of their extracranial carotid arteries. Of the 13,384 individuals with complete B-mode data at the carotid bifurcation, those with mean carotid bifurcation intima-media wall thickness at or above the 90th percentile of the population distribution (approximately 1.2 mm) were considered to have carotid atherosclerosis. Lp(a) was measured as its total protein content by double-antibody ELISA for apo(a) detection. Blacks in this study had mean Lp(a) protein values that were twice as high as those of whites (168.9, 147.1, 86.6, and 75.1 micrograms/ml for black females, black males, white females, and white males, respectively). For all race and gender groups, Lp(a) protein concentrations were higher among individuals with carotid atherosclerosis than for those without. From these cross-sectional data, we conclude that Lp(a) protein is a risk factor for preclinical atherosclerosis as well as for clinically manifest cardiovascular disease.(ABSTRACT TRUNCATED AT 250 WORDS)

DOI10.1016/0009-3084(94)90163-5
Alternate JournalChem Phys Lipids
PubMed ID8187241