| Title | The relation of lipoprotein[a] concentrations and apolipoprotein[a] phenotypes with asymptomatic atherosclerosis in subjects of the Atherosclerosis Risk in Communities (ARIC) Study. |
| Publication Type | Journal Article |
| Year of Publication | 1993 |
| Authors | Brown SA, Morrisett JD, Boerwinkle E, Hutchinson R, Patsch W |
| Journal | Arterioscler Thromb |
| Volume | 13 |
| Issue | 11 |
| Pagination | 1558-66 |
| Date Published | 1993 Nov |
| ISSN | 1049-8834 |
| Keywords | Alleles, Apolipoproteins A, Apolipoproteins B, Arteriosclerosis, Carotid Artery Diseases, Case-Control Studies, Cholesterol, HDL, Estrogen Replacement Therapy, Female, Humans, Lipoprotein(a), Male, Middle Aged, Phenotype, Polymorphism, Genetic, Risk Factors |
| Abstract | Plasma levels of lipoprotein[a] (Lp[a]) are associated with increased risk of coronary artery disease and show an inverse correlation with apolipoprotein[a] (apo[a]) molecular weight. We determined Lp[a] levels and apo[a] phenotypes in 171 cases with preclinical extracranial carotid atherosclerosis as ascertained by B-mode ultrasound and in 274 control subjects free of carotid atherosclerosis. Lp[a] protein levels measured by enzyme-linked immunosorbent assay ranged from 4 to 361 micrograms/mL in cases and from 2 to 392 micrograms/mL in controls, but median levels of Lp[a] were higher in cases than in controls (51 micrograms/mL versus 33 micrograms/mL, P |
| DOI | 10.1161/01.atv.13.11.1558 |
| Alternate Journal | Arterioscler Thromb |
| PubMed ID | 8218095 |
| Grant List | N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States |